HUP9802372A2 - Szomatosztatin gyűrűs peptid analógjai - Google Patents

Szomatosztatin gyűrűs peptid analógjai

Info

Publication number
HUP9802372A2
HUP9802372A2 HU9802372A HUP9802372A HUP9802372A2 HU P9802372 A2 HUP9802372 A2 HU P9802372A2 HU 9802372 A HU9802372 A HU 9802372A HU P9802372 A HUP9802372 A HU P9802372A HU P9802372 A2 HUP9802372 A2 HU P9802372A2
Authority
HU
Hungary
Prior art keywords
carbon
alkyl
pipe
seeded
hydroxy
Prior art date
Application number
HU9802372A
Other languages
English (en)
Inventor
David H. Coy
John E. Taylor
Original Assignee
Biomeasure, Incorporated
The Administrators Of The Tulane Educational Fund
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biomeasure, Incorporated, The Administrators Of The Tulane Educational Fund filed Critical Biomeasure, Incorporated
Publication of HUP9802372A2 publication Critical patent/HUP9802372A2/hu
Publication of HUP9802372A3 publication Critical patent/HUP9802372A3/hu
Publication of HU221979B1 publication Critical patent/HU221979B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C07K14/6555—Somatostatins at least 1 amino acid in D-form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/16—Somatostatin; related peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

A találmány tárgya általánős képletű peptid, ahől A1 jelentése Cys vagy Mpa D- vagy L-izőmerje, A2 jelentése Asn, Gin, alifás aminősav, arőmás aminősav, vagy nemszerepel ez a rész, A3 jelentése arőmás aminősav, A4 jelentése His vagy arőmás aminősav, A7 jelentése Thr, Ser vagy alifás aminősav, A8 jelentése arőmás aminősav, A9 jelentése Cys D- vagy L-izőmerje, R1 és R2 jelentése egymástól függetlenül hidrőgénatőm, 1-12 szénatőmősalkilcsőpőrt, 7-20 szénatőmős fenil-alkil-csőpőrt, 11-20 szénatőmősnaftil-alkil-csőpőrt, 1-12 szénatőmős hidrőxi-alkil-csőpőrt, 7-20szénatőmős hidrőxi-fenil-csőpőrt, 11-20 szénatőmős hidrőxi-naftil-alkil-csőpőrt, vagy egy COE1, általánős képletű csőpőrt, amelyben E1jelentése 1-12 szénatőmős alkilcsőpőrt, 7-20 szénatőmős fenil-alkil-csőpőrt, 11-20 szénatőmős naftil-alkil-csőpőrt, 1-12 szénatőmőshidrőxi-alkil-csőpőrt, 7-20 szénatőmős hidrőxi-fenil-alkil-vagy 11-20szénatőmős hidrőxi-naftil-alkil-csőpőrt, és R3 jelentése NH2 vagy NH-Y-CH2Z általánős képletű csőpőrt, amelyben Yjelentése 1-12 szénatőmős szénhidrőgéncsőpőrt (kétértékű, példáűlegyenes vagy elágazó szénláncú alkilcsőpőrt), és Z jelentésehidrőgénatőm, hidrőxil-, karbőxil- vagyCONH2-csőpőrt, és az A1 és A2 csőpőrt őldalláncait diszűlfid híd köti össze, ésgyógyszerészetileg alkalmazható sói. A találmány szerinti peptideket inzűlinleadás gátlására lehetfelhasználni. ŕ
HU9802372A 1995-09-29 1996-09-04 Szomatosztatin gyűrűs peptid analógjai HU221979B1 (hu)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US463395P 1995-09-29 1995-09-29
US08/578,037 US5708135A (en) 1995-09-29 1995-12-26 Cyclic peptide analogs of somatostatin
PCT/US1996/014230 WO1997011962A1 (en) 1995-09-29 1996-09-04 Cyclic peptide analogs of somatostatin

Publications (3)

Publication Number Publication Date
HUP9802372A2 true HUP9802372A2 (hu) 1999-02-01
HUP9802372A3 HUP9802372A3 (en) 2000-03-28
HU221979B1 HU221979B1 (hu) 2003-03-28

Family

ID=26673267

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9802372A HU221979B1 (hu) 1995-09-29 1996-09-04 Szomatosztatin gyűrűs peptid analógjai

Country Status (23)

