ATE502115T1 - Verfahren zur produktion von hyaluronan in einer rekombinanten wirtszelle - Google Patents
Verfahren zur produktion von hyaluronan in einer rekombinanten wirtszelleInfo
- Publication number
- ATE502115T1 ATE502115T1 AT02805661T AT02805661T ATE502115T1 AT E502115 T1 ATE502115 T1 AT E502115T1 AT 02805661 T AT02805661 T AT 02805661T AT 02805661 T AT02805661 T AT 02805661T AT E502115 T1 ATE502115 T1 AT E502115T1
- Authority
- AT
- Austria
- Prior art keywords
- udp
- glucose
- gene
- host cell
- hyaluronan synthase
- Prior art date
Links
- 229920002674 hyaluronan Polymers 0.000 title abstract 4
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- KIUKXJAPPMFGSW-MNSSHETKSA-N hyaluronan Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)C1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H](C(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-MNSSHETKSA-N 0.000 title 1
- 229940099552 hyaluronan Drugs 0.000 title 1
- 108090000320 Hyaluronan Synthases Proteins 0.000 abstract 4
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 abstract 3
- 102000003918 Hyaluronan Synthases Human genes 0.000 abstract 3
- 229960003160 hyaluronic acid Drugs 0.000 abstract 3
- 150000007523 nucleic acids Chemical class 0.000 abstract 3
- 241000193830 Bacillus <bacterium> Species 0.000 abstract 2
- 101710167959 Putative UTP-glucose-1-phosphate uridylyltransferase Proteins 0.000 abstract 2
- 108030001662 UDP-glucose 6-dehydrogenases Proteins 0.000 abstract 2
- 108010061048 UDPacetylglucosamine pyrophosphorylase Proteins 0.000 abstract 2
- 108010070600 Glucose-6-phosphate isomerase Proteins 0.000 abstract 1
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- 102100037921 UDP-N-acetylglucosamine pyrophosphorylase Human genes 0.000 abstract 1
- 102100029640 UDP-glucose 6-dehydrogenase Human genes 0.000 abstract 1
- 102000048175 UTP-glucose-1-phosphate uridylyltransferases Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1051—Hexosyltransferases (2.4.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Medicinal Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34264401P | 2001-12-21 | 2001-12-21 | |
| PCT/US2002/041067 WO2003054163A2 (en) | 2001-12-21 | 2002-12-20 | Methods for producing hyaluronan in a recombinant host cell |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE502115T1 true ATE502115T1 (de) | 2011-04-15 |
Family
ID=23342668
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02805661T ATE502115T1 (de) | 2001-12-21 | 2002-12-20 | Verfahren zur produktion von hyaluronan in einer rekombinanten wirtszelle |
Country Status (18)
| Country | Link |
|---|---|
| US (5) | US7811806B2 (de) |
| EP (1) | EP1572895B1 (de) |
| JP (1) | JP2005525091A (de) |
| KR (2) | KR100879908B1 (de) |
| CN (1) | CN1636052B (de) |
| AT (1) | ATE502115T1 (de) |
| AU (1) | AU2002366711C1 (de) |
| BR (1) | BR0215220A (de) |
| CA (2) | CA2471148C (de) |
| CZ (1) | CZ2004765A3 (de) |
| DE (1) | DE60239495D1 (de) |
| DK (1) | DK1572895T3 (de) |
| ES (1) | ES2362354T3 (de) |
| HU (2) | HU228693B1 (de) |
