EA199800468A1 - 25-гидрокси-16-ен-26,27-бисгомохолекальциферолы - Google Patents

25-гидрокси-16-ен-26,27-бисгомохолекальциферолы

Info

Publication number
EA199800468A1
EA199800468A1 EA199800468A EA199800468A EA199800468A1 EA 199800468 A1 EA199800468 A1 EA 199800468A1 EA 199800468 A EA199800468 A EA 199800468A EA 199800468 A EA199800468 A EA 199800468A EA 199800468 A1 EA199800468 A1 EA 199800468A1
Authority
EA
Eurasian Patent Office
Prior art keywords
denotes
carbon
hydrogen
bishomoholecalciferols
hydroxy
Prior art date
Application number
EA199800468A
Other languages
English (en)
Other versions
EA002772B1 (ru
Inventor
Джером Антони Йякобелли
Милан Радойе Ускоковиц
Original Assignee
Ф.Хоффманн-Ля Рош Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ф.Хоффманн-Ля Рош Аг filed Critical Ф.Хоффманн-Ля Рош Аг
Publication of EA199800468A1 publication Critical patent/EA199800468A1/ru
Publication of EA002772B1 publication Critical patent/EA002772B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C35/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C35/22—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system
    • C07C35/23—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system with hydroxy on a condensed ring system having two rings
    • C07C35/32—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system with hydroxy on a condensed ring system having two rings the condensed ring system being a (4.3.0) system, e.g. indenols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/29—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups
    • C07C45/292—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups with chromium derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/30—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation with halogen containing compounds, e.g. hypohalogenation
    • C07C45/305—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation with halogen containing compounds, e.g. hypohalogenation with halogenochromate reagents, e.g. pyridinium chlorochromate
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/385—Saturated compounds containing a keto group being part of a ring
    • C07C49/487—Saturated compounds containing a keto group being part of a ring containing hydroxy groups
    • C07C49/507—Saturated compounds containing a keto group being part of a ring containing hydroxy groups polycyclic
    • C07C49/513—Saturated compounds containing a keto group being part of a ring containing hydroxy groups polycyclic a keto group being part of a condensed ring system

Abstract

В заявке описаны соединения формулы (I)где A обозначает углерод-углеродную двойную связь, характеризующуюся стереохимической E- или Z-конфигурацией, или A обозначает углерод-углеродную тройную связь, Et обозначает этил, R обозначает гидроксил, a Rобозначает водород или =CH, или R обозначает водород или фтор, а Rобозначает =CH. Эти соединения стимулируют дифференцирование клеток HL-60 и, соответственно, могут быть использованы в качестве средств для лечения неопластических заболеваний, таких как лейкоз.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199800468A 1995-11-22 1996-11-13 25-гидрокси-16-ен-26,27-бисгомохолекальциферолы EA002772B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US874495P 1995-11-22 1995-11-22
PCT/EP1996/004954 WO1997019058A1 (en) 1995-11-22 1996-11-13 25-hydroxy-16-ene-26,27-bishomo-cholecalciferols

Publications (2)

Publication Number Publication Date
EA199800468A1 true EA199800468A1 (ru) 1998-12-24
EA002772B1 EA002772B1 (ru) 2002-08-29

Family

ID=21733405

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199800468A EA002772B1 (ru) 1995-11-22 1996-11-13 25-гидрокси-16-ен-26,27-бисгомохолекальциферолы

Country Status (27)

