HUP0700154A2 - Methods for producing hyaluronan in a recombinant host cell - Google Patents
Methods for producing hyaluronan in a recombinant host cellInfo
- Publication number
- HUP0700154A2 HUP0700154A2 HU0700154A HUP0700154A HUP0700154A2 HU P0700154 A2 HUP0700154 A2 HU P0700154A2 HU 0700154 A HU0700154 A HU 0700154A HU P0700154 A HUP0700154 A HU P0700154A HU P0700154 A2 HUP0700154 A2 HU P0700154A2
- Authority
- HU
- Hungary
- Prior art keywords
- methods
- host cell
- recombinant host
- producing hyaluronan
- hyaluronan
- Prior art date
Links
- KIUKXJAPPMFGSW-MNSSHETKSA-N hyaluronan Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)C1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H](C(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-MNSSHETKSA-N 0.000 title 1
- 229940099552 hyaluronan Drugs 0.000 title 1
- 229920002674 hyaluronan Polymers 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1051—Hexosyltransferases (2.4.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34264401P | 2001-12-21 | 2001-12-21 | |
| PCT/US2002/041067 WO2003054163A2 (en) | 2001-12-21 | 2002-12-20 | Methods for producing hyaluronan in a recombinant host cell |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0700154A2 true HUP0700154A2 (en) | 2007-05-29 |
| HU228693B1 HU228693B1 (hu) | 2013-05-28 |
Family
ID=23342668
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0700154A HU228693B1 (hu) | 2001-12-21 | 2002-12-20 | Eljárás hialuronán elõállítására egy rekombináns gazdasejtben |
| HUP1300136 HU1300136D0 (hu) | 2001-12-21 | 2007-05-29 | Eljárás hialuronán elõálltására egy rekombináns gazdasejtben |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HUP1300136 HU1300136D0 (hu) | 2001-12-21 | 2007-05-29 | Eljárás hialuronán elõálltására egy rekombináns gazdasejtben |
Country Status (18)
| Country | Link |
|---|---|
| US (5) | US7811806B2 (hu) |
| EP (1) | EP1572895B1 (hu) |
| JP (1) | JP2005525091A (hu) |
| KR (2) | KR100885163B1 (hu) |
| CN (1) | CN1636052B (hu) |
| AT (1) | ATE502115T1 (hu) |
| AU (1) | AU2002366711C1 (hu) |
| BR (1) | BR0215220A (hu) |
| CA (2) | CA2803931A1 (hu) |
| CZ (1) | CZ2004765A3 (hu) |
| DE (1) | DE60239495D1 (hu) |
| DK (1) | DK1572895T3 (hu) |
| ES (1) | ES2362354T3 (hu) |
| HU (2) | HU228693B1 (hu) |
| IL (2) | IL162302A0 (hu) |
| PL (2) | PL399352A1 (hu) |
| RU (1) | RU2346049C2 (hu) |
| WO (1) | WO2003054163A2 (hu) |
Families Citing this family (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7091008B1 (en) * | 1994-07-01 | 2006-08-15 | The Board Of Regents Of The University Of Oklahoma | Hyaluronan synthase genes and expression thereof in Bacillus hosts |
| EP1522579A3 (en) * | 1997-10-31 | 2007-11-07 | The Board Of Regents Of The University Of Oklahoma | Hyaluronan synthase gene and uses thereof |
