HUT61468A - Process for producing pharmaceutical compositions against human retrovirus and comprising xanthine derivatives as active ingredient - Google Patents
Process for producing pharmaceutical compositions against human retrovirus and comprising xanthine derivatives as active ingredient Download PDFInfo
- Publication number
- HUT61468A HUT61468A HU913502A HU350291A HUT61468A HU T61468 A HUT61468 A HU T61468A HU 913502 A HU913502 A HU 913502A HU 350291 A HU350291 A HU 350291A HU T61468 A HUT61468 A HU T61468A
- Authority
- HU
- Hungary
- Prior art keywords
- formula
- group
- methyl
- active ingredient
- hiv
- Prior art date
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- LRFVTYWOQMYALW-UHFFFAOYSA-N 9H-xanthine Chemical class O=C1NC(=O)NC2=C1NC=N2 LRFVTYWOQMYALW-UHFFFAOYSA-N 0.000 title claims abstract description 115
- 238000000034 method Methods 0.000 title claims description 63
- 239000004480 active ingredient Substances 0.000 title claims description 28
- 230000008569 process Effects 0.000 title claims description 25
- 239000008194 pharmaceutical composition Substances 0.000 title claims 3
- 241001430294 unidentified retrovirus Species 0.000 title abstract description 28
- 229940083747 low-ceiling diuretics xanthine derivative Drugs 0.000 title description 65
- 150000001875 compounds Chemical class 0.000 claims abstract description 77
- 208000031886 HIV Infections Diseases 0.000 claims abstract description 42
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims abstract description 25
- 230000010076 replication Effects 0.000 claims abstract description 24
- 230000002401 inhibitory effect Effects 0.000 claims abstract description 21
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 15
- 125000004432 carbon atom Chemical group C* 0.000 claims abstract description 13
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims abstract description 11
- 229930195733 hydrocarbon Natural products 0.000 claims abstract description 8
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims abstract description 5
- 239000004215 Carbon black (E152) Substances 0.000 claims abstract description 4
- 125000001931 aliphatic group Chemical group 0.000 claims abstract description 4
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims abstract description 4
- 125000004430 oxygen atom Chemical group O* 0.000 claims abstract description 4
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims abstract 2
- -1 methoxyethoxymethyl Chemical group 0.000 claims description 73
- 241000713772 Human immunodeficiency virus 1 Species 0.000 claims description 24
- BYPFEZZEUUWMEJ-UHFFFAOYSA-N Pentoxifylline Chemical compound O=C1N(CCCCC(=O)C)C(=O)N(C)C2=C1N(C)C=N2 BYPFEZZEUUWMEJ-UHFFFAOYSA-N 0.000 claims description 23
- 229960001476 pentoxifylline Drugs 0.000 claims description 21
- 230000001177 retroviral effect Effects 0.000 claims description 21
- 229940075420 xanthine Drugs 0.000 claims description 18
- 238000002360 preparation method Methods 0.000 claims description 10
- 239000003814 drug Substances 0.000 claims description 9
- 125000001424 substituent group Chemical group 0.000 claims description 9
- 229940079593 drug Drugs 0.000 claims description 8
- 125000005188 oxoalkyl group Chemical group 0.000 claims description 7
- 206010029897 Obsessive thoughts Diseases 0.000 claims description 6
- 239000001257 hydrogen Substances 0.000 claims description 6
- 229910052739 hydrogen Inorganic materials 0.000 claims description 6
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims description 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 3
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 3
- 239000003085 diluting agent Substances 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims description 2
- 125000001650 tertiary alcohol group Chemical group 0.000 claims description 2
- 125000005745 ethoxymethyl group Chemical group [H]C([H])([H])C([H])([H])OC([H])([H])* 0.000 claims 1
