IE38883B1 - Diazepine derivatives - Google Patents
Diazepine derivativesInfo
- Publication number
- IE38883B1 IE38883B1 IE00221/74A IE22174A IE38883B1 IE 38883 B1 IE38883 B1 IE 38883B1 IE 00221/74 A IE00221/74 A IE 00221/74A IE 22174 A IE22174 A IE 22174A IE 38883 B1 IE38883 B1 IE 38883B1
- Authority
- IE
- Ireland
- Prior art keywords
- alkyl
- compound
- hydroxyalkyl
- alkylcarbonyloxyalkyl
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/36—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Abstract
1456161 Thienotriazolodiazepines F HOFFMANN-LA ROCHE & CO AG 7 Feb 1974 [8 Feb 1973] 05683/74 Heading C2C Compounds of the general formula (R 1 = halogen, NO 2 , NH 2 , alkanoyl; R 2 = pyridyl or thienyl optionally substituted adjacent to linking position, phenyl, o-trifluoromethylphenyl, o - halophenyl, o,o<SP>1</SP> - dihalophenyl, o - nitrophenyl; R 3 = H, OH, alkoxycarbonyl, alkanoyloxy; R 4 = H, alkyl, alkanoyl, hydroxyalkyl, mercaptoalkyl, alkoxycarbonyl, aminocarbonyl, haloalkyl, alkoxyalkyl, alkylthioalkyl, aralkoxyalkyl, cyanoalkyl, alkoxycarbonylalkyl, alkoxycarbonylaminoalkyl, alkylcarbonyloxyalkyl, aminocarbonyloxyalkyl, dialkylaminocarbonyloxyalkyl, CN, alkyl NR 5 R 6 , COO alkyl NR 5 R 6 , CONH alkyl NR 5 R 6 ; R 5,6 = H, alkyl, hydroxyalkyl or NR 5 R 6 = monocyclic saturated 5-6 membered ring optionally containing an oxygen or further nitrogen atom; n = 0,1) and their acid addition salts are prepared by (a) cyclizing a compound of the formula (b) -n = O- cyclising a compound of the formula (c) -R 1 = halogen or NO 2 - halogenating or nitrating the corresponding 2-unsubstituted compound, (d) -R 4 = alkanoyloxidizing the corresponding 9-(α-hydroxyalkyl) compound, (e) -R 4 = alkylcarbonyloxyalkyl or aminocarbonyloxyalkylesterifying the corresponding alcohol, (f) -R 4 = alkoxyalkyl, aralkoxyalkyl, alkylthioalkyl or alkyl NR 5 R 6 - reacting a corresponding 9-A. alkyl compound with BR (one of A,B = OH, SH or NHR 5 and the other = leaving atom or group; R = alkyl or (one of A,B = OH) aralkyl, or (B = NHR 5 )H or hydroxyalkyl, or NRR 5 = monocyclic saturated 5-6 membered ring optionally containing an oxygen or further nitrogen atom), (g) -R 4 = alkylcarbonyloxyalkyl or dialkylaminocarbonyloxyalkyl-reacting the corresponding alcohol with a reactive derivative of the appropriate alkanoic or dialkylcarbamic acid, (h) -R 4 = alkoxycarbonylaminoalkylreacting a corresponding 9-K alkyl compound with L.COO- alkyl (one of K,L = NH 2 and the other = leaving atom or group) or (i) -R 4 = primary hydroxyalkylreducing a corresponding 9-alkoxy carbonyl or alkoxycarbonylalkyl compound, optionally followed by salt formation. The preparation of thienodiagepines of the formulµ and 2-amino, chloroacetamido and aminoacetamido-3-thienyl 2<SP>1</SP>-pyridyl ketone is described. The above compounds are anticonvulsants, sedatives, muscle relaxants, tranquilizerx and anxiolytics and may be administered in the form of pharmacetuical preparations containing them in association with a carrier.