| IL (2) | IL162302A0 (de) |
| PL (2) | PL399352A1 (de) |
| RU (1) | RU2346049C2 (de) |
| WO (1) | WO2003054163A2 (de) |
Families Citing this family (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7091008B1 (en) * | 1994-07-01 | 2006-08-15 | The Board Of Regents Of The University Of Oklahoma | Hyaluronan synthase genes and expression thereof in Bacillus hosts |
| DK1025211T3 (da) * | 1997-10-31 | 2005-04-04 | Univ Oklahoma | Hyaluronansyntasegen og anvendelser deraf |
| JP2005514059A (ja) * | 2001-06-13 | 2005-05-19 | ザ ボード オブ リージェンツ オブ ザ ユニヴァーシティー オブ オクラホマ | ヒアルロナンシンターゼ遺伝子およびそれらの発現 |
| ATE502115T1 (de) * | 2001-12-21 | 2011-04-15 | Novozymes Biopharma Dk As | Verfahren zur produktion von hyaluronan in einer rekombinanten wirtszelle |
| BRPI0309937B1 (pt) * | 2002-05-14 | 2016-05-31 | Novozymes As | variante de uma enzima precursora, célula hospedeira microbiana, método para produzir uma variante da pectato liase, método para melhorar a estabilidade em detergente de uma pectato liase, composição de limpeza ou detergente, uso de uma pectato liase variante, método de limpeza por esfregamento enzimático, e, método para a remoção enzimática do material da parede celular de tecido |
| KR101023049B1 (ko) * | 2002-06-20 | 2011-03-24 | 노보자임스 바이오파마 디케이 에이/에스 | 2가 염을 사용한 응집 방법 |
| US7476516B2 (en) * | 2002-07-26 | 2009-01-13 | Novozymes, Inc. | Methods for producing biological substances in pigment-deficient mutants of Bacillus cells |
| EP3018140A3 (de) * | 2004-01-09 | 2016-08-17 | Basf Se | Inaktivierung von glutamylpolypeptidsynthese in bacillus |
| EP1735455A2 (de) * | 2004-03-31 | 2006-12-27 | Novozymes Biopolymer A/S | Verfahren zur produktion von hyaluronsäure in einer bacillus-zelle |
| US7002007B2 (en) * | 2004-05-28 | 2006-02-21 | Calcigen Corporation | Production of high molecular weight hyaluronates |
| US20080044853A1 (en) | 2004-06-21 | 2008-02-21 | Novozymes A/S | Stably Maintained Multiple Copies of at Least Two Orf in the Same Orientation |
| WO2006032538A1 (en) | 2004-09-23 | 2006-03-30 | Bayer Cropscience Gmbh | Methods and means for producing hyaluronan |
| EP1640457A1 (de) * | 2004-09-23 | 2006-03-29 | Bayer CropScience GmbH | Verfahren und Mittel zur Herstellung von Hyaluronan |
| WO2006056204A1 (en) * | 2004-11-24 | 2006-06-01 | Novozymes Biopolymer A/S | Method of cross-linking hyaluronic acid with divinylsulfone |
| WO2006069578A1 (en) * | 2004-12-30 | 2006-07-06 | Novozymes Biopolymer A/S | Hyaluronic acid linked with a polymer of an alpha hydroxy acid |
| EP1696032A1 (de) | 2005-02-23 | 2006-08-30 | Bayer CropScience GmbH | Verfahren und Mittel zur Herstellung von Hyaluronan in Pilzen |
| JP4639904B2 (ja) | 2005-03-30 | 2011-02-23 | チッソ株式会社 | 蛍光活性を有するルシフェラーゼの活性増強方法 |
| JP4609177B2 (ja) | 2005-04-28 | 2011-01-12 | チッソ株式会社 | カルシウム結合型発光蛋白質溶液の発光時間延長方法 |
| US20060287512A1 (en) * | 2005-05-04 | 2006-12-21 | Novozymes Biopolymer A/S | Method of controlling the content of selected component(s) from polymer(s) using molecular sieve(s) |
| WO2007023682A1 (ja) * | 2005-08-25 | 2007-03-01 | Toyo Boseki Kabushiki Kaisha | ヒアルロン酸生産植物 |
