HUP0402674A2 - Egy vagy több szteroidot, egy vagy több tetrahidrofolát komponenst és B12 vitamint tartalmazó gyógyszerkészítmények - Google Patents

Egy vagy több szteroidot, egy vagy több tetrahidrofolát komponenst és B12 vitamint tartalmazó gyógyszerkészítmények

Info

Publication number
HUP0402674A2
HUP0402674A2 HU0402674A HUP0402674A HUP0402674A2 HU P0402674 A2 HUP0402674 A2 HU P0402674A2 HU 0402674 A HU0402674 A HU 0402674A HU P0402674 A HUP0402674 A HU P0402674A HU P0402674 A2 HUP0402674 A2 HU P0402674A2
Authority
HU
Hungary
Prior art keywords
tetrahydrofolic acid
vitamin
steroids
tetrahydrofolic
pharmaceutical compositions
Prior art date
Application number
HU0402674A
Other languages
English (en)
Inventor
Herman Jan Tijmen Coelingh Bennink
Original Assignee
Schering Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Aktiengesellschaft filed Critical Schering Aktiengesellschaft
Publication of HUP0402674A2 publication Critical patent/HUP0402674A2/hu
Publication of HUP0402674A3 publication Critical patent/HUP0402674A3/hu

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7135Compounds containing heavy metals
    • A61K31/714Cobalamins, e.g. cyanocobalamin, i.e. vitamin B12
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/567Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18Feminine contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/24Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30Oestrogens

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Reproductive Health (AREA)
  • Molecular Biology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)

Abstract

A találmány nőivarú emlősök hormonális fogamzásgátlásához éshormonpótló terápiájához használható gyógyszerkészletre vonatkozik. Anevezett készlet legalább 10 orális dózisegységből áll, melydózisegység az ösztrogének és progesztogének közül kiválasztott,legalább 1 <g mennyiségben levő egy vagy több szteroidot; a (6S)-tetrahidrofolsav, 5-metil-(6S)-tetrahidrofolsav, 5-formil-(6S)-tetrahidrofolsav, 10-formil-(6R)-tetrahidrofolsav, 5,10-metilén-(6R)-tetrahidrofolsav, 5,10-metenil-(6R)-tetrahidrofolsav, 5-formimino-(6S)-tetrahidrofolsav, ezen tetrahidrofolsavak gyógyszerészetilegalkalmazható sói és glutamilszármazékai közül kiválasztott, legalább0,1 mg mennyiségben levő egy vagy több tetrahidrofolát alkotórészt éslegalább 0,1 mg B12 vitamint tartalmaz. Ó
HU0402674A 2002-02-21 2002-11-15 Pharmaceutical compositions comprising one or more steroids one or more tetrahydrofolate components and vitamin b12 HUP0402674A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02075695 2002-02-21
PCT/NL2002/000741 WO2003070255A1 (en) 2002-02-21 2002-11-15 Pharmaceutical compositions comprising one or more steroids one or more tetrahydrofolate components and vitamin b12

Publications (2)

Publication Number Publication Date
HUP0402674A2 true HUP0402674A2 (hu) 2005-04-28
HUP0402674A3 HUP0402674A3 (en) 2012-12-28

Family

ID=27741182

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0402674A HUP0402674A3 (en) 2002-02-21 2002-11-15 Pharmaceutical compositions comprising one or more steroids one or more tetrahydrofolate components and vitamin b12

Country Status (29)

Country Link
US (1) US20050164977A1 (hu)
EP (1) EP1478373B1 (hu)
JP (1) JP5037779B2 (hu)
KR (1) KR100936827B1 (hu)
CN (1) CN1620302B (hu)
AT (1) ATE341333T1 (hu)
AU (1) AU2002343249B2 (hu)
BR (1) BR0215613A (hu)
CA (1) CA2476940C (hu)
CR (1) CR7420A (hu)
CY (1) CY1106273T1 (hu)
DE (1) DE60215224T2 (hu)
DK (1) DK1478373T3 (hu)
EA (1) EA007599B1 (hu)
EC (1) ECSP045305A (hu)
ES (1) ES2274107T3 (hu)
HK (1) HK1078780A1 (hu)
HU (1) HUP0402674A3 (hu)
IL (2) IL163579A0 (hu)
ME (1) MEP37208A (hu)
MX (1) MXPA04008185A (hu)
NO (1) NO20043932L (hu)
NZ (1) NZ534806A (hu)
PL (1) PL209558B1 (hu)
PT (1) PT1478373E (hu)
RS (1) RS50909B (hu)
UA (1) UA80965C2 (hu)
WO (1) WO2003070255A1 (hu)
ZA (1) ZA200407545B (hu)

