AU5669298A - Cyclosporin derivatives, their preparation and pharmaceutical compositions containing them - Google Patents

Cyclosporin derivatives, their preparation and pharmaceutical compositions containing them

Info

Publication number
AU5669298A
AU5669298A AU56692/98A AU5669298A AU5669298A AU 5669298 A AU5669298 A AU 5669298A AU 56692/98 A AU56692/98 A AU 56692/98A AU 5669298 A AU5669298 A AU 5669298A AU 5669298 A AU5669298 A AU 5669298A
Authority
AU
Australia
Prior art keywords
preparation
pharmaceutical compositions
compositions containing
cyclosporin derivatives
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU56692/98A
Inventor
Jean-Claude Barriere
Georges Bashiardes
Jean-Christophe Carry
Michel Evers
Bruno Filoche
Jean-Pierre Leconte
Serge Mignani
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Rhone Poulenc Rorer SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Rorer SA filed Critical Rhone Poulenc Rorer SA
Publication of AU5669298A publication Critical patent/AU5669298A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

A cyclosporin compound of the formula (I): wherein Alk and R are as defined herein, or a pharmaceutically acceptable salt thereof, which derivatives are is useful in the treatment and/or prophylaxis of retrovirus infections.
AU56692/98A 1996-12-24 1997-12-23 Cyclosporin derivatives, their preparation and pharmaceutical compositions containing them Abandoned AU5669298A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9615956 1996-12-24
FR9615956A FR2757522B1 (en) 1996-12-24 1996-12-24 CYCLOSPORIN DERIVATIVES, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
PCT/FR1997/002405 WO1998028329A1 (en) 1996-12-24 1997-12-23 Cyclosporin derivatives, their preparation and pharmaceutical compositions containing them

Publications (1)

Publication Number Publication Date
AU5669298A true AU5669298A (en) 1998-07-17

Family

ID=9499089

Family Applications (1)

Application Number Title Priority Date Filing Date
AU56692/98A Abandoned AU5669298A (en) 1996-12-24 1997-12-23 Cyclosporin derivatives, their preparation and pharmaceutical compositions containing them

Country Status (14)