| EP1772052A1 (de) | 2005-10-05 | 2007-04-11 | Bayer CropScience GmbH | Verbesserte Verfahren und Mittel zur Herstellung von Hyaluronan |
| WO2007039314A2 (en) * | 2005-10-05 | 2007-04-12 | Bayer Cropscience Ag | Plants with increased hyaluronan production |
| JP2007174957A (ja) * | 2005-12-27 | 2007-07-12 | Toyobo Co Ltd | ヒアルロン酸生産酵母 |
| US20080038780A1 (en) * | 2006-02-15 | 2008-02-14 | Novozymes Biopolymer A/S | Production of low molecular weight hyaluronic acid |
| CA2647481A1 (en) * | 2006-03-14 | 2007-09-20 | Novozymes Biopolymer A/S | Acrylated hyaluronic acid |
| WO2008014787A1 (en) | 2006-08-04 | 2008-02-07 | Novozymes Biopolymer A/S | Branched hyaluronic acid and method of manufacture |
| CN101595214B (zh) | 2006-11-29 | 2013-06-12 | 诺维信股份有限公司 | 改进向细菌细胞中导入dna的方法 |
| EP2104739B1 (de) | 2006-12-21 | 2013-06-19 | Novozymes Inc. | MODIFIZIERTE mRNA-STABILISIERENDE SEQUENZEN ZUR GENEXPRESSION IN BAKTERIENZELLEN |
| EP2031053A1 (de) * | 2007-08-31 | 2009-03-04 | The University Of Queensland | HA-Herstellung |
| US20110281817A1 (en) * | 2007-08-31 | 2011-11-17 | Sugar Industry Innovation Pty. Ltd. | Production of hyaluronic acid |
| EP2036983A1 (de) | 2007-09-12 | 2009-03-18 | Bayer CropScience AG | Pflanzen, die erhöhte Mengen an Glucosaminglycanen synthetisieren |
| EP2222715B1 (de) * | 2007-12-19 | 2019-07-24 | Evonik Degussa GmbH | Vernetzte hyaluronsäure in einer emulsion |
| WO2010068955A2 (en) | 2008-12-13 | 2010-06-17 | Dna Microarray | MICROENVIRONMENT NICHE ASSAY FOR CiPS SCREENING |
| EP2213315A1 (de) | 2009-01-30 | 2010-08-04 | Mero S.r.L. | Antibakterielles Hydrogel und dessen Verwendungen in der Orthopädie |
| CN102021213B (zh) * | 2009-09-17 | 2014-07-09 | 上海佰加壹医药有限公司 | 一种发酵生产透明质酸发酵液的方法 |
| CA2791353A1 (en) | 2010-03-03 | 2011-09-09 | Novozymes, Inc. | Xylanase variants and polynucleotides encoding same |
| IT1401498B1 (it) | 2010-07-30 | 2013-07-26 | Mero Srl | Idrogelo a base di acido ialuronico e suo uso in ortopedia |
| IT1402384B1 (it) * | 2010-09-09 | 2013-09-04 | Fidia Farmaceutici | Processo per la produzione di acido ialuronico in escherichia coli o bacillus megaterium |
| IT1402385B1 (it) | 2010-09-09 | 2013-09-04 | Fidia Farmaceutici | Processo per la produzione di acido ialuronico in escherichia coli o bacillus subtilis |
| US20140155347A1 (en) | 2011-05-30 | 2014-06-05 | Novozymes Biopharma Dk A/S | Spray Drying of High Molecular Weight Hyaluronic Acid |
| CN102911887A (zh) * | 2011-08-02 | 2013-02-06 | 山东省生物药物研究院 | 一种利用毕赤酵母基因调控发酵生产不同分子量透明质酸的方法 |
| AU2012300815A1 (en) | 2011-09-02 | 2014-02-20 | Novozymes Biopharma Dk A/S | Oral formulations containing hyaluronic acid for sustained drug release |
| DE102012201297A1 (de) * | 2012-01-31 | 2013-08-01 | Basf Se | Expressionsverfahren |
| CN102559559A (zh) * | 2012-02-21 | 2012-07-11 | 山东福瑞达生物医药有限公司 | 一种芽孢杆菌及采用该菌种生产透明质酸酶的方法 |
| WO2013123791A1 (zh) * | 2012-02-21 | 2013-08-29 | 华熙福瑞达生物医药有限公司 | 一种芽孢杆菌、一种透明质酸酶、以及其用途 |
| JP6306519B2 (ja) * | 2012-02-22 | 2018-04-04 | ノボザイムス アクティーゼルスカブ | 高度発酵制御 |