Country Link
US (1) US6030963A (ru)
EP (1) EP0874814B1 (ru)
JP (2) JP3917184B2 (ru)
KR (1) KR19990071535A (ru)
CN (1) CN1076347C (ru)
AR (1) AR004726A1 (ru)
AT (1) ATE241599T1 (ru)
AU (1) AU705942B2 (ru)
BR (1) BR9611741A (ru)
CA (1) CA2237897C (ru)
CZ (1) CZ293489B6 (ru)
DE (1) DE69628458T2 (ru)
DK (1) DK0874814T3 (ru)
EA (1) EA002772B1 (ru)
ES (1) ES2198501T3 (ru)
HU (1) HUP9903715A3 (ru)
IL (1) IL124290A (ru)
MX (1) MX9803966A (ru)
MY (1) MY116582A (ru)
NO (1) NO982304L (ru)
NZ (1) NZ322035A (ru)
PL (1) PL186845B1 (ru)
PT (1) PT874814E (ru)
TR (1) TR199800908T2 (ru)
TW (1) TW403735B (ru)
WO (1) WO1997019058A1 (ru)
ZA (1) ZA969625B (ru)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5939408A (en) * 1996-05-23 1999-08-17 Hoffman-La Roche Inc. Vitamin D3 analogs
GB9625271D0 (en) * 1996-12-04 1997-01-22 Leo Pharm Prod Ltd Chemical compounds
US5919986A (en) * 1997-10-17 1999-07-06 Hoffmann-La Roche Inc. D-homo vitamin D3 derivatives
EP1663250A4 (en) * 2003-09-24 2006-12-20 Bioxell Spa TREATMENT OF MALFUNCTION OF BLADDER
SG110107A1 (en) * 2003-09-24 2005-04-28 Bioxell Spa Compound and use in treatment
CH698144B1 (fr) * 2003-09-24 2009-05-29 Bioxell Spa Analogue de la vitamine D3
GB2407499B (en) * 2003-11-03 2008-02-27 Bioxell Spa Vitamin D3 analogue for use in the treatment of BPH
WO2006036813A2 (en) * 2004-09-24 2006-04-06 Bioxell S.P.A. 20-cycloalkyl,26,27-alkyl/haloalkyl vitamin d3 compounds and methods of use thereof
US20100009949A1 (en) * 2006-03-24 2010-01-14 Bioxell S.P.A. Novel method
JP5950413B2 (ja) * 2011-03-02 2016-07-13 学校法人日本大学 パーシャルアゴニスト活性を持つ新規ビタミンｄ受容体モジュレーター

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5145846A (en) * 1988-01-20 1992-09-08 Hoffmann-La Roche Inc. Vitamin D3 analogs
US5087619A (en) * 1988-01-20 1992-02-11 Hoffman-La Roche Inc. Vitamin D3 analogs
ZA8923B (en) * 1988-01-20 1989-09-27 Hoffmann La Roche 16-dehydro-vitamin d3-derivatives
TW267161B (ru) * 1992-11-20 1996-01-01 Hoffmann La Roche

Also Published As

Publication number Publication date
CZ293489B6 (cs) 2004-05-12
AU705942B2 (en) 1999-06-03
AU7570296A (en) 1997-06-11
NO982304L (no) 1998-07-07
TW403735B (en) 2000-09-01
TR199800908T2 (xx) 2001-05-21
HUP9903715A2 (hu) 2000-03-28
JP2007126458A (ja) 2007-05-24
ZA969625B (en) 1997-05-22
MX9803966A (es) 1998-09-30
US6030963A (en) 2000-02-29
EP0874814B1 (en) 2003-05-28
ES2198501T3 (es) 2004-02-01
NZ322035A (en) 1998-11-25
CN1076347C (zh) 2001-12-19
BR9611741A (pt) 1999-02-23
EP0874814A1 (en) 1998-11-04
CA2237897A1 (en) 1997-05-29
MY116582A (en) 2004-02-28
AR004726A1 (es) 1999-03-10
IL124290A (en) 2002-09-12
PT874814E (pt) 2003-09-30
DK0874814T3 (da) 2003-09-22
DE69628458T2 (de) 2004-03-18
CZ157298A3 (cs) 1998-09-16
WO1997019058A1 (en) 1997-05-29
NO982304D0 (no) 1998-05-20
JP2000500476A (ja) 2000-01-18
CA2237897C (en) 2006-01-03
HUP9903715A3 (en) 2000-09-28
JP3917184B2 (ja) 2007-05-23
ATE241599T1 (de) 2003-06-15
KR19990071535A (ko) 1999-09-27
EA002772B1 (ru) 2002-08-29
DE69628458D1 (de) 2003-07-03
CN1202885A (zh) 1998-12-23
PL186845B1 (pl) 2004-03-31
PL326837A1 (en) 1998-10-26

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU