ES2184123T3 - Nuevos polisacaridos sinteticos que poseen las actividades farmacologicas anticoagulante y antitrombotica de la heparina. - Google Patents

Nuevos polisacaridos sinteticos que poseen las actividades farmacologicas anticoagulante y antitrombotica de la heparina.

Info

Publication number
ES2184123T3
ES2184123T3 ES97934596T ES97934596T ES2184123T3 ES 2184123 T3 ES2184123 T3 ES 2184123T3 ES 97934596 T ES97934596 T ES 97934596T ES 97934596 T ES97934596 T ES 97934596T ES 2184123 T3 ES2184123 T3 ES 2184123T3
Authority
ES
Spain
Prior art keywords
polysacarids
antitrombotic
heparine
anticoagulant
possess
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97934596T
Other languages
English (en)
Inventor
Pierre Alexandre Driguez
Philippe Duchaussoy
Jean-Marc Herbert
Maurice Petitou
Boeckel Constant Van
Peter Grootenhuis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Akzo Nobel NV
Original Assignee
Sanofi Synthelabo SA
Akzo Nobel NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Synthelabo SA, Akzo Nobel NV filed Critical Sanofi Synthelabo SA
Application granted granted Critical
Publication of ES2184123T3 publication Critical patent/ES2184123T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

ESTA INVENCION SE REFIERE A UN POLISACARIDO DE SINTESIS QUE COMPRENDE UN CAMPO DE ENLACE A LA ANTITROMBINA III CONSTITUIDO POR UN ENCADENAMIENTO DE CINCO MONOSACARIDOS QUE TIENEN EN TOTAL DOS FUNCIONES ACIDO CARBOXILICO Y AL MENOS CUATRO GRUPOS SULFO, ESTANDO ESTE CAMPO DIRECTAMENTE UNIDO A SU EXTREMO NO REDUCTOR POR UN CAMPO DE ENLACE A LA TROMBINA QUE COMPRENDE UN ENCADENAMIENTO DE 10 A 25 UNIDADES MONOSACARIDICAS ELEGIDAS ENTRE HEXOSAS, PENTOSAS O AZUCARES DESOXI EN LOS QUE TODOS LOS GRUPOS HIDROXILOS ESTAN ESTERIFICADOS POR UN GRUPO (C 1 -C SUB,6 ) O ESTERIFICADOS EN FORMA DE GRUPOS SULFO ASI COMO SUS SALES, EN PARTICULAR FARMACEUTICAMENTE ACEPTABLES.
ES97934596T 1996-07-19 1997-07-18 Nuevos polisacaridos sinteticos que poseen las actividades farmacologicas anticoagulante y antitrombotica de la heparina. Expired - Lifetime ES2184123T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9609116A FR2751334B1 (fr) 1996-07-19 1996-07-19 Polysaccharides synthetiques, procede pour leur preparation et compositions pharmaceutiques les contenant

Publications (1)

Publication Number Publication Date
ES2184123T3 true ES2184123T3 (es) 2003-04-01

Family

ID=9494266

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97934596T Expired - Lifetime ES2184123T3 (es) 1996-07-19 1997-07-18 Nuevos polisacaridos sinteticos que poseen las actividades farmacologicas anticoagulante y antitrombotica de la heparina.

Country Status (36)

