HUP9802372A2 - Szomatosztatin gyűrűs peptid analógjai - Google Patents

Szomatosztatin gyűrűs peptid analógjai

Info

Publication number
HUP9802372A2
HUP9802372A2 HU9802372A HUP9802372A HUP9802372A2 HU P9802372 A2 HUP9802372 A2 HU P9802372A2 HU 9802372 A HU9802372 A HU 9802372A HU P9802372 A HUP9802372 A HU P9802372A HU P9802372 A2 HUP9802372 A2 HU P9802372A2
Authority
HU
Hungary
Prior art keywords
carbon
alkyl
pipe
seeded
hydroxy
Prior art date
Application number
HU9802372A
Other languages
English (en)
Inventor
David H. Coy
John E. Taylor
Original Assignee
Biomeasure, Incorporated
The Administrators Of The Tulane Educational Fund
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biomeasure, Incorporated, The Administrators Of The Tulane Educational Fund filed Critical Biomeasure, Incorporated
Publication of HUP9802372A2 publication Critical patent/HUP9802372A2/hu
Publication of HUP9802372A3 publication Critical patent/HUP9802372A3/hu
Publication of HU221979B1 publication Critical patent/HU221979B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C07K14/6555—Somatostatins at least 1 amino acid in D-form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/16—Somatostatin; related peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

A találmány tárgya általánős képletű peptid, ahől A1 jelentése Cys vagy Mpa D- vagy L-izőmerje, A2 jelentése Asn, Gin, alifás aminősav, arőmás aminősav, vagy nemszerepel ez a rész, A3 jelentése arőmás aminősav, A4 jelentése His vagy arőmás aminősav, A7 jelentése Thr, Ser vagy alifás aminősav, A8 jelentése arőmás aminősav, A9 jelentése Cys D- vagy L-izőmerje, R1 és R2 jelentése egymástól függetlenül hidrőgénatőm, 1-12 szénatőmősalkilcsőpőrt, 7-20 szénatőmős fenil-alkil-csőpőrt, 11-20 szénatőmősnaftil-alkil-csőpőrt, 1-12 szénatőmős hidrőxi-alkil-csőpőrt, 7-20szénatőmős hidrőxi-fenil-csőpőrt, 11-20 szénatőmős hidrőxi-naftil-alkil-csőpőrt, vagy egy COE1, általánős képletű csőpőrt, amelyben E1jelentése 1-12 szénatőmős alkilcsőpőrt, 7-20 szénatőmős fenil-alkil-csőpőrt, 11-20 szénatőmős naftil-alkil-csőpőrt, 1-12 szénatőmőshidrőxi-alkil-csőpőrt, 7-20 szénatőmős hidrőxi-fenil-alkil-vagy 11-20szénatőmős hidrőxi-naftil-alkil-csőpőrt, és R3 jelentése NH2 vagy NH-Y-CH2Z általánős képletű csőpőrt, amelyben Yjelentése 1-12 szénatőmős szénhidrőgéncsőpőrt (kétértékű, példáűlegyenes vagy elágazó szénláncú alkilcsőpőrt), és Z jelentésehidrőgénatőm, hidrőxil-, karbőxil- vagyCONH2-csőpőrt, és az A1 és A2 csőpőrt őldalláncait diszűlfid híd köti össze, ésgyógyszerészetileg alkalmazható sói. A találmány szerinti peptideket inzűlinleadás gátlására lehetfelhasználni. ŕ
HU9802372A 1995-09-29 1996-09-04 Szomatosztatin gyűrűs peptid analógjai HU221979B1 (hu)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US463395P 1995-09-29 1995-09-29
US08/578,037 US5708135A (en) 1995-09-29 1995-12-26 Cyclic peptide analogs of somatostatin
PCT/US1996/014230 WO1997011962A1 (en) 1995-09-29 1996-09-04 Cyclic peptide analogs of somatostatin

Publications (3)

Publication Number Publication Date
HUP9802372A2 true HUP9802372A2 (hu) 1999-02-01
HUP9802372A3 HUP9802372A3 (en) 2000-03-28
HU221979B1 HU221979B1 (hu) 2003-03-28

Family

ID=26673267

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9802372A HU221979B1 (hu) 1995-09-29 1996-09-04 Szomatosztatin gyűrűs peptid analógjai

Country Status (23)

