HUP0400565A2 - Ciklohexil-(alkil)-propanol-aminok, előállítási eljárásuk és az azokat tartalmazó gyógyszerkészítmények - Google Patents
Ciklohexil-(alkil)-propanol-aminok, előállítási eljárásuk és az azokat tartalmazó gyógyszerkészítményekInfo
- Publication number
- HUP0400565A2 HUP0400565A2 HU0400565A HUP0400565A HUP0400565A2 HU P0400565 A2 HUP0400565 A2 HU P0400565A2 HU 0400565 A HU0400565 A HU 0400565A HU P0400565 A HUP0400565 A HU P0400565A HU P0400565 A2 HUP0400565 A2 HU P0400565A2
- Authority
- HU
- Hungary
- Prior art keywords
- group
- alkyl
- phenyl
- carbon atom
- atom
- Prior art date
Links
- 125000000217 alkyl group Chemical group 0.000 title abstract 6
- 238000002360 preparation method Methods 0.000 title abstract 2
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 229910052799 carbon Inorganic materials 0.000 abstract 8
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 5
- 125000004432 carbon atom Chemical group C* 0.000 abstract 4
- 125000005843 halogen group Chemical group 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- -1 -CONR4R5 Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 2
- 125000004429 atom Chemical group 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 239000013067 intermediate product Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/06—Antiabortive agents; Labour repressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/46—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C317/22—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Ophthalmology & Optometry (AREA)
- Gynecology & Obstetrics (AREA)
- Child & Adolescent Psychology (AREA)
- Pregnancy & Childbirth (AREA)
- Neurology (AREA)
- Emergency Medicine (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Psychiatry (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
Abstract
A találmány (I) általános képletű vegyületekre, a képletben Ajelentése (a) vagy (b) általános képletű csoport, ahol R jelentésehidrogén- vagy halogénatom, -S(O)z(1-4 szénatomos alkil) csoport, -NHSO2(1-4 szénatomos alkil) csoport, -SO2NH(1-4 szénatomos alkil)csoport, -NHSO2fenil-(1-4 szénatomos alkil) csoport vagy -NHSO2fenil-csoport, ahol a fenilcsoport halogénatommal, 1-4 szénatomosalkilcsoporttal vagy 1-4 szénatomos alkoxicsoporttal helyettesítettlehet; R1 jelentése hidrogénatom vagy 1-4 szénatomos alkilcsoport, -CO(1-4 szénatomos alkil) csoport, fenil-(1-4 szénatomos alkil) csoportvagy -CO-fenilcsoport, ahol a fenilcsoport halogénatommal vagy 1-4szénatomos alkoxicsoporttal helyettesített lehet; R2 jelentésehidrogénatom, -SO2(1-4 szénatomos alkil) csoport, -SO2fenil-(1-4szénatomos alkil) csoport vagy -SO2fenilcsoport; X jelentése 5-8atomból álló gyűrű, amely telített vagy telítetlen, és egy vagy két 1-4 szénatomos alkilcsoporttal helyettesített lehet és egy vagy kétkarbonilcsoportot hordozhat; n, m és z értéke egymástól függetlenül 0,1 vagy 2; R3 jelentése hidrogén- vagy halogénatom, 1-6 szénatomosalkilcsoport, 1-4 szénatomos alkoxicsoport, -COO(1-4 szénatomos alkil)csoport, -CO(1-4 szénatomos alkil) csoport, -NHSO2(1-4 szénatomosalkil) csoport, -NHSO2fenil-(1-4 szénatomos alkil) csoport, -NO2, -CN,-CONR4R5 általános képletű, -COOH vagy 4,5dihidro-l,3-oxazol-2-il-vagy 4,4-dimetil-4,5-dihidro-l,3-oxazol-2-ilcsoport; R4 és R5jelentése egymástól függetlenül hidrogénatom, fenilcsoport, 1-4szénatomos alkilcsoport vagy fenil-(1-4 szénatomos alkil) csoport;vagy R4 és R5 együtt a nitrogénatommal, amelyhez kapcsolódnak;összesen 5-7 atomból álló gyűrűt alkothat; és a vegyületek sóira vagyszolvátjaira, a vegyületeket tartalmazó gyógyászati készítményekre,előállításukra alkalmas eljárásra és az eljárás közbenső termékeirevonatkozik. Ó
