HUP0402508A2 - 1,2,3,4-Tetrahidro-izokinolin-származékok mint urotenzin II receptor antagonisták és a vegyületeket tartalmazó gyógyszerkészítmények - Google Patents
1,2,3,4-Tetrahidro-izokinolin-származékok mint urotenzin II receptor antagonisták és a vegyületeket tartalmazó gyógyszerkészítmények Download PDFInfo
- Publication number
- HUP0402508A2 HUP0402508A2 HU0402508A HUP0402508A HUP0402508A2 HU P0402508 A2 HUP0402508 A2 HU P0402508A2 HU 0402508 A HU0402508 A HU 0402508A HU P0402508 A HUP0402508 A HU P0402508A HU P0402508 A2 HUP0402508 A2 HU P0402508A2
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- Hungary
- Prior art keywords
- ethyl
- dihydro
- dimethoxy
- urea
- isoquinolin
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- 150000001875 compounds Chemical class 0.000 title claims abstract description 168
- 108050002984 Urotensin II receptors Proteins 0.000 title claims description 10
- 102000012327 Urotensin II receptors Human genes 0.000 title claims description 10
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- 239000002464 receptor antagonist Substances 0.000 title claims 2
- 229940044551 receptor antagonist Drugs 0.000 title claims 2
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- 239000000203 mixture Substances 0.000 claims abstract description 58
- -1 [1,8]naphthyridin-4-yl group Chemical group 0.000 claims abstract description 43
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 38
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract description 18
- 125000003545 alkoxy group Chemical group 0.000 claims abstract description 17
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract description 16
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims abstract description 14
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- 125000004093 cyano group Chemical group *C#N 0.000 claims abstract description 12
- 229910052736 halogen Inorganic materials 0.000 claims abstract description 12
- 150000002367 halogens Chemical group 0.000 claims abstract description 12
- 125000003118 aryl group Chemical group 0.000 claims abstract description 9
- 125000004432 carbon atom Chemical group C* 0.000 claims abstract description 7
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
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Landscapes
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| EP0103422 | 2001-03-27 | ||
| EP0109845 | 2001-08-27 | ||
| PCT/EP2002/003131 WO2002076979A1 (en) | 2001-03-27 | 2002-03-20 | 1,2,3,4-tetrahydroisoquinolines derivatives as urotensin ii receptor antagonists |
Publications (1)
| Publication Number | Publication Date |
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| HUP0402508A2 true HUP0402508A2 (hu) | 2005-03-29 |
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| HU0402508A HUP0402508A2 (hu) | 2001-03-27 | 2002-03-20 | 1,2,3,4-Tetrahidro-izokinolin-származékok mint urotenzin II receptor antagonisták és a vegyületeket tartalmazó gyógyszerkészítmények |
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| NO (1) | NO20034230D0 (enExample) |
| NZ (1) | NZ527276A (enExample) |
| WO (1) | WO2002076979A1 (enExample) |
Families Citing this family (47)
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| PT1243262E (pt) | 2001-03-20 | 2006-10-31 | Sanol Arznei Schwarz Gmbh | Nova utilizacao de uma classe de compostos peptideos para o tratamento da dor inflamatoria nao neuropatica |
