HUP9900619A2 - Heterodimereket létrehozó hibrid proteinek - Google Patents

Heterodimereket létrehozó hibrid proteinek

Info

Publication number
HUP9900619A2
HUP9900619A2 HU9900619A HUP9900619A HUP9900619A2 HU P9900619 A2 HUP9900619 A2 HU P9900619A2 HU 9900619 A HU9900619 A HU 9900619A HU P9900619 A HUP9900619 A HU P9900619A HU P9900619 A2 HUP9900619 A2 HU P9900619A2
Authority
HU
Hungary
Prior art keywords
heterodimer
hybrid proteins
form heterodimers
expressed
proteins
Prior art date
Application number
HU9900619A
Other languages
English (en)
Inventor
Robert K. Campbell
Scott C. Chappel
Bradford A. Jameson
Original Assignee
Applied Research Systems, ARS Holding M.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applied Research Systems, ARS Holding M.V. filed Critical Applied Research Systems, ARS Holding M.V.
Publication of HUP9900619A2 publication Critical patent/HUP9900619A2/hu
Publication of HUP9900619A3 publication Critical patent/HUP9900619A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/04—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups
    • C07C209/22—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups by substitution of other functional groups
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/24—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A61P5/16—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4 for decreasing, blocking or antagonising the activity of the thyroid hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Reproductive Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Egy hibrid prőtein két kőexpresszált, dimert képző aminősav-szekvenciát tartalmaz. Az egyes szekvenciák tartalmazzák egy receptőr,mind példáűl a TBP1, vagy a TBP2 vagy egy ligandűm, mint példáűl azIL-6, az IFN-és a TPO kötő részletét egy heterődimer fehérjeszerűhőrmőn, mint péládűl a hCG egy alegységéhez kapcsőlódva. Az egyeskőexpresszált szekvenciák a megfelelő hőrmőn alegységeket úgytartalmazzák, hőgy az expresszió sőrán heterődimert képezzenek. Amegfelelő DNS-mőlekűlák, expressziós vektőrők és a gazdasejtet szinténleírásra kerültek, akárcsak a gyógyszerészeti készítmények és az ilyenprőteinek előállítására szőlgáló módszerek. ŕ
HU9900619A 1996-02-20 1997-02-20 Hybrid proteins which form heterodimers HUP9900619A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US1193696P 1996-02-20 1996-02-20

Publications (2)

Publication Number Publication Date
HUP9900619A2 true HUP9900619A2 (hu) 1999-06-28
HUP9900619A3 HUP9900619A3 (en) 2001-11-28

Family

ID=21752599

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9900619A HUP9900619A3 (en) 1996-02-20 1997-02-20 Hybrid proteins which form heterodimers

Country Status (25)

Country Link
US (5) US6193972B1 (hu)
EP (1) EP0894141B1 (hu)
JP (2) JP4140927B2 (hu)
KR (1) KR100369985B1 (hu)
CN (1) CN1261579C (hu)
AT (1) ATE295887T1 (hu)
AU (1) AU706504B2 (hu)
BG (1) BG64510B1 (hu)
BR (1) BR9707589A (hu)
CA (1) CA2245877C (hu)
CZ (1) CZ291212B6 (hu)
DE (1) DE69733309T2 (hu)
DK (1) DK0894141T3 (hu)
EA (1) EA002474B1 (hu)
EE (1) EE04025B1 (hu)
ES (1) ES2241040T3 (hu)
HU (1) HUP9900619A3 (hu)
IL (1) IL125864A (hu)
NO (1) NO321777B1 (hu)
NZ (1) NZ331539A (hu)
PL (1) PL187400B1 (hu)
PT (1) PT894141E (hu)
SK (1) SK282326B6 (hu)
UA (1) UA52646C2 (hu)
WO (1) WO1997030161A1 (hu)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA52646C2 (uk) * 1996-02-20 2003-01-15 Еплайд Рісьорч Системз Ерс Холдінг Н.В. Гібридні білки, фармацевтична композиція, що містить гібридний білок, ізольована молекула днк, що містить гібридний білок, вектор експресії, клітина-хазяїн, спосіб продукування гібридного білка, спосіб індукування визрівання фолікулів
US6635740B1 (en) * 1997-03-27 2003-10-21 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Ligand/lytic peptide compositions and methods of use
AU750244B2 (en) 1997-09-04 2002-07-11 Gryphon Sciences Modular protein libraries and methods of preparation
CA2399020A1 (en) * 2000-02-22 2001-08-30 Applied Research Systems Ars Holding N.V. Process of purification of hcg and recombinant hcg purified by that method
US20030228600A1 (en) * 2000-07-14 2003-12-11 Eppendorf 5 Prime, Inc. DNA isolation method and kit
IL147414A0 (en) * 2001-12-31 2002-08-14 Yeda Res & Dev Ifnar2 mutants, their production and use
US20030157091A1 (en) * 2002-02-14 2003-08-21 Dyax Corporation Multi-functional proteins
DE10247755B4 (de) * 2002-10-14 2006-01-19 Pfizenmaier, Klaus, Prof. Dr. Selektive, lokale Aktivierung von Mitgliedern der TNF-Rezeptorfamilie durch systemisch inaktive nicht-Antikörper-TNF-Liganden-Fusionsproteine
EP1711610A2 (en) * 2004-01-28 2006-10-18 Syntonix Pharmaceuticals, Inc. HETERODIMERIC FOLLICLE STIMULATING HORMONE-Fc (FSH-Fc) FUSION PROTEINS FOR THE TREATMENT OF INFERTILITY
US7947805B2 (en) 2004-12-23 2011-05-24 Merck Serono S.A. BCMA polypeptides and uses thereof
WO2006128908A1 (en) 2005-06-03 2006-12-07 Ares Trading S.A. Production of recombinant il-18 binding protein
MX2010003099A (es) * 2007-09-21 2010-05-17 Univ California Interferon de objetivo demuestra actividades potentes apoptoticas y antitumorales.
KR20100122491A (ko) * 2008-02-01 2010-11-22 크로모셀 코포레이션 세포주 및 이의 제조 및 사용 방법
CN102002495B (zh) * 2009-08-31 2012-07-18 成都蓉生药业有限责任公司 用于表达异二聚体糖蛋白激素的表达框、表达载体及制备方法
CN108285488B (zh) * 2011-03-25 2023-01-24 伊克诺斯科学公司 异二聚体免疫球蛋白
SI2956476T1 (sl) 2013-02-18 2020-03-31 Vegenics Pty Limited Molekule za vezavo na ligande in uporabe le-teh
MX2020014031A (es) * 2018-06-21 2021-05-12 Shattuck Labs Inc Proteinas heterodimericas y usos de las mismas.
CA3136992A1 (en) * 2019-05-24 2020-12-03 Proviva Therapeutics (Hong Kong) Limited Il-2 compositions and methods of use thereof

