FI57758C - Foerfarande foer framstaellning av terapeutiskt verksamt racematiskt eller optiskt aktivt 2-(furylmetyl)-2'-hydroxi-alfa-5,9-dialkyl-6,7-benzomorfan och dess syraadditionssalter - Google Patents

Foerfarande foer framstaellning av terapeutiskt verksamt racematiskt eller optiskt aktivt 2-(furylmetyl)-2'-hydroxi-alfa-5,9-dialkyl-6,7-benzomorfan och dess syraadditionssalter Download PDF

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Publication number
FI57758C
FI57758C FI327/72A FI32772A FI57758C FI 57758 C FI57758 C FI 57758C FI 327/72 A FI327/72 A FI 327/72A FI 32772 A FI32772 A FI 32772A FI 57758 C FI57758 C FI 57758C
Authority
FI
Finland
Prior art keywords
benzomorphane
hydroxy
methyl
formula
furylmethyl
Prior art date
Application number
FI327/72A
Other languages
English (en)
Finnish (fi)
Other versions
FI57758B (fi
Inventor
Herbert Merz
Adolf Langbein
Helmut Wick
Klaus Stockhaus
Original Assignee
Boehringer Sohn Ingelheim
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE2105743A external-priority patent/DE2105743C3/de
Priority claimed from DE19712108954 external-priority patent/DE2108954A1/de
Application filed by Boehringer Sohn Ingelheim filed Critical Boehringer Sohn Ingelheim
Application granted granted Critical
Publication of FI57758B publication Critical patent/FI57758B/fi
Publication of FI57758C publication Critical patent/FI57758C/fi

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/26—Benzomorphans

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
FI327/72A 1971-02-08 1972-02-07 Foerfarande foer framstaellning av terapeutiskt verksamt racematiskt eller optiskt aktivt 2-(furylmetyl)-2'-hydroxi-alfa-5,9-dialkyl-6,7-benzomorfan och dess syraadditionssalter FI57758C (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE2105743A DE2105743C3 (de) 1971-02-08 1971-02-08 2-(Furylmethyl)- a -5,9-dialkyl -6,7benzomorphane, Verfahren zu ihrer Herstellung und deren Verwendung
DE2105743 1971-02-08
DE2108954 1971-02-25
DE19712108954 DE2108954A1 (en) 1971-02-25 1971-02-25 2-(furylmethyl)-6,7-benzomorphans - useful as cns active agents

Publications (2)

Publication Number Publication Date
FI57758B FI57758B (fi) 1980-06-30
FI57758C true FI57758C (fi) 1980-10-10

Family

ID=25760626

Family Applications (1)

Application Number Title Priority Date Filing Date
FI327/72A FI57758C (fi) 1971-02-08 1972-02-07 Foerfarande foer framstaellning av terapeutiskt verksamt racematiskt eller optiskt aktivt 2-(furylmetyl)-2'-hydroxi-alfa-5,9-dialkyl-6,7-benzomorfan och dess syraadditionssalter

Country Status (25)

Country Link
US (1) US3823150A (en, 2012)
JP (1) JPS5545555B1 (en, 2012)
AT (3) AT318602B (en, 2012)
BE (1) BE779058A (en, 2012)
BG (3) BG19800A3 (en, 2012)
CA (1) CA969938A (en, 2012)
CH (4) CH573934A5 (en, 2012)
CS (4) CS166803B2 (en, 2012)
DD (1) DD95847A5 (en, 2012)
DK (1) DK129127B (en, 2012)
ES (4) ES399536A1 (en, 2012)
FI (1) FI57758C (en, 2012)
FR (1) FR2124564B1 (en, 2012)
GB (1) GB1384115A (en, 2012)
HU (1) HU162946B (en, 2012)
IE (1) IE36071B1 (en, 2012)
IL (1) IL38699A (en, 2012)
NL (1) NL171898C (en, 2012)
NO (1) NO134054C (en, 2012)
PH (1) PH10743A (en, 2012)
PL (2) PL78312B1 (en, 2012)
RO (5) RO59193A (en, 2012)
SE (1) SE363630B (en, 2012)
SU (4) SU469246A3 (en, 2012)
YU (3) YU27972A (en, 2012)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2229695A1 (de) * 1972-06-19 1974-01-31 Boehringer Sohn Ingelheim 2-(heteroaryl-methyl)-5,9 beta-dialkyl6,7-benzomorphane, deren saeureadditionssalze sowie verfahren zu deren herstellung
US4010164A (en) * 1973-03-28 1977-03-01 Boehringer Ingelheim Gmbh N-(furyl-methyl)-2-hydroxy-5,9,9-trimethyl-benzomorphans and salts thereof
SU510999A3 (ru) * 1973-10-27 1976-04-15 К.Х.Берингер Зон, (Фирма) Способ получени (метоксиметил-фурилметил)6,7-бензоморфанов илиморфинанов
US4087532A (en) * 1974-03-09 1978-05-02 Boehringer Ingelheim Gmbh Analgesically useful 2-tetrahydrofurfuryl-5-lower alkyl-2-oxy-6,7-benzomorphans and salts thereof
DE2437610A1 (de) * 1974-08-05 1976-02-26 Boehringer Sohn Ingelheim Neue 5,9-beta-disubstituierte 2-tetrahydrofurfuryl-6,7-benzomorphane, deren saeureadditionssalze, ihre verwendung als arzneimittel und verfahren zu deren herstellung
GB1575009A (en) * 1976-06-21 1980-09-17 Acf Chemiefarma Nv 6,7-benzomorphan derivatives
DE2716687A1 (de) * 1977-04-15 1978-10-19 Boehringer Sohn Ingelheim 2'-hydroxy-2-(5-isoxazolylmethyl)-6,7benzomorphane, deren saeureadditionssalze und diese enthaltende arzneimittel
DE3839659A1 (de) * 1988-11-24 1990-05-31 Boehringer Ingelheim Kg Verwendung von benzomorphanen zur zytoprotektion
EP2220048B1 (en) * 2007-11-16 2017-01-25 Boehringer Ingelheim International GmbH Aryl- and heteroarylcarbonyl derivatives of benzomorphanes and related scaffolds, medicaments containing such compounds and their use
ATE531696T1 (de) * 2008-02-12 2011-11-15 Boehringer Ingelheim Int Harnstoff-derivate von benzomorphanen, entsprechende gerüste, medikamente mit solchen verbindungen und ihre verwendung
JP5711115B2 (ja) 2008-05-13 2015-04-30 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ベンゾモルファン及び関連骨格のアリサイクリックカルボン酸誘導体、そのような化合物を含有する医薬及びその使用
JP2014524438A (ja) 2011-08-17 2014-09-22 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング インデノピリジン誘導体

