HUP9902287A1 - Szintetikus poliszacharidok, eljárás előállításukra és a vegyületeket tartalmazó gyógyszerkészítmények - Google Patents

Szintetikus poliszacharidok, eljárás előállításukra és a vegyületeket tartalmazó gyógyszerkészítmények

Info

Publication number
HUP9902287A1
HUP9902287A1 HU9902287A HUP9902287A HUP9902287A1 HU P9902287 A1 HUP9902287 A1 HU P9902287A1 HU 9902287 A HU9902287 A HU 9902287A HU P9902287 A HUP9902287 A HU P9902287A HU P9902287 A1 HUP9902287 A1 HU P9902287A1
Authority
HU
Hungary
Prior art keywords
compounds
preparation
pharmaceutical compositions
compositions containing
method therefor
Prior art date
Application number
HU9902287A
Other languages
English (en)
Inventor
Pierre Alexandre Driguez
Philippe Duchaussoy
Peter Diederik Jan Grootenhuis
Jean-Marc Herbert
Maurice Petitou
Constant Adriaan Anton Van Boeckel
Original Assignee
Akzo Nobel N.V.
Sanofi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel N.V., Sanofi filed Critical Akzo Nobel N.V.
Publication of HUP9902287A1 publication Critical patent/HUP9902287A1/hu
Publication of HUP9902287A3 publication Critical patent/HUP9902287A3/hu
Publication of HU223691B1 publication Critical patent/HU223691B1/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof

Abstract

A találmány tárgya szintetikűs pőliszacharidők, amelyek tartalmaznakegy kapcsőló dőmént a III antitrőmbinhőz, és amelyek őlyan ötmőnőszacharidőt tartalmazó láncból állnak, amelyek összesen kétkarbőnsavcsőpőrtőt és legalább négy szűlfátcsőpőrtőt tartalmaznak,ahől a dőmén a nem redűkáló végén közvetlenül kapcsőlódik egy kapcsőlódőménőn keresztül a trőmbinhőz, és 10-25 mőnőszacharid egységből állóláncőt tartalmaz, a mőnőszacharid őlyan hexóz, pentóz vagy dezőxicűkőr, amelynek valamennyi hidrőxilcsőpőrtja egymástól függetlenül 1-6szénatőmős alkilcsőpőrttal éteresítve van, vagy szűlfátfőrmábanéeszteresítve van, és sóik, különösen gyógyszerészetileg alkalmazhatósóik. A vegyületek kőagűlációs rendellenességek kezelésérehasználhatók. A találmány a vegyületek előállítására szőlgáló eljárásra és avegyületeket hatóanyagként tartalmazó gyógyszerkészítményekre isvőnatkőzik. ŕ
HU9902287A 1996-07-19 1997-07-18 Szintetikus poliszacharidok, eljárás előállításukra és a vegyületeket tartalmazó gyógyszerkészítmények HU223691B1 (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9609116A FR2751334B1 (fr) 1996-07-19 1996-07-19 Polysaccharides synthetiques, procede pour leur preparation et compositions pharmaceutiques les contenant
PCT/FR1997/001344 WO1998003554A1 (fr) 1996-07-19 1997-07-18 Polysaccharides synthetiques, procede pour leur preparation et compositions pharmaceutiques les contenant

Publications (3)

Publication Number Publication Date
HUP9902287A1 true HUP9902287A1 (hu) 1999-10-28
HUP9902287A3 HUP9902287A3 (en) 2001-09-28
HU223691B1 HU223691B1 (hu) 2004-12-28

Family

ID=9494266

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9902287A HU223691B1 (hu) 1996-07-19 1997-07-18 Szintetikus poliszacharidok, eljárás előállításukra és a vegyületeket tartalmazó gyógyszerkészítmények

Country Status (36)

