MXPA03010584A - Derivados de tiazol u oxazol que son utiles en el tratamiento de enfermedades cardiovasculares y relacionadas. - Google Patents
Derivados de tiazol u oxazol que son utiles en el tratamiento de enfermedades cardiovasculares y relacionadas.Info
- Publication number
- MXPA03010584A MXPA03010584A MXPA03010584A MXPA03010584A MXPA03010584A MX PA03010584 A MXPA03010584 A MX PA03010584A MX PA03010584 A MXPA03010584 A MX PA03010584A MX PA03010584 A MXPA03010584 A MX PA03010584A MX PA03010584 A MXPA03010584 A MX PA03010584A
- Authority
- MX
- Mexico
- Prior art keywords
- alkyl
- halogen
- optionally substituted
- thiazole
- cardiovascular
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Abstract
Un compuesto de formula (I) y sus sales, solvatos y eteres hidrolizables farmaceuticamente aceptables: (ver formula) en donde R1 y R2 son independientemente H o alquilo de C1-3 o R1 y R2 los cuales estan unidos al mismo atomo de carbono pueden junto con el atomo de carbono al cual estan unidos formar un anillo cicloalquilo de 3 a 5 miembros; X1 representa O o S; cada R3, R4, R8 y R9 representa independientemente H, halogeno, -CH3 o -OCH3; R5 representa H o alquilo de C1-6 o R4 y R5 juntos forman un anillo cicloalquilo de 3-6 miembros. X2 representa NH, NCH3 u O; uno de Y y Z es N, y el otro es O o S; R6 representa fenilo o piridilo (en donde el N esta en la posicion 2 o 3) y es sustituido opcionalmente por uno o mas halogenos, CF3, alquilo C1-6 lineal o ramificado (sustituido opcionalmente por halogeno), con la condicion de que cuando R6 es piridilo, el N es insustituido. R7 representa alquilo de C1-6 (sustituido opcionalmente por uno o mas halogenos), alquilo de C0-6-heteroarilo de 5 miembros, alquilo de C0-6-(O)n-fenilo, en donde n es 0 o 1 con la condicion de que cuando R1 y R2 son metilo, R8 y R9 son H, R5 es H, entonces R7 no puede ser CH3 o CF3.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0113233.1A GB0113233D0 (en) | 2001-05-31 | 2001-05-31 | Chemical compounds |
| PCT/EP2002/005885 WO2002096894A1 (en) | 2001-05-31 | 2002-05-29 | Thiazole or oxazole derivatives which are useful in the treatment of cardiovascular and related diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA03010584A true MXPA03010584A (es) | 2004-03-09 |
Family
ID=9915638
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MXPA03010584A MXPA03010584A (es) | 2001-05-31 | 2002-05-29 | Derivados de tiazol u oxazol que son utiles en el tratamiento de enfermedades cardiovasculares y relacionadas. |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US6867225B2 (es) |
| EP (1) | EP1392665B1 (es) |
| JP (1) | JP2004532266A (es) |
| KR (1) | KR20040007633A (es) |
| CN (1) | CN1529698A (es) |
| AT (1) | ATE377007T1 (es) |
| AU (1) | AU2002312954B2 (es) |
| BR (1) | BR0210077A (es) |
| CA (1) | CA2448103A1 (es) |
| CO (1) | CO5540299A2 (es) |
| CZ (1) | CZ20033250A3 (es) |
| DE (1) | DE60223245T2 (es) |
| ES (1) | ES2295352T3 (es) |
| GB (1) | GB0113233D0 (es) |
| HU (1) | HUP0400056A2 (es) |
| IL (1) | IL158818A0 (es) |
| MX (1) | MXPA03010584A (es) |
| NO (1) | NO20035316D0 (es) |
| PL (1) | PL367215A1 (es) |
| WO (1) | WO2002096894A1 (es) |
| ZA (1) | ZA200308864B (es) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7105551B2 (en) * | 2000-12-20 | 2006-09-12 | Smithkline Beecham Corporation | Thiazole derivatives for treating PPAR related disorders |
| GB0113231D0 (en) * | 2001-05-31 | 2001-07-25 | Glaxo Group Ltd | Chemical compounds |