| DE60236688D1 (de) * | 2001-06-13 | 2010-07-22 | Univ Oklahoma State | Hyaluronansynthase-gene und expression davon |
| PL399352A1 (pl) * | 2001-12-21 | 2012-10-08 | Novozymes Biopharma Dk A/S | Sposoby wytwarzania hialuronanu w rekombinowanej komórce gospodarzu |
| WO2003095638A1 (en) * | 2002-05-14 | 2003-11-20 | Novozymes A/S | Pectate lyase variants |
| ATE352637T1 (de) * | 2002-06-20 | 2007-02-15 | Novozymes Biopolymer As | Ausflockung mit zweiwertigem salz |
| AU2003254196A1 (en) * | 2002-07-26 | 2004-02-16 | Novozymes Biotech, Inc. | Methods for producing biological substances in pigment-deficient mutants of bacillus cells |
| EP2216640A1 (en) * | 2004-01-09 | 2010-08-11 | Novozymes, Inc. | Bacillus licheniformis chromosome |
| JP2007535917A (ja) * | 2004-03-31 | 2007-12-13 | ノボザイムス バイオポリマー アクティーゼルスカブ | 細菌細胞中でのヒアルロン酸の生産方法 |
| US7002007B2 (en) * | 2004-05-28 | 2006-02-21 | Calcigen Corporation | Production of high molecular weight hyaluronates |
| EP1766002B1 (en) | 2004-06-21 | 2015-11-18 | Novozymes A/S | Stably maintained multiple copies of at least two orf in the same orientation |
| EP1640457A1 (de) * | 2004-09-23 | 2006-03-29 | Bayer CropScience GmbH | Verfahren und Mittel zur Herstellung von Hyaluronan |
| DE602005015473D1 (de) * | 2004-09-23 | 2009-08-27 | Bayer Cropscience Ag | Verfahren und mittel zur herstellung von hyaluronan |
| EP1817347B1 (en) * | 2004-11-24 | 2017-05-17 | Albumedix A/S | Method of cross-linking hyaluronic acid with divinylsulfone |
| WO2006069578A1 (en) * | 2004-12-30 | 2006-07-06 | Novozymes Biopolymer A/S | Hyaluronic acid linked with a polymer of an alpha hydroxy acid |
| EP1696032A1 (de) * | 2005-02-23 | 2006-08-30 | Bayer CropScience GmbH | Verfahren und Mittel zur Herstellung von Hyaluronan in Pilzen |
| JP4639904B2 (ja) | 2005-03-30 | 2011-02-23 | チッソ株式会社 | 蛍光活性を有するルシフェラーゼの活性増強方法 |
| JP4609177B2 (ja) | 2005-04-28 | 2011-01-12 | チッソ株式会社 | カルシウム結合型発光蛋白質溶液の発光時間延長方法 |
| US20060287512A1 (en) * | 2005-05-04 | 2006-12-21 | Novozymes Biopolymer A/S | Method of controlling the content of selected component(s) from polymer(s) using molecular sieve(s) |
| EP1932909A4 (en) * | 2005-08-25 | 2009-04-08 | Toyo Boseki | VEGETABLE PRODUCING HYALURONIC ACID |
| AU2006298961B2 (en) * | 2005-10-05 | 2013-05-02 | Bayer Intellectual Property Gmbh | Plants with increased hyaluronan production |
| EP1772052A1 (de) | 2005-10-05 | 2007-04-11 | Bayer CropScience GmbH | Verbesserte Verfahren und Mittel zur Herstellung von Hyaluronan |
| JP2007174957A (ja) * | 2005-12-27 | 2007-07-12 | Toyobo Co Ltd | ヒアルロン酸生産酵母 |
| US20080038780A1 (en) | 2006-02-15 | 2008-02-14 | Novozymes Biopolymer A/S | Production of low molecular weight hyaluronic acid |