| DE60100055T2 (de) | 2001-03-21 | 2003-07-24 | Schwarz Pharma Ag | Neue Verwendung einer Klasse von Peptidverbindungen zur Behandlung von Allodynie oder andere Arten von chronischen oder Phantomschmerzen |
| CA2478909A1 (en) * | 2002-03-13 | 2003-09-25 | Duane D. Miller | Substituted tetrahydroisoquinoline compounds, methods of making, and their use |
| KR20050043967A (ko) * | 2002-09-17 | 2005-05-11 | 액테리온 파마슈티칼 리미티드 | 1-피리딘-4-일-요소 유도체 |
| EP1594439A2 (en) | 2003-02-13 | 2005-11-16 | Albert Einstein College Of Medicine Of Yeshiva University | REGULATION OF FOOD INTAKE AND GLUCOSE PRODUCTION BY MODULATION OF LONG-CHAIN FATTY ACYL-CoA LEVELS IN THE HYPOTHALAMUS |
| EP1631565A1 (en) * | 2003-05-07 | 2006-03-08 | Actelion Pharmaceuticals Ltd. | Piperazine-alkyl-ureido derivatives |
| CN1784394A (zh) * | 2003-05-08 | 2006-06-07 | 埃科特莱茵药品有限公司 | 新型哌啶衍生物 |
| CN1856305B (zh) * | 2003-09-26 | 2010-04-28 | 埃科特莱茵药品有限公司 | 用作尾加压素ⅱ拮抗剂的吡啶衍生物 |
| ATE428413T1 (de) | 2003-12-02 | 2009-05-15 | Sanol Arznei Schwarz Gmbh | Neue verwendung von peptidverbindungen zur behandlung ovn zentralen neuropathischen schmerzen |
| EP1604655A1 (en) | 2004-06-09 | 2005-12-14 | Schwarz Pharma Ag | Novel use of peptide compounds for treating pain in trigeminal neuralgia |
| EA014055B1 (ru) | 2004-08-27 | 2010-08-30 | Шварц Фарма Аг | Применение пептидных соединений для лечения боли при раке кости, а также боли, вызванной химиотерапией и нуклеозидами |
| CN101039930B (zh) | 2004-10-12 | 2010-08-11 | 埃科特莱茵药品有限公司 | 作为结晶硫酸盐的1-[2-(4-甲苯基-4-羟基-哌啶-1-基)-乙基]-3-(2-甲基-喹啉-4-基)-脲 |
| WO2006126255A1 (ja) * | 2005-05-24 | 2006-11-30 | Daito Chemix Corporation | N-(2-ブロモエチル)カルバミン酸tert-ブチルの製造方法 |
| TW200804347A (en) * | 2006-01-10 | 2008-01-16 | Janssen Pharmaceutica Nv | Urotensin II receptor antagonists |
| US20070196510A1 (en) * | 2006-02-17 | 2007-08-23 | Gerber Michael J | Method for treating resistant hypertension |
| WO2007144195A2 (en) | 2006-06-15 | 2007-12-21 | Schwarz Pharma Ag | Pharmaceutical composition with synergistic anticonvulsant effect |
| CL2007002097A1 (es) * | 2006-07-20 | 2008-01-18 | Smithkline Beecham Corp | Compuestos derivados de pirrolidina o morfolina antagonistas de urotensina ii; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar insuficiencia cardiaca congestiva, insuficiencia cardiaca isquemica, angina, isquemia del miocardio, vejiga hiperactiva, asma y/o copd, entre otras. |
| JP5313881B2 (ja) * | 2007-04-04 | 2013-10-09 | 興和株式会社 | テトラヒドロイソキノリン化合物 |
| ES2397764T3 (es) * | 2008-04-01 | 2013-03-11 | Abbott Gmbh & Co. Kg | Tetrahidroisoquinolinas, composiciones farmacéuticas que las contienen, y su uso en terapia |
| LT2960244T (lt) | 2008-10-31 | 2016-11-25 | Shionogi & Co., Ltd. | Cefalosporinas, turintis katecholio grupę |
| AR075442A1 (es) | 2009-02-16 | 2011-03-30 | Abbott Gmbh & Co Kg | Derivados de aminotetralina, composiciones farmaceuticas que las contienen y sus usos en terapia |
| CN102378574B (zh) | 2009-03-30 | 2013-11-20 | 转化技术制药公司 | 取代的偶氮蒽衍生物、药物组合物及其使用方法 |
| US20100312480A1 (en) * | 2009-04-24 | 2010-12-09 | Hansteen Fredrik | Method for monitoring fluid flow in a multi-layered system |
| US9045459B2 (en) | 2010-08-13 | 2015-06-02 | AbbVie Deutschland GmbH & Co. KG | Phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy |
| US8846743B2 (en) | 2010-08-13 | 2014-09-30 | Abbott Laboratories | Aminoindane derivatives, pharmaceutical compositions containing them, and their use in therapy |
| US8877794B2 (en) | 2010-08-13 | 2014-11-04 | Abbott Laboratories | Phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy |
| US8883839B2 (en) | 2010-08-13 | 2014-11-11 | Abbott Laboratories | Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy |
| US9051280B2 (en) | 2010-08-13 | 2015-06-09 | AbbVie Deutschland GmbH & Co. KG | Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy |
| US9309200B2 (en) | 2011-05-12 | 2016-04-12 | AbbVie Deutschland GmbH & Co. KG | Benzazepine derivatives, pharmaceutical compositions containing them, and their use in therapy |
| US8853196B2 (en) | 2011-08-05 | 2014-10-07 | AbbVie Deutschland GmbH & Co. KG | Aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives, pharmaceutical compositions containing them, and their use in therapy |
| TWI537262B (zh) * | 2011-08-17 | 2016-06-11 | 美國禮來大藥廠 | 供治療糖尿病使用之新穎1,2,3,4-四氫喹啉衍生物 |
| CA2853254A1 (en) | 2011-11-18 | 2013-05-23 | Abbvie Inc. | N-substituted aminobenzocycloheptene, aminotetraline, aminoindane and phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy |
| US9365512B2 (en) | 2012-02-13 | 2016-06-14 | AbbVie Deutschland GmbH & Co. KG | Isoindoline derivatives, pharmaceutical compositions containing them, and their use in therapy |
| EP3498701B1 (en) * | 2012-12-21 | 2023-02-22 | Epizyme Inc | Prmt5 inhibitors and uses thereof |
| US9650334B2 (en) | 2013-03-15 | 2017-05-16 | Abbvie Inc. | Pyrrolidine derivatives, pharmaceutical compositions containing them, and their use in therapy |
| US9656955B2 (en) | 2013-03-15 | 2017-05-23 | Abbvie Inc. | Pyrrolidine derivatives, pharmaceutical compositions containing them, and their use in therapy |
| MX2016004936A (es) | 2013-10-17 | 2016-12-20 | Abbvie Deutschland | Derivados de aminocromano, aminotiocromano y amino-1,2,3,4-tetrahi droquinilina, composiciones farmaceuticas que los contienen, y su uso en terapia. |
| CA2924699A1 (en) | 2013-10-17 | 2015-04-23 | AbbVie Deutschland GmbH & Co. KG | Aminotetraline and aminoindane derivatives, pharmaceutical compositions containing them, and their use in therapy |
| JP7065951B2 (ja) | 2017-09-22 | 2022-05-12 | ジュビラント エピパッド エルエルシー | Pad阻害剤としての複素環式化合物 |
| WO2019077631A1 (en) | 2017-10-18 | 2019-04-25 | Jubilant Biosys Limited | IMIDAZO-PYRIDINE COMPOUNDS FOR USE AS PAD INHIBITORS |
| EP3707135A1 (en) | 2017-11-06 | 2020-09-16 | Jubilant Prodel LLC | Pyrimidine derivatives as inhibitors of pd1/pd-l1 activation |
| IL274762B2 (en) | 2017-11-24 | 2023-10-01 | Jubilant Episcribe Llc | Novel heterocyclic compounds as prmt5 inhibitors |
| US11466012B2 (en) * | 2018-01-10 | 2022-10-11 | Allinky Biopharma | Tetrahydroisoquinoline compounds |
| WO2019175897A1 (en) | 2018-03-13 | 2019-09-19 | Jubilant Biosys Limited | Bicyclic compounds as inhibitors of pd1/pd-l1 interaction/activation |
| CN110755434B (zh) * | 2018-07-27 | 2022-03-15 | 中国医学科学院药物研究所 | 化合物palosuran防治骨骼肌萎缩等疾病的用途 |
| US12024521B2 (en) * | 2020-06-30 | 2024-07-02 | Prosetta Biosciences, Inc. | Isoquinoline derivatives, methods of synthesis and uses thereof |
