PT874814E - 25-hidroxi-16-eno-26,27-bis-homo-colecalciferois - Google Patents

25-hidroxi-16-eno-26,27-bis-homo-colecalciferois

Info

Publication number
PT874814E
PT874814E PT96938187T PT96938187T PT874814E PT 874814 E PT874814 E PT 874814E PT 96938187 T PT96938187 T PT 96938187T PT 96938187 T PT96938187 T PT 96938187T PT 874814 E PT874814 E PT 874814E
Authority
PT
Portugal
Prior art keywords
colecalciferois
eno
homo
bis
hydroxy
Prior art date
Application number
PT96938187T
Other languages
English (en)
Inventor
Milan Radoje Uskokovic
Jerome Anthony Iacobelli
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PT874814E publication Critical patent/PT874814E/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/59Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C35/00Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C35/22Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system
    • C07C35/23Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system with hydroxy on a condensed ring system having two rings
    • C07C35/32Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system with hydroxy on a condensed ring system having two rings the condensed ring system being a (4.3.0) system, e.g. indenols
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/29Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups
    • C07C45/292Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups with chromium derivatives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/30Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation with halogen containing compounds, e.g. hypohalogenation
    • C07C45/305Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation with halogen containing compounds, e.g. hypohalogenation with halogenochromate reagents, e.g. pyridinium chlorochromate
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/385Saturated compounds containing a keto group being part of a ring
    • C07C49/487Saturated compounds containing a keto group being part of a ring containing hydroxy groups
    • C07C49/507Saturated compounds containing a keto group being part of a ring containing hydroxy groups polycyclic
    • C07C49/513Saturated compounds containing a keto group being part of a ring containing hydroxy groups polycyclic a keto group being part of a condensed ring system
PT96938187T 1995-11-22 1996-11-13 25-hidroxi-16-eno-26,27-bis-homo-colecalciferois PT874814E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US874495P 1995-11-22 1995-11-22

Publications (1)

Publication Number Publication Date
PT874814E true PT874814E (pt) 2003-09-30

Family

ID=21733405

Family Applications (1)

Application Number Title Priority Date Filing Date
PT96938187T PT874814E (pt) 1995-11-22 1996-11-13 25-hidroxi-16-eno-26,27-bis-homo-colecalciferois

Country Status (27)

Country Link
US (1) US6030963A (pt)
EP (1) EP0874814B1 (pt)
JP (2) JP3917184B2 (pt)
KR (1) KR19990071535A (pt)
CN (1) CN1076347C (pt)
AR (1) AR004726A1 (pt)
AT (1) ATE241599T1 (pt)
AU (1) AU705942B2 (pt)
BR (1) BR9611741A (pt)
CA (1) CA2237897C (pt)
CZ (1) CZ293489B6 (pt)
DE (1) DE69628458T2 (pt)
DK (1) DK0874814T3 (pt)
EA (1) EA002772B1 (pt)
ES (1) ES2198501T3 (pt)
HU (1) HUP9903715A3 (pt)
IL (1) IL124290A (pt)
MX (1) MX9803966A (pt)
MY (1) MY116582A (pt)
NO (1) NO982304L (pt)
NZ (1) NZ322035A (pt)
PL (1) PL186845B1 (pt)
PT (1) PT874814E (pt)
TR (1) TR199800908T2 (pt)
TW (1) TW403735B (pt)
WO (1) WO1997019058A1 (pt)
ZA (1) ZA969625B (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5939408A (en) * 1996-05-23 1999-08-17 Hoffman-La Roche Inc. Vitamin D3 analogs
GB9625271D0 (en) * 1996-12-04 1997-01-22 Leo Pharm Prod Ltd Chemical compounds
US5919986A (en) * 1997-10-17 1999-07-06 Hoffmann-La Roche Inc. D-homo vitamin D3 derivatives
GB2407499B (en) * 2003-11-03 2008-02-27 Bioxell Spa Vitamin D3 analogue for use in the treatment of BPH
EP1663250A4 (en) * 2003-09-24 2006-12-20 Bioxell Spa TREATMENT OF MALFUNCTION OF BLADDER
CH698144B1 (fr) * 2003-09-24 2009-05-29 Bioxell Spa Analogue de la vitamine D3
PT103177A (pt) * 2003-09-24 2005-03-31 Bioxell Spa 1-alfa-fluoro-25-hidroxi-16,23e-dieno-26,27-bis-homo-20-epi-colecalciferol, seus sais ou esteres e sua utilizacao no fabrico de medicamentos
JP2008514621A (ja) * 2004-09-24 2008-05-08 ビオクセル エッセ ピ ア 20−シクロアルキル,26,27−アルキル/ハロアルキル−ビタミンd3化合物及びその使用方法
US20100009949A1 (en) * 2006-03-24 2010-01-14 Bioxell S.P.A. Novel method
US9018194B2 (en) * 2011-03-02 2015-04-28 Nibon University Vitamin D receptor modulators with partial agonist activity

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5145846A (en) * 1988-01-20 1992-09-08 Hoffmann-La Roche Inc. Vitamin D3 analogs
US5087619A (en) * 1988-01-20 1992-02-11 Hoffman-La Roche Inc. Vitamin D3 analogs
ZA8923B (en) * 1988-01-20 1989-09-27 Hoffmann La Roche 16-dehydro-vitamin d3-derivatives
TW267161B (pt) * 1992-11-20 1996-01-01 Hoffmann La Roche

Also Published As

Publication number Publication date
JP2007126458A (ja) 2007-05-24
EP0874814A1 (en) 1998-11-04
CN1076347C (zh) 2001-12-19
KR19990071535A (ko) 1999-09-27
US6030963A (en) 2000-02-29
DE69628458T2 (de) 2004-03-18
EP0874814B1 (en) 2003-05-28
JP3917184B2 (ja) 2007-05-23
NZ322035A (en) 1998-11-25
EA002772B1 (ru) 2002-08-29
CZ293489B6 (cs) 2004-05-12
NO982304D0 (no) 1998-05-20
BR9611741A (pt) 1999-02-23
PL326837A1 (en) 1998-10-26
CA2237897C (en) 2006-01-03
CZ157298A3 (cs) 1998-09-16
WO1997019058A1 (en) 1997-05-29
AU7570296A (en) 1997-06-11
CN1202885A (zh) 1998-12-23
CA2237897A1 (en) 1997-05-29
PL186845B1 (pl) 2004-03-31
MX9803966A (es) 1998-09-30
HUP9903715A2 (hu) 2000-03-28
DK0874814T3 (da) 2003-09-22
ATE241599T1 (de) 2003-06-15
AR004726A1 (es) 1999-03-10
ZA969625B (en) 1997-05-22
TR199800908T2 (xx) 2001-05-21
JP2000500476A (ja) 2000-01-18
DE69628458D1 (de) 2003-07-03
AU705942B2 (en) 1999-06-03
EA199800468A1 (ru) 1998-12-24
HUP9903715A3 (en) 2000-09-28
NO982304L (no) 1998-07-07
TW403735B (en) 2000-09-01
IL124290A (en) 2002-09-12
ES2198501T3 (es) 2004-02-01
MY116582A (en) 2004-02-28

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