Country Link
US (2) US5708135A (hu)
EP (1) EP0859785B1 (hu)
JP (1) JP3983806B2 (hu)
KR (1) KR100430716B1 (hu)
CN (1) CN1154657C (hu)
AT (1) ATE201696T1 (hu)
AU (1) AU711423B2 (hu)
BR (1) BR9610725A (hu)
CA (1) CA2229544C (hu)
CZ (1) CZ289282B6 (hu)
DE (1) DE69613137T2 (hu)
DK (1) DK0859785T3 (hu)
ES (1) ES2158340T3 (hu)
GR (1) GR3036447T3 (hu)
HU (1) HU221979B1 (hu)
IL (2) IL123357A0 (hu)
NO (1) NO318369B1 (hu)
NZ (1) NZ316822A (hu)
PL (1) PL325959A1 (hu)
PT (1) PT859785E (hu)
SK (1) SK29298A3 (hu)
TW (1) TW514642B (hu)
WO (1) WO1997011962A1 (hu)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6864234B1 (en) 1999-06-25 2005-03-08 Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. Somatostatin agonists

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7238340B1 (en) * 1991-11-27 2007-07-03 Cis Bio International Monoamine, diamide, thiol-containing metal chelating agents
US5708135A (en) * 1995-09-29 1998-01-13 Biomeasure Incorporated Cyclic peptide analogs of somatostatin
US6262229B1 (en) 1996-12-04 2001-07-17 Biomeasure Incorporated Somatostatin antagonists
DE69736193T2 (de) * 1996-12-04 2007-05-03 Société de Conseils de Recherches et D'Applications Scientifiques (S.C.R.A.S.) Somatostatin-antagonisten
WO1998050063A1 (en) * 1997-05-01 1998-11-12 Cedars-Sinai Medical Center Method of treating hyperprolactinemia and prolactinomas
US5972893A (en) * 1997-05-06 1999-10-26 Cedars-Sinai Medical Center Method of treating hyperprolactinemia and prolactinomas
EP1332762A1 (en) * 1997-05-01 2003-08-06 Cedars-Sinai Medical Center Method of treating hyperprolactinemia and prolactinomas
DK0981363T3 (da) 1997-05-13 2003-12-01 Sod Conseils Rech Applic Somatostatinagonister til reduktion af legemsvægt
US7026289B2 (en) * 1997-05-13 2006-04-11 Societe De Conseils De Recherches Et D'applications Scientifiques, Sas Method and compositions for treating hyperlipidemia and other conditions
US6004928A (en) * 1997-05-13 1999-12-21 Biomeasure, Incorporated Method of treating hyperlipidemia
DE69822810T2 (de) * 1997-05-13 2005-02-03 Société de Conseils de Recherches et d'Applications Scientifiques S.A.S. Somatostatin und somatostatin agoniste zur behandlung der insulinsunempfindlichkeit und syndrome x
US6465613B1 (en) 1998-11-19 2002-10-15 Tulane University Hydrophilic somatostatin analogs
US6903074B1 (en) 1999-06-04 2005-06-07 Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. Neuromedin b and somatostatin receptor agonists
US6358491B1 (en) 1999-08-27 2002-03-19 Berlex Laboratories, Inc. Somatostatin analogs
US6579967B1 (en) 1999-12-14 2003-06-17 The Salk Institute For Biological Studies Receptor-selective somatostatin analogs
US7019109B2 (en) * 2001-03-16 2006-03-28 The Salk Institute For Bilogical Studies SSTR1-selective analogs
EP1435826A4 (en) 2001-09-21 2009-07-15 Univ Tulane CONJUGATES OF SOMATOSTATIN OR BOMBESIN ANALOGUES WITH A DIAGNOSTIC OR THERAPEUTIC VOCATION, AND USES THEREOF
EP1487493B1 (en) * 2002-03-01 2010-01-20 The Administrators of The Tulane Educational Fund Conjugates of cytotoxic agents and biologically active peptides
AU2003259172A1 (en) * 2002-07-24 2004-02-09 The Salk Institute For Biological Studies Receptor (sstr4)- selective somatostatin analogs
CA2518406A1 (en) * 2003-03-10 2004-09-23 Biogen Idec Ma Inc. Thiol-mediated drug attachment to targeting peptides
WO2005018682A2 (en) 2003-08-20 2005-03-03 The Regents Of The University Of California Somatostatin analogs with inhibitory activity to growth hormone release
US8691761B2 (en) 2006-10-16 2014-04-08 Jean E. F. Rivier Somatostatin receptor 2 antagonists
BRPI0717135B8 (pt) 2006-10-16 2021-05-25 Salk Inst Biological Studies antagonista peptídico cíclico de somastotatina e composição farmacêutica
US9072841B2 (en) 2010-11-29 2015-07-07 Sanofi-Aventis Deutschland Gmbh Medicated module with automatic reservoir engagement

