HUP9701690A2 - Gombaellenes hatású tetrahidrofuránszármazékok és az ezeket tartalmazó gyógyszerkészítmények - Google Patents

Gombaellenes hatású tetrahidrofuránszármazékok és az ezeket tartalmazó gyógyszerkészítmények

Info

Publication number
HUP9701690A2
HUP9701690A2 HU9701690A HUP9701690A HUP9701690A2 HU P9701690 A2 HUP9701690 A2 HU P9701690A2 HU 9701690 A HU9701690 A HU 9701690A HU P9701690 A HUP9701690 A HU P9701690A HU P9701690 A2 HUP9701690 A2 HU P9701690A2
Authority
HU
Hungary
Prior art keywords
antifungals
same
pharmaceutical compositions
compositions containing
tetrahydrofuran derivatives
Prior art date
Application number
HU9701690A
Other languages
English (en)
Inventor
Frank Bennett
Ashit K. Ganguly
Viyyoor M. Girijavallabhan
Yi-Tsung Liu
Raymond G. Lovey
Russel E. Pike
Anil K. Saksena
Haiyan Wang
Original Assignee
Schering Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/458,543 external-priority patent/US5714490A/en
Priority claimed from US08/459,225 external-priority patent/US5710154A/en
Priority claimed from US08/459,145 external-priority patent/US5693626A/en
Application filed by Schering Corporation filed Critical Schering Corporation
Publication of HUP9701690A2 publication Critical patent/HUP9701690A2/hu
Publication of HUP9701690A3 publication Critical patent/HUP9701690A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

A találmány (I) általánős képletű, új vegyületekre - amelyekképletében X mindegyikének jelentése flűőratőm vagy klóratőm, vagy egymástólfüggetlenül az egyik jelentése flűőratőm, és a másik jelentéseklóratőm; és R1 jelentése egyszeresen vagy kétszeresen őlyan csőpőrtőkkal szűbsz-titűált 4-5 szénatőmős, egyenes vagy elágazó láncú alkilcsőpőrt, amelycsőpőrtők in vivő hidrőxicsőpőrtőkká alakíthatók - és gyógyszerészetileg elfőgadható sóira vőnatkőzik. A találmány kiterjed a vegyületeket hatóanyagként tartalmazóantifűngális gyógyszerkészítményekre is. ŕ
HU9701690A 1995-06-02 1996-05-30 Tetrahydrofuran derivatives as antifungals and pharmaceutical compositions containing the same HUP9701690A3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/458,543 US5714490A (en) 1993-12-21 1995-06-02 Tetrahydrofuran antifungals
US08/459,225 US5710154A (en) 1993-12-21 1995-06-02 Tetrahydrofuran antifungals
US08/459,145 US5693626A (en) 1993-12-21 1995-06-02 Tetrahydrofuran antifungals

Publications (2)

Publication Number Publication Date
HUP9701690A2 true HUP9701690A2 (hu) 1998-03-02
HUP9701690A3 HUP9701690A3 (en) 1998-04-28

Family

ID=27412736

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9701690A HUP9701690A3 (en) 1995-06-02 1996-05-30 Tetrahydrofuran derivatives as antifungals and pharmaceutical compositions containing the same

Country Status (19)