- 241000725303 Human immunodeficiency virus Species 0.000 abstract description 38
- 208000037357 HIV infectious disease Diseases 0.000 abstract description 12
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 abstract description 12
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract description 6
- 230000005764 inhibitory process Effects 0.000 abstract description 6
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract description 5
- 241000282412 Homo Species 0.000 abstract description 5
- 229940065721 systemic for obstructive airway disease xanthines Drugs 0.000 abstract description 2
- 125000004043 oxo group Chemical group O=* 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 description 46
- 238000006243 chemical reaction Methods 0.000 description 33
- 241000700605 Viruses Species 0.000 description 32
- 230000000694 effects Effects 0.000 description 25
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- 208000030507 AIDS Diseases 0.000 description 13
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Natural products CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 13
- 239000002253 acid Substances 0.000 description 13
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- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 11
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 10
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 10
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 10
- 230000003612 virological effect Effects 0.000 description 10
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 9
- 210000001744 T-lymphocyte Anatomy 0.000 description 9
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 9
- 238000003556 assay Methods 0.000 description 9
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- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 8
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- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical class CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 7
- 108010035563 Chloramphenicol O-acetyltransferase Proteins 0.000 description 7
- 241000713340 Human immunodeficiency virus 2 Species 0.000 description 7
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- 229910052744 lithium Inorganic materials 0.000 description 7
- 239000011777 magnesium Substances 0.000 description 7
- 238000012360 testing method Methods 0.000 description 7
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 6
- 102100020873 Interleukin-2 Human genes 0.000 description 6
- 108010002350 Interleukin-2 Proteins 0.000 description 6
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 6
- 239000000427 antigen Substances 0.000 description 6
- 102000036639 antigens Human genes 0.000 description 6
- 108091007433 antigens Proteins 0.000 description 6
- 210000000987 immune system Anatomy 0.000 description 6
- 238000001727 in vivo Methods 0.000 description 6
- 239000013615 primer Substances 0.000 description 6
- 239000000243 solution Substances 0.000 description 6
- 239000003826 tablet Substances 0.000 description 6
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 6
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 5
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 description 5
- 241000713311 Simian immunodeficiency virus Species 0.000 description 5
- 239000002168 alkylating agent Substances 0.000 description 5
- 229940100198 alkylating agent Drugs 0.000 description 5
- 239000000010 aprotic solvent Substances 0.000 description 5
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 5
- 230000015572 biosynthetic process Effects 0.000 description 5
- 239000002775 capsule Substances 0.000 description 5
- 229910052799 carbon Inorganic materials 0.000 description 5
- 239000003153 chemical reaction reagent Substances 0.000 description 5
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- 239000002773 nucleotide Substances 0.000 description 5
- 125000003729 nucleotide group Chemical group 0.000 description 5