Country Link
US (1) US6534481B1 (es)
EP (1) EP0912613B1 (es)
JP (1) JP3345020B2 (es)
KR (1) KR100311857B1 (es)
CN (1) CN1200003C (es)
AR (1) AR008068A1 (es)
AT (1) ATE224917T1 (es)
AU (1) AU726679B2 (es)
BR (1) BR9710739B1 (es)
CA (1) CA2261597C (es)
CZ (1) CZ301009B6 (es)
DE (1) DE69715866T2 (es)
DK (1) DK0912613T3 (es)
EE (1) EE03929B1 (es)
ES (1) ES2184123T3 (es)
FR (1) FR2751334B1 (es)
HK (1) HK1019757A1 (es)
HU (1) HU223691B1 (es)
ID (1) ID20604A (es)
IL (2) IL128018A0 (es)
IS (1) IS1968B (es)
MY (1) MY124548A (es)
NO (1) NO319682B1 (es)
NZ (1) NZ333721A (es)
PL (1) PL190397B1 (es)
PT (1) PT912613E (es)
RU (1) RU2167163C2 (es)
SA (1) SA99200037B1 (es)
SI (1) SI0912613T1 (es)
SK (1) SK284881B6 (es)
TR (1) TR199900114T2 (es)
TW (1) TW520376B (es)
UA (1) UA61921C2 (es)
WO (1) WO1998003554A1 (es)
YU (1) YU49247B (es)
ZA (1) ZA976340B (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2773801B1 (fr) 1998-01-19 2000-05-12 Sanofi Sa Nouveaux pentasaccharides, procedes pour leurs preparations et compositions pharmaceutiques les contenant
FR2814463B1 (fr) * 2000-09-22 2002-11-15 Sanofi Synthelabo Nouveaux polysaccharides a activite antithrombotique comprenant au moins une liaison covalente avec la biotine ou un derive de la biotine
US7138531B2 (en) * 2001-10-15 2006-11-21 Kemin Pharma B.V.B.A. Preparation and use of carbohydrate-based bicyclic ring structures with antimicrobial and cytostatic activity
EP1574516A1 (en) * 2004-03-05 2005-09-14 Sanofi-Aventis Antithrombotic compound
US7563780B1 (en) * 2004-06-18 2009-07-21 Advanced Cardiovascular Systems, Inc. Heparin prodrugs and drug delivery stents formed therefrom
FR2874924B1 (fr) * 2004-09-09 2006-12-01 Sanofi Aventis Sa Hexadecasaccharides biotinyles, leur preparation et leur utilisation therapeutique
TWI403334B (zh) * 2004-12-23 2013-08-01 Merck Sharp & Dohme 包含生物素殘基之抗血栓雙重抑制劑
TWI376234B (en) * 2005-02-01 2012-11-11 Msd Oss Bv Conjugates of a polypeptide and an oligosaccharide
IL181431A0 (en) * 2007-02-19 2007-07-04 Micha Shemer Fruit juice and puree with a lowered amount of available sugars
MX338213B (es) 2007-10-16 2016-04-07 Progen Pharmaceuticals Ltd Derivados de oligosacaridos sulfatados novedosos.
WO2009155108A1 (en) 2008-05-30 2009-12-23 Momenta Pharmaceuticals, Inc. Saccharide structures and methods of making and using such structures
FR2935386B1 (fr) * 2008-08-26 2010-09-10 Sanofi Aventis Nouveaux polysaccharides a activite antithrombotique comprenant une liaion covalente avec une chaine amine
WO2011014793A2 (en) 2009-07-31 2011-02-03 Reliable Biopharmaceutical Corporation Process for preparing fondaparinux sodium and intermediates useful in the synthesis thereof
FR2949114B1 (fr) 2009-08-14 2011-08-26 Sanofi Aventis OCTASACCHARIDES N-ACYLES ACTIVATEURS DES RECEPTEURS DES FGFs, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
FR2949115B1 (fr) 2009-08-14 2012-11-02 Sanofi Aventis OLIGOSACCHARIDES N-SULFATES ACTIVATEURS DES RECEPTEURS DES FGFs, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
US8420790B2 (en) 2009-10-30 2013-04-16 Reliable Biopharmaceutical Corporation Efficient and scalable process for the manufacture of Fondaparinux sodium
KR101682466B1 (ko) * 2010-02-01 2016-12-05 롯데정밀화학 주식회사 아세틸화 셀룰로오스 에테르 및 이를 포함하는 물품
JP2013537181A (ja) 2010-09-10 2013-09-30 サノフイ 抗血栓活性及び改善された代謝安定性を有するビオチン化多糖類
FR2970969B1 (fr) 2011-01-27 2013-10-18 Sanofi Aventis Oligosaccharides 3-o-alkyles activateurs des recepteurs des fgfs, leur preparation et leur application en therapeutique
CN109134554B (zh) * 2017-06-15 2021-09-28 南京正大天晴制药有限公司 抗凝血的五糖类化合物及其制备方法和医药用途
CN109134553B (zh) * 2017-06-15 2021-09-28 南京正大天晴制药有限公司 抗凝血的五糖类化合物及其制备方法和医药用途
CN109134555B (zh) * 2017-06-15 2021-09-28 南京正大天晴制药有限公司 抗凝血的五糖类化合物及其制备方法和医药用途