[GB1456161A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH179973A CH584223A5 (en) | 1973-02-08 | 1973-02-08 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE38883L IE38883L (en) | 1974-08-08 |
| IE38883B1 true IE38883B1 (en) | 1978-06-21 |
Family
ID=4218866
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE00221/74A IE38883B1 (en) | 1973-02-08 | 1974-02-06 | Diazepine derivatives |
Country Status (24)
| Country | Link |
|---|---|
| JP (1) | JPS5833234B2 (en) |
| AR (2) | AR203188A1 (en) |
| AT (1) | AT343118B (en) |
| BE (1) | BE810705A (en) |
| CA (1) | CA1049009A (en) |
| CH (1) | CH584223A5 (en) |
| DD (1) | DD112454A5 (en) |
| DE (1) | DE2405682C3 (en) |
| DK (1) | DK137679B (en) |
| FI (1) | FI58129C (en) |
| FR (1) | FR2217007B1 (en) |
| GB (2) | GB1456162A (en) |
| HU (2) | HU170423B (en) |
| IE (1) | IE38883B1 (en) |
| IL (1) | IL44095A (en) |
| LU (1) | LU69338A1 (en) |
| NL (1) | NL174045C (en) |
| NO (1) | NO142260C (en) |
| PH (1) | PH12303A (en) |
| PL (3) | PL97304B1 (en) |
| SE (1) | SE416399B (en) |
| SU (3) | SU715028A3 (en) |
| YU (1) | YU39716B (en) |
| ZA (1) | ZA74472B (en) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT338799B (en) * | 1974-03-02 | 1977-09-12 | Boehringer Sohn Ingelheim | PROCESS FOR PREPARING NEW SUBSTITUTED 6-ARYL-4H-S-TRIAZOLO- (3,4C) -THIENO- (2,3E) -1,4-DIAZEPINE AND THEIR SALTS |
| DE2533924C3 (en) * | 1975-07-30 | 1979-05-03 | C.H. Boehringer Sohn, 6507 Ingelheim | Process for the preparation of 6-aryl-4H-striazolo [3,4-c] thieno [2,3-e] 1,4-diazepines |
| DE2531678C3 (en) * | 1975-07-16 | 1979-06-28 | C.H. Boehringer Sohn, 6507 Ingelheim | Thieno [2,3e] triazole [3,4c] 5,6-dihydro-1,4-diazepines and processes for their preparation |
| DE2708121A1 (en) * | 1977-02-25 | 1978-09-07 | Boehringer Sohn Ingelheim | TRIAZOLO-THIENO-DIAZEPIN-L-ONE, METHOD FOR THEIR PRODUCTION AND MEDICINAL PRODUCTS |
| FI63033C (en) * | 1977-07-21 | 1983-04-11 | Boehringer Sohn Ingelheim | FREQUENCY REQUIREMENT FOR ANXIOLYTIC TRANSQUILLATION OF SEED / ELLER NEUROLEPTIC SUBSTITUTES 1-PIPERAZINYL-4H-S-TRIAZOLO (3,4-C) THIENO (2,3-E) -1,4-DIAZEPERE |
| DE3502392A1 (en) * | 1985-01-25 | 1986-07-31 | Boehringer Ingelheim KG, 6507 Ingelheim | NEW THIENO-TRIAZOLO-1,4-DIAZEPINO-2-CARBONIC ACID AMIDES, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS |
| EP0230942B1 (en) * | 1986-01-21 | 1992-04-29 | Boehringer Ingelheim Kg | Thieno-1,4-diazepines |
| JP2582225B2 (en) * | 1994-04-15 | 1997-02-19 | ナショナル住宅産業株式会社 | Fittings |
| WO1995032963A1 (en) * | 1994-06-01 | 1995-12-07 | Yoshitomi Pharmaceutical Industries, Ltd. | Thienylazole compound and thienotriazolodiazepine compound |
| WO1997009048A1 (en) * | 1995-09-09 | 1997-03-13 | F. Hoffmann-La Roche Ag | Use of a thienotriazolodiazepine to increase apolipoprotein a-i levels |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3904641A (en) * | 1971-06-18 | 1975-09-09 | Yoshitomi Pharmaceutical | Triazolothienodiazepine compounds |
-
1973
- 1973-01-29 PH PH7315453A patent/PH12303A/en unknown
- 1973-02-08 CH CH179973A patent/CH584223A5/xx not_active IP Right Cessation
-
1974
- 1974-01-22 ZA ZA740472A patent/ZA74472B/en unknown
- 1974-01-28 IL IL44095A patent/IL44095A/en unknown
- 1974-01-28 NL NLAANVRAGE7401117,A patent/NL174045C/en not_active IP Right Cessation
- 1974-01-30 YU YU2287/74A patent/YU39716B/en unknown
- 1974-02-06 DE DE2405682A patent/DE2405682C3/en not_active Expired
- 1974-02-06 CA CA74191917A patent/CA1049009A/en not_active Expired
- 1974-02-06 LU LU69338A patent/LU69338A1/xx unknown
- 1974-02-06 FR FR7403922A patent/FR2217007B1/fr not_active Expired
- 1974-02-06 DD DD176414A patent/DD112454A5/xx unknown
- 1974-02-06 IE IE00221/74A patent/IE38883B1/en unknown
- 1974-02-07 BE BE140629A patent/BE810705A/en not_active IP Right Cessation
- 1974-02-07 HU HUHO1644A patent/HU170423B/hu unknown
- 1974-02-07 DK DK66874AA patent/DK137679B/en unknown
- 1974-02-07 PL PL1974191791A patent/PL97304B1/en unknown
- 1974-02-07 SE SE7401664A patent/SE416399B/en not_active IP Right Cessation
- 1974-02-07 NO NO740405A patent/NO142260C/en unknown
- 1974-02-07 AT AT96474A patent/AT343118B/en not_active IP Right Cessation
- 1974-02-07 PL PL1974191789A patent/PL97275B1/en unknown
- 1974-02-07 HU HU74HO1865A patent/HU173741B/en unknown
- 1974-02-07 PL PL1974168647A patent/PL96107B1/en unknown
- 1974-02-07 GB GB539676A patent/GB1456162A/en not_active Expired
- 1974-02-07 GB GB568374A patent/GB1456161A/en not_active Expired
- 1974-02-07 SU SU741994653A patent/SU715028A3/en active
- 1974-02-08 JP JP49015549A patent/JPS5833234B2/en not_active Expired
- 1974-02-08 FI FI357/74A patent/FI58129C/en active
- 1974-02-08 AR AR252265A patent/AR203188A1/en active
- 1974-12-04 AR AR256777A patent/AR217034A1/en active
-
1978
- 1978-06-10 SU SU782633846A patent/SU1060115A3/en active
- 1978-07-10 SU SU782633659A patent/SU747429A4/en active
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