GB1456161A - Diazepine derivatives - Google Patents
Diazepine derivativesInfo
- Publication number
- GB1456161A GB1456161A GB568374A GB568374A GB1456161A GB 1456161 A GB1456161 A GB 1456161A GB 568374 A GB568374 A GB 568374A GB 568374 A GB568374 A GB 568374A GB 1456161 A GB1456161 A GB 1456161A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkyl
- compound
- hydroxyalkyl
- alkylcarbonyloxyalkyl
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/36—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
Abstract
1456161 Thienotriazolodiazepines F HOFFMANN-LA ROCHE & CO AG 7 Feb 1974 [8 Feb 1973] 05683/74 Heading C2C Compounds of the general formula (R 1 = halogen, NO 2 , NH 2 , alkanoyl; R 2 = pyridyl or thienyl optionally substituted adjacent to linking position, phenyl, o-trifluoromethylphenyl, o - halophenyl, o,o<SP>1</SP> - dihalophenyl, o - nitrophenyl; R 3 = H, OH, alkoxycarbonyl, alkanoyloxy; R 4 = H, alkyl, alkanoyl, hydroxyalkyl, mercaptoalkyl, alkoxycarbonyl, aminocarbonyl, haloalkyl, alkoxyalkyl, alkylthioalkyl, aralkoxyalkyl, cyanoalkyl, alkoxycarbonylalkyl, alkoxycarbonylaminoalkyl, alkylcarbonyloxyalkyl, aminocarbonyloxyalkyl, dialkylaminocarbonyloxyalkyl, CN, alkyl NR 5 R 6 , COO alkyl NR 5 R 6 , CONH alkyl NR 5 R 6 ; R 5,6 = H, alkyl, hydroxyalkyl or NR 5 R 6 = monocyclic saturated 5-6 membered ring optionally containing an oxygen or further nitrogen atom; n = 0,1) and their acid addition salts are prepared by (a) cyclizing a compound of the formula (b) -n = O- cyclising a compound of the formula (c) -R 1 = halogen or NO 2 - halogenating or nitrating the corresponding 2-unsubstituted compound, (d) -R 4 = alkanoyloxidizing the corresponding 9-(α-hydroxyalkyl) compound, (e) -R 4 = alkylcarbonyloxyalkyl or aminocarbonyloxyalkylesterifying the corresponding alcohol, (f) -R 4 = alkoxyalkyl, aralkoxyalkyl, alkylthioalkyl or alkyl NR 5 R 6 - reacting a corresponding 9-A. alkyl compound with BR (one of A,B = OH, SH or NHR 5 and the other = leaving atom or group; R = alkyl or (one of A,B = OH) aralkyl, or (B = NHR 5 )H or hydroxyalkyl, or NRR 5 = monocyclic saturated 5-6 membered ring optionally containing an oxygen or further nitrogen atom), (g) -R 4 = alkylcarbonyloxyalkyl or dialkylaminocarbonyloxyalkyl-reacting the corresponding alcohol with a reactive derivative of the appropriate alkanoic or dialkylcarbamic acid, (h) -R 4 = alkoxycarbonylaminoalkylreacting a corresponding 9-K alkyl compound with L.COO- alkyl (one of K,L = NH 2 and the other = leaving atom or group) or (i) -R 4 = primary hydroxyalkylreducing a corresponding 9-alkoxy carbonyl or alkoxycarbonylalkyl compound, optionally followed by salt formation. The preparation of thienodiagepines of the formulµ and 2-amino, chloroacetamido and aminoacetamido-3-thienyl 2<SP>1</SP>-pyridyl ketone is described. The above compounds are anticonvulsants, sedatives, muscle relaxants, tranquilizerx and anxiolytics and may be administered in the form of pharmacetuical preparations containing them in association with a carrier.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH179973A CH584223A5 (en) | 1973-02-08 | 1973-02-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1456161A true GB1456161A (en) | 1976-11-17 |
Family
ID=4218866
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB539676A Expired GB1456162A (en) | 1973-02-08 | 1974-02-07 | Thienodiazepine derivatives |
| GB568374A Expired GB1456161A (en) | 1973-02-08 | 1974-02-07 | Diazepine derivatives |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB539676A Expired GB1456162A (en) | 1973-02-08 | 1974-02-07 | Thienodiazepine derivatives |
Country Status (24)
| Country | Link |
|---|---|
| JP (1) | JPS5833234B2 (en) |
| AR (2) | AR203188A1 (en) |
| AT (1) | AT343118B (en) |
| BE (1) | BE810705A (en) |
| CA (1) | CA1049009A (en) |
| CH (1) | CH584223A5 (en) |
| DD (1) | DD112454A5 (en) |
| DE (1) | DE2405682C3 (en) |
| DK (1) | DK137679B (en) |
| FI (1) | FI58129C (en) |
| FR (1) | FR2217007B1 (en) |
| GB (2) | GB1456162A (en) |
| HU (2) | HU170423B (en) |
| IE (1) | IE38883B1 (en) |
| IL (1) | IL44095A (en) |
| LU (1) | LU69338A1 (en) |
| NL (1) | NL174045C (en) |
| NO (1) | NO142260C (en) |
| PH (1) | PH12303A (en) |