| CN115677579B (zh) * | 2022-11-02 | 2024-05-24 | 上海药坦药物研究开发有限公司 | 四氢罂粟碱及其中间体的制备方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI97540C (fi) | 1989-11-06 | 1997-01-10 | Sanofi Sa | Menetelmä terapeuttisesti käyttökelpoisten, aromaattisesti substituoitujen piperidiini- ja piperatsiinijohdannaisten valmistamiseksi |
| CA2061260A1 (en) | 1991-02-27 | 1992-08-28 | Kiyofumi Ishikawa | Isoquinoline derivatives |
| AUPP003197A0 (en) | 1997-09-03 | 1997-11-20 | Fujisawa Pharmaceutical Co., Ltd. | New heterocyclic compounds |
| EP1200395B1 (en) | 1999-07-28 | 2006-03-29 | Kirin Beer Kabushiki Kaisha | Urea derivatives as inhibitors of ccr-3 receptor |
| ES2225297T3 (es) | 1999-12-21 | 2005-03-16 | Smithkline Beecham Corporation | Antagonistas del receptor de urotensina ii. |
| ATE249831T1 (de) * | 1999-12-21 | 2003-10-15 | Smithkline Beecham Corp | Carboxamidderivate von pyrrolidine und piperidine als urotensin-ii rezeptorantagonisten |
| AU2441801A (en) | 1999-12-21 | 2001-07-03 | Smithkline Beecham Corporation | Urotensin-ii receptor antagonists |
| AU2001266346A1 (en) | 2000-06-28 | 2002-01-08 | Takeda Chemical Industries Ltd. | Biphenyl compound |
| WO2002002530A1 (en) | 2000-07-04 | 2002-01-10 | Takeda Chemical Industries, Ltd. | Gpr14 antagonist |
-
2002
- 2002-03-20 US US10/471,724 patent/US6815451B2/en not_active Expired - Fee Related
- 2002-03-20 DE DE60205234T patent/DE60205234T2/de not_active Expired - Fee Related
- 2002-03-20 BR BR0207715-9A patent/BR0207715A/pt not_active IP Right Cessation
- 2002-03-20 ES ES02730036T patent/ES2246399T3/es not_active Expired - Lifetime
- 2002-03-20 KR KR10-2003-7012299A patent/KR20040016844A/ko not_active Withdrawn
- 2002-03-20 AT AT02730036T patent/ATE300533T1/de not_active IP Right Cessation
- 2002-03-20 CA CA002441790A patent/CA2441790A1/en not_active Abandoned
- 2002-03-20 MX MXPA03008639A patent/MXPA03008639A/es active IP Right Grant
- 2002-03-20 CN CNB028059417A patent/CN1288148C/zh not_active Expired - Fee Related
- 2002-03-20 IL IL15709302A patent/IL157093A0/xx unknown
- 2002-03-20 EP EP02730036A patent/EP1379523B1/en not_active Expired - Lifetime
- 2002-03-20 JP JP2002576237A patent/JP2004529132A/ja not_active Abandoned
- 2002-03-20 HU HU0402508A patent/HUP0402508A2/hu unknown
- 2002-03-20 NZ NZ527276A patent/NZ527276A/en unknown
- 2002-03-20 WO PCT/EP2002/003131 patent/WO2002076979A1/en not_active Ceased
-
2003
- 2003-09-23 NO NO20034230A patent/NO20034230D0/no not_active Application Discontinuation
-
2004
- 2004-07-13 US US10/889,182 patent/US20040242564A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20040242564A1 (en) | 2004-12-02 |
| US6815451B2 (en) | 2004-11-09 |
| IL157093A0 (en) | 2004-02-08 |
| CN1494542A (zh) | 2004-05-05 |
| MXPA03008639A (es) | 2005-03-07 |
| CA2441790A1 (en) | 2002-10-03 |
| WO2002076979A8 (en) | 2003-11-06 |
| NO20034230L (no) | 2003-09-23 |
| NZ527276A (en) | 2004-11-26 |
| BR0207715A (pt) | 2004-03-23 |
| EP1379523B1 (en) | 2005-07-27 |
| EP1379523A1 (en) | 2004-01-14 |
| ATE300533T1 (de) | 2005-08-15 |
| DE60205234D1 (de) | 2005-09-01 |
| WO2002076979A1 (en) | 2002-10-03 |
| US20040110744A1 (en) | 2004-06-10 |
| JP2004529132A (ja) | 2004-09-24 |
| KR20040016844A (ko) | 2004-02-25 |
| NO20034230D0 (no) | 2003-09-23 |
| CN1288148C (zh) | 2006-12-06 |
| ES2246399T3 (es) | 2006-02-16 |
| DE60205234T2 (de) | 2006-05-24 |
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| FD9A | Lapse of provisional protection due to non-payment of fees |