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Publication number Priority date Publication date Assignee Title
DE68926888T2 (de) * 1988-01-22 1997-01-09 Zymogenetics Inc Verfahren zur Herstellung von sekretierten Rezeptoranalogen
US5705478A (en) * 1989-02-21 1998-01-06 Washington University Covalently linked β subunits of the glycoprotein hormones as antagonists
US6225449B1 (en) * 1991-10-04 2001-05-01 Washington University Hormone analogs with multiple CTP extensions
US5116964A (en) * 1989-02-23 1992-05-26 Genentech, Inc. Hybrid immunoglobulins
AU5355790A (en) * 1989-04-19 1990-11-16 Cetus Corporation Multifunctional m-csf proteins and genes encoding therefor
US5650150A (en) * 1990-11-09 1997-07-22 Gillies; Stephen D. Recombinant antibody cytokine fusion proteins
IL99120A0 (en) * 1991-08-07 1992-07-15 Yeda Res & Dev Multimers of the soluble forms of tnf receptors,their preparation and pharmaceutical compositions containing them
US5932448A (en) * 1991-11-29 1999-08-03 Protein Design Labs., Inc. Bispecific antibody heterodimers
EP0670730B1 (en) 1992-03-30 2003-06-04 Immunex Corporation Fusion protein comprising two tumor necrosis factor receptors
US5447851B1 (en) * 1992-04-02 1999-07-06 Univ Texas System Board Of Dna encoding a chimeric polypeptide comprising the extracellular domain of tnf receptor fused to igg vectors and host cells
IL111125A0 (en) 1994-05-11 1994-12-29 Yeda Res & Dev Soluble oligomeric tnf/ngf super family ligand receptors and their use
UA52646C2 (uk) * 1996-02-20 2003-01-15 Еплайд Рісьорч Системз Ерс Холдінг Н.В. Гібридні білки, фармацевтична композиція, що містить гібридний білок, ізольована молекула днк, що містить гібридний білок, вектор експресії, клітина-хазяїн, спосіб продукування гібридного білка, спосіб індукування визрівання фолікулів
US6194177B1 (en) * 1996-02-20 2001-02-27 Applied Research Systems Ars Holding N.V. DNA encoding a hybrid heterodimeric protein

Also Published As

Publication number Publication date
BG64510B1 (bg) 2005-05-31
AU2125297A (en) 1997-09-02
KR19990082482A (ko) 1999-11-25
BR9707589A (pt) 2000-01-04
US6193972B1 (en) 2001-02-27
NO983799D0 (no) 1998-08-19
BG102705A (en) 1999-04-30
IL125864A0 (en) 1999-04-11
US20010014333A1 (en) 2001-08-16
EE04025B1 (et) 2003-04-15
NZ331539A (en) 2000-01-28
CN1212017A (zh) 1999-03-24
EP0894141A1 (en) 1999-02-03
AU706504B2 (en) 1999-06-17
DE69733309T2 (de) 2006-01-19
PT894141E (pt) 2005-09-30
NO983799L (no) 1998-10-19
CZ264498A3 (cs) 1998-12-16
SK282326B6 (sk) 2002-01-07
JP2000504586A (ja) 2000-04-18
DK0894141T3 (da) 2005-08-22
PL187400B1 (pl) 2004-06-30
ES2241040T3 (es) 2005-10-16
IL125864A (en) 2007-07-04
HUP9900619A3 (en) 2001-11-28
EE9800256A (et) 1999-02-15
JP4140927B2 (ja) 2008-08-27
NO321777B1 (no) 2006-07-03
CA2245877A1 (en) 1997-08-21
SK114898A3 (en) 1999-07-12
DE69733309D1 (de) 2005-06-23
KR100369985B1 (ko) 2004-03-26
US20040230034A1 (en) 2004-11-18
EA002474B1 (ru) 2002-06-27
EP0894141B1 (en) 2005-05-18
ATE295887T1 (de) 2005-06-15
CN1261579C (zh) 2006-06-28
US20100075402A1 (en) 2010-03-25
CA2245877C (en) 2013-09-03
UA52646C2 (uk) 2003-01-15
US7291339B2 (en) 2007-11-06
US20090240039A1 (en) 2009-09-24
WO1997030161A1 (en) 1997-08-21
PL328454A1 (en) 1999-02-01
JP2008019258A (ja) 2008-01-31
US6663867B2 (en) 2003-12-16
EA199800744A1 (ru) 1999-02-25
CZ291212B6 (cs) 2003-01-15

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