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0015477A FR2817257B1 (fr) | 2000-11-30 | 2000-11-30 | Cyclohexyl(alkyl)-propanolamines, leur preparation et compositions pharmaceutiques en contenant |
| PCT/FR2001/003784 WO2002044139A1 (fr) | 2000-11-30 | 2001-11-30 | Cyclohexyl(alkyl)-propanolamines, leur preparation et compositions pharmaceutiques en contenant |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| HUP0400565A2 true HUP0400565A2 (hu) | 2004-06-28 |
| HUP0400565A3 HUP0400565A3 (en) | 2004-08-30 |
| HU229583B1 HU229583B1 (en) | 2014-02-28 |
Family
ID=8857054
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0400565A HU229583B1 (en) | 2000-11-30 | 2001-11-30 | Cyclohexyl(alkyl)-propanolamines, preparation method and pharmaceutical compositions containing same |
Country Status (25)
| Country | Link |
|---|---|
| US (3) | US7388031B2 (hu) |
| EP (1) | EP1341753B1 (hu) |
| JP (1) | JP4024149B2 (hu) |
| CN (2) | CN1283622C (hu) |
| AR (1) | AR031438A1 (hu) |
| AT (1) | ATE374177T1 (hu) |
| AU (2) | AU2207902A (hu) |
| BR (1) | BR0115768A (hu) |
| CA (1) | CA2429267C (hu) |
| CY (1) | CY1106997T1 (hu) |
| CZ (1) | CZ305140B6 (hu) |
| DE (1) | DE60130676T2 (hu) |
| DK (1) | DK1341753T3 (hu) |
| ES (1) | ES2290201T3 (hu) |
| FR (1) | FR2817257B1 (hu) |
| HK (1) | HK1055945A1 (hu) |
| HU (1) | HU229583B1 (hu) |
| ME (1) | MEP23308A (hu) |
| MX (1) | MXPA03004884A (hu) |
| PL (1) | PL206695B1 (hu) |
| PT (1) | PT1341753E (hu) |
| RS (1) | RS51571B (hu) |
| SI (1) | SI1341753T1 (hu) |
| SK (1) | SK287551B6 (hu) |
| WO (1) | WO2002044139A1 (hu) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2817257B1 (fr) * | 2000-11-30 | 2009-03-20 | Sanofi Synthelabo | Cyclohexyl(alkyl)-propanolamines, leur preparation et compositions pharmaceutiques en contenant |
| FR2840301B1 (fr) * | 2002-05-29 | 2007-03-23 | Sanofi Synthelabo | Derives de phenyl-cyclohexyl-propanolamine, leur preparation et leur applicaton en therapeutique |
| FR2840304B1 (fr) * | 2002-05-29 | 2007-05-18 | Sanofi Synthelabo | Derives d'oxophenyl-cyclohexyl-propanolamine, leur preparation et leur application en therapeutique |
| EP2011490A1 (en) * | 2007-07-05 | 2009-01-07 | Sanofi-Aventis | Beta adrenergic receptor ligand derivatives for modulating apoptosis |
| FR2935141B1 (fr) * | 2008-08-21 | 2010-10-08 | Sanofi Aventis | Procede de preparation de l'ester ethylique de l'acide 4-[trans-4-[(phenylmethyl)-amino]cyclohexyl]benzoique et de son sel hemifumarate |
| AU2009308708B2 (en) * | 2008-10-31 | 2015-11-19 | Medivation Technologies, Inc. | Azepino [4, 5-b] indoles and methods of use |
| CN116143575B (zh) * | 2023-04-21 | 2023-06-30 | 研峰(天津)科学技术应用研究有限公司 | 昆虫信息素原料3-环己基-1-丙炔合成方法 |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4004028A (en) * | 1975-08-06 | 1977-01-18 | Smithkline Corporation | Phenoxypropanolamines |
| ES2067541T3 (es) * | 1988-06-03 | 1995-04-01 | Lilly Co Eli | Mejoras en antagonistas de la serotonina y relacionadas con ellos. |
| US5096908A (en) | 1990-05-04 | 1992-03-17 | Eli Lilly And Company | Method of inhibiting gastric acid secretion |
