IE36071B1 - Furylmethyl-benzomorphane derivatives and pharmaceutical compositions containing them - Google Patents
Furylmethyl-benzomorphane derivatives and pharmaceutical compositions containing themInfo
- Publication number
- IE36071B1 IE36071B1 IE156/72A IE15672A IE36071B1 IE 36071 B1 IE36071 B1 IE 36071B1 IE 156/72 A IE156/72 A IE 156/72A IE 15672 A IE15672 A IE 15672A IE 36071 B1 IE36071 B1 IE 36071B1
- Authority
- IE
- Ireland
- Prior art keywords
- formula
- compound
- feb
- reacting
- alkyl
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 11
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 abstract 3
- 230000000397 acetylating effect Effects 0.000 abstract 2
- 125000002252 acyl group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 abstract 2
- 230000001035 methylating effect Effects 0.000 abstract 2
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 2
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 abstract 1
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000005278 alkyl sulfonyloxy group Chemical group 0.000 abstract 1
- 125000005279 aryl sulfonyloxy group Chemical group 0.000 abstract 1
- 229940051805 benzomorphan derivative analgesics Drugs 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 230000000911 decarboxylating effect Effects 0.000 abstract 1
- 235000019253 formic acid Nutrition 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
- C07D221/26—Benzomorphans
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Furan Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2105743A DE2105743C3 (de) | 1971-02-08 | 1971-02-08 | 2-(Furylmethyl)- a -5,9-dialkyl -6,7benzomorphane, Verfahren zu ihrer Herstellung und deren Verwendung |
| DE19712108954 DE2108954A1 (en) | 1971-02-25 | 1971-02-25 | 2-(furylmethyl)-6,7-benzomorphans - useful as cns active agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE36071L IE36071L (en) | 1973-06-08 |
| IE36071B1 true IE36071B1 (en) | 1976-08-04 |
Family
ID=25760626
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE156/72A IE36071B1 (en) | 1971-02-08 | 1972-02-08 | Furylmethyl-benzomorphane derivatives and pharmaceutical compositions containing them |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US3823150A (en, 2012) |
| JP (1) | JPS5545555B1 (en, 2012) |
| AT (3) | AT318602B (en, 2012) |
| BE (1) | BE779058A (en, 2012) |
| BG (3) | BG19800A3 (en, 2012) |
| CA (1) | CA969938A (en, 2012) |
| CH (4) | CH573934A5 (en, 2012) |
| CS (4) | CS166803B2 (en, 2012) |
| DD (1) | DD95847A5 (en, 2012) |
| DK (1) | DK129127B (en, 2012) |
| ES (4) | ES399536A1 (en, 2012) |
| FI (1) | FI57758C (en, 2012) |
| FR (1) | FR2124564B1 (en, 2012) |
| GB (1) | GB1384115A (en, 2012) |
| HU (1) | HU162946B (en, 2012) |
| IE (1) | IE36071B1 (en, 2012) |
| IL (1) | IL38699A (en, 2012) |
| NL (1) | NL171898C (en, 2012) |
| NO (1) | NO134054C (en, 2012) |
| PH (1) | PH10743A (en, 2012) |
| PL (2) | PL78312B1 (en, 2012) |
| RO (5) | RO59193A (en, 2012) |
| SE (1) | SE363630B (en, 2012) |
| SU (4) | SU469246A3 (en, 2012) |
| YU (3) | YU27972A (en, 2012) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2229695A1 (de) * | 1972-06-19 | 1974-01-31 | Boehringer Sohn Ingelheim | 2-(heteroaryl-methyl)-5,9 beta-dialkyl6,7-benzomorphane, deren saeureadditionssalze sowie verfahren zu deren herstellung |
| US4010164A (en) * | 1973-03-28 | 1977-03-01 | Boehringer Ingelheim Gmbh | N-(furyl-methyl)-2-hydroxy-5,9,9-trimethyl-benzomorphans and salts thereof |
| SU510999A3 (ru) * | 1973-10-27 | 1976-04-15 | К.Х.Берингер Зон, (Фирма) | Способ получени (метоксиметил-фурилметил)6,7-бензоморфанов илиморфинанов |
| US4087532A (en) * | 1974-03-09 | 1978-05-02 | Boehringer Ingelheim Gmbh | Analgesically useful 2-tetrahydrofurfuryl-5-lower alkyl-2-oxy-6,7-benzomorphans and salts thereof |
| DE2437610A1 (de) * | 1974-08-05 | 1976-02-26 | Boehringer Sohn Ingelheim | Neue 5,9-beta-disubstituierte 2-tetrahydrofurfuryl-6,7-benzomorphane, deren saeureadditionssalze, ihre verwendung als arzneimittel und verfahren zu deren herstellung |
| GB1575009A (en) * | 1976-06-21 | 1980-09-17 | Acf Chemiefarma Nv | 6,7-benzomorphan derivatives |