| GB0113232D0 (en) * | 2001-05-31 | 2001-07-25 | Glaxo Group Ltd | Chemical process |
| JP2006502134A (ja) * | 2002-08-09 | 2006-01-19 | アストラゼネカ アクチボラグ | 代謝調節型グルタミン酸受容体において活性を有する化合物 |
| CA2497901A1 (en) | 2002-09-06 | 2004-03-18 | Takeda Pharmaceutical Company Limited | Furan or thiophene derivative and medicinal use thereof |
| GB0314370D0 (en) * | 2003-06-19 | 2003-07-23 | Glaxo Group Ltd | Chemical compounds |
| WO2005060958A1 (en) * | 2003-12-19 | 2005-07-07 | Kalypsys, Inc. | (5- (2-phenyl)-thiazol-5-ylmethoxy)-indol-1-yl) -acetic acid derivatives and related compounds as modulators of the human ppar-delta receptor for the treatment of metabolic disorders such as type 2 diabetes |
| FR2866339B1 (fr) * | 2004-02-18 | 2006-05-05 | Pf Medicament | Derives de 1,2,4-triazines, leur preparation et leur application en therapeutique humaine |
| DE102004051277A1 (de) | 2004-10-21 | 2006-04-27 | Merck Patent Gmbh | Heterocyclische Carbonylverbindungen |
| FR2882359A1 (fr) * | 2005-02-24 | 2006-08-25 | Negma Lerads Soc Par Actions S | Derives activateurs de ppar, procede de preparation et application en therapeutique |
| FR2882750B1 (fr) | 2005-03-03 | 2007-05-11 | Pierre Fabre Medicament Sa | Derives de 1,2,4-triazines, leur preparation et leur application en therapeutique humaine |
| WO2007126043A1 (ja) * | 2006-04-27 | 2007-11-08 | Mitsubishi Tanabe Pharma Corporation | チアゾール環を含むカルボン酸誘導体の医薬用途 |
| FR2901792A1 (fr) * | 2006-06-06 | 2007-12-07 | Negma Lerads Soc Par Actions S | DERIVES ACTIVATEURS DE PPARs, PROCEDE DE PREPARATION ET APPLICATION EN THERAPEUTIQUE |
| WO2008035359A2 (en) * | 2006-06-12 | 2008-03-27 | Cadila Healthcare Limited | Oximinophenoxyalkanoic acid and phenylalkanoic acid derivatives |
| RU2009108280A (ru) | 2006-08-08 | 2010-09-20 | Санофи-Авентис (Fr) | Ариламиноарилалкилзамещенные имидазолидин-2,4-дионы, способы их получения, содержащие эти соединения лекарственные средства и их применение |
| EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| DE102007054497B3 (de) | 2007-11-13 | 2009-07-23 | Sanofi-Aventis Deutschland Gmbh | Neue kristalline Diphenylazetidinonhydrate und Verfahren zu deren Herstellung |
| UY31968A (es) | 2008-07-09 | 2010-01-29 | Sanofi Aventis | Nuevos derivados heterocíclicos, sus procesos para su preparación, y sus usos terapéuticos |
| WO2010064633A1 (ja) | 2008-12-01 | 2010-06-10 | 田辺三菱製薬株式会社 | チアゾール環を含むカルボン酸誘導体およびその医薬用途 |
| WO2010068601A1 (en) | 2008-12-08 | 2010-06-17 | Sanofi-Aventis | A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof |
| SG178880A1 (en) | 2009-08-26 | 2012-04-27 | Sanofi Sa | Novel crystalline heteroaromatic fluoroglycoside hydrates, pharmaceuticals comprising these compounds and their use |
| WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
| WO2011157827A1 (de) | 2010-06-18 | 2011-12-22 | Sanofi | Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen |
| US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
| TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
| TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
| TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
| WO2012120052A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
| WO2012120054A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| US8871758B2 (en) | 2011-03-08 | 2014-10-28 | Sanofi | Tetrasubstituted oxathiazine derivatives, method for producing them, their use as medicine and drug containing said derivatives and the use thereof |