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US20060293295A1 (en) * 2005-05-13 2006-12-28 Kai Strothmann Pharmaceutical composition comprising progestogens and/or estrogens and 5-methyl- (6S)-tetrahydrofolate
DE102005023301B4 (de) * 2005-05-13 2012-05-31 Bayer Schering Pharma Aktiengesellschaft Pharmazeutische Zusammensetzung enthaltend Gestagene und/oder Estrogene und 5-Methyl-(6S)-tetrahydrofolat
AU2012227235B2 (en) * 2005-05-13 2015-06-11 Bayer Intellectual Property Gmbh Pharmaceutical composition comprising progestogens and/or estrogens and 5-methyl-(6S)-tetrahydrofolate
UY29527A1 (es) * 2005-05-13 2006-12-29 Schering Ag Composicinn farmaccutica que contienen gestrgenos y/o estrngenos y 5-metil - (6s) - tetrhidrofolato.
AU2013202756B2 (en) * 2006-07-06 2015-06-04 Bayer Intellectual Property Gmbh Pharmaceutical composition containing a tetrahydrofolic acid
US8617597B2 (en) * 2006-07-06 2013-12-31 Bayer Intellectual Property Gmbh Pharmaceutical composition containing a tetrahydrofolic acid
BRPI0713999A2 (pt) * 2006-07-06 2012-11-20 Bayer Schering Pharma Ag produÇço farmacÊutica para contracepÇço e para reduÇço do risco de malformaÇÕes congÊnitas
EP1891959A1 (de) * 2006-08-14 2008-02-27 Bayer Schering Pharma Aktiengesellschaft Pharmazeutische Zusammensetzung zur Kontrazeption und zur Verminderung des Risikos angeborener Fehlbildungen
CN101489563A (zh) * 2006-07-06 2009-07-22 拜耳先灵医药股份有限公司 用于避孕和预防先天性畸形风险的药物制剂
GB0715502D0 (en) * 2007-08-08 2007-09-19 Univ Manchester Methods
CN101945646A (zh) * 2008-02-13 2011-01-12 拜耳先灵医药股份有限公司 含雌二醇的药物递送系统
UY32836A (es) 2009-08-12 2011-03-31 Bayer Schering Pharma Ag Partículas estabilizadas que comprenden 5-metil-(6s)-tetrahidrofolato
EP2324832B2 (de) * 2009-11-09 2016-11-30 Biogena Naturprodukte GmbH & Co KG Nahrungsergänzungsmittel bei Einnahme von hormonellen Kontrazeptiva
KR101994805B1 (ko) 2011-06-01 2019-07-01 에스테트라 에스.피.알.엘. 에스테트롤 중간체의 제조 방법
MX342537B (es) 2011-06-01 2016-10-04 Estetra Sprl Proceso para la produccion de intermediarios de estetrol.
EP2383279A1 (en) 2011-07-19 2011-11-02 Pantarhei Bioscience B.V. Process for the preparation of estetrol
ES2925534T3 (es) * 2011-11-05 2022-10-18 South Alabama Medical Science Found Métodos, formulaciones y kits para reponer rápidamente los niveles de folato en mujeres
CA2856520C (en) 2011-11-23 2021-04-06 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US9301920B2 (en) 2012-06-18 2016-04-05 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US20150196640A1 (en) 2012-06-18 2015-07-16 Therapeuticsmd, Inc. Progesterone formulations having a desirable pk profile
US10806697B2 (en) 2012-12-21 2020-10-20 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US20130338122A1 (en) 2012-06-18 2013-12-19 Therapeuticsmd, Inc. Transdermal hormone replacement therapies
US10806740B2 (en) 2012-06-18 2020-10-20 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US10471072B2 (en) 2012-12-21 2019-11-12 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US9180091B2 (en) 2012-12-21 2015-11-10 Therapeuticsmd, Inc. Soluble estradiol capsule for vaginal insertion
US11246875B2 (en) 2012-12-21 2022-02-15 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10537581B2 (en) 2012-12-21 2020-01-21 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10568891B2 (en) 2012-12-21 2020-02-25 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11266661B2 (en) 2012-12-21 2022-03-08 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
CA2932855C (en) * 2013-12-12 2022-07-19 Donesta Bioscience B.V. Orally disintegrating solid dosage unit containing an estetrol component
AU2015264003A1 (en) 2014-05-22 2016-11-17 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
CU24523B1 (es) 2015-06-18 2021-06-08 Estetra Sprl Unidad de dosificación orodispersable que contiene un componente estetrol
WO2016203044A1 (en) 2015-06-18 2016-12-22 Mithra Pharmaceuticals S.A. Orodispersible tablet containing estetrol
CN116077455A (zh) 2015-06-18 2023-05-09 埃斯特拉有限责任公司 含雌四醇组分的口腔分散剂量单位
SI3310345T1 (sl) 2015-06-18 2021-05-31 Estetra Sprl Orodisperzibilna tableta, ki vsebuje estetrol
US10328087B2 (en) 2015-07-23 2019-06-25 Therapeuticsmd, Inc. Formulations for solubilizing hormones
WO2017173044A1 (en) 2016-04-01 2017-10-05 Therapeuticsmd Inc. Steroid hormone compositions in medium chain oils
CA3020153A1 (en) 2016-04-01 2017-10-05 Therapeuticsmd, Inc. Steroid hormone pharmaceutical composition
KR20220144885A (ko) 2016-08-05 2022-10-27 에스테트라, 소시에떼 아 레스폰서빌리떼 리미떼 월경통 및 생리통의 관리방법
TWI801561B (zh) 2018-04-19 2023-05-11 比利時商依思特拉私人有限責任公司 化合物及其用於緩解絕經相關症狀的用途
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Also Published As