| US5258379A (en) | 1990-05-04 | 1993-11-02 | Eli Lilly And Company | Method of inhibiting gastric acid secretion with n-arylpiperazines |
| US5158956A (en) | 1990-05-04 | 1992-10-27 | Eli Lilly And Company | Method of inhibiting gastric acid secretion with benzodioxanes |
| US5340838A (en) | 1990-05-04 | 1994-08-23 | Eli Lilly And Company | Method of inhibiting gastric acid secretion with 2-phenylcyclopropylamines |
| DE4035961A1 (de) * | 1990-11-02 | 1992-05-07 | Thomae Gmbh Dr K | Cyclische iminoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| IL107611A0 (en) | 1992-11-18 | 1994-02-27 | Smithkline Beecham Corp | Steroid compounds and pharmaceutical compositions containing them |
| US5451677A (en) * | 1993-02-09 | 1995-09-19 | Merck & Co., Inc. | Substituted phenyl sulfonamides as selective β 3 agonists for the treatment of diabetes and obesity |
| IL110857A0 (en) | 1993-09-09 | 1994-11-28 | Lilly Co Eli | Cessation of tobacco use |
| CA2134038C (en) | 1994-06-16 | 1997-06-03 | David Taiwai Wong | Potentiation of drug response |
| EP0714663A3 (en) | 1994-11-28 | 1997-01-15 | Lilly Co Eli | Potentiation of drug responses by serotonin 1A receptor antagonists |
| US5776959A (en) | 1995-06-05 | 1998-07-07 | Washington University | Anticonvulsant and anxiolytic lactam and thiolactam derivatives |
| CN1202106A (zh) * | 1995-09-21 | 1998-12-16 | 伊莱利利公司 | 选择性的β3肾上腺素能激动剂 |
| EP0792649A1 (en) | 1996-02-29 | 1997-09-03 | Eli Lilly And Company | Treatment of sleep disorders |
| US5958429A (en) | 1996-08-16 | 1999-09-28 | Eli Lilly And Company | Potentiation of serotonin response |
| US20020019440A1 (en) * | 1996-11-05 | 2002-02-14 | Virbac Sa | Aryloxypropanolamine derivatives, method of preparation and applications thereof |
| FR2755439B1 (fr) | 1996-11-05 | 1998-12-24 | Virbac Sa | Derives aryloxypropanolamines, leur procede de preparation et leurs applications |
| FR2758460B1 (fr) * | 1997-01-21 | 1999-12-31 | Sanofi Sa | Utilisation des agonistes des recepteurs beta-3 adrenergiques pour la preparation de medicaments cicatrisants |
| US5776969A (en) | 1997-02-27 | 1998-07-07 | Eli Lilly And Company | Treatment of sleep disorders |
| FR2780057B1 (fr) * | 1998-06-18 | 2002-09-13 | Sanofi Sa | Phenoxypropanolamines, procede pour leur preparation et compositions pharmaceutiques les contenant |
| JP2000086603A (ja) | 1998-07-15 | 2000-03-28 | Yoshitomi Pharmaceut Ind Ltd | 桂皮酸アミド誘導体および３―フェニルプロピオン酸アミド誘導体 |
| AU2400300A (en) | 1998-12-30 | 2000-07-31 | Eli Lilly And Company | Solution phase synthesis of compounds including amine alcohol functionality |
| US6248739B1 (en) | 1999-01-08 | 2001-06-19 | Pharmacia & Upjohn Company | Quinolinecarboxamides as antiviral agents |
| US20020019940A1 (en) * | 2000-06-16 | 2002-02-14 | Matteson Craig S. | Method and apparatus for assigning test and assessment instruments to users |
| AUPQ841300A0 (en) * | 2000-06-27 | 2000-07-20 | Fujisawa Pharmaceutical Co., Ltd. | New aminoalcohol derivatives |
| SK632003A3 (en) | 2000-07-13 | 2003-06-03 | Lilly Co Eli | Beta3 adrenergic agonists |
| FR2817257B1 (fr) | 2000-11-30 | 2009-03-20 | Sanofi Synthelabo | Cyclohexyl(alkyl)-propanolamines, leur preparation et compositions pharmaceutiques en contenant |
| US6693125B2 (en) | 2001-01-24 | 2004-02-17 | Combinatorx Incorporated | Combinations of drugs (e.g., a benzimidazole and pentamidine) for the treatment of neoplastic disorders |
