HUP0402605A2 - Eszköz mikroszkopikus bemetszések ejtésére állat bőrszövetén - Google Patents

Eszköz mikroszkopikus bemetszések ejtésére állat bőrszövetén

Info

Publication number
HUP0402605A2
HUP0402605A2 HU0402605A HUP0402605A HUP0402605A2 HU P0402605 A2 HUP0402605 A2 HU P0402605A2 HU 0402605 A HU0402605 A HU 0402605A HU P0402605 A HUP0402605 A HU P0402605A HU P0402605 A2 HUP0402605 A2 HU P0402605A2
Authority
HU
Hungary
Prior art keywords
penetration depth
piercing
skin
microprotrusions
tip
Prior art date
Application number
HU0402605A
Other languages
English (en)
Inventor
Joseph C. Trautman
Michel J.N. Cormier
Original Assignee
Alza Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corporation filed Critical Alza Corporation
Publication of HUP0402605A2 publication Critical patent/HUP0402605A2/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/20—Surgical instruments, devices or methods, e.g. tourniquets for vaccinating or cleaning the skin previous to the vaccination
    • A61B17/205—Vaccinating by means of needles or other puncturing devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14507—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood
    • A61B5/1451—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid
    • A61B5/14514—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid using means for aiding extraction of interstitial fluid, e.g. microneedles or suction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • A61N1/303—Constructional details
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/03—Automatic limiting or abutting means, e.g. for safety
    • A61B2090/033—Abutting means, stops, e.g. abutting on tissue or skin
    • A61B2090/034—Abutting means, stops, e.g. abutting on tissue or skin abutting on parts of the device itself
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023—Drug applicators using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0038—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a channel at the side surface
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0046—Solid microneedles

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Surgery (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Dermatology (AREA)
  • Optics & Photonics (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Surgical Instruments (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

Abstract

A talátmány tárgya eszköz mikroszkopikus bemetszések ejtésére állatbőrszövetén, ahol a bemetszéseknek előre meghatározott behatolásimélysége van, és az eszköz első elemmel van ellátva, amelyen számos, abőrszövetet előre meghatározott, Iegfeljebb 500 mm behatolásimélységben bemetszeni képes, az elemből kiálló mikronyúlvány (10) vanelrendezve, továbbá mikronyúlványainak (10) mindegyike alappal, abehatolási mélységgel egyenlő hosszúságú behatoló résszel (15),csúccsal (14), peremmel, felülettel van kialakítva, továbbá amikronyúlvány csúcsa (14) és alapja közötti távolság nagyobb, mint azelőre meghatározott behatolási mélység, valamint egy vagy többmikronyúlványához (10) rendelt, a csúcs (14) és az alap közöttelrendezett, a behatolási mélységet meghatározó határolóelemmel (12)van ellátva, ahol a határolóelem (12) megakadályozza, hogy amikronyúlvány (10) az előre meghatározott behatolási mélységnélmélyebben behatoljon a bőrszövetbe. Ó
HU0402605A 2001-12-20 2002-12-20 Eszköz mikroszkopikus bemetszések ejtésére állat bőrszövetén HUP0402605A2 (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34255301P 2001-12-20 2001-12-20
PCT/US2002/041208 WO2003053258A1 (en) 2001-12-20 2002-12-20 Skin-piercing microprojections having piercing depth control

Publications (1)

Publication Number Publication Date
HUP0402605A2 true HUP0402605A2 (hu) 2005-06-28

Family

ID=23342327

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0402605A HUP0402605A2 (hu) 2001-12-20 2002-12-20 Eszköz mikroszkopikus bemetszések ejtésére állat bőrszövetén

Country Status (12)

Country Link
US (1) US20030181936A1 (hu)
EP (1) EP1465535B1 (hu)
AU (1) AU2002357372B2 (hu)
DE (1) DE60223844T2 (hu)
DK (1) DK1465535T3 (hu)
ES (1) ES2297056T3 (hu)
HU (1) HUP0402605A2 (hu)
NO (1) NO20043044L (hu)
PT (1) PT1465535E (hu)
RU (1) RU2314760C2 (hu)
WO (1) WO2003053258A1 (hu)
ZA (1) ZA200405732B (hu)