| PL (3) | PL97304B1 (en) |
| SE (1) | SE416399B (en) |
| SU (3) | SU715028A3 (en) |
| YU (1) | YU39716B (en) |
| ZA (1) | ZA74472B (en) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT338799B (en) * | 1974-03-02 | 1977-09-12 | Boehringer Sohn Ingelheim | PROCESS FOR PREPARING NEW SUBSTITUTED 6-ARYL-4H-S-TRIAZOLO- (3,4C) -THIENO- (2,3E) -1,4-DIAZEPINE AND THEIR SALTS |
| DE2531678C3 (en) * | 1975-07-16 | 1979-06-28 | C.H. Boehringer Sohn, 6507 Ingelheim | Thieno [2,3e] triazole [3,4c] 5,6-dihydro-1,4-diazepines and processes for their preparation |
| DE2533924C3 (en) * | 1975-07-30 | 1979-05-03 | C.H. Boehringer Sohn, 6507 Ingelheim | Process for the preparation of 6-aryl-4H-striazolo [3,4-c] thieno [2,3-e] 1,4-diazepines |
| DE2708121A1 (en) * | 1977-02-25 | 1978-09-07 | Boehringer Sohn Ingelheim | TRIAZOLO-THIENO-DIAZEPIN-L-ONE, METHOD FOR THEIR PRODUCTION AND MEDICINAL PRODUCTS |
| FI63033C (en) * | 1977-07-21 | 1983-04-11 | Boehringer Sohn Ingelheim | FREQUENCY REQUIREMENT FOR ANXIOLYTIC TRANSQUILLATION OF SEED / ELLER NEUROLEPTIC SUBSTITUTES 1-PIPERAZINYL-4H-S-TRIAZOLO (3,4-C) THIENO (2,3-E) -1,4-DIAZEPERE |
| DE3502392A1 (en) * | 1985-01-25 | 1986-07-31 | Boehringer Ingelheim KG, 6507 Ingelheim | NEW THIENO-TRIAZOLO-1,4-DIAZEPINO-2-CARBONIC ACID AMIDES, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS |
| EP0230942B1 (en) * | 1986-01-21 | 1992-04-29 | Boehringer Ingelheim Kg | Thieno-1,4-diazepines |
| JP2582225B2 (en) * | 1994-04-15 | 1997-02-19 | ナショナル住宅産業株式会社 | Fittings |
| WO1995032963A1 (en) * | 1994-06-01 | 1995-12-07 | Yoshitomi Pharmaceutical Industries, Ltd. | Thienylazole compound and thienotriazolodiazepine compound |
| US5854238A (en) * | 1995-09-09 | 1998-12-29 | Hoffmann-La Roche Inc. | Use of a thienotriazolodiazephine to increase apolipoprotein A-I levels |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3904641A (en) * | 1971-06-18 | 1975-09-09 | Yoshitomi Pharmaceutical | Triazolothienodiazepine compounds |
-
1973
- 1973-01-29 PH PH7315453A patent/PH12303A/en unknown
- 1973-02-08 CH CH179973A patent/CH584223A5/xx not_active IP Right Cessation
-
1974
- 1974-01-22 ZA ZA740472A patent/ZA74472B/en unknown
- 1974-01-28 NL NLAANVRAGE7401117,A patent/NL174045C/en not_active IP Right Cessation
- 1974-01-28 IL IL44095A patent/IL44095A/en unknown
- 1974-01-30 YU YU2287/74A patent/YU39716B/en unknown
- 1974-02-06 FR FR7403922A patent/FR2217007B1/fr not_active Expired
- 1974-02-06 LU LU69338A patent/LU69338A1/xx unknown
- 1974-02-06 DD DD176414A patent/DD112454A5/xx unknown
- 1974-02-06 DE DE2405682A patent/DE2405682C3/en not_active Expired
- 1974-02-06 CA CA74191917A patent/CA1049009A/en not_active Expired
- 1974-02-06 IE IE00221/74A patent/IE38883B1/en unknown
- 1974-02-07 AT AT96474A patent/AT343118B/en not_active IP Right Cessation
- 1974-02-07 SE SE7401664A patent/SE416399B/en not_active IP Right Cessation
- 1974-02-07 GB GB539676A patent/GB1456162A/en not_active Expired
- 1974-02-07 HU HUHO1644A patent/HU170423B/hu unknown
- 1974-02-07 DK DK66874AA patent/DK137679B/en unknown
- 1974-02-07 BE BE140629A patent/BE810705A/en not_active IP Right Cessation
- 1974-02-07 NO NO740405A patent/NO142260C/en unknown
- 1974-02-07 SU SU741994653A patent/SU715028A3/en active
- 1974-02-07 PL PL1974191791A patent/PL97304B1/en unknown
- 1974-02-07 GB GB568374A patent/GB1456161A/en not_active Expired
- 1974-02-07 PL PL1974191789A patent/PL97275B1/en unknown
- 1974-02-07 HU HU74HO1865A patent/HU173741B/en unknown
- 1974-02-07 PL PL1974168647A patent/PL96107B1/en unknown
- 1974-02-08 FI FI357/74A patent/FI58129C/en active
- 1974-02-08 JP JP49015549A patent/JPS5833234B2/en not_active Expired
- 1974-02-08 AR AR252265A patent/AR203188A1/en active
- 1974-12-04 AR AR256777A patent/AR217034A1/en active
-
1978
- 1978-06-10 SU SU782633846A patent/SU1060115A3/en active
- 1978-07-10 SU SU782633659A patent/SU747429A4/en active
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| 704A | Declaration that licence is not available as of right for an excepted use (par. 4a/1977) | ||
| 732 | Registration of transactions, instruments or events in the register (sect. 32/1977) | ||
| PE20 | Patent expired after termination of 20 years |
Effective date: 19940206 |