Country Link
US (1) US6534481B1 (hu)
EP (1) EP0912613B1 (hu)
JP (1) JP3345020B2 (hu)
KR (1) KR100311857B1 (hu)
CN (1) CN1200003C (hu)
AR (1) AR008068A1 (hu)
AT (1) ATE224917T1 (hu)
AU (1) AU726679B2 (hu)
BR (1) BR9710739B1 (hu)
CA (1) CA2261597C (hu)
CZ (1) CZ301009B6 (hu)
DE (1) DE69715866T2 (hu)
DK (1) DK0912613T3 (hu)
EE (1) EE03929B1 (hu)
ES (1) ES2184123T3 (hu)
FR (1) FR2751334B1 (hu)
HK (1) HK1019757A1 (hu)
HU (1) HU223691B1 (hu)
ID (1) ID20604A (hu)
IL (2) IL128018A0 (hu)
IS (1) IS1968B (hu)
MY (1) MY124548A (hu)
NO (1) NO319682B1 (hu)
NZ (1) NZ333721A (hu)
PL (1) PL190397B1 (hu)
PT (1) PT912613E (hu)
RU (1) RU2167163C2 (hu)
SA (1) SA99200037B1 (hu)
SI (1) SI0912613T1 (hu)
SK (1) SK284881B6 (hu)
TR (1) TR199900114T2 (hu)
TW (1) TW520376B (hu)
UA (1) UA61921C2 (hu)
WO (1) WO1998003554A1 (hu)
YU (1) YU49247B (hu)
ZA (1) ZA976340B (hu)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2773801B1 (fr) 1998-01-19 2000-05-12 Sanofi Sa Nouveaux pentasaccharides, procedes pour leurs preparations et compositions pharmaceutiques les contenant
FR2814463B1 (fr) * 2000-09-22 2002-11-15 Sanofi Synthelabo Nouveaux polysaccharides a activite antithrombotique comprenant au moins une liaison covalente avec la biotine ou un derive de la biotine
US7138531B2 (en) * 2001-10-15 2006-11-21 Kemin Pharma B.V.B.A. Preparation and use of carbohydrate-based bicyclic ring structures with antimicrobial and cytostatic activity
EP1574516A1 (en) * 2004-03-05 2005-09-14 Sanofi-Aventis Antithrombotic compound
US7563780B1 (en) * 2004-06-18 2009-07-21 Advanced Cardiovascular Systems, Inc. Heparin prodrugs and drug delivery stents formed therefrom
FR2874924B1 (fr) 2004-09-09 2006-12-01 Sanofi Aventis Sa Hexadecasaccharides biotinyles, leur preparation et leur utilisation therapeutique
TWI403334B (zh) * 2004-12-23 2013-08-01 Merck Sharp & Dohme 包含生物素殘基之抗血栓雙重抑制劑
TWI376234B (en) * 2005-02-01 2012-11-11 Msd Oss Bv Conjugates of a polypeptide and an oligosaccharide
IL181431A0 (en) * 2007-02-19 2007-07-04 Micha Shemer Fruit juice and puree with a lowered amount of available sugars
USRE46955E1 (en) * 2007-10-16 2018-07-17 Progen Pg500 Series Pty Ltd Sulfated oligosaccharide derivatives
CN102046781A (zh) 2008-05-30 2011-05-04 动量制药公司 糖结构以及制造和使用此类结构的方法
FR2935386B1 (fr) * 2008-08-26 2010-09-10 Sanofi Aventis Nouveaux polysaccharides a activite antithrombotique comprenant une liaion covalente avec une chaine amine
ES2939741T3 (es) * 2009-07-31 2023-04-26 Reliable Biopharmaceutical Llc Proceso para preparar fondaparinux sódico y productos intermedios útiles en la síntesis del mismo
FR2949115B1 (fr) 2009-08-14 2012-11-02 Sanofi Aventis OLIGOSACCHARIDES N-SULFATES ACTIVATEURS DES RECEPTEURS DES FGFs, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
FR2949114B1 (fr) 2009-08-14 2011-08-26 Sanofi Aventis OCTASACCHARIDES N-ACYLES ACTIVATEURS DES RECEPTEURS DES FGFs, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
US8420790B2 (en) 2009-10-30 2013-04-16 Reliable Biopharmaceutical Corporation Efficient and scalable process for the manufacture of Fondaparinux sodium
KR101682466B1 (ko) * 2010-02-01 2016-12-05 롯데정밀화학 주식회사 아세틸화 셀룰로오스 에테르 및 이를 포함하는 물품
WO2012042123A1 (fr) 2010-09-10 2012-04-05 Sanofi Polysaccharides biotinyles a activite antithrombotique et presentant une stabilite metabolique amelioree
FR2970969B1 (fr) 2011-01-27 2013-10-18 Sanofi Aventis Oligosaccharides 3-o-alkyles activateurs des recepteurs des fgfs, leur preparation et leur application en therapeutique
CN109134554B (zh) * 2017-06-15 2021-09-28 南京正大天晴制药有限公司 抗凝血的五糖类化合物及其制备方法和医药用途
CN109134555B (zh) * 2017-06-15 2021-09-28 南京正大天晴制药有限公司 抗凝血的五糖类化合物及其制备方法和医药用途
CN109134553B (zh) * 2017-06-15 2021-09-28 南京正大天晴制药有限公司 抗凝血的五糖类化合物及其制备方法和医药用途