Country Link
US (1) US5965527A (en)
EP (1) EP0948527B1 (en)
JP (1) JP4172822B2 (en)
AT (1) ATE218580T1 (en)
AU (1) AU5669298A (en)
DE (1) DE69713148D1 (en)
DK (1) DK0948527T3 (en)
ES (1) ES2178037T3 (en)
FR (1) FR2757522B1 (en)
MA (1) MA26459A1 (en)
PT (1) PT948527E (en)
TN (1) TNSN97211A1 (en)
WO (1) WO1998028329A1 (en)
ZA (1) ZA9711606B (en)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1205220C (en) * 1998-06-12 2005-06-08 斯－凯穆公司 Novel cyclosporins
ES2255275T3 (en) 1998-07-01 2006-06-16 Debiopharm S.A. NEW CYCLOSPORINE WITH IMPROVED ACTIVITY PROFILE.
US6254860B1 (en) 1999-04-13 2001-07-03 Allergan Sales, Inc. Ocular treatment using cyclosporin-A derivatives
KR100982466B1 (en) 2001-10-19 2010-09-16 이소테크니카 인코포레이티드 Synthesis of cyclosporin analogs
ES2330625T3 (en) * 2001-10-19 2009-12-14 Isotechnika Inc. PRE-CONCENTRATED MICROEMULSION OF NEW CYCLOSPORINE ANALOGS.
US6987090B2 (en) * 2002-05-09 2006-01-17 Lg Household & Health Care Ltd. Use of 3-position cyclosporin derivatives for hair growth
KR20040039622A (en) * 2002-11-04 2004-05-12 주식회사 엘지생활건강 Use of 3-position cyclosporin derivatives for hair growth
GB0320638D0 (en) 2003-09-03 2003-10-01 Novartis Ag Organic compounds
NZ554514A (en) * 2004-10-01 2010-10-29 Scynexis Inc 3-ether and 3-thioether substituted cyclosporin derivatives for the treatment and prevention of hepatitis C infection
US7196161B2 (en) * 2004-10-01 2007-03-27 Scynexis Inc. 3-ether and 3-thioether substituted cyclosporin derivatives for the treatment and prevention of hepatitis C infection
UA88484C2 (en) * 2004-10-01 2009-10-26 Дебиофарм Са Use of [d-meala]3-[etval]4-cyclosporin for the treatment of hepatitis c infection and pharmaceutical composition comprising said [d-meala]3-[etval]4-cyclosporin
NZ555143A (en) * 2004-12-23 2009-12-24 Novartis Ag Compositions for HCV treatment
US20090214464A1 (en) * 2004-12-23 2009-08-27 Beat Weidmann Compounds for flaviviridae treatment
WO2007041631A1 (en) 2005-09-30 2007-04-12 Scynexis, Inc. ARYIiALKYL AND HETEROARYLALKYL DERIVATIVES OF CYCLOSPORINE A FOR THE TREATMENT AND PREVENTION OF VIRAL INFECTION
US7754685B2 (en) 2005-09-30 2010-07-13 Scynexis, Inc. Methods and pharmaceutical compositions for the treatment and prevention of hepatitis C infection
US7696165B2 (en) 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders
US7696166B2 (en) 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders
JP5377293B2 (en) 2006-05-19 2013-12-25 スシネキス インク Methods for treating and preventing eye diseases
US20100194497A1 (en) * 2006-06-02 2010-08-05 Claude Annie Perrichon Management of active electrons
MX2009003743A (en) * 2006-10-12 2009-06-18 Novartis Ag Use of modified cyclosporins.
US7576057B2 (en) 2006-11-20 2009-08-18 Scynexis, Inc. Cyclic peptides
WO2008127613A1 (en) * 2007-04-11 2008-10-23 Scynexis, Inc. New pharmaceutical compositions
NZ584356A (en) 2007-09-26 2011-10-28 Univ Oregon Health & Science Cyclic undecapeptides and derivatives as multiple sclerosis therapies
US20090306033A1 (en) * 2008-06-06 2009-12-10 Keqiang Li Novel cyclic peptides
EP2280989B1 (en) 2008-06-06 2016-02-10 Scynexis, Inc. Cyclosporin analogs and their use in the treatment of hcv infections
WO2010006117A2 (en) * 2008-07-10 2010-01-14 Allergan, Inc. Cyclosporin derivatives for treating ocular and dermal diseases and conditions
DE102008060549A1 (en) 2008-12-04 2010-06-10 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Drug-peptide construct for extracellular accumulation
CA2748389A1 (en) * 2008-12-31 2010-07-08 Scynexis, Inc. Derivatives of cyclosporin a
US8524671B2 (en) 2009-05-27 2013-09-03 Allergan, Inc Cyclosporin derivatives for treating inflammatory diseases and conditions
GB0912584D0 (en) * 2009-07-20 2009-08-26 Ucl Business Plc Cyclosporin conjugates
US9217015B2 (en) * 2010-07-16 2015-12-22 S&T Global Inc. Cyclosporin derivatives for the treatment and prevention of a viral infection
CN103153330B (en) * 2010-08-12 2017-08-18 美国科技环球有限公司 Application of the new cyclosporin derivative in the treatment and prevention of virus infection
RU2013120927A (en) * 2010-10-12 2014-11-20 Аллерган, Инк. ANALOGUES OF CYCLOSPORIN
US20120088734A1 (en) 2010-10-12 2012-04-12 Allergan, Inc. Cyclosporin Analogs
US9890198B2 (en) 2010-12-03 2018-02-13 S&T Global Inc. Cyclosporin derivatives and uses thereof
DK2651965T3 (en) 2010-12-15 2019-02-18 Contravir Pharmaceuticals Inc CYCLOSPORIN ANALOGUAL MODULES MODIFIED BY AMINO ACID 1 AND 3
EP2705856A1 (en) 2012-09-07 2014-03-12 Deutsches Zentrum für Neurodegenerative Erkrankungen e.V. Compounds for the treatment of neurodegenerative disorders

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0194972B1 (en) * 1985-03-11 1992-07-29 Sandoz Ag Novel cyclosporins
US4814323A (en) * 1986-03-25 1989-03-21 Andrieu J M Process for the treatment and the prevention of AIDS and other disorders induced by the LAV/HTLV III virus
CZ280909B6 (en) * 1990-11-02 1996-05-15 Novartis Ag Cyclosporins, their use when preparing a medicament for treating and prevention of aids, process of their preparation and mould strains usable in the process
AU722858B2 (en) * 1995-07-17 2000-08-10 Scynexis, Inc. Cyclosporin derivatives having an anti-HIV effect

Also Published As

Publication number Publication date
DE69713148D1 (en) 2002-07-11
US5965527A (en) 1999-10-12
EP0948527B1 (en) 2002-06-05
ZA9711606B (en) 1998-06-25
JP4172822B2 (en) 2008-10-29
MA26459A1 (en) 2004-12-20
TNSN97211A1 (en) 2005-03-15
DK0948527T3 (en) 2002-09-16
ATE218580T1 (en) 2002-06-15
WO1998028329A1 (en) 1998-07-02
FR2757522B1 (en) 1999-01-29
EP0948527A1 (en) 1999-10-13
FR2757522A1 (en) 1998-06-26
ES2178037T3 (en) 2002-12-16
JP2001507346A (en) 2001-06-05
PT948527E (en) 2002-11-29

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