| DE2716687A1 (de) * | 1977-04-15 | 1978-10-19 | Boehringer Sohn Ingelheim | 2'-hydroxy-2-(5-isoxazolylmethyl)-6,7benzomorphane, deren saeureadditionssalze und diese enthaltende arzneimittel |
| DE3839659A1 (de) * | 1988-11-24 | 1990-05-31 | Boehringer Ingelheim Kg | Verwendung von benzomorphanen zur zytoprotektion |
| EP2220048B1 (en) * | 2007-11-16 | 2017-01-25 | Boehringer Ingelheim International GmbH | Aryl- and heteroarylcarbonyl derivatives of benzomorphanes and related scaffolds, medicaments containing such compounds and their use |
| ATE531696T1 (de) * | 2008-02-12 | 2011-11-15 | Boehringer Ingelheim Int | Harnstoff-derivate von benzomorphanen, entsprechende gerüste, medikamente mit solchen verbindungen und ihre verwendung |
| JP5711115B2 (ja) | 2008-05-13 | 2015-04-30 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ベンゾモルファン及び関連骨格のアリサイクリックカルボン酸誘導体、そのような化合物を含有する医薬及びその使用 |
| JP2014524438A (ja) | 2011-08-17 | 2014-09-22 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | インデノピリジン誘導体 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1281227A (fr) * | 1958-09-22 | 1962-01-12 | Smith Kline French Lab | Perfectionnements apportés aux procédés pour la préparation de dérivés d'aralcoylbenzomorphane |
| FR1538362A (fr) * | 1966-05-20 | 1968-09-06 | Merck & Co Inc | Dérivés du benzomorphane |
-
1972
- 1972-01-26 CS CS7060*A patent/CS166803B2/cs unknown
- 1972-01-26 CS CS483A patent/CS166801B2/cs unknown
- 1972-01-26 CS CS7061*A patent/CS166804B2/cs unknown
- 1972-01-26 CS CS7059*A patent/CS166802B2/cs unknown
- 1972-02-01 US US00222669A patent/US3823150A/en not_active Expired - Lifetime
- 1972-02-03 CH CH1565375A patent/CH573934A5/xx not_active IP Right Cessation
- 1972-02-03 CH CH1565475A patent/CH574442A5/xx not_active IP Right Cessation
- 1972-02-03 CH CH1565575A patent/CH573935A5/xx not_active IP Right Cessation
- 1972-02-03 CH CH158472A patent/CH573933A5/xx not_active IP Right Cessation
- 1972-02-04 JP JP1276272A patent/JPS5545555B1/ja active Pending
- 1972-02-04 SU SU1918909A patent/SU469246A3/ru active
- 1972-02-04 SU SU1744912A patent/SU421187A3/ru active
- 1972-02-04 SU SU1918905A patent/SU467519A3/ru active
- 1972-02-04 SU SU1918908A patent/SU479290A3/ru active
- 1972-02-05 BG BG019654A patent/BG19800A3/xx unknown
- 1972-02-05 BG BG22164A patent/BG19600A3/xx unknown
- 1972-02-05 BG BG022165A patent/BG20792A3/xx unknown
- 1972-02-07 BE BE779058A patent/BE779058A/xx not_active IP Right Cessation
- 1972-02-07 DD DD160731A patent/DD95847A5/xx unknown
- 1972-02-07 CA CA134,023A patent/CA969938A/en not_active Expired
- 1972-02-07 NO NO325/72*[A patent/NO134054C/no unknown
- 1972-02-07 GB GB559472A patent/GB1384115A/en not_active Expired
- 1972-02-07 YU YU00279/72A patent/YU27972A/xx unknown
- 1972-02-07 YU YU1657/72A patent/YU35016B/xx unknown
- 1972-02-07 SE SE01397/72A patent/SE363630B/xx unknown
- 1972-02-07 PL PL1972153362A patent/PL78312B1/pl unknown
- 1972-02-07 NL NLAANVRAGE7201551,A patent/NL171898C/xx not_active IP Right Cessation
- 1972-02-07 FI FI327/72A patent/FI57758C/fi active
- 1972-02-07 AT AT168773A patent/AT318602B/de not_active IP Right Cessation
- 1972-02-07 AT AT168673A patent/AT318601B/de not_active IP Right Cessation
- 1972-02-07 ES ES399536A patent/ES399536A1/es not_active Expired
- 1972-02-07 DK DK53372AA patent/DK129127B/da not_active IP Right Cessation
- 1972-02-07 IL IL38699A patent/IL38699A/xx unknown
- 1972-02-07 AT AT96272A patent/AT312587B/de active
- 1972-02-08 RO RO72543A patent/RO59193A/ro unknown
- 1972-02-08 RO RO72541A patent/RO59251A/ro unknown
- 1972-02-08 PH PH13256A patent/PH10743A/en unknown
- 1972-02-08 RO RO69695A patent/RO58981A/ro unknown
- 1972-02-08 FR FR7204151A patent/FR2124564B1/fr not_active Expired
- 1972-02-08 IE IE156/72A patent/IE36071B1/xx unknown
- 1972-02-08 RO RO72542A patent/RO59165A/ro unknown
- 1972-02-08 HU HUBO1349A patent/HU162946B/hu unknown
- 1972-05-09 PL PL1972155268A patent/PL84115B3/pl unknown
- 1972-10-17 RO RO7200080094A patent/RO63052A/ro unknown
- 1972-11-04 ES ES408275A patent/ES408275A1/es not_active Expired
- 1972-11-04 ES ES408276A patent/ES408276A1/es not_active Expired
- 1972-11-04 ES ES408274A patent/ES408274A1/es not_active Expired
-
1978
- 1978-07-18 YU YU1720/78A patent/YU35255B/xx unknown
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