| FR2840304B1 (fr) * | 2002-05-29 | 2007-05-18 | Sanofi Synthelabo | Derives d'oxophenyl-cyclohexyl-propanolamine, leur preparation et leur application en therapeutique |
| FR2840301B1 (fr) | 2002-05-29 | 2007-03-23 | Sanofi Synthelabo | Derives de phenyl-cyclohexyl-propanolamine, leur preparation et leur applicaton en therapeutique |
| WO2004006849A2 (en) | 2002-07-15 | 2004-01-22 | Combinatorx, Incorporated | Combinations of drugs for the treatment of neoplasms |
| WO2004019932A1 (en) | 2002-08-30 | 2004-03-11 | Pharmacia & Upjohn Company | Method of preventing or treating atherosclerosis or restenosis |
| PL378295A1 (pl) | 2003-02-24 | 2006-03-20 | Arena Pharmaceuticals, Inc. | Podstawione pochodne arylowe i heteroarylowe jako modulatory metabolizmu glukozy oraz profilaktyka i leczenie zaburzeń tego metabolizmu |
| JP2007528400A (ja) | 2004-03-09 | 2007-10-11 | エラン ファーマシューティカルズ，インコーポレイテッド | 置換ヒドロキシエチルアミン系のアスパラギン酸プロテアーゼ阻害薬 |
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2000
- 2000-11-30 FR FR0015477A patent/FR2817257B1/fr not_active Expired - Fee Related
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2001
- 2001-11-29 AR ARP010105555A patent/AR031438A1/es not_active Application Discontinuation
- 2001-11-30 CN CNB018198880A patent/CN1283622C/zh not_active Expired - Fee Related
- 2001-11-30 PT PT01998533T patent/PT1341753E/pt unknown
- 2001-11-30 SI SI200130783T patent/SI1341753T1/sl unknown
- 2001-11-30 HU HU0400565A patent/HU229583B1/hu not_active IP Right Cessation
- 2001-11-30 AT AT01998533T patent/ATE374177T1/de active
- 2001-11-30 ME MEP-233/08A patent/MEP23308A/xx unknown
- 2001-11-30 CN CNA2006101518761A patent/CN1935787A/zh active Pending
- 2001-11-30 WO PCT/FR2001/003784 patent/WO2002044139A1/fr active IP Right Grant
- 2001-11-30 ES ES01998533T patent/ES2290201T3/es not_active Expired - Lifetime
- 2001-11-30 CA CA2429267A patent/CA2429267C/fr not_active Expired - Fee Related
- 2001-11-30 RS YU41703A patent/RS51571B/en unknown
- 2001-11-30 DE DE60130676T patent/DE60130676T2/de not_active Expired - Lifetime
- 2001-11-30 AU AU2207902A patent/AU2207902A/xx active Pending
- 2001-11-30 DK DK01998533T patent/DK1341753T3/da active
- 2001-11-30 JP JP2002546509A patent/JP4024149B2/ja not_active Expired - Fee Related
- 2001-11-30 BR BR0115768-0A patent/BR0115768A/pt active Search and Examination
- 2001-11-30 US US10/432,493 patent/US7388031B2/en not_active Expired - Lifetime
- 2001-11-30 SK SK652-2003A patent/SK287551B6/sk not_active IP Right Cessation
- 2001-11-30 CZ CZ2003-1499A patent/CZ305140B6/cs not_active IP Right Cessation
- 2001-11-30 MX MXPA03004884A patent/MXPA03004884A/es active IP Right Grant
- 2001-11-30 PL PL364746A patent/PL206695B1/pl unknown
- 2001-11-30 EP EP01998533A patent/EP1341753B1/fr not_active Expired - Lifetime
- 2001-11-30 AU AU2002222079A patent/AU2002222079B2/en not_active Ceased
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2003
- 2003-11-14 HK HK03108328A patent/HK1055945A1/xx not_active IP Right Cessation
-
2006
- 2006-08-15 US US11/464,537 patent/US7419974B2/en not_active Expired - Lifetime
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2007
- 2007-11-08 CY CY20071101450T patent/CY1106997T1/el unknown
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2008
- 2008-06-24 US US12/144,843 patent/US7718646B2/en not_active Expired - Lifetime
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