| US8828995B2 (en) | 2011-03-08 | 2014-09-09 | Sanofi | Branched oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
| EP2683699B1 (de) | 2011-03-08 | 2015-06-24 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| EP2760862B1 (en) | 2011-09-27 | 2015-10-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5859051A (en) * | 1996-02-02 | 1999-01-12 | Merck & Co., Inc. | Antidiabetic agents |
| US6207422B1 (en) * | 1998-04-17 | 2001-03-27 | The Metrohealth System | Protein that enhances expression of potassium channels on cell surfaces and nucleic acids that encode the same |
| WO2000018903A2 (en) * | 1998-09-29 | 2000-04-06 | The Johns Hopkins University | Inducible genetic suppression of cellular excitability |
| PE20011010A1 (es) * | 1999-12-02 | 2001-10-18 | Glaxo Group Ltd | Oxazoles y tiazoles sustituidos como agonista del receptor activado por el proliferador de peroxisomas humano |
| JP2004517100A (ja) * | 2000-12-20 | 2004-06-10 | グラクソ グループ リミテッド | ｈＰＰＡＲアルファアゴニストとしての置換オキサゾールおよびチアゾール |
-
2001
- 2001-05-31 GB GBGB0113233.1A patent/GB0113233D0/en not_active Ceased
-
2002
- 2002-05-29 KR KR10-2003-7015688A patent/KR20040007633A/ko not_active Application Discontinuation
- 2002-05-29 AT AT02738123T patent/ATE377007T1/de not_active IP Right Cessation
- 2002-05-29 WO PCT/EP2002/005885 patent/WO2002096894A1/en not_active Application Discontinuation
- 2002-05-29 US US10/478,259 patent/US6867225B2/en not_active Expired - Fee Related
- 2002-05-29 MX MXPA03010584A patent/MXPA03010584A/es unknown
- 2002-05-29 PL PL02367215A patent/PL367215A1/xx not_active Application Discontinuation
- 2002-05-29 IL IL15881802A patent/IL158818A0/xx unknown
- 2002-05-29 CN CNA028110803A patent/CN1529698A/zh active Pending
- 2002-05-29 HU HU0400056A patent/HUP0400056A2/hu unknown
- 2002-05-29 CA CA002448103A patent/CA2448103A1/en not_active Abandoned
- 2002-05-29 DE DE60223245T patent/DE60223245T2/de not_active Expired - Fee Related
- 2002-05-29 BR BR0210077-0A patent/BR0210077A/pt not_active IP Right Cessation
- 2002-05-29 JP JP2003500073A patent/JP2004532266A/ja active Pending
- 2002-05-29 AU AU2002312954A patent/AU2002312954B2/en not_active Ceased
- 2002-05-29 CZ CZ20033250A patent/CZ20033250A3/cs unknown
- 2002-05-29 ES ES02738123T patent/ES2295352T3/es not_active Expired - Lifetime
- 2002-05-29 EP EP02738123A patent/EP1392665B1/en not_active Expired - Lifetime
-
2003
- 2003-11-13 ZA ZA200308864A patent/ZA200308864B/en unknown
- 2003-11-28 NO NO20035316A patent/NO20035316D0/no not_active Application Discontinuation
- 2003-12-02 CO CO03106071A patent/CO5540299A2/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NO20035316L (no) | 2003-11-28 |
| JP2004532266A (ja) | 2004-10-21 |
| NO20035316D0 (no) | 2003-11-28 |
| CN1529698A (zh) | 2004-09-15 |
| AU2002312954B2 (en) | 2004-12-02 |
| CA2448103A1 (en) | 2002-12-05 |
| PL367215A1 (en) | 2005-02-21 |
| DE60223245T2 (de) | 2008-08-14 |
| CZ20033250A3 (en) | 2004-03-17 |
| EP1392665A1 (en) | 2004-03-03 |
| US6867225B2 (en) | 2005-03-15 |
| DE60223245D1 (de) | 2007-12-13 |
| ZA200308864B (en) | 2005-02-14 |
| IL158818A0 (en) | 2004-05-12 |
| KR20040007633A (ko) | 2004-01-24 |
| BR0210077A (pt) | 2004-06-22 |
| HUP0400056A2 (hu) | 2004-04-28 |
| CO5540299A2 (es) | 2005-07-29 |
| ES2295352T3 (es) | 2008-04-16 |
| WO2002096894A1 (en) | 2002-12-05 |
| ATE377007T1 (de) | 2007-11-15 |
| US20040176427A1 (en) | 2004-09-09 |
| GB0113233D0 (en) | 2001-07-25 |
| EP1392665B1 (en) | 2007-10-31 |
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