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- 150000003509 tertiary alcohols Chemical group 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- XTHFKEDIFFGKHM-UHFFFAOYSA-N Dimethoxyethane Chemical compound COCCOC XTHFKEDIFFGKHM-UHFFFAOYSA-N 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 4
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 4
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical class CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 4
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 4
- 108020005202 Viral DNA Proteins 0.000 description 4
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- 150000001298 alcohols Chemical class 0.000 description 4
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- 230000000120 cytopathologic effect Effects 0.000 description 4
- 238000001514 detection method Methods 0.000 description 4
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- 108020004999 messenger RNA Proteins 0.000 description 4
- 150000002736 metal compounds Chemical class 0.000 description 4
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 4
- 239000011707 mineral Substances 0.000 description 4
- 239000002777 nucleoside Substances 0.000 description 4
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- 239000006187 pill Substances 0.000 description 4
- 239000007858 starting material Substances 0.000 description 4
- UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 description 4
- 150000003512 tertiary amines Chemical class 0.000 description 4
- 230000029812 viral genome replication Effects 0.000 description 4
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 3
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- 125000005982 diphenylmethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])(*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 3
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- PHEDXBVPIONUQT-RGYGYFBISA-N phorbol 13-acetate 12-myristate Chemical compound C([C@]1(O)C(=O)C(C)=C[C@H]1[C@@]1(O)[C@H](C)[C@H]2OC(=O)CCCCCCCCCCCCC)C(CO)=C[C@H]1[C@H]1[C@]2(OC(C)=O)C1(C)C PHEDXBVPIONUQT-RGYGYFBISA-N 0.000 description 3
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US61023090A | 1990-11-07 | 1990-11-07 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HU913502D0 HU913502D0 (en) | 1992-01-28 |
| HUT61468A true HUT61468A (en) | 1993-01-28 |
Family
ID=24444220
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU913502A HUT61468A (en) | 1990-11-07 | 1991-11-07 | Process for producing pharmaceutical compositions against human retrovirus and comprising xanthine derivatives as active ingredient |
Country Status (16)
| Country | Link |
|---|---|
| EP (1) | EP0484785B1 (enExample) |
| JP (1) | JPH054922A (enExample) |
| KR (1) | KR920009397A (enExample) |
| AT (1) | ATE138266T1 (enExample) |
| AU (1) | AU649278B2 (enExample) |
| CA (1) | CA2055041A1 (enExample) |
| DE (1) | DE69119700T2 (enExample) |
| DK (1) | DK0484785T3 (enExample) |
| ES (1) | ES2087205T3 (enExample) |
| GR (1) | GR3020017T3 (enExample) |
| HU (1) | HUT61468A (enExample) |
| IE (1) | IE913879A1 (enExample) |
| IL (1) | IL99966A0 (enExample) |
| PT (1) | PT99434A (enExample) |
| TW (1) | TW209169B (enExample) |
| ZA (1) | ZA918801B (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE59304710D1 (de) * | 1992-02-22 | 1997-01-23 | Hoechst Ag | Verwendung von Xanthinderivaten zur Behandlung von Muskelschädigungen nach vollständiger Unterbrechung der Blutzirkulation |
| JP2004525109A (ja) | 2001-02-15 | 2004-08-19 | キング・ファーマシューティカルズ・インコーポレイティッド | 安定化された甲状腺ホルモン医薬組成物、及びその製法 |
| US7101569B2 (en) | 2001-08-14 | 2006-09-05 | Franz G Andrew | Methods of administering levothyroxine pharmaceutical compositions |
| ES2275400B1 (es) * | 2005-04-20 | 2008-04-01 | Universidad Autonoma De Madrid | Uso de compuestos agonistas de la actividad tubulina desacetilasa de la proteina hdac6 en la elaboracion de composiciones farmaceuticas, dichas composiciones farmaceuticas y sus aplicaciones en el tratamiento de infecciones virales. |
