DE69613137T2 - Zyklische peptidanaloga von somatostatin - Google Patents

Zyklische peptidanaloga von somatostatin

Info

Publication number
DE69613137T2
DE69613137T2 DE69613137T DE69613137T DE69613137T2 DE 69613137 T2 DE69613137 T2 DE 69613137T2 DE 69613137 T DE69613137 T DE 69613137T DE 69613137 T DE69613137 T DE 69613137T DE 69613137 T2 DE69613137 T2 DE 69613137T2
Authority
DE
Germany
Prior art keywords
cyclic peptide
peptide analog
somatostatin
somatostatin cyclic
terminus residue
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69613137T
Other languages
English (en)
Other versions
DE69613137D1 (de
Inventor
H Coy
E Taylor
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ipsen Pharma SAS
Tulane University
Original Assignee
Tulane University
Ipsen Bioscience Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tulane University, Ipsen Bioscience Inc filed Critical Tulane University
Publication of DE69613137D1 publication Critical patent/DE69613137D1/de
Application granted granted Critical
Publication of DE69613137T2 publication Critical patent/DE69613137T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C07K14/6555—Somatostatins at least 1 amino acid in D-form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/16—Somatostatin; related peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE69613137T 1995-09-29 1996-09-04 Zyklische peptidanaloga von somatostatin Expired - Lifetime DE69613137T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US463395P 1995-09-29 1995-09-29
US08/578,037 US5708135A (en) 1995-09-29 1995-12-26 Cyclic peptide analogs of somatostatin
PCT/US1996/014230 WO1997011962A1 (en) 1995-09-29 1996-09-04 Cyclic peptide analogs of somatostatin

Publications (2)

Publication Number Publication Date
DE69613137D1 DE69613137D1 (de) 2001-07-05
DE69613137T2 true DE69613137T2 (de) 2001-11-15

Family

ID=26673267

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69613137T Expired - Lifetime DE69613137T2 (de) 1995-09-29 1996-09-04 Zyklische peptidanaloga von somatostatin

Country Status (23)

Country Link
US (2) US5708135A (de)
EP (1) EP0859785B1 (de)
JP (1) JP3983806B2 (de)
KR (1) KR100430716B1 (de)
CN (1) CN1154657C (de)
AT (1) ATE201696T1 (de)
AU (1) AU711423B2 (de)
BR (1) BR9610725A (de)
CA (1) CA2229544C (de)
CZ (1) CZ289282B6 (de)
DE (1) DE69613137T2 (de)
DK (1) DK0859785T3 (de)
ES (1) ES2158340T3 (de)
GR (1) GR3036447T3 (de)
HU (1) HU221979B1 (de)
IL (2) IL123357A0 (de)
NO (1) NO318369B1 (de)
NZ (1) NZ316822A (de)
PL (1) PL325959A1 (de)
PT (1) PT859785E (de)
SK (1) SK29298A3 (de)
TW (1) TW514642B (de)
WO (1) WO1997011962A1 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7238340B1 (en) * 1991-11-27 2007-07-03 Cis Bio International Monoamine, diamide, thiol-containing metal chelating agents
US5708135A (en) * 1995-09-29 1998-01-13 Biomeasure Incorporated Cyclic peptide analogs of somatostatin
US6262229B1 (en) 1996-12-04 2001-07-17 Biomeasure Incorporated Somatostatin antagonists
ATE330966T1 (de) * 1996-12-04 2006-07-15 Sod Conseils Rech Applic Somatostatin-antagonisten
ATE234113T1 (de) * 1997-05-01 2003-03-15 Cedars Sinai Medical Center Verfahren zur behandlung von hyperprolaktinämia und prolaktinomen
US5972893A (en) * 1997-05-06 1999-10-26 Cedars-Sinai Medical Center Method of treating hyperprolactinemia and prolactinomas
EP1332762A1 (de) * 1997-05-01 2003-08-06 Cedars-Sinai Medical Center Methode zur Behandlung von Hyperprolaktinämia und Prolaktinomen
EP0981363B1 (de) * 1997-05-13 2003-07-30 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) Somatostatin agoniste zur reduzierung von körpergewicht
EP0981364B1 (de) * 1997-05-13 2006-03-01 Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. Methoden und zusammensetzungen zur behandlung der hyperlipidämie
US6004928A (en) * 1997-05-13 1999-12-21 Biomeasure, Incorporated Method of treating hyperlipidemia
ES2216290T3 (es) * 1997-05-13 2004-10-16 Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. Somatostatina y agonistas de la somatostatina para el tratamiento de insensibilidad a la insulina y de sindrome x.
US6465613B1 (en) 1998-11-19 2002-10-15 Tulane University Hydrophilic somatostatin analogs
US6903074B1 (en) 1999-06-04 2005-06-07 Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. Neuromedin b and somatostatin receptor agonists
US6864234B1 (en) 1999-06-25 2005-03-08 Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. Somatostatin agonists
US6358491B1 (en) 1999-08-27 2002-03-19 Berlex Laboratories, Inc. Somatostatin analogs
US6579967B1 (en) 1999-12-14 2003-06-17 The Salk Institute For Biological Studies Receptor-selective somatostatin analogs
US7019109B2 (en) * 2001-03-16 2006-03-28 The Salk Institute For Bilogical Studies SSTR1-selective analogs
PL369336A1 (en) 2001-09-21 2005-04-18 The Administrators Of The Tulane Educational Fund Diagnostic or therapeutic somatostatin or bombesin analog conjugates and uses thereof
WO2003074551A2 (en) * 2002-03-01 2003-09-12 The Administrators Of The Tulane Educational Fund Conjugates of therapeutic or cytotoxic agents and biologically active peptides
AU2003259172A1 (en) * 2002-07-24 2004-02-09 The Salk Institute For Biological Studies Receptor (sstr4)- selective somatostatin analogs
US20050118099A1 (en) * 2003-03-10 2005-06-02 Braslawsky Gary R. Thiol-mediated drug attachment to targeting peptides
CN100475271C (zh) 2003-08-20 2009-04-08 加利福尼亚大学董事会 具有抑制生长激素释放活性的促生长素抑制素类似物
US8691761B2 (en) 2006-10-16 2014-04-08 Jean E. F. Rivier Somatostatin receptor 2 antagonists
BRPI0717135B8 (pt) 2006-10-16 2021-05-25 Salk Inst Biological Studies antagonista peptídico cíclico de somastotatina e composição farmacêutica
CA2818833A1 (en) 2010-11-29 2012-06-07 Thomas Urs Thueer Medicated module with automatic reservoir engagement