Families Citing this family (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69719761T2 (de) * 1996-06-18 2003-12-18 Alza Corp., Palo Alto Vorrichtung zur verbesserung der transdermalen verabreichung von medikamenten oder der abnahme von körperflüssigkeiten
US6918901B1 (en) * 1997-12-10 2005-07-19 Felix Theeuwes Device and method for enhancing transdermal agent flux
NZ525295A (en) * 2000-10-13 2005-05-27 Alza Corp Microprotrusion member retainer for impact applicator
CZ20031037A3 (cs) * 2000-10-13 2003-10-15 Alza Corporation Zařízení a způsob probodnutí kůže mikrovýčnělky
US7419481B2 (en) * 2000-10-13 2008-09-02 Alza Corporation Apparatus and method for piercing skin with microprotrusions
WO2002094368A1 (en) * 2000-10-26 2002-11-28 Alza Corporation Transdermal drug delivery devices having coated microprotrusions
US6855372B2 (en) * 2001-03-16 2005-02-15 Alza Corporation Method and apparatus for coating skin piercing microprojections
US20020193729A1 (en) * 2001-04-20 2002-12-19 Cormier Michel J.N. Microprojection array immunization patch and method
US6908453B2 (en) * 2002-01-15 2005-06-21 3M Innovative Properties Company Microneedle devices and methods of manufacture
EP1523367A1 (en) 2002-07-19 2005-04-20 3M Innovative Properties Company Microneedle devices and microneedle delivery apparatus
EP1590033A2 (en) * 2002-09-30 2005-11-02 Alza Corporation Drug delivery device having coated microprojections incorporating vasoconstrictors
AR042815A1 (es) * 2002-12-26 2005-07-06 Alza Corp Dispositivo de suministro de agente activo que tiene miembros compuestos
BRPI0412029A (pt) * 2003-06-30 2006-09-05 Alza Corp formulações para microprojeções revestidas contendo contra-ìons não-voláteis
US20050123507A1 (en) * 2003-06-30 2005-06-09 Mahmoud Ameri Formulations for coated microprojections having controlled solubility
PE20050288A1 (es) * 2003-07-02 2005-04-29 Alza Corp Metodo y parche de inmunizacion por disposicion de microproyeccion
JP2007501071A (ja) * 2003-08-04 2007-01-25 アルザ・コーポレーシヨン 経皮作用剤流率を向上させる方法および装置
EP1678293A2 (en) * 2003-10-23 2006-07-12 Alza Corporation Compositions of stabilized dna for coating microprojections
BRPI0415466A (pt) * 2003-10-24 2006-12-19 Alza Corp método e sistema de pré-tratamento para intensificar a distribuição transdérmica de fármacos
KR20060120156A (ko) * 2003-10-28 2006-11-24 알자 코포레이션 담배의 이용빈도를 감소시키기 위한 방법 및 장치
CN100571643C (zh) 2003-10-31 2009-12-23 阿尔扎公司 用于微凸起阵列的自驱动施加器
US8535299B2 (en) * 2004-01-23 2013-09-17 Joseph Giovannoli Method and apparatus for skin reduction
GB0402131D0 (en) 2004-01-30 2004-03-03 Isis Innovation Delivery method
EP1718452A1 (en) * 2004-02-23 2006-11-08 3M Innovative Properties Company Method of molding for microneedle arrays