Country Link
US (2) US5708135A (hu)
EP (1) EP0859785B1 (hu)
JP (1) JP3983806B2 (hu)
KR (1) KR100430716B1 (hu)
CN (1) CN1154657C (hu)
AT (1) ATE201696T1 (hu)
AU (1) AU711423B2 (hu)
BR (1) BR9610725A (hu)
CA (1) CA2229544C (hu)
CZ (1) CZ289282B6 (hu)
DE (1) DE69613137T2 (hu)
DK (1) DK0859785T3 (hu)
ES (1) ES2158340T3 (hu)
GR (1) GR3036447T3 (hu)
HU (1) HU221979B1 (hu)
IL (2) IL155693A0 (hu)
NO (1) NO318369B1 (hu)
NZ (1) NZ316822A (hu)
PL (1) PL325959A1 (hu)
PT (1) PT859785E (hu)
SK (1) SK29298A3 (hu)
TW (1) TW514642B (hu)
WO (1) WO1997011962A1 (hu)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6864234B1 (en) 1999-06-25 2005-03-08 Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. Somatostatin agonists

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7238340B1 (en) * 1991-11-27 2007-07-03 Cis Bio International Monoamine, diamide, thiol-containing metal chelating agents
US5708135A (en) * 1995-09-29 1998-01-13 Biomeasure Incorporated Cyclic peptide analogs of somatostatin
NZ335879A (en) * 1996-12-04 2000-11-24 Univ Tulane Somatostatin antagonist peptides having a D-amino acid at the second residue
US6262229B1 (en) 1996-12-04 2001-07-17 Biomeasure Incorporated Somatostatin antagonists
US5972893A (en) * 1997-05-06 1999-10-26 Cedars-Sinai Medical Center Method of treating hyperprolactinemia and prolactinomas
EP1332762A1 (en) * 1997-05-01 2003-08-06 Cedars-Sinai Medical Center Method of treating hyperprolactinemia and prolactinomas
DE69812084T2 (de) * 1997-05-01 2003-12-24 Cedars Sinai Medical Center Verfahren zur behandlung von hyperprolaktinämia und prolaktinomen
CA2290592A1 (en) * 1997-05-13 1998-11-19 Michael Anthony Cawthorne Somatostatin and somatostatin agonists for decreasing body weight
US7026289B2 (en) * 1997-05-13 2006-04-11 Societe De Conseils De Recherches Et D'applications Scientifiques, Sas Method and compositions for treating hyperlipidemia and other conditions
EP0980253B1 (en) * 1997-05-13 2004-03-31 Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. Somatostatin and somatostatin agonists for treating insulin insensitivity and syndrome x
US6004928A (en) * 1997-05-13 1999-12-21 Biomeasure, Incorporated Method of treating hyperlipidemia
US6465613B1 (en) 1998-11-19 2002-10-15 Tulane University Hydrophilic somatostatin analogs
US6903074B1 (en) 1999-06-04 2005-06-07 Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. Neuromedin b and somatostatin receptor agonists
US6358491B1 (en) 1999-08-27 2002-03-19 Berlex Laboratories, Inc. Somatostatin analogs
US6579967B1 (en) 1999-12-14 2003-06-17 The Salk Institute For Biological Studies Receptor-selective somatostatin analogs
US7019109B2 (en) * 2001-03-16 2006-03-28 The Salk Institute For Bilogical Studies SSTR1-selective analogs
CA2461099A1 (en) 2001-09-21 2003-04-10 The Administrators Of The Tulane Educational Fund Diagnostic or therapeutic somatostatin or bombesin analog conjugates and uses thereof
KR101003622B1 (ko) * 2002-03-01 2010-12-24 더 어드미니스트레이터 오브 더 튜레인 에듀케이셔널 펀드 치료제 또는 세포독성제와 생물학적 활성 펩티드의컨쥬게이트
WO2004009614A2 (en) * 2002-07-24 2004-01-29 The Salk Institute For Biological Studies Receptor (sstr4)- selective somatostatin analogs
WO2004081031A2 (en) * 2003-03-10 2004-09-23 Biogen Idec Inc. Thiol-mediated drug attachment to targeting peptides
US7968080B2 (en) 2003-08-20 2011-06-28 The Regents Of The University Of California Somatostatin analogs with inhibitory activity to growth hormone release
US8691761B2 (en) 2006-10-16 2014-04-08 Jean E. F. Rivier Somatostatin receptor 2 antagonists
DK2076535T3 (da) 2006-10-16 2013-06-10 Salk Inst For Biological Studi Receptor(SSTR2)-selektive somatostatinantagonister
US9072841B2 (en) 2010-11-29 2015-07-07 Sanofi-Aventis Deutschland Gmbh Medicated module with automatic reservoir engagement