| BRPI0708776A2 (pt) * | 2006-03-14 | 2011-06-14 | Novozymes Biopolymer As | produto de Ácido hialurânico acrilado, e, processo para preparaÇço e mÉtodo para polimerizaÇço/reticulaÇço do mesmo |
| EP2049572A1 (en) | 2006-08-04 | 2009-04-22 | Novozymes Biopolymer A/S | Branched hyaluronic acid and method of manufacture |
| ATE533838T1 (de) | 2006-11-29 | 2011-12-15 | Novozymes Inc | Verfahren zur verbesserten einführung von dna in bakterienzellen |
| DK2104739T3 (da) | 2006-12-21 | 2013-10-07 | Novozymes Inc | Modificerede messenger-RNA-stabiliseringssekvenser til ekspression af gener i bakterieceller |
| EP2031053A1 (en) * | 2007-08-31 | 2009-03-04 | The University Of Queensland | Production of HA |
| WO2009026635A1 (en) * | 2007-08-31 | 2009-03-05 | The University Of Queensland | Production of hyaluronic acid |
| EP2036983A1 (de) | 2007-09-12 | 2009-03-18 | Bayer CropScience AG | Pflanzen, die erhöhte Mengen an Glucosaminglycanen synthetisieren |
| CN101878230B (zh) * | 2007-12-19 | 2012-11-21 | 赢创高施米特有限公司 | 乳液中的交联透明质酸 |
| WO2010068955A2 (en) * | 2008-12-13 | 2010-06-17 | Dna Microarray | MICROENVIRONMENT NICHE ASSAY FOR CiPS SCREENING |
| EP2213315A1 (en) | 2009-01-30 | 2010-08-04 | Mero S.r.L. | Antibacterial hydrogel and use thereof in orthopedics |
| CN102021213B (zh) * | 2009-09-17 | 2014-07-09 | 上海佰加壹医药有限公司 | 一种发酵生产透明质酸发酵液的方法 |
| WO2011109524A2 (en) | 2010-03-03 | 2011-09-09 | Novozymes, Inc. | Xylanase variants and polynucleotides encoding same |
| IT1401498B1 (it) | 2010-07-30 | 2013-07-26 | Mero Srl | Idrogelo a base di acido ialuronico e suo uso in ortopedia |
| IT1402384B1 (it) * | 2010-09-09 | 2013-09-04 | Fidia Farmaceutici | Processo per la produzione di acido ialuronico in escherichia coli o bacillus megaterium |
| IT1402385B1 (it) * | 2010-09-09 | 2013-09-04 | Fidia Farmaceutici | Processo per la produzione di acido ialuronico in escherichia coli o bacillus subtilis |
| WO2012163884A1 (en) | 2011-05-30 | 2012-12-06 | Novozymes Biopharma Dk A/S | Spray drying of high molecular weight hyaluronic acid |
| CN102911887A (zh) * | 2011-08-02 | 2013-02-06 | 山东省生物药物研究院 | 一种利用毕赤酵母基因调控发酵生产不同分子量透明质酸的方法 |
| KR20140058581A (ko) | 2011-09-02 | 2014-05-14 | 노보자임스 바이오파마 디케이 에이/에스 | 지연된 약물 방출용 히알루론산 함유 경구 제형 |
| DE102012201297A1 (de) * | 2012-01-31 | 2013-08-01 | Basf Se | Expressionsverfahren |
| CN102559559A (zh) * | 2012-02-21 | 2012-07-11 | 山东福瑞达生物医药有限公司 | 一种芽孢杆菌及采用该菌种生产透明质酸酶的方法 |
| CN103255187B (zh) * | 2012-02-21 | 2015-02-18 | 华熙福瑞达生物医药有限公司 | 一种低分子透明质酸盐、其制备方法及用途 |
| DK2817410T3 (en) * | 2012-02-22 | 2016-07-04 | Novozymes As | Improved fermentation management |
| WO2014100837A1 (en) | 2012-12-17 | 2014-06-26 | Bui The Duy | Computer aided implantation of body implants |
| CA2931726C (en) | 2013-11-25 | 2022-03-15 | Deuteria Biomaterials, Llc | Deuterium-enriched hyaluronan |