KR20070011481A (ko) * 2004-04-13 2007-01-24 알자 코포레이션 다중 백신의 경피 전달용 기구 및 방법
EP1744683B1 (en) 2004-05-13 2016-03-16 Alza Corporation Apparatus and method for transdermal delivery of parathyroid hormone agents
US20060030811A1 (en) * 2004-08-03 2006-02-09 Wong Patrick S Method and device for enhancing transdermal agent flux
EP1786505A1 (en) * 2004-09-08 2007-05-23 Alza Corporation Microprojection array with improved skin adhesion and compliance
CN101151061B (zh) * 2005-01-31 2011-05-25 阿尔扎公司 可变性减小的经涂覆的微凸起及其制作方法
EP1898807A1 (en) * 2005-03-28 2008-03-19 Alza Corporation Microprojections with capillary control features and method
US20070078414A1 (en) 2005-08-05 2007-04-05 Mcallister Devin V Methods and devices for delivering agents across biological barriers
EP1924364A1 (en) * 2005-09-12 2008-05-28 Alza Corporation Coatable transdermal delivery microprojection assembly
US7962192B2 (en) 2005-09-30 2011-06-14 Restoration Robotics, Inc. Systems and methods for aligning a tool with a desired location or object
US10299871B2 (en) 2005-09-30 2019-05-28 Restoration Robotics, Inc. Automated system and method for hair removal
US7658728B2 (en) * 2006-01-10 2010-02-09 Yuzhakov Vadim V Microneedle array, patch, and applicator for transdermal drug delivery
AU2007225056A1 (en) * 2006-03-15 2007-09-20 Alza Corporation Apparatus and method for transdermal delivery of parathyroid hormone agents to prevent or treat osteopenia
US20070224252A1 (en) * 2006-03-27 2007-09-27 Trautman Joseph C Microprojections with capillary control features and method
WO2007127815A2 (en) * 2006-04-25 2007-11-08 Alza Corporation Microprojection array application with multilayered microprojection member for high drug loading
US20070293816A1 (en) * 2006-04-25 2007-12-20 Alza Corporation Microprojection Array Application with Grouped Microprojections for High Drug Loading
CA2745339C (en) 2007-12-24 2016-06-28 The University Of Queensland Coating method
AU2009212106B9 (en) 2008-02-07 2014-05-22 Vaxxas Pty Limited Patch production
US20110251602A1 (en) * 2008-04-01 2011-10-13 The General Hospital Corporation Method and apparatus for tissue expansion
CA2760680A1 (en) 2008-05-23 2009-11-26 The University Of Queensland Analyte detection by microneedle patch with analyte selective reagents
US20100331867A1 (en) * 2009-06-26 2010-12-30 Joseph Giovannoli Apparatus and method for dermal incision
CA2801247C (en) * 2010-05-04 2018-09-04 Corium International, Inc. Applicators for microneedles
US9943673B2 (en) 2010-07-14 2018-04-17 Vaxxas Pty Limited Patch applying apparatus
KR20120119250A (ko) * 2011-04-21 2012-10-31 (주)마이티시스템 단턱이 형성된 미세바늘
EP4233839A3 (en) 2011-10-12 2023-09-27 Vaxxas Pty Limited Delivery device
