HUP9903715A2 - 25-Hidroxi-16-én-26,27-bisz-homo-kolekalciferolok, alkalmazásuk és ezeket tartalmazó gyógyszerkészítmények - Google Patents

25-Hidroxi-16-én-26,27-bisz-homo-kolekalciferolok, alkalmazásuk és ezeket tartalmazó gyógyszerkészítmények

Info

Publication number
HUP9903715A2
HUP9903715A2 HU9903715A HUP9903715A HUP9903715A2 HU P9903715 A2 HUP9903715 A2 HU P9903715A2 HU 9903715 A HU9903715 A HU 9903715A HU P9903715 A HUP9903715 A HU P9903715A HU P9903715 A2 HUP9903715 A2 HU P9903715A2
Authority
HU
Hungary
Prior art keywords
carbon
cholecalciferols
bishomo
ene
hydroxy
Prior art date
Application number
HU9903715A
Other languages
English (en)
Inventor
Jerome Anthony Iacobelli
Milan Radoje Uskokovic
Original Assignee
F.Hoffmann-La Roche Ag.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F.Hoffmann-La Roche Ag. filed Critical F.Hoffmann-La Roche Ag.
Publication of HUP9903715A2 publication Critical patent/HUP9903715A2/hu
Publication of HUP9903715A3 publication Critical patent/HUP9903715A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C35/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C35/22—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system
    • C07C35/23—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system with hydroxy on a condensed ring system having two rings
    • C07C35/32—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system with hydroxy on a condensed ring system having two rings the condensed ring system being a (4.3.0) system, e.g. indenols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/29—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups
    • C07C45/292—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups with chromium derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/30—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation with halogen containing compounds, e.g. hypohalogenation
    • C07C45/305—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation with halogen containing compounds, e.g. hypohalogenation with halogenochromate reagents, e.g. pyridinium chlorochromate
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/385—Saturated compounds containing a keto group being part of a ring
    • C07C49/487—Saturated compounds containing a keto group being part of a ring containing hydroxy groups
    • C07C49/507—Saturated compounds containing a keto group being part of a ring containing hydroxy groups polycyclic
    • C07C49/513—Saturated compounds containing a keto group being part of a ring containing hydroxy groups polycyclic a keto group being part of a condensed ring system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

A találmány szerinti (I) általánős képletű vegyületek (mely képletben A jelentése E vagy Z sztereőkémiai kőnfigűrációjú szén-szénkettőskötés, vagy szén-szén hármaskötés; Et jelentése etilcsőpőrt, és R jelentése hidrőxilcsőpőrt és R1jelentése hidrőgénatőm vagy =CH2; vagy R jelentése hidrőgén- vagyflűőratőm és R1 jelentése =CH2). HL-60 sejtek differenciálódásátserkentik, és ezért daganatős betegségek (pl. leűkémia) kezelésérealkalmazhatók. ŕ
HU9903715A 1995-11-22 1996-11-13 25-hydroxy-16-ene-26,27-bishomo-cholecalciferols, their use and medicaments containing them HUP9903715A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US874495P 1995-11-22 1995-11-22
PCT/EP1996/004954 WO1997019058A1 (en) 1995-11-22 1996-11-13 25-hydroxy-16-ene-26,27-bishomo-cholecalciferols

Publications (2)

Publication Number Publication Date
HUP9903715A2 true HUP9903715A2 (hu) 2000-03-28
HUP9903715A3 HUP9903715A3 (en) 2000-09-28

Family

ID=21733405

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9903715A HUP9903715A3 (en) 1995-11-22 1996-11-13 25-hydroxy-16-ene-26,27-bishomo-cholecalciferols, their use and medicaments containing them

Country Status (27)