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2416048A1 (de) * 1974-04-03 1975-10-30 Hoechst Ag Neue peptide mit biologischer wirkung
US4133782A (en) * 1976-06-07 1979-01-09 The Salk Institute For Biological Studies Somatostatin analogs with dissociated biological activities
US4211693A (en) * 1977-09-20 1980-07-08 The Salk Institute For Biological Studies Peptides with para-substituted phenylalanine
US4225472A (en) * 1979-05-29 1980-09-30 American Home Products Corporation Truncated somatostatin analogs
FR2523125A1 (fr) * 1982-03-08 1983-09-16 Sanofi Sa Analogues de la somatostatine a activite biologique modifiee et medicaments en contenant
US4428942A (en) * 1982-05-17 1984-01-31 The Salk Institute For Biological Studies Analogs of somatostatin
GB8318552D0 (en) * 1983-07-08 1983-08-10 Sandoz Ltd Organic compounds
US4853371A (en) * 1986-06-17 1989-08-01 The Administrators Of The Tulane Educational Fund Therapeutic somatostatin analogs
US4798821A (en) * 1987-03-02 1989-01-17 Merck & Co., Inc. Antihypertensive therapy for diabetics
AU639371B2 (en) * 1987-07-10 1993-07-22 Novartis Ag Method of treating breast cancer
CA2046594A1 (en) * 1989-12-08 1991-06-09 David H. Coy Octapeptide analogs of somatostatin having threonine at the sixth position
JPH03252783A (ja) * 1990-03-02 1991-11-12 Hitachi Ltd データ処理装置
JPH04227540A (ja) * 1990-04-04 1992-08-17 Hitachi Ltd 演算処理装置及びディジタル信号処理プロセッサ
EP0945504A3 (en) * 1992-12-11 1999-12-08 The University Of Florida Materials and method for control of pests
JP3904244B2 (ja) * 1993-09-17 2007-04-11 株式会社ルネサステクノロジ シングル・チップ・データ処理装置
US5708135A (en) * 1995-09-29 1998-01-13 Biomeasure Incorporated Cyclic peptide analogs of somatostatin
JP3767085B2 (ja) * 1996-09-04 2006-04-19 セイコーエプソン株式会社 情報処理回路及びマイクロコンピュータ

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6864234B1 (en) 1999-06-25 2005-03-08 Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. Somatostatin agonists
US7144859B2 (en) 1999-06-25 2006-12-05 Societe De Conseils De Recherches Et D'applications Scientifiques Sas Somatostatin agonists

Also Published As

Publication number Publication date
ATE201696T1 (de) 2001-06-15
CN1154657C (zh) 2004-06-23
EP0859785B1 (en) 2001-05-30
NO318369B1 (no) 2005-03-14
CN1197460A (zh) 1998-10-28
CA2229544C (en) 2007-11-20
JP3983806B2 (ja) 2007-09-26
PT859785E (pt) 2001-11-30
WO1997011962A1 (en) 1997-04-03
EP0859785A1 (en) 1998-08-26
CA2229544A1 (en) 1997-04-03
GR3036447T3 (en) 2001-11-30
DE69613137D1 (de) 2001-07-05
IL123357A0 (en) 1998-09-24
NO981395D0 (no) 1998-03-27
NZ316822A (en) 1999-10-28
HUP9802372A3 (en) 2000-03-28
BR9610725A (pt) 1999-07-13
CZ48998A3 (cs) 1998-07-15
DE69613137T2 (de) 2001-11-15
IL155693A0 (en) 2003-11-23
JPH11512707A (ja) 1999-11-02
TW514642B (en) 2002-12-21
KR20000004896A (ko) 2000-01-25
ES2158340T3 (es) 2001-09-01
KR100430716B1 (ko) 2004-09-08
DK0859785T3 (da) 2001-08-27
AU711423B2 (en) 1999-10-14
NO981395L (no) 1998-03-27
US5708135A (en) 1998-01-13
SK29298A3 (en) 1998-08-05
AU6914596A (en) 1997-04-17
US6001801A (en) 1999-12-14
CZ289282B6 (cs) 2001-12-12
HU221979B1 (hu) 2003-03-28
EP0859785A4 (en) 1999-05-26
PL325959A1 (en) 1998-08-17

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Legal Events

Date Code Title Description
HFG4 Patent granted, date of granting

Effective date: 20030106

HPC4 Succession in title of patentee

Owner name: THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND

Owner name: SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATION

MM4A Lapse of definitive patent protection due to non-payment of fees