| CA2896038C (en) | 2015-07-03 | 2022-08-09 | Glycobiosciences Inc. | Polymer matrix compositions comprising a high concentration of bio-fermented sodium hyaluronate and uses thereof |
| CN106755022B (zh) * | 2015-11-25 | 2020-08-04 | 中国科学院大连化学物理研究所 | 乙酰葡萄糖胺磷酸变位酶AtAGM编码基因及其酶、制备、应用与酶活性检测方法 |
| MX2019000133A (es) | 2016-07-05 | 2019-04-22 | Novozymes As | Variantes de pectato liasa y polinucleotidos que las codifican. |
| CN107653280B (zh) * | 2016-07-25 | 2021-05-04 | 安琪酵母股份有限公司 | 透明质酸发酵用的组合物、培养基和方法及其应用 |
| CN106381279B (zh) * | 2016-08-29 | 2019-11-05 | 中国药科大学 | 一种细菌胞外多糖、其制备方法及其应用 |
| WO2020122429A1 (ko) * | 2018-12-10 | 2020-06-18 | 대화제약 주식회사 | 히알루론산 합성효소 변이 단백질 및 이를 이용한 히알루론산 생산 방법 |
| WO2020122430A1 (ko) * | 2018-12-10 | 2020-06-18 | 대화제약 주식회사 | 비병원성 세균을 이용하여 히알루론산 생산을 위한 발현 시스템 및 상기 발현 시스템을 이용한 히알루론산 생산방법 |
| KR102135044B1 (ko) * | 2018-12-10 | 2020-07-17 | 대화제약 주식회사 | 히알루론산 합성효소 변이 단백질 및 이를 이용한 히알루론산 생산 방법 |
| CN110055201B (zh) * | 2019-03-05 | 2021-05-28 | 江南大学 | 一种高产透明质酸寡糖的重组枯草芽孢杆菌的构建方法 |
| RU2719140C1 (ru) | 2019-07-26 | 2020-04-17 | Общество с ограниченной ответственностью "ЦЕНТР ТРАНСФЕРА БИОТЕХНОЛОГИЙ ОКА-Биотех" | Бактерия рода bacillus, продуцирующая гиалуроновую кислоту, и способ получения гиалуроновой кислоты с использованием указанной бактерии |
| RU2723722C1 (ru) * | 2019-07-26 | 2020-06-17 | Общество с ограниченной ответственностью "ЦЕНТР ТРАНСФЕРА БИОТЕХНОЛОГИЙ ОКА-Биотех" | ТАНДЕМНЫЙ ПРОМОТОР, ФУНКЦИОНИРУЮЩИЙ В БАКТЕРИИ РОДА Bacillus, ТРАНСФОРМИРОВАННАЯ БАКТЕРИЯ РОДА Bacillus - ПРОДУЦЕНТ ЦЕЛЕВОГО ПРОДУКТА, СОДЕРЖАЩАЯ УКАЗАННЫЙ ПРОМОТОР, И СПОСОБ ПОЛУЧЕНИЯ ЦЕЛЕВОГО ПРОДУКТА С ИСПОЛЬЗОВАНИЕМ УКАЗАННОЙ БАКТЕРИИ |
| CN111518825B (zh) * | 2020-04-30 | 2022-10-11 | 浙江工业大学 | 一种多基因组合表达制备蛹虫草多糖的方法 |
| US20240101611A1 (en) * | 2021-02-22 | 2024-03-28 | Danisco Us Inc. | Methods and compositions for producing proteins of interest in pigment deficient bacillus cells |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60251898A (ja) | 1984-05-25 | 1985-12-12 | Shiseido Co Ltd | 醗酵法によるヒアルロン酸の製造方法 |
| US6455304B1 (en) * | 1994-07-01 | 2002-09-24 | The Board Of Regents Of The University Of Oklahoma | Hyaluronate synthase gene and uses thereof |
| US6951743B2 (en) | 1997-10-31 | 2005-10-04 | University Of Oklahoma Board Of Regents | Hyaluronan synthase genes and expression thereof in bacillus hosts |
| IT1271001B (it) | 1994-07-26 | 1997-05-26 | Poli Ind Chimica Spa | Procedimento di preparazione di acido ialuronico mediante fermentazione con streptococcus |
| EP1522579A3 (en) | 1997-10-31 | 2007-11-07 | The Board Of Regents Of The University Of Oklahoma | Hyaluronan synthase gene and uses thereof |
| US5955310A (en) * | 1998-02-26 | 1999-09-21 | Novo Nordisk Biotech, Inc. | Methods for producing a polypeptide in a bacillus cell |
| CN101275143A (zh) * | 1998-04-02 | 2008-10-01 | 俄克拉何马大学董事会 | 编码透明质酸合酶的核酸及其应用方法 |
| CA2351593C (en) | 1998-11-11 | 2012-02-21 | The Board Of Regents Of The University Of Oklahoma | Polymer grafting by polysaccharide synthases |
| AU2002306849A1 (en) | 2001-03-21 | 2002-10-08 | Elitra Pharmaceuticals, Inc. | Identification of essential genes in microorganisms |
| DE60236688D1 (de) * | 2001-06-13 | 2010-07-22 | Univ Oklahoma State | Hyaluronansynthase-gene und expression davon |
| PL399352A1 (pl) * | 2001-12-21 | 2012-10-08 | Novozymes Biopharma Dk A/S | Sposoby wytwarzania hialuronanu w rekombinowanej komórce gospodarzu |
-
2002
- 2002-12-20 PL PL399352A patent/PL399352A1/pl unknown
- 2002-12-20 IL IL16230202A patent/IL162302A0/xx active IP Right Grant
- 2002-12-20 RU RU2004122420/13A patent/RU2346049C2/ru active
- 2002-12-20 BR BRPI0215220-7A patent/BR0215220A/pt not_active Application Discontinuation
- 2002-12-20 EP EP02805661A patent/EP1572895B1/en not_active Expired - Lifetime
- 2002-12-20 KR KR1020087002156A patent/KR100885163B1/ko active IP Right Grant
- 2002-12-20 PL PL375190A patent/PL212928B1/pl unknown
- 2002-12-20 CA CA2803931A patent/CA2803931A1/en not_active Abandoned
- 2002-12-20 CZ CZ2004765A patent/CZ2004765A3/cs unknown
- 2002-12-20 AT AT02805661T patent/ATE502115T1/de active
- 2002-12-20 DK DK02805661.2T patent/DK1572895T3/da active
- 2002-12-20 CN CN02828283.3A patent/CN1636052B/zh not_active Expired - Lifetime
- 2002-12-20 JP JP2003554868A patent/JP2005525091A/ja active Pending
- 2002-12-20 ES ES02805661T patent/ES2362354T3/es not_active Expired - Lifetime
- 2002-12-20 HU HU0700154A patent/HU228693B1/hu unknown
- 2002-12-20 WO PCT/US2002/041067 patent/WO2003054163A2/en active Search and Examination
- 2002-12-20 US US10/326,185 patent/US7811806B2/en not_active Expired - Lifetime
- 2002-12-20 AU AU2002366711A patent/AU2002366711C1/en not_active Expired
- 2002-12-20 DE DE60239495T patent/DE60239495D1/de not_active Expired - Lifetime
- 2002-12-20 CA CA2471148A patent/CA2471148C/en not_active Expired - Lifetime
- 2002-12-20 KR KR1020047009883A patent/KR100879908B1/ko active IP Right Grant
-
2004
- 2004-06-02 IL IL162302A patent/IL162302A/en unknown
-
2007
- 2007-05-29 HU HUP1300136 patent/HU1300136D0/hu not_active Application Discontinuation
-
2010
- 2010-09-27 US US12/891,548 patent/US8093036B2/en not_active Expired - Fee Related
-
2011
- 2011-04-11 US US13/084,230 patent/US8137951B2/en not_active Expired - Fee Related
-
2012
- 2012-02-21 US US13/401,663 patent/US8574886B2/en not_active Expired - Lifetime
-
2013
- 2013-10-10 US US14/050,866 patent/US20140038235A1/en not_active Abandoned
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