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1281227A (fr) * 1958-09-22 1962-01-12 Smith Kline French Lab Perfectionnements apportés aux procédés pour la préparation de dérivés d'aralcoylbenzomorphane
FR1538362A (fr) * 1966-05-20 1968-09-06 Merck & Co Inc Dérivés du benzomorphane

Also Published As

Publication number Publication date
BG19800A3 (bg) 1975-10-10
RO63052A (fr) 1978-06-15
DK129127C (en, 2012) 1975-02-10
SU467519A3 (ru) 1975-04-15
BG20792A3 (bg) 1975-12-20
CS166801B2 (en, 2012) 1976-03-29
FR2124564A1 (en, 2012) 1972-09-22
NO134054C (en, 2012) 1976-08-11
SU421187A3 (ru) 1974-03-25
RO58981A (en, 2012) 1975-11-15
RO59165A (en, 2012) 1976-02-15
IE36071L (en) 1973-06-08
CS166804B2 (en, 2012) 1976-03-29
CH574442A5 (en, 2012) 1976-04-15
IL38699A (en) 1975-12-31
BE779058A (fr) 1972-08-07
PL78312B1 (en) 1975-06-30
BG19600A3 (en, 2012) 1975-06-25
CH573933A5 (en, 2012) 1976-03-31
PH10743A (en) 1977-09-01
SU479290A3 (ru) 1975-07-30
AT312587B (de) 1974-01-10
RO59251A (en, 2012) 1976-05-15
CS166802B2 (en, 2012) 1976-03-29
ES408274A1 (es) 1976-02-01
YU35016B (en) 1980-06-30
US3823150A (en) 1974-07-09
JPS5545555B1 (en, 2012) 1980-11-18
HU162946B (en, 2012) 1973-05-28
SE363630B (en, 2012) 1974-01-28
DD95847A5 (en, 2012) 1973-02-20
YU172078A (en) 1980-04-30
CS166803B2 (en, 2012) 1976-03-29
SU469246A3 (ru) 1975-04-30
AT318601B (de) 1974-11-11
CH573934A5 (en, 2012) 1976-03-31
FI57758B (fi) 1980-06-30
IL38699A0 (en) 1972-04-27
NL171898C (nl) 1983-06-01
GB1384115A (en) 1975-02-19
NL171898B (nl) 1983-01-03
PL84115B3 (en) 1976-03-31
IE36071B1 (en) 1976-08-04
NL7201551A (en, 2012) 1972-08-10
ES408276A1 (es) 1975-11-16
CA969938A (en) 1975-06-24
FR2124564B1 (en, 2012) 1975-10-31
AT318602B (de) 1974-11-11
YU35255B (en) 1980-10-31
DK129127B (da) 1974-08-26
NO134054B (en, 2012) 1976-05-03
CH573935A5 (en, 2012) 1976-03-31
ES399536A1 (es) 1974-11-01
ES408275A1 (es) 1976-02-16
YU27972A (en) 1979-12-31
RO59193A (en, 2012) 1976-01-15

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