Country Link
EP (1) EP0773941B1 (hu)
CN (1) CN1073109C (hu)
AR (1) AR002751A1 (hu)
AT (1) ATE240319T1 (hu)
AU (1) AU5928096A (hu)
CA (1) CA2197672C (hu)
CZ (1) CZ59497A3 (hu)
DE (1) DE69628117T2 (hu)
ES (1) ES2199291T3 (hu)
HK (1) HK1008821A1 (hu)
HU (1) HUP9701690A3 (hu)
IL (1) IL118464A (hu)
MX (1) MX9701229A (hu)
NO (1) NO971218D0 (hu)
NZ (1) NZ309281A (hu)
PL (1) PL319635A1 (hu)
SK (1) SK27097A3 (hu)
TW (1) TW357146B (hu)
WO (1) WO1996038443A1 (hu)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4347911B2 (ja) * 1997-02-11 2009-10-21 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ アミノ酸エステル含有アゾール抗真菌剤
ZA989063B (en) * 1997-10-07 1999-04-06 Schering Corp Crystalline antifungal polymorph
AU9592998A (en) * 1997-10-07 1999-04-27 Schering Corporation Crystalline antifungal glycine ester polymorph
US6713481B1 (en) * 1997-10-17 2004-03-30 David R. Andrews Crystalline antifungal polymorph
US5883097A (en) * 1998-04-16 1999-03-16 Schering Corporation Soluble azole antifungal salt
EP0957101A1 (en) 1998-05-14 1999-11-17 Janssen Pharmaceutica N.V. Water soluble azoles as broad-spectrum antifungals
WO2000030655A1 (en) 1998-11-20 2000-06-02 Bristol-Myers Squibb Company Water soluble prodrugs of azole compounds
BR0010279A (pt) * 1999-05-04 2002-05-14 Janssen Phamaceutica N V éteres antifúngicos
US6362172B2 (en) 2000-01-20 2002-03-26 Bristol-Myers Squibb Company Water soluble prodrugs of azole compounds
US6448401B1 (en) 2000-11-20 2002-09-10 Bristol-Myers Squibb Company Process for water soluble azole compounds
EP2130540A1 (en) 2008-06-02 2009-12-09 Sandoz AG Pharmaceutical compositions containing a crystalline form of posaconazole
EP2141159A1 (en) 2008-07-03 2010-01-06 Sandoz AG A Crystalline form of posaconazole
EP2451805A1 (en) 2009-07-09 2012-05-16 Sandoz AG A crystalline form of posaconazole
CN102234267A (zh) * 2010-04-21 2011-11-09 中国科学院上海药物研究所 新型三氮唑类抗真菌化合物、其药物组合物及其制备方法和用途
MX342850B (es) 2010-05-19 2016-10-14 Sandoz Ag Proceso para la preparacion de triazolonas quirales.
EP2571868B1 (en) * 2010-05-19 2016-05-04 Sandoz AG Preparation of posaconazole intermediates
BR112012029228A2 (pt) * 2010-05-19 2021-08-03 Sandoz Ag processo para a preparação de um sal de cloreto de hidrogênio, sal de cloreto de hidrogênio, sal de cloreto de hidrogênio cristalino, uso de um sal e uso do processo
AU2011254656B2 (en) 2010-05-19 2015-04-16 Sandoz Ag Process for the preparation of chiral hydrazides
CN103635465A (zh) 2011-06-16 2014-03-12 桑多斯股份公司 制备手性化合物的方法
WO2015011224A1 (en) 2013-07-25 2015-01-29 Sandoz Ag Improved process for the preparation of crystalline form iv of posaconazole
ITMI20132114A1 (it) 2013-12-18 2015-06-19 Djada Pharmaceutical Sa Una forma cristallina di posaconazolo
CN104370894A (zh) * 2014-10-21 2015-02-25 江苏恒盛药业有限公司 无定型泊沙康唑的制备工艺
CN105622591B (zh) * 2014-11-06 2018-09-21 博瑞生物医药（苏州）股份有限公司 一种新型三唑类抗真菌药物的制备方法
MX370412B (es) 2014-12-05 2019-12-11 Pulmocide Ltd Compuesto antimicotico.
KR102653821B1 (ko) 2015-05-21 2024-04-02 풀모사이드 리미티드 항진균성 4-(4-(4-(((3r,5r)-5-((1h-1,2,4-트리아졸-1-일)메틸)-5-(2,4-디플루오로페닐)테트라하이드로푸란-3-일)메톡시)-3-메틸페닐)피페라진-1-일)-n-(2-하이드록시사이클로헥실)벤즈아미드 또는 이의 약학적으로 허용가능한 염.
CN106432338A (zh) * 2015-08-08 2017-02-22 陕西合成药业股份有限公司 泊沙康唑衍生物、合成和在长效制剂中的用途
CN105606736A (zh) * 2016-01-27 2016-05-25 重庆华邦制药有限公司 分离测定泊沙康唑中间体z1及其有关物质的方法
US10517867B2 (en) 2016-02-04 2019-12-31 Wuhan Ll Science And Technology Development Co., Ltd. Posaconazole derivative, pharmaceutical composition and use thereof
CN105949278B (zh) * 2016-03-30 2019-12-06 南京曼杰生物科技有限公司 一种取代的四氢呋喃水溶性衍生物及其应用
CN106986787A (zh) * 2017-03-30 2017-07-28 成都绿林科技有限公司 一种泊沙康唑中间体的合成方法
CN106866459A (zh) * 2017-03-30 2017-06-20 成都绿林科技有限公司 一种抗真菌药物中间体的制备方法
CN110938093B (zh) * 2018-09-21 2022-08-19 华创合成制药股份有限公司 一种泊沙康唑磷酸酯单胆碱盐及其制备方法和用途
CN113666915B (zh) * 2021-08-27 2022-08-16 江苏海洋大学 一种泊沙康唑中间体的制备方法
CN114315811B (zh) * 2021-11-19 2024-04-30 江苏恒盛药业有限公司 一种三氮唑类似物化合物及其制备方法和应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL103558A0 (en) * 1991-10-30 1993-03-15 Schering Corp Tri-substituted tetrahydrofuran antifungals
CZ294823B6 (cs) * 1993-12-21 2005-03-16 Schering Corporation Fungicidní tetrahydrofurany
SI0741737T1 (en) * 1994-01-24 2000-02-29 Janssen Pharmaceutica N.V. Watersoluble azole antifungals

Also Published As

Publication number Publication date
AU5928096A (en) 1996-12-18
HK1008821A1 (en) 1999-05-21
PL319635A1 (en) 1997-08-18
MX9701229A (es) 1997-05-31
SK27097A3 (en) 1997-09-10
DE69628117T2 (de) 2004-04-01
AR002751A1 (es) 1998-04-29
ATE240319T1 (de) 2003-05-15
NO971218L (no) 1997-03-17
EP0773941B1 (en) 2003-05-14
CN1073109C (zh) 2001-10-17
HUP9701690A3 (en) 1998-04-28
CN1161038A (zh) 1997-10-01
DE69628117D1 (de) 2003-06-18
NZ309281A (en) 1998-07-28
ES2199291T3 (es) 2004-02-16
NO971218D0 (no) 1997-03-17
CZ59497A3 (en) 1997-08-13
CA2197672A1 (en) 1996-12-05
IL118464A (en) 2000-08-13
IL118464A0 (en) 1996-09-12
TW357146B (en) 1999-05-01
CA2197672C (en) 2011-05-17
EP0773941A1 (en) 1997-05-21
WO1996038443A1 (en) 1996-12-05

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