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4801583A (en) 1982-01-15 1989-01-31 Choay S.A. Oligosaccharides and their biological applications
EP0300099A1 (en) 1987-07-20 1989-01-25 Akzo N.V. New pentasaccharides
US5382570A (en) 1990-04-23 1995-01-17 Akzo, N.V. Sulfated glycosaminoglycanoid derivatives of the dermatan sulfate and chondroitin sulfate type
US5378829A (en) 1990-04-23 1995-01-03 Akzo N.V. Sulfated glycosaminoglycanoid derivatives of the heparin and heparan sulfate type
IL102758A (en) 1991-08-23 1997-03-18 Akzo Nv Glycosaminoglycanoid derivatives, their preparation and pharmaceutical compositions comprising them
FR2704226B1 (fr) 1993-04-22 1995-07-21 Sanofi Elf 3-desoxy oligosaccharides, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
ATE190619T1 (de) 1993-09-01 2000-04-15 Akzo Nobel Nv Biskonjugate, die zwei saccharide und einen spacer enthalten
FR2749849B1 (fr) * 1996-06-14 1998-09-04 Sanofi Sa Polysaccharides synthetiques, procede pour leur preparation et compositions pharmaceutiques les contenant

Also Published As

Publication number Publication date
ZA976340B (en) 1999-01-22
CN1200003C (zh) 2005-05-04
FR2751334B1 (fr) 1998-10-16
SK284881B6 (sk) 2006-02-02
CA2261597C (fr) 2004-12-14
JP2000500807A (ja) 2000-01-25
ATE224917T1 (de) 2002-10-15
YU49247B (sh) 2004-12-31
NO990215D0 (no) 1999-01-18
HK1019757A1 (en) 2000-02-25
IL128018A (en) 2007-10-31
CZ301009B6 (cs) 2009-10-14
US6534481B1 (en) 2003-03-18
KR100311857B1 (ko) 2001-11-14
HUP9902287A3 (en) 2001-09-28
HU223691B1 (hu) 2004-12-28
SA99200037B1 (ar) 2006-08-23
TR199900114T2 (xx) 1999-03-22
DE69715866T2 (de) 2003-05-28
PT912613E (pt) 2003-01-31
DE69715866D1 (de) 2002-10-31
JP3345020B2 (ja) 2002-11-18
RU2167163C2 (ru) 2001-05-20
BR9710739B1 (pt) 2008-11-18
UA61921C2 (uk) 2003-12-15
TW520376B (en) 2003-02-11
IS4945A (is) 1999-01-18
AU726679B2 (en) 2000-11-16
PL190397B1 (pl) 2005-12-30
PL331259A1 (en) 1999-07-05
AR008068A1 (es) 1999-12-09
IS1968B (is) 2004-12-15
AU3774797A (en) 1998-02-10
IL128018A0 (en) 1999-11-30
BR9710739A (pt) 1999-08-17
CA2261597A1 (fr) 1998-01-29
ID20604A (id) 1999-01-21
SI0912613T1 (en) 2003-04-30
NO319682B1 (no) 2005-09-05
SK5399A3 (en) 2000-05-16
DK0912613T3 (da) 2003-01-27
CN1228785A (zh) 1999-09-15
NZ333721A (en) 2000-08-25
CZ16099A3 (cs) 1999-06-16
EP0912613B1 (fr) 2002-09-25
YU1999A (sh) 2000-03-21
FR2751334A1 (fr) 1998-01-23
KR20000067909A (ko) 2000-11-25
EE9900015A (et) 1999-08-16
NO990215L (no) 1999-03-18
EP0912613A1 (fr) 1999-05-06
EE03929B1 (et) 2002-12-16
WO1998003554A1 (fr) 1998-01-29
HUP9902287A1 (hu) 1999-10-28
MY124548A (en) 2006-06-30