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2416048A1 (de) * 1974-04-03 1975-10-30 Hoechst Ag Neue peptide mit biologischer wirkung
US4133782A (en) * 1976-06-07 1979-01-09 The Salk Institute For Biological Studies Somatostatin analogs with dissociated biological activities
US4211693A (en) * 1977-09-20 1980-07-08 The Salk Institute For Biological Studies Peptides with para-substituted phenylalanine
US4225472A (en) * 1979-05-29 1980-09-30 American Home Products Corporation Truncated somatostatin analogs
FR2523125A1 (fr) * 1982-03-08 1983-09-16 Sanofi Sa Analogues de la somatostatine a activite biologique modifiee et medicaments en contenant
US4428942A (en) * 1982-05-17 1984-01-31 The Salk Institute For Biological Studies Analogs of somatostatin
GB8318552D0 (en) * 1983-07-08 1983-08-10 Sandoz Ltd Organic compounds
US4853371A (en) * 1986-06-17 1989-08-01 The Administrators Of The Tulane Educational Fund Therapeutic somatostatin analogs
US4798821A (en) * 1987-03-02 1989-01-17 Merck & Co., Inc. Antihypertensive therapy for diabetics
AU639371B2 (en) * 1987-07-10 1993-07-22 Novartis Ag Method of treating breast cancer
ATE140237T1 (de) * 1989-12-08 1996-07-15 Univ Tulane Oktapeptidanaloge von somatostatin mit threonin in position 6
JPH03252783A (ja) * 1990-03-02 1991-11-12 Hitachi Ltd データ処理装置
JPH04227540A (ja) * 1990-04-04 1992-08-17 Hitachi Ltd 演算処理装置及びディジタル信号処理プロセッサ
US5358934A (en) * 1992-12-11 1994-10-25 The United States Of America As Represented By The Secretary Of Agriculture Materials and methods for control of pests
JP3904244B2 (ja) * 1993-09-17 2007-04-11 株式会社ルネサステクノロジ シングル・チップ・データ処理装置
US5708135A (en) * 1995-09-29 1998-01-13 Biomeasure Incorporated Cyclic peptide analogs of somatostatin
JP3767085B2 (ja) * 1996-09-04 2006-04-19 セイコーエプソン株式会社 情報処理回路及びマイクロコンピュータ

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6864234B1 (en) 1999-06-25 2005-03-08 Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. Somatostatin agonists
US7144859B2 (en) 1999-06-25 2006-12-05 Societe De Conseils De Recherches Et D'applications Scientifiques Sas Somatostatin agonists

Also Published As

Publication number Publication date
DE69613137D1 (de) 2001-07-05
NO981395L (no) 1998-03-27
CZ289282B6 (cs) 2001-12-12
SK29298A3 (en) 1998-08-05
ATE201696T1 (de) 2001-06-15
KR100430716B1 (ko) 2004-09-08
GR3036447T3 (en) 2001-11-30
BR9610725A (pt) 1999-07-13
NO318369B1 (no) 2005-03-14
IL123357A0 (en) 1998-09-24
EP0859785A4 (en) 1999-05-26
AU6914596A (en) 1997-04-17
CN1197460A (zh) 1998-10-28
WO1997011962A1 (en) 1997-04-03
KR20000004896A (ko) 2000-01-25
HU221979B1 (hu) 2003-03-28
PT859785E (pt) 2001-11-30
JP3983806B2 (ja) 2007-09-26
ES2158340T3 (es) 2001-09-01
CN1154657C (zh) 2004-06-23
TW514642B (en) 2002-12-21
EP0859785A1 (en) 1998-08-26
DE69613137T2 (de) 2001-11-15
NO981395D0 (no) 1998-03-27
IL155693A0 (en) 2003-11-23
HUP9802372A3 (en) 2000-03-28
PL325959A1 (en) 1998-08-17
EP0859785B1 (en) 2001-05-30
NZ316822A (en) 1999-10-28
US6001801A (en) 1999-12-14
CZ48998A3 (cs) 1998-07-15
AU711423B2 (en) 1999-10-14
US5708135A (en) 1998-01-13
CA2229544A1 (en) 1997-04-03
JPH11512707A (ja) 1999-11-02
CA2229544C (en) 2007-11-20
DK0859785T3 (da) 2001-08-27

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Legal Events

Date Code Title Description
HFG4 Patent granted, date of granting

Effective date: 20030106

HPC4 Succession in title of patentee

Owner name: THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND

Owner name: SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATION

MM4A Lapse of definitive patent protection due to non-payment of fees