HUP9901579A2 - A humán béta-2 integrin alfa-alegysége - Google Patents

A humán béta-2 integrin alfa-alegysége

Info

Publication number
HUP9901579A2
HUP9901579A2 HU9901579A HUP9901579A HUP9901579A2 HU P9901579 A2 HUP9901579 A2 HU P9901579A2 HU 9901579 A HU9901579 A HU 9901579A HU P9901579 A HUP9901579 A HU P9901579A HU P9901579 A2 HUP9901579 A2 HU P9901579A2
Authority
HU
Hungary
Prior art keywords
alpha subunit
human beta
integrin alpha
discloses
fragments
Prior art date
Application number
HU9901579A
Other languages
English (en)
Inventor
W. Michael Gallatin
Monica Van Der Vieren
Original Assignee
Icos Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Icos Corporation filed Critical Icos Corporation
Publication of HUP9901579A2 publication Critical patent/HUP9901579A2/hu
Publication of HUP9901579A3 publication Critical patent/HUP9901579A3/hu
Publication of HU223977B1 publication Critical patent/HU223977B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70546—Integrin superfamily
    • C07K14/70553—Integrin beta2-subunit-containing molecules, e.g. CD11, CD18
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • C07K16/2845—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta2-subunit-containing molecules, e.g. CD11, CD18
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6818—Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/04—Endocrine or metabolic disorders
    • G01N2800/042—Disorders of carbohydrate metabolism, e.g. diabetes, glucose metabolism

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

A találmány közzéteszi az ad-nek nevezett új hűmán b2 integrin a-alegységét, és az ezt előállító eljárásőkat és anyagőkat. Ezenkívülközzétesz fúziós fehérjéket is, amelyek tartalmazzák azextracellűláris ad fehérje fragmenseket, az ad I dőmain fragmenseketvagy a teljes hősszúságú ad pőlipeptideket és a hűmán imműnőglőbűlinkőnstans régióit. Az ad-re specifikűs kötőmőlekűlákat is közzéteszi atalálmány, mivel ezek hasznősak más fajőkból izőlált ad DNS biőlógiaiaktivitásának mérséklésére, melyek egyben a hűmán ad-t kódőlószekvenciákkal hőmőlógiát műtatnak. ŕ
HU9901579A 1996-02-22 1997-02-24 Alfa-d-integrin-re specifikus antitestek HU223977B1 (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/605,672 US5817515A (en) 1993-12-23 1996-02-22 Human B2 integrin alpha subunit antibodies
PCT/US1997/002713 WO1997031099A1 (en) 1996-02-22 1997-02-24 Human beta 2 integrin alpha subunit

Publications (3)

Publication Number Publication Date
HUP9901579A2 true HUP9901579A2 (hu) 1999-08-30
HUP9901579A3 HUP9901579A3 (en) 2001-10-29
HU223977B1 HU223977B1 (hu) 2005-03-29

Family

ID=24424704

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9901579A HU223977B1 (hu) 1996-02-22 1997-02-24 Alfa-d-integrin-re specifikus antitestek

Country Status (18)

Country Link
US (1) US5817515A (hu)
EP (1) EP0835301B1 (hu)
JP (1) JP2001526524A (hu)
CN (1) CN1103812C (hu)
AT (1) ATE293685T1 (hu)
AU (1) AU723110B2 (hu)
BR (1) BR9702101A (hu)
CA (1) CA2218755C (hu)
CZ (1) CZ287921B6 (hu)
DE (1) DE69733051D1 (hu)
FI (1) FI974018A (hu)
HU (1) HU223977B1 (hu)
IL (1) IL122011A (hu)
NO (1) NO318764B1 (hu)
PL (1) PL187013B1 (hu)
RU (1) RU2183671C2 (hu)
SK (1) SK283135B6 (hu)
WO (1) WO1997031099A1 (hu)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5837478A (en) * 1993-12-23 1998-11-17 Icos Corporation Method of identifying modulators of binding between and VCAM-1
US6620915B2 (en) * 1993-12-23 2003-09-16 Icos Corporation Monoclonal antibodies specific for integrin α-d subunit
US20030055231A1 (en) * 1998-10-28 2003-03-20 Jian Ni 12 human secreted proteins
JP2003527439A (ja) 2000-03-17 2003-09-16 ミレニアム・ファーマシューティカルズ・インコーポレイテッド 抗ｃｄ１８抗体と抗ｃｃｒ２抗体の混合物を用いる狭窄および再狭窄を抑制する方法
WO2023235971A1 (en) * 2022-06-08 2023-12-14 The Regents Of The University Of California Antibodies and immunotherapies that target the active conformation of integrin beta 2

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4271139A (en) * 1978-03-27 1981-06-02 Hiram Hart Scintillation proximity assay
US4568649A (en) * 1983-02-22 1986-02-04 Immunex Corporation Immediate ligand detection assay
WO1992006697A1 (en) * 1990-10-23 1992-04-30 Repligen Corporation Anti-inflammatory composition
CA2120500A1 (en) * 1991-10-01 1993-04-15 Mitsuaki Isobe Preventing allograft rejection with antibodies to adhesion molecules
DE69229275T2 (de) * 1991-10-04 1999-12-30 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, Rockville Herstellung eines arzneimittels zur behandlung von augenentzündung durch blockierung von zelladhäsionsmolekulen
US5470953A (en) * 1993-12-23 1995-11-28 Icos Corporation Human β2 integrin α subunit
WO1995027736A1 (en) * 1994-04-12 1995-10-19 Boehringer Ingelheim Pharmaceuticals, Inc. Use of agents which block intercellular adhesion molecule/receptor interaction in the treatment of respiratory viral infection

Also Published As

Publication number Publication date
SK283135B6 (sk) 2003-03-04
CA2218755A1 (en) 1997-08-28
EP0835301A1 (en) 1998-04-15
BR9702101A (pt) 1999-07-20
IL122011A0 (en) 1998-03-10
FI974018A (fi) 1997-12-03
HUP9901579A3 (en) 2001-10-29
AU2133397A (en) 1997-09-10
PL187013B1 (pl) 2004-04-30
US5817515A (en) 1998-10-06
HU223977B1 (hu) 2005-03-29
SK140997A3 (en) 1998-09-09
NO974852L (no) 1997-12-19
CN1189851A (zh) 1998-08-05
CA2218755C (en) 1999-08-31
CZ328697A3 (cs) 1998-07-15
DE69733051D1 (de) 2005-05-25
NO318764B1 (no) 2005-05-02
RU2183671C2 (ru) 2002-06-20
NO974852D0 (no) 1997-10-21
CZ287921B6 (cs) 2001-03-14
WO1997031099A1 (en) 1997-08-28
PL323195A1 (en) 1998-03-16
IL122011A (en) 2001-05-20
CN1103812C (zh) 2003-03-26
FI974018A0 (fi) 1997-10-21
ATE293685T1 (de) 2005-05-15
JP2001526524A (ja) 2001-12-18
AU723110B2 (en) 2000-08-17
EP0835301B1 (en) 2005-04-20

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Legal Events

Date Code Title Description
HFG4 Patent granted, date of granting

Effective date: 20050218

MM4A Lapse of definitive patent protection due to non-payment of fees