| WO2014100837A1 (en) | 2012-12-17 | 2014-06-26 | Bui The Duy | Computer aided implantation of body implants |
| CA2931726C (en) | 2013-11-25 | 2022-03-15 | Deuteria Biomaterials, Llc | Deuterium-enriched hyaluronan |
| CA2896038C (en) * | 2015-07-03 | 2022-08-09 | Glycobiosciences Inc. | Polymer matrix compositions comprising a high concentration of bio-fermented sodium hyaluronate and uses thereof |
| CN106755022B (zh) * | 2015-11-25 | 2020-08-04 | 中国科学院大连化学物理研究所 | 乙酰葡萄糖胺磷酸变位酶AtAGM编码基因及其酶、制备、应用与酶活性检测方法 |
| EP3481949B1 (de) | 2016-07-05 | 2021-06-09 | Novozymes A/S | Pektatlyasevarianten und dafür codierende polynukleotide |
| CN107653280B (zh) * | 2016-07-25 | 2021-05-04 | 安琪酵母股份有限公司 | 透明质酸发酵用的组合物、培养基和方法及其应用 |
| CN106381279B (zh) * | 2016-08-29 | 2019-11-05 | 中国药科大学 | 一种细菌胞外多糖、其制备方法及其应用 |
| WO2020122429A1 (ko) * | 2018-12-10 | 2020-06-18 | 대화제약 주식회사 | 히알루론산 합성효소 변이 단백질 및 이를 이용한 히알루론산 생산 방법 |
| WO2020122430A1 (ko) * | 2018-12-10 | 2020-06-18 | 대화제약 주식회사 | 비병원성 세균을 이용하여 히알루론산 생산을 위한 발현 시스템 및 상기 발현 시스템을 이용한 히알루론산 생산방법 |
| KR102135044B1 (ko) * | 2018-12-10 | 2020-07-17 | 대화제약 주식회사 | 히알루론산 합성효소 변이 단백질 및 이를 이용한 히알루론산 생산 방법 |
| CN110055201B (zh) * | 2019-03-05 | 2021-05-28 | 江南大学 | 一种高产透明质酸寡糖的重组枯草芽孢杆菌的构建方法 |
| RU2719140C1 (ru) | 2019-07-26 | 2020-04-17 | Общество с ограниченной ответственностью "ЦЕНТР ТРАНСФЕРА БИОТЕХНОЛОГИЙ ОКА-Биотех" | Бактерия рода bacillus, продуцирующая гиалуроновую кислоту, и способ получения гиалуроновой кислоты с использованием указанной бактерии |
| RU2723722C1 (ru) * | 2019-07-26 | 2020-06-17 | Общество с ограниченной ответственностью "ЦЕНТР ТРАНСФЕРА БИОТЕХНОЛОГИЙ ОКА-Биотех" | ТАНДЕМНЫЙ ПРОМОТОР, ФУНКЦИОНИРУЮЩИЙ В БАКТЕРИИ РОДА Bacillus, ТРАНСФОРМИРОВАННАЯ БАКТЕРИЯ РОДА Bacillus - ПРОДУЦЕНТ ЦЕЛЕВОГО ПРОДУКТА, СОДЕРЖАЩАЯ УКАЗАННЫЙ ПРОМОТОР, И СПОСОБ ПОЛУЧЕНИЯ ЦЕЛЕВОГО ПРОДУКТА С ИСПОЛЬЗОВАНИЕМ УКАЗАННОЙ БАКТЕРИИ |
| CN111518825B (zh) * | 2020-04-30 | 2022-10-11 | 浙江工业大学 | 一种多基因组合表达制备蛹虫草多糖的方法 |
| CN116897160A (zh) * | 2021-02-22 | 2023-10-17 | 丹尼斯科美国公司 | 在色素缺陷型芽孢杆菌属细胞中产生目的蛋白的方法和组合物 |
| CA3213227A1 (en) * | 2021-04-01 | 2022-10-06 | Dominique Louis | Hyaluronic acid-producing recombinant cells |
| WO2025012149A1 (en) | 2023-07-07 | 2025-01-16 | Nupep As | Consensus peptides in hya |
| EP4487863A1 (de) | 2023-07-07 | 2025-01-08 | NuPep AS | Konsensuspeptide in hya zur verwendung bei der behandlung degenerierter gelenke |
| EP4487834A1 (de) | 2023-07-07 | 2025-01-08 | NuPep AS | Konsensuspeptide in hya |
| KR20250148458A (ko) * | 2024-04-01 | 2025-10-14 | 씨제이제일제당 (주) | 신규한 바실러스 프로모터 변이체 및 이를 이용한 단백질 생산 방법 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60251898A (ja) * | 1984-05-25 | 1985-12-12 | Shiseido Co Ltd | 醗酵法によるヒアルロン酸の製造方法 |
| US6951743B2 (en) * | 1997-10-31 | 2005-10-04 | University Of Oklahoma Board Of Regents | Hyaluronan synthase genes and expression thereof in bacillus hosts |
| US6455304B1 (en) * | 1994-07-01 | 2002-09-24 | The Board Of Regents Of The University Of Oklahoma | Hyaluronate synthase gene and uses thereof |