ES2786508T3 (es) * 2012-06-12 2020-10-13 Hisamitsu Pharmaceutical Co Lámina de microagujas
CA2900505C (en) 2013-02-20 2023-10-24 Cytrellis Biosystems, Inc. Methods and devices for skin tightening
BR112016002695B1 (pt) 2013-08-09 2022-09-20 Cytrellis Biosystems, Inc Dispositivo com um aparelho ablativo, um aparelho de remoção e um aparelho de posicionamento
JP6272333B2 (ja) * 2013-09-06 2018-01-31 久光製薬株式会社 マイクロニードル・シート
US10953143B2 (en) 2013-12-19 2021-03-23 Cytrellis Biosystems, Inc. Methods and devices for manipulating subdermal fat
EP2905047A1 (de) * 2014-02-10 2015-08-12 LTS LOHMANN Therapie-Systeme AG Mikronadelsystem und Verfahren seiner Herstellung
KR20240090941A (ko) 2014-11-14 2024-06-21 사이트렐리스 바이오시스템즈, 인크. 피부 절제를 위한 디바이스 및 방법
EP3253440B1 (en) 2015-02-02 2022-12-21 Vaxxas Pty Limited Microprojection array applicator
WO2016149152A1 (en) 2015-03-13 2016-09-22 The University Of North Carolina At Chapel Hill Polymeric microneedles and rapid additive manufacturing of the same
US10070886B2 (en) 2015-04-22 2018-09-11 Medline Industries, Inc. Method of harvesting tissue using sequential sections of a two dimensional array of needles
RU2747228C2 (ru) 2015-04-29 2021-04-29 Радиус Фармасьютикалз, Инк. Способы лечения рака
WO2017045031A1 (en) 2015-09-18 2017-03-23 Vaxxas Pty Limited Microprojection arrays with microprojections having large surface area profiles
WO2017054040A1 (en) 2015-09-28 2017-04-06 Vaxxas Pty Limited Microprojection arrays with enhanced skin penetrating properties and methods thereof
GB201517373D0 (en) 2015-10-01 2015-11-18 Ge Healthcare Uk Ltd Micro-Needle Sampling Device And Use Thereof
EP3363491B1 (en) * 2015-10-15 2019-12-11 Toppan Printing Co., Ltd. Administration instrument
KR102561605B1 (ko) 2016-03-29 2023-08-01 사이트렐리스 바이오시스템즈, 인크. 미용 피부 리설페이싱용 디바이스 및 방법
CN109922740B (zh) 2016-09-21 2022-08-23 希特利斯生物系统有限公司 用于美容皮肤重建的装置和方法
PL3565542T3 (pl) 2017-01-05 2024-07-29 Radius Pharmaceuticals, Inc. Postacie polimorficzne rad1901-2hcl
EP3606760B1 (en) 2017-03-31 2023-09-27 Vaxxas Pty Limited Device and method for coating surfaces
EP3639010A4 (en) 2017-06-13 2021-03-17 Vaxxas Pty Limited QUALITY CONTROL OF SUBSTRATE COATINGS
US11464957B2 (en) 2017-08-04 2022-10-11 Vaxxas Pty Limited Compact high mechanical energy storage and low trigger force actuator for the delivery of microprojection array patches (MAP)
JP6920179B2 (ja) * 2017-11-15 2021-08-18 新光電気工業株式会社 生体用電極部品及びその製造方法
WO2020010216A1 (en) 2018-07-04 2020-01-09 Radius Pharmaceuticals, Inc. Polymorphic forms of rad 1901-2hcl
WO2020069564A1 (en) * 2018-10-02 2020-04-09 WearOptimo Pty Ltd A system for determining fluid level in a biological subject

