DE69733051D1 - Monoklonaler antikörper gegen ratte beta-2-integrin alpha d untereinheit und entsprechendes hybridoma - Google Patents

Monoklonaler antikörper gegen ratte beta-2-integrin alpha d untereinheit und entsprechendes hybridoma

Info

Publication number
DE69733051D1
DE69733051D1 DE69733051T DE69733051T DE69733051D1 DE 69733051 D1 DE69733051 D1 DE 69733051D1 DE 69733051 T DE69733051 T DE 69733051T DE 69733051 T DE69733051 T DE 69733051T DE 69733051 D1 DE69733051 D1 DE 69733051D1
Authority
DE
Germany
Prior art keywords
sub
unit
monoclonal antibody
integrin alpha
antibody against
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69733051T
Other languages
English (en)
Inventor
Michael Gallatin
Der Vieren Monica Van
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Icos Corp
Original Assignee
Icos Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Icos Corp filed Critical Icos Corp
Application granted granted Critical
Publication of DE69733051D1 publication Critical patent/DE69733051D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70546—Integrin superfamily
    • C07K14/70553—Integrin beta2-subunit-containing molecules, e.g. CD11, CD18
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • C07K16/2845—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta2-subunit-containing molecules, e.g. CD11, CD18
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6818—Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/04—Endocrine or metabolic disorders
    • G01N2800/042—Disorders of carbohydrate metabolism, e.g. diabetes, glucose metabolism

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DE69733051T 1996-02-22 1997-02-24 Monoklonaler antikörper gegen ratte beta-2-integrin alpha d untereinheit und entsprechendes hybridoma Expired - Lifetime DE69733051D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/605,672 US5817515A (en) 1993-12-23 1996-02-22 Human B2 integrin alpha subunit antibodies
PCT/US1997/002713 WO1997031099A1 (en) 1996-02-22 1997-02-24 Human beta 2 integrin alpha subunit

Publications (1)

Publication Number Publication Date
DE69733051D1 true DE69733051D1 (de) 2005-05-25

Family

ID=24424704

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69733051T Expired - Lifetime DE69733051D1 (de) 1996-02-22 1997-02-24 Monoklonaler antikörper gegen ratte beta-2-integrin alpha d untereinheit und entsprechendes hybridoma

Country Status (18)

Country Link
US (1) US5817515A (de)
EP (1) EP0835301B1 (de)
JP (1) JP2001526524A (de)
CN (1) CN1103812C (de)
AT (1) ATE293685T1 (de)
AU (1) AU723110B2 (de)
BR (1) BR9702101A (de)
CA (1) CA2218755C (de)
CZ (1) CZ287921B6 (de)
DE (1) DE69733051D1 (de)
FI (1) FI974018A (de)
HU (1) HU223977B1 (de)
IL (1) IL122011A (de)
NO (1) NO318764B1 (de)
PL (1) PL187013B1 (de)
RU (1) RU2183671C2 (de)
SK (1) SK283135B6 (de)
WO (1) WO1997031099A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5837478A (en) * 1993-12-23 1998-11-17 Icos Corporation Method of identifying modulators of binding between and VCAM-1
US6620915B2 (en) * 1993-12-23 2003-09-16 Icos Corporation Monoclonal antibodies specific for integrin α-d subunit
US20030055231A1 (en) * 1998-10-28 2003-03-20 Jian Ni 12 human secreted proteins
EP1267926A2 (de) 2000-03-17 2003-01-02 Millennium Pharmaceuticals, Inc. Verfahren zur hemmung von stenose und restenose mit einer mischung von antikörpern gegen cd18 und ccr2
WO2023235971A1 (en) * 2022-06-08 2023-12-14 The Regents Of The University Of California Antibodies and immunotherapies that target the active conformation of integrin beta 2

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4271139A (en) * 1978-03-27 1981-06-02 Hiram Hart Scintillation proximity assay
US4568649A (en) * 1983-02-22 1986-02-04 Immunex Corporation Immediate ligand detection assay
WO1992006697A1 (en) * 1990-10-23 1992-04-30 Repligen Corporation Anti-inflammatory composition
JPH07502727A (ja) * 1991-10-01 1995-03-23 ザ・ジエネラル・ホスピタル・コーポレーシヨン 接着分子に対する抗体を用いた同種移植片拒絶の防止
JP3679112B2 (ja) * 1991-10-04 2005-08-03 アメリカ合衆国 細胞接着分子の遮断による眼の炎症の治療
US5470953A (en) * 1993-12-23 1995-11-28 Icos Corporation Human β2 integrin α subunit
EP0757697A4 (de) * 1994-04-12 2000-05-17 Boehringer Ingelheim Pharma Verwendung von agentien, die die interzellülare wechselwirkung inhibieren, in der behandlung von viralen infektionen des atemweges

Also Published As

Publication number Publication date
NO974852D0 (no) 1997-10-21
JP2001526524A (ja) 2001-12-18
HU223977B1 (hu) 2005-03-29
SK283135B6 (sk) 2003-03-04
WO1997031099A1 (en) 1997-08-28
US5817515A (en) 1998-10-06
HUP9901579A3 (en) 2001-10-29
SK140997A3 (en) 1998-09-09
CN1189851A (zh) 1998-08-05
CA2218755A1 (en) 1997-08-28
PL187013B1 (pl) 2004-04-30
EP0835301A1 (de) 1998-04-15
PL323195A1 (en) 1998-03-16
AU723110B2 (en) 2000-08-17
EP0835301B1 (de) 2005-04-20
ATE293685T1 (de) 2005-05-15
BR9702101A (pt) 1999-07-20
NO974852L (no) 1997-12-19
AU2133397A (en) 1997-09-10
NO318764B1 (no) 2005-05-02
CA2218755C (en) 1999-08-31
FI974018A (fi) 1997-12-03
HUP9901579A2 (hu) 1999-08-30
FI974018A0 (fi) 1997-10-21
IL122011A0 (en) 1998-03-10
IL122011A (en) 2001-05-20
CZ328697A3 (cs) 1998-07-15
CN1103812C (zh) 2003-03-26
RU2183671C2 (ru) 2002-06-20
CZ287921B6 (cs) 2001-03-14

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Legal Events

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