Publication number Publication date
CA2476940C (en) 2011-11-01
JP5037779B2 (ja) 2012-10-03
MEP37208A (en) 2011-02-10
HUP0402674A3 (en) 2012-12-28
BR0215613A (pt) 2004-12-07
NZ534806A (en) 2006-05-26
RS73304A (en) 2007-02-05
ECSP045305A (es) 2004-10-26
MXPA04008185A (es) 2004-11-26
AU2002343249B2 (en) 2009-02-05
ATE341333T1 (de) 2006-10-15
EP1478373B1 (en) 2006-10-04
PT1478373E (pt) 2007-01-31
CA2476940A1 (en) 2003-08-28
KR20040094711A (ko) 2004-11-10
IL163579A0 (en) 2005-12-18
ES2274107T3 (es) 2007-05-16
PL209558B1 (pl) 2011-09-30
ZA200407545B (en) 2006-06-28
DE60215224D1 (de) 2006-11-16
EP1478373A1 (en) 2004-11-24
CN1620302B (zh) 2011-04-27
JP2005523283A (ja) 2005-08-04
PL371441A1 (en) 2005-06-13
CN1620302A (zh) 2005-05-25
CY1106273T1 (el) 2011-10-12
US20050164977A1 (en) 2005-07-28
NO20043932L (no) 2004-11-19
DE60215224T2 (de) 2007-08-23
KR100936827B1 (ko) 2010-01-14
AU2002343249A1 (en) 2003-09-09
DK1478373T3 (da) 2007-01-15
HK1078780A1 (en) 2006-03-24
WO2003070255A1 (en) 2003-08-28
IL163579A (en) 2011-03-31
EA007599B1 (ru) 2006-12-29
CR7420A (es) 2006-02-06
RS50909B (sr) 2010-08-31
UA80965C2 (en) 2007-11-26
EA200401014A1 (ru) 2006-10-27

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Legal Events

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Owner name: BAYER SCHERING PHARMA AKTIENGESELLSCHAFT, DE

Free format text: FORMER OWNER(S): SCHERING AKTIENGESELLSCHAFT, DE

FA9A Lapse of provisional patent protection due to relinquishment or protection considered relinquished