| WO2009108383A2 (en) | 2008-02-29 | 2009-09-03 | Concert Pharmaceuticals, Inc. | Substituted xanthine derivatives |
| US20110053961A1 (en) | 2009-02-27 | 2011-03-03 | Concert Pharmaceuticals, Inc. | Substituted xanthine derivatives |
| WO2011028835A1 (en) | 2009-09-02 | 2011-03-10 | Concert Pharmaceuticals, Inc. | Substituted xanthine derivatives |
| EP2611807A2 (en) | 2010-09-01 | 2013-07-10 | Concert Pharmaceuticals Inc. | Polymorphs of (s)-1-(4,4,6,6,6-pentadeutero-5-hydroxyhexyl)-3-7-dimethyl-1h-purine-2,6(3h,7h)dione |
| WO2013013052A1 (en) | 2011-07-19 | 2013-01-24 | Concert Pharmaceuticals, Inc. | Substituted xanthine derivatives |
| MX2014012384A (es) | 2012-04-13 | 2014-11-26 | Concert Pharmaceuticals Inc | Derivados sustituidos de xantina. |
| WO2013159006A1 (en) | 2012-04-20 | 2013-10-24 | Concert Pharmaceuticals, Inc. | Polymorphs of (s)-1-(4,4,6,6,6-pentadeutero-5-hydroxyhexyl)-3,7-dimethyl-1h-purine-2,6(3h,7h)-dione |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3737433A (en) * | 1964-09-05 | 1973-06-05 | Albert Ag Chem Werke | Certain oxoalkyldimethylxanthines |
| CH608236A5 (enExample) * | 1974-01-22 | 1978-12-29 | Wuelfing J A Fa | |
| US4663317A (en) * | 1984-04-18 | 1987-05-05 | Board Of Regents, University Of Texas System | Methods and compositions for treating viral infections |
| US4636507A (en) * | 1984-04-30 | 1987-01-13 | Hoechst-Roussel Pharmaceuticals Inc. | Host defense mechanism enhancement |
| DE3525801A1 (de) * | 1985-07-19 | 1987-01-22 | Hoechst Ag | Tertiaere hydroxyalkylxanthine, verfahren zu ihrer herstellung, die sie enthaltenden arzneimittel und ihre verwendung |
| GB8610136D0 (en) * | 1986-04-25 | 1986-05-29 | Wellcome Found | Compounds |
| DE3725554A1 (de) * | 1987-08-01 | 1989-02-09 | Hoechst Ag | Pharmazeutisches kombinationspraeparat sowie dessen herstellung und verwendung |
-
1991
- 1991-10-28 DK DK91118347.3T patent/DK0484785T3/da active
- 1991-10-28 ES ES91118347T patent/ES2087205T3/es not_active Expired - Lifetime
- 1991-10-28 DE DE69119700T patent/DE69119700T2/de not_active Expired - Fee Related
- 1991-10-28 AT AT91118347T patent/ATE138266T1/de not_active IP Right Cessation
- 1991-10-28 EP EP91118347A patent/EP0484785B1/en not_active Expired - Lifetime
- 1991-11-05 IL IL99966A patent/IL99966A0/xx unknown
- 1991-11-05 AU AU86998/91A patent/AU649278B2/en not_active Ceased
- 1991-11-06 JP JP3289900A patent/JPH054922A/ja active Pending
- 1991-11-06 ZA ZA918801A patent/ZA918801B/xx unknown
- 1991-11-06 IE IE387991A patent/IE913879A1/en not_active Application Discontinuation
- 1991-11-06 PT PT99434A patent/PT99434A/pt not_active Application Discontinuation
- 1991-11-06 CA CA002055041A patent/CA2055041A1/en not_active Abandoned
- 1991-11-07 KR KR1019910019714A patent/KR920009397A/ko not_active Ceased
- 1991-11-07 HU HU913502A patent/HUT61468A/hu unknown
-
1992
- 1992-01-25 TW TW081100520A patent/TW209169B/zh active
-
1996
- 1996-05-23 GR GR960401329T patent/GR3020017T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2055041A1 (en) | 1992-05-08 |
| DE69119700T2 (de) | 1996-11-07 |
| IE913879A1 (en) | 1992-05-20 |
| TW209169B (enExample) | 1993-07-11 |
| ZA918801B (en) | 1992-12-30 |
| AU8699891A (en) | 1992-05-14 |
| AU649278B2 (en) | 1994-05-19 |
| JPH054922A (ja) | 1993-01-14 |
| EP0484785B1 (en) | 1996-05-22 |
| DE69119700D1 (de) | 1996-06-27 |
| ES2087205T3 (es) | 1996-07-16 |
| ATE138266T1 (de) | 1996-06-15 |
| EP0484785A2 (en) | 1992-05-13 |
| EP0484785A3 (en) | 1992-12-16 |
| GR3020017T3 (en) | 1996-08-31 |
| KR920009397A (ko) | 1992-06-25 |
| PT99434A (pt) | 1992-09-30 |
| IL99966A0 (en) | 1992-08-18 |
| HU913502D0 (en) | 1992-01-28 |
| DK0484785T3 (da) | 1996-09-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| DGB9 | Succession in title of applicant |
Owner name: DANA-FARBER CANCER INSTITUTE, US Owner name: HOECHST MARION ROUSSEL, INCORPORATED, US |
|
| DFC4 | Cancellation of temporary protection due to refusal |