HUP9801704A2 - A protein tirozin-kináz által mediált sejtproliferáció gátlására szolgáló pirido[2,3-d]pirimidinek és ezeket tartalmazó gyógyszerkészítmények - Google Patents

A protein tirozin-kináz által mediált sejtproliferáció gátlására szolgáló pirido[2,3-d]pirimidinek és ezeket tartalmazó gyógyszerkészítmények

Info

Publication number
HUP9801704A2
HUP9801704A2 HU9801704A HUP9801704A HUP9801704A2 HU P9801704 A2 HUP9801704 A2 HU P9801704A2 HU 9801704 A HU9801704 A HU 9801704A HU P9801704 A HUP9801704 A HU P9801704A HU P9801704 A2 HUP9801704 A2 HU P9801704A2
Authority
HU
Hungary
Prior art keywords
tyrosine kinase
protein tyrosine
pyrido
pyrimidines
nr5r6
Prior art date
Application number
HU9801704A
Other languages
English (en)
Inventor
Clifton John Blankley
Diane Harris Boschelli
Annette Marian Doherty
James Marino Hamby
Sylvester Klutchko
Robert Lee Panek
Original Assignee
Warner-Lambert Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/433,294 external-priority patent/US5620981A/en
Application filed by Warner-Lambert Company filed Critical Warner-Lambert Company
Publication of HUP9801704A2 publication Critical patent/HUP9801704A2/hu
Publication of HUP9801704A3 publication Critical patent/HUP9801704A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A találmány a prőtein tirőzin-kináz (PTK) által mediált sejtprő-liferáció gátlására, közelebbről piridő[2,3-d]pirimidinekre és avegyületeknek a sejtprőliferáció gátlásában, illetve a prőteintirizin-kináz enzimatikűs aktivitásának gátlásában történőfelhasználására vőnatkőzik A találmány szerinti vegyületek ésgyógyászatilag elfőgadható sóik általánős képletében X iminő-, acil-iminő-csőpőrt, őxigén- vagy kénatőm, R1 -NR3R4, -S(O)0, 1 vagy 2-R3 vagy -OR3, R2, R3 és R4 hidrőgénatőm, -(CH2)nPh, ahől Ph adőtt esetben szűbsztitűált fenilcsőpőrt, és n 0, 1, 2 vagy 3, adőtt esetben szűbsztitűált heterőarőmás,ciklőalkil-, alkanőil-, alkil-, alkenil- vagy alkinilcsőpőrt, R4 tővábbi jelentése -C(=O)R3, -C(=O)OR3, -SO2R3, -SO2NR5R6, -C(=O)NR5R6, -C(=S)NR5R6, -C(=NH)R3, -C(=NH)NR5R6, valamint R3 és R4 azzal a nitrőgéatőmmal, amelyhez kapcsőlódnak, adőtt esetbenegy-hárőm heterőatőmőt tartalmazó gyűrűt képeznek, és Ar adőtt esetben szűbsztitűált fenil- vagy heterőarőmás csőpőrt. ŕ
HU9801704A 1995-05-03 1996-04-26 Pyrido[2,3-d]pyrimidines for inhibiting protein tyrosine kinase mediated cellular proliferation and medicaments containing them HUP9801704A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/433,294 US5620981A (en) 1995-05-03 1995-05-03 Pyrido [2,3-D]pyrimidines for inhibiting protein tyrosine kinase mediated cellular proliferation
US08/611,279 US5733914A (en) 1995-05-03 1996-04-03 Pyrido 2, 3-d!pyrimidines for inhibiting protein tyrosine kinase mediated cellular proliferation

Publications (2)

Publication Number Publication Date
HUP9801704A2 true HUP9801704A2 (hu) 1998-11-30
HUP9801704A3 HUP9801704A3 (en) 1999-03-01

Family

ID=27029804

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9801704A HUP9801704A3 (en) 1995-05-03 1996-04-26 Pyrido[2,3-d]pyrimidines for inhibiting protein tyrosine kinase mediated cellular proliferation and medicaments containing them

Country Status (21)

Country Link
EP (1) EP0823908B1 (hu)
JP (1) JP3885116B2 (hu)
CN (1) CN1083452C (hu)
AT (1) ATE344263T1 (hu)
AU (1) AU713727B2 (hu)
BG (1) BG62617B1 (hu)
CA (1) CA2214219C (hu)
CZ (1) CZ288160B6 (hu)
DE (1) DE69636671T2 (hu)
EA (1) EA000897B1 (hu)
EE (1) EE03770B1 (hu)
ES (1) ES2274526T3 (hu)
GE (1) GEP20002032B (hu)
HU (1) HUP9801704A3 (hu)
IL (1) IL117923A (hu)
MX (1) MX9706529A (hu)
NO (1) NO310110B1 (hu)
NZ (1) NZ307021A (hu)
PL (1) PL184093B1 (hu)
SK (1) SK283952B6 (hu)
WO (1) WO1996034867A1 (hu)

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SK141097A3 (en) 1998-07-08
EE9700274A (et) 1998-06-15
PL184093B1 (pl) 2002-08-30
CZ288160B6 (en) 2001-05-16
EP0823908A1 (en) 1998-02-18
DE69636671D1 (de) 2006-12-14
NO975033L (no) 1997-10-31
PL323089A1 (en) 1998-03-02
GEP20002032B (en) 2000-04-10
CA2214219A1 (en) 1996-11-07
CN1083452C (zh) 2002-04-24
CZ327597A3 (cs) 1998-03-18
CA2214219C (en) 2008-09-30
IL117923A (en) 2000-06-01
WO1996034867A1 (en) 1996-11-07
BG102003A (en) 1998-12-30
EA199700356A1 (ru) 1998-06-25
AU713727B2 (en) 1999-12-09
NO310110B1 (no) 2001-05-21
ES2274526T3 (es) 2007-05-16
NO975033D0 (no) 1997-10-31
CN1183099A (zh) 1998-05-27
MX9706529A (es) 1997-11-29
EA000897B1 (ru) 2000-06-26
DE69636671T2 (de) 2007-08-30
HUP9801704A3 (en) 1999-03-01
ATE344263T1 (de) 2006-11-15
SK283952B6 (sk) 2004-06-08
AU5576996A (en) 1996-11-21
JPH11504922A (ja) 1999-05-11
BG62617B1 (bg) 2000-03-31
EP0823908B1 (en) 2006-11-02
EE03770B1 (et) 2002-06-17
JP3885116B2 (ja) 2007-02-21
IL117923A0 (en) 1996-08-04
NZ307021A (en) 2001-04-27

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