| IT1271001B (it) | 1994-07-26 | 1997-05-26 | Poli Ind Chimica Spa | Procedimento di preparazione di acido ialuronico mediante fermentazione con streptococcus |
| DK1025211T3 (da) | 1997-10-31 | 2005-04-04 | Univ Oklahoma | Hyaluronansyntasegen og anvendelser deraf |
| US5955310A (en) * | 1998-02-26 | 1999-09-21 | Novo Nordisk Biotech, Inc. | Methods for producing a polypeptide in a bacillus cell |
| DE69943276D1 (de) | 1998-04-02 | 2011-04-21 | Univ Oklahoma State | Chondroitin-Synthase kodierendes DNA der Pasteurella multocida und Verwendungsverfahren |
| DE69940353D1 (en) | 1998-11-11 | 2009-03-12 | Univ Oklahoma | Polymerpfropfung mittels polysaccharide-synthase |
| WO2002077183A2 (en) | 2001-03-21 | 2002-10-03 | Elitra Pharmaceuticals, Inc. | Identification of essential genes in microorganisms |
| JP2005514059A (ja) * | 2001-06-13 | 2005-05-19 | ザ ボード オブ リージェンツ オブ ザ ユニヴァーシティー オブ オクラホマ | ヒアルロナンシンターゼ遺伝子およびそれらの発現 |
| ATE502115T1 (de) * | 2001-12-21 | 2011-04-15 | Novozymes Biopharma Dk As | Verfahren zur produktion von hyaluronan in einer rekombinanten wirtszelle |
-
2002
- 2002-12-20 AT AT02805661T patent/ATE502115T1/de active
- 2002-12-20 AU AU2002366711A patent/AU2002366711C1/en not_active Expired
- 2002-12-20 DE DE60239495T patent/DE60239495D1/de not_active Expired - Lifetime
- 2002-12-20 RU RU2004122420/13A patent/RU2346049C2/ru active
- 2002-12-20 WO PCT/US2002/041067 patent/WO2003054163A2/en not_active Ceased
- 2002-12-20 US US10/326,185 patent/US7811806B2/en not_active Expired - Lifetime
- 2002-12-20 KR KR1020047009883A patent/KR100879908B1/ko not_active Expired - Lifetime
- 2002-12-20 CZ CZ2004765A patent/CZ2004765A3/cs unknown
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- 2002-12-20 EP EP02805661A patent/EP1572895B1/de not_active Expired - Lifetime
- 2002-12-20 CN CN02828283.3A patent/CN1636052B/zh not_active Expired - Lifetime
- 2002-12-20 JP JP2003554868A patent/JP2005525091A/ja active Pending
- 2002-12-20 CA CA2471148A patent/CA2471148C/en not_active Expired - Lifetime
- 2002-12-20 CA CA2803931A patent/CA2803931A1/en not_active Abandoned
- 2002-12-20 DK DK02805661.2T patent/DK1572895T3/da active
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- 2002-12-20 ES ES02805661T patent/ES2362354T3/es not_active Expired - Lifetime
- 2002-12-20 BR BRPI0215220-7A patent/BR0215220A/pt not_active Application Discontinuation
- 2002-12-20 HU HU0700154A patent/HU228693B1/hu unknown
- 2002-12-20 KR KR1020087002156A patent/KR100885163B1/ko not_active Expired - Lifetime
- 2002-12-20 PL PL375190A patent/PL212928B1/pl unknown
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2004
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2007
- 2007-05-29 HU HUP1300136 patent/HU1300136D0/hu not_active Application Discontinuation
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2010
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2011
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2012
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2013
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