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2416048A1 (de) * 1974-04-03 1975-10-30 Hoechst Ag Neue peptide mit biologischer wirkung
US4133782A (en) * 1976-06-07 1979-01-09 The Salk Institute For Biological Studies Somatostatin analogs with dissociated biological activities
US4211693A (en) * 1977-09-20 1980-07-08 The Salk Institute For Biological Studies Peptides with para-substituted phenylalanine
US4225472A (en) * 1979-05-29 1980-09-30 American Home Products Corporation Truncated somatostatin analogs
FR2523125A1 (fr) * 1982-03-08 1983-09-16 Sanofi Sa Analogues de la somatostatine a activite biologique modifiee et medicaments en contenant
US4428942A (en) * 1982-05-17 1984-01-31 The Salk Institute For Biological Studies Analogs of somatostatin
GB8318552D0 (en) * 1983-07-08 1983-08-10 Sandoz Ltd Organic compounds
US4853371A (en) * 1986-06-17 1989-08-01 The Administrators Of The Tulane Educational Fund Therapeutic somatostatin analogs
US4798821A (en) * 1987-03-02 1989-01-17 Merck & Co., Inc. Antihypertensive therapy for diabetics
AU639371B2 (en) * 1987-07-10 1993-07-22 Novartis Ag Method of treating breast cancer
ATE140237T1 (de) * 1989-12-08 1996-07-15 Univ Tulane Oktapeptidanaloge von somatostatin mit threonin in position 6
JPH03252783A (ja) * 1990-03-02 1991-11-12 Hitachi Ltd データ処理装置
JPH04227540A (ja) * 1990-04-04 1992-08-17 Hitachi Ltd 演算処理装置及びディジタル信号処理プロセッサ
EP0673387B1 (de) * 1992-12-11 1999-09-22 University Of Florida Materialien und methoden zur schädlingsbekämpfung
JP3904244B2 (ja) * 1993-09-17 2007-04-11 株式会社ルネサステクノロジ シングル・チップ・データ処理装置
US5708135A (en) * 1995-09-29 1998-01-13 Biomeasure Incorporated Cyclic peptide analogs of somatostatin
JP3767085B2 (ja) * 1996-09-04 2006-04-19 セイコーエプソン株式会社 情報処理回路及びマイクロコンピュータ

Also Published As

Publication number Publication date
KR20000004896A (ko) 2000-01-25
DK0859785T3 (da) 2001-08-27
CN1154657C (zh) 2004-06-23
JPH11512707A (ja) 1999-11-02
US6001801A (en) 1999-12-14
IL155693A0 (en) 2003-11-23
DE69613137D1 (de) 2001-07-05
AU6914596A (en) 1997-04-17
NO981395D0 (no) 1998-03-27
KR100430716B1 (ko) 2004-09-08
HUP9802372A2 (hu) 1999-02-01
JP3983806B2 (ja) 2007-09-26
ATE201696T1 (de) 2001-06-15
HUP9802372A3 (en) 2000-03-28
BR9610725A (pt) 1999-07-13
WO1997011962A1 (en) 1997-04-03
EP0859785A1 (de) 1998-08-26
HU221979B1 (hu) 2003-03-28
CZ48998A3 (cs) 1998-07-15
TW514642B (en) 2002-12-21
IL123357A0 (en) 1998-09-24
EP0859785B1 (de) 2001-05-30
PL325959A1 (en) 1998-08-17
SK29298A3 (en) 1998-08-05
CN1197460A (zh) 1998-10-28
CA2229544C (en) 2007-11-20
AU711423B2 (en) 1999-10-14
NO318369B1 (no) 2005-03-14
US5708135A (en) 1998-01-13
PT859785E (pt) 2001-11-30
NZ316822A (en) 1999-10-28
ES2158340T3 (es) 2001-09-01
GR3036447T3 (en) 2001-11-30
EP0859785A4 (de) 1999-05-26
NO981395L (no) 1998-03-27
CZ289282B6 (cs) 2001-12-12
CA2229544A1 (en) 1997-04-03

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATION

Owner name: THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND,

8327 Change in the person/name/address of the patent owner

Owner name: IPSEN PHARMA S.A.S., BOULOGNE-BILLANCOURT, FR

Owner name: THE ADMINISTRATORS OF THE TULANE EDUCATIONAL F, US