Similar Documents

Publication Publication Date Title
ES2184123T3 (es) Nuevos polisacaridos sinteticos que poseen las actividades farmacologicas anticoagulante y antitrombotica de la heparina.
DE69013224D1 (de) Fiberoptisches Defektmeldesystem.
DE69021680D1 (de) Optischer Verzweiger für multimodale faseroptische Systeme.
DE69022892D1 (de) Modulares Batterieneinbausystem, das aus mehreren Einzelmoduleinheiten besteht.
FI855055A0 (fi) Foerening, som baserar sig pao aotminstone ett cellulosa-estergrupp innehaollande derivat, foerfarande foer erhaollande av foereningen och cellulosa-estergrupper innehaollande fiber.
ES2112851T3 (es) Separacion por afinidad con membranas microporosas de poliamida activadas.
AR022358A1 (es) Una composicion de epo, un procedimiento para su obtencion, un preparado farmaceutico que la contiene y un procedimiento para aumentar la actividadespecifica de una composicion de epo
NO974564L (no) Karbohydratmodifiserte cytostatika
BR9908176A (pt) Sistema de monitoramento de linha de ramal e método de monitoramento de linha de ramal
FI883511A (fi) Derivat av tiometyl och svavelmetyl som har en effekt som motverkar sekretion av magsyra, processer foer deras framstaellning samt farmaceutiska sammansaettningar som ingaor i dem.
ES2047874T3 (es) Captador de membrana con concentracion de deformaciones.
FI990238A (fi) OptinenADd/drop-laite
ES2059321T3 (es) Heparinas, fracciones y fragmentos de heparinas libres de edta, procedimiento para su preparacion y composiciones farmaceuticas que los contienen.
PT1049706E (pt) Novos penta-sacaridos os respectivos metodos de producao e as composicoes farmaceuticas que os contem
DE68908495D1 (de) Optischer strahlteiler.
ES2160308T3 (es) Nuevos derivados amino-metil-heterociclicos, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.
BRPI0418210A (pt) enlace de fibra óptica, linha de cabo óptico, e, métodos para obter um enlace de fibra óptica, para produzir um cabo óptico, e para obter uma linha de cabo óptico
DK0904299T3 (da) Syntetiske polysaccharider, fremgangsmåde til fremstilling heraf og farmaceutiske sammensætninger indeholdende sådanne polysaccharider
FI895794A0 (fi) Foerfarande och anstalt foer maskinel torkning av fiberbaserat loesmaterial, som straomaterial, torv, traeflis och motsvarande.
BR0016579A (pt) Rede de comunicação, método para comunicar em uma rede incluindo uma pluralidade de primeiras estações e uma pluralidade de segundas estações, e, elemento de rede para uso em uma rede
ES2046345T3 (es) Procedimiento para la obtencion de esteres substituidos del acido acrilico.
AR057837A1 (es) Sistema de juego de bingo y de gestion de premios especiales para una pluralidad de salas y maquinas electronicas
DE58908505D1 (de) Faseroptischer Strahlteiler.
FI875075A (fi) Blandningar som baserar sig pao vinylaromatiska polymerer och som har hoeg formpressningsflytfoermaoga och vaermehaollfasthet.
AR017282A1 (es) Lineas de maiz endocriadas