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3123212A (en) * 1964-03-03 Multiple disposable intracutaneous injector package
US2619962A (en) * 1948-02-19 1952-12-02 Res Foundation Vaccination appliance
US2893392A (en) * 1958-01-08 1959-07-07 American Cyanamid Co Article of manufacture for intracutaneous injections
US3072122A (en) * 1959-01-15 1963-01-08 Rosenthal Sol Roy Package for transcutaneous injection
US3034507A (en) * 1960-05-10 1962-05-15 American Cyanamid Co Intracutaneous injection device
US3221739A (en) * 1962-03-26 1965-12-07 Rosenthal Sol Roy Injection device
US3221740A (en) * 1962-08-31 1965-12-07 Rosenthal Sol Roy Injection device
US3678150A (en) * 1971-07-27 1972-07-18 American Cyanamid Co Process for improving the stability of ppd, qt and histoplasmin on tine applicators
SE8501990D0 (sv) * 1985-04-24 1985-04-24 Pharmacia Ab Beleggningsforfarande
US5810857A (en) * 1993-08-12 1998-09-22 Mackool; Richard J. Surgical knife for controlled lengthening of an incision
US5643308A (en) * 1995-02-28 1997-07-01 Markman; Barry Stephen Method and apparatus for forming multiple cavities for placement of hair grafts
WO1996037155A1 (en) 1995-05-22 1996-11-28 Silicon Microdevices, Inc. Micromechanical device and method for enhancing delivery of compounds through the skin
DE69719761T2 (de) * 1996-06-18 2003-12-18 Alza Corp., Palo Alto Vorrichtung zur verbesserung der transdermalen verabreichung von medikamenten oder der abnahme von körperflüssigkeiten
US5820562A (en) * 1997-11-05 1998-10-13 Hsiao; Ray-Ling Skin allergy test device having step-shaped punctures
US6918901B1 (en) * 1997-12-10 2005-07-19 Felix Theeuwes Device and method for enhancing transdermal agent flux
DE69831268T2 (de) * 1997-12-11 2006-03-09 Alza Corp., Palo Alto Vorrichtung zur erhöhung des transdermalen wirkstoffeflusses
DE69839969D1 (de) * 1997-12-11 2008-10-16 Alza Corp Vorrichtung zur verbesserung des transdermalen flusses von medikamenten
US6050988A (en) * 1997-12-11 2000-04-18 Alza Corporation Device for enhancing transdermal agent flux
JP3109470B2 (ja) * 1998-03-11 2000-11-13 日本電気株式会社 角質層穿刺針及び角質層穿刺部材
US6091975A (en) 1998-04-01 2000-07-18 Alza Corporation Minimally invasive detecting device
GB2354446A (en) * 1999-09-21 2001-03-28 John Arthur Lunn Multiple puncture device
US6623457B1 (en) * 1999-09-22 2003-09-23 Becton, Dickinson And Company Method and apparatus for the transdermal administration of a substance
US6197039B1 (en) * 1999-12-09 2001-03-06 Bahman Ashraf Triple pointed micro knife
EP1239916B1 (en) 1999-12-10 2005-11-23 ALZA Corporation Device and method for enhancing microprotrusion skin piercing
US6558361B1 (en) * 2000-03-09 2003-05-06 Nanopass Ltd. Systems and methods for the transport of fluids through a biological barrier and production techniques for such systems
US6645226B1 (en) * 2000-05-19 2003-11-11 Coapt Systems, Inc. Multi-point tension distribution system device and method of tissue approximation using that device to improve wound healing
US6589202B1 (en) * 2000-06-29 2003-07-08 Becton Dickinson And Company Method and apparatus for transdermally sampling or administering a substance to a patient
CZ20031037A3 (cs) * 2000-10-13 2003-10-15 Alza Corporation Zařízení a způsob probodnutí kůže mikrovýčnělky
EP1341442B1 (en) * 2000-10-13 2005-06-29 Alza Corporation Microblade array impact applicator
NZ525295A (en) * 2000-10-13 2005-05-27 Alza Corp Microprotrusion member retainer for impact applicator
WO2002094368A1 (en) * 2000-10-26 2002-11-28 Alza Corporation Transdermal drug delivery devices having coated microprotrusions
US6855372B2 (en) * 2001-03-16 2005-02-15 Alza Corporation Method and apparatus for coating skin piercing microprojections
ATE444773T1 (de) * 2001-04-20 2009-10-15 Alza Corp Mikroprojektionsanordnung mit einem überzug, der ein vorteilhaftes mittel enthält

Also Published As

Publication number Publication date
DE60223844T2 (de) 2008-08-28
AU2002357372B2 (en) 2008-11-20
DK1465535T3 (da) 2008-04-07
NO20043044L (no) 2004-09-17
EP1465535A1 (en) 2004-10-13
RU2004122100A (ru) 2005-03-20
WO2003053258A1 (en) 2003-07-03
DE60223844D1 (de) 2008-01-10
US20030181936A1 (en) 2003-09-25
ES2297056T3 (es) 2008-05-01
EP1465535B1 (en) 2007-11-28
RU2314760C2 (ru) 2008-01-20
ZA200405732B (en) 2005-08-11
PT1465535E (pt) 2008-02-08
AU2002357372A1 (en) 2003-07-09

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