Country Link
US (1) US6030963A (hu)
EP (1) EP0874814B1 (hu)
JP (2) JP3917184B2 (hu)
KR (1) KR19990071535A (hu)
CN (1) CN1076347C (hu)
AR (1) AR004726A1 (hu)
AT (1) ATE241599T1 (hu)
AU (1) AU705942B2 (hu)
BR (1) BR9611741A (hu)
CA (1) CA2237897C (hu)
CZ (1) CZ293489B6 (hu)
DE (1) DE69628458T2 (hu)
DK (1) DK0874814T3 (hu)
EA (1) EA002772B1 (hu)
ES (1) ES2198501T3 (hu)
HU (1) HUP9903715A3 (hu)
IL (1) IL124290A (hu)
MX (1) MX9803966A (hu)
MY (1) MY116582A (hu)
NO (1) NO982304L (hu)
NZ (1) NZ322035A (hu)
PL (1) PL186845B1 (hu)
PT (1) PT874814E (hu)
TR (1) TR199800908T2 (hu)
TW (1) TW403735B (hu)
WO (1) WO1997019058A1 (hu)
ZA (1) ZA969625B (hu)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5939408A (en) * 1996-05-23 1999-08-17 Hoffman-La Roche Inc. Vitamin D3 analogs
GB9625271D0 (en) * 1996-12-04 1997-01-22 Leo Pharm Prod Ltd Chemical compounds
US5919986A (en) * 1997-10-17 1999-07-06 Hoffmann-La Roche Inc. D-homo vitamin D3 derivatives
AU2004203436A1 (en) * 2003-09-24 2005-04-14 Bioxell Spa Compound and use in treatment
BRPI0404050A (pt) * 2003-09-24 2005-06-14 Bioxell Spa Uso de um composto ou de um seu sal ou éster farmaceuticamente aceitável, formulação farmacêutica, formulação acondicionada, composto, e, método para prevenir e/ou tratar hiperplasia benigna da próstata em pacientes em necessidade de tal prevenção ou tratamento
GB2407499B (en) * 2003-11-03 2008-02-27 Bioxell Spa Vitamin D3 analogue for use in the treatment of BPH
US20070054887A1 (en) * 2003-09-24 2007-03-08 Bioxell S.P.A Methods for treating bladder dysfunction
JP2008514621A (ja) * 2004-09-24 2008-05-08 ビオクセル エッセ ピ ア ２０−シクロアルキル，２６，２７−アルキル／ハロアルキル−ビタミンｄ３化合物及びその使用方法
US20100009949A1 (en) * 2006-03-24 2010-01-14 Bioxell S.P.A. Novel method
WO2012118154A1 (ja) * 2011-03-02 2012-09-07 学校法人日本大学 パーシャルアゴニスト活性を持つ新規ビタミンd受容体モジュレーター

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5145846A (en) * 1988-01-20 1992-09-08 Hoffmann-La Roche Inc. Vitamin D3 analogs
US5087619A (en) * 1988-01-20 1992-02-11 Hoffman-La Roche Inc. Vitamin D3 analogs
ZA8923B (en) * 1988-01-20 1989-09-27 Hoffmann La Roche 16-dehydro-vitamin d3-derivatives
TW267161B (hu) * 1992-11-20 1996-01-01 Hoffmann La Roche

Also Published As

Publication number Publication date
WO1997019058A1 (en) 1997-05-29
EA199800468A1 (ru) 1998-12-24
TR199800908T2 (xx) 2001-05-21
NO982304D0 (no) 1998-05-20
DE69628458T2 (de) 2004-03-18
IL124290A (en) 2002-09-12
EA002772B1 (ru) 2002-08-29
AU7570296A (en) 1997-06-11
ES2198501T3 (es) 2004-02-01
CZ157298A3 (cs) 1998-09-16
ATE241599T1 (de) 2003-06-15
HUP9903715A3 (en) 2000-09-28
CA2237897C (en) 2006-01-03
CZ293489B6 (cs) 2004-05-12
CN1076347C (zh) 2001-12-19
DE69628458D1 (de) 2003-07-03
BR9611741A (pt) 1999-02-23
KR19990071535A (ko) 1999-09-27
PL186845B1 (pl) 2004-03-31
JP3917184B2 (ja) 2007-05-23
JP2007126458A (ja) 2007-05-24
US6030963A (en) 2000-02-29
NZ322035A (en) 1998-11-25
MY116582A (en) 2004-02-28
EP0874814B1 (en) 2003-05-28
JP2000500476A (ja) 2000-01-18
CN1202885A (zh) 1998-12-23
DK0874814T3 (da) 2003-09-22
AR004726A1 (es) 1999-03-10
NO982304L (no) 1998-07-07
EP0874814A1 (en) 1998-11-04
PT874814E (pt) 2003-09-30
PL326837A1 (en) 1998-10-26
MX9803966A (es) 1998-09-30
ZA969625B (en) 1997-05-22
AU705942B2 (en) 1999-06-03
CA2237897A1 (en) 1997-05-29
TW403735B (en) 2000-09-01

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