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4801583A (en) 1982-01-15 1989-01-31 Choay S.A. Oligosaccharides and their biological applications
EP0300099A1 (en) 1987-07-20 1989-01-25 Akzo N.V. New pentasaccharides
US5382570A (en) 1990-04-23 1995-01-17 Akzo, N.V. Sulfated glycosaminoglycanoid derivatives of the dermatan sulfate and chondroitin sulfate type
US5378829A (en) 1990-04-23 1995-01-03 Akzo N.V. Sulfated glycosaminoglycanoid derivatives of the heparin and heparan sulfate type
IL102758A (en) 1991-08-23 1997-03-18 Akzo Nv Glycosaminoglycanoid derivatives, their preparation and pharmaceutical compositions comprising them
FR2704226B1 (fr) 1993-04-22 1995-07-21 Sanofi Elf 3-desoxy oligosaccharides, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
PT649854E (pt) 1993-09-01 2000-07-31 Akzo Nobel Nv Bisconjugados compreendendo dois sacaridos e um espacador
FR2749849B1 (fr) * 1996-06-14 1998-09-04 Sanofi Sa Polysaccharides synthetiques, procede pour leur preparation et compositions pharmaceutiques les contenant

Also Published As

Publication number Publication date
TR199900114T2 (xx) 1999-03-22
AU3774797A (en) 1998-02-10
US6534481B1 (en) 2003-03-18
BR9710739B1 (pt) 2008-11-18
EP0912613A1 (fr) 1999-05-06
EP0912613B1 (fr) 2002-09-25
NO319682B1 (no) 2005-09-05
NZ333721A (en) 2000-08-25
CN1200003C (zh) 2005-05-04
KR100311857B1 (ko) 2001-11-14
CZ301009B6 (cs) 2009-10-14
ES2184123T3 (es) 2003-04-01
RU2167163C2 (ru) 2001-05-20
CA2261597C (fr) 2004-12-14
YU1999A (sh) 2000-03-21
NO990215L (no) 1999-03-18
DE69715866D1 (de) 2002-10-31
JP3345020B2 (ja) 2002-11-18
CN1228785A (zh) 1999-09-15
HK1019757A1 (en) 2000-02-25
CZ16099A3 (cs) 1999-06-16
HU223691B1 (hu) 2004-12-28
SK5399A3 (en) 2000-05-16
IS1968B (is) 2004-12-15
SI0912613T1 (en) 2003-04-30
ID20604A (id) 1999-01-21
TW520376B (en) 2003-02-11
PL331259A1 (en) 1999-07-05
IS4945A (is) 1999-01-18
MY124548A (en) 2006-06-30
ATE224917T1 (de) 2002-10-15
CA2261597A1 (fr) 1998-01-29
DK0912613T3 (da) 2003-01-27
AU726679B2 (en) 2000-11-16
FR2751334A1 (fr) 1998-01-23
SA99200037B1 (ar) 2006-08-23
SK284881B6 (sk) 2006-02-02
IL128018A (en) 2007-10-31
EE9900015A (et) 1999-08-16
JP2000500807A (ja) 2000-01-25
FR2751334B1 (fr) 1998-10-16
BR9710739A (pt) 1999-08-17
EE03929B1 (et) 2002-12-16
DE69715866T2 (de) 2003-05-28
IL128018A0 (en) 1999-11-30
KR20000067909A (ko) 2000-11-25
UA61921C2 (uk) 2003-12-15
PT912613E (pt) 2003-01-31
WO1998003554A1 (fr) 1998-01-29
PL190397B1 (pl) 2005-12-30
ZA976340B (en) 1999-01-22
NO990215D0 (no) 1999-01-18
HUP9902287A3 (en) 2001-09-28
YU49247B (sh) 2004-12-31
AR008068A1 (es) 1999-12-09

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HFG4 Patent granted, date of granting

Effective date: 20041006