CY1106997T1 - Κυκλοεξυλ(αλκυλο)-προπανολαμινες, η διαδικασια παρασκευης τους και οι φαρμακευτικες συνθεσεις στις οποιες περιεχονται - Google Patents
Κυκλοεξυλ(αλκυλο)-προπανολαμινες, η διαδικασια παρασκευης τους και οι φαρμακευτικες συνθεσεις στις οποιες περιεχονταιInfo
- Publication number
- CY1106997T1 CY1106997T1 CY20071101450T CY071101450T CY1106997T1 CY 1106997 T1 CY1106997 T1 CY 1106997T1 CY 20071101450 T CY20071101450 T CY 20071101450T CY 071101450 T CY071101450 T CY 071101450T CY 1106997 T1 CY1106997 T1 CY 1106997T1
- Authority
- CY
- Cyprus
- Prior art keywords
- formula
- compounds
- well
- diseases
- pharmaceutical compositions
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 3
- 208000002551 irritable bowel syndrome Diseases 0.000 abstract 2
- 208000005171 Dysmenorrhea Diseases 0.000 abstract 1
- 206010013935 Dysmenorrhoea Diseases 0.000 abstract 1
- 208000018522 Gastrointestinal disease Diseases 0.000 abstract 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 abstract 1
- 208000005107 Premature Birth Diseases 0.000 abstract 1
- 206010046543 Urinary incontinence Diseases 0.000 abstract 1
- 208000036029 Uterine contractions during pregnancy Diseases 0.000 abstract 1
- 230000001430 anti-depressive effect Effects 0.000 abstract 1
- 230000001384 anti-glaucoma Effects 0.000 abstract 1
- 230000003579 anti-obesity Effects 0.000 abstract 1
- 239000000935 antidepressant agent Substances 0.000 abstract 1
- 229940125708 antidiabetic agent Drugs 0.000 abstract 1
- 239000003472 antidiabetic agent Substances 0.000 abstract 1
- -1 as anti-obesity Substances 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000035876 healing Effects 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000013067 intermediate product Substances 0.000 abstract 1
- 230000003871 intestinal function Effects 0.000 abstract 1
- 230000002366 lipolytic effect Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 239000004089 psychotropic agent Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 229940125712 tocolytic agent Drugs 0.000 abstract 1
- 239000003675 tocolytic agent Substances 0.000 abstract 1
- 230000003195 tocolytic effect Effects 0.000 abstract 1
- 230000002485 urinary effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/06—Antiabortive agents; Labour repressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/46—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C317/22—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Reproductive Health (AREA)
- Ophthalmology & Optometry (AREA)
- Gynecology & Obstetrics (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Emergency Medicine (AREA)
- Neurology (AREA)
- Child & Adolescent Psychology (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Pregnancy & Childbirth (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
Abstract
Αντικείμενο της παρούσας εφεύρεσης είναι οι ενώσεις τύπου (Ι), όπου το Α αντιστοιχεί σε μία ομάδα τύπου (α) ή (β), καθώς και στα άλατα ή τους διαλύτες τους, οι φαρμακευτικές συνθέσεις που τις περιέχουν, η διαδικασία παρασκευής τους, καθώς και ενδιάμεσα προϊόντα της διαδικασίας αυτής. Οι ενώσεις τύπου (Ι) μπορούν να επιλεγούν για τη θεραπεία γαστρεντερικών ασθενειών όπως είναι οι φλεγμονώδεις νόσους του εντέρου, όπως παραδείγματος χάρη το σύνδρομο ευερέθιστου εντέρου (Σ.Ε.Ε.), να χρησιμοποιηθούν ως ρυθμιστές της λειτουργίας του εντέρου, ως λιπολυτικές ουσίες, ως παράγοντες κατά της παχυσαρκίας, κατά του διαβήτη, ως ψυχότροπες ουσίες, ως αντι-γλαυκωματικές, επουλωτικές, αντικαταθλιπτικές, ως αναστολέας των συστολών της μήτρας, ως τοκολυτικά για την πρόληψη ή την καθυστέρηση πρόωρων τοκετών, για τη θεραπεία και/ή ως μέτρο προφύλαξης της δυσμηνόρροιας. Γενικά, οι ενώσεις τύπου (Ι) μπορούν να χρησιμοποιηθούν στα πλαίσια της θεραπείας ασθενειών του κεντρικού νευρικού συστήματος, όπως παραδείγματος χάρη η κατάθλιψη, καθώς και για ορισμένα προβλήματα του ουροποιητικού συστήματος, όπως η ακράτεια ούρων.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0015477A FR2817257B1 (fr) | 2000-11-30 | 2000-11-30 | Cyclohexyl(alkyl)-propanolamines, leur preparation et compositions pharmaceutiques en contenant |
PCT/FR2001/003784 WO2002044139A1 (fr) | 2000-11-30 | 2001-11-30 | Cyclohexyl(alkyl)-propanolamines, leur preparation et compositions pharmaceutiques en contenant |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1106997T1 true CY1106997T1 (el) | 2012-01-25 |
Family
ID=8857054
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20071101450T CY1106997T1 (el) | 2000-11-30 | 2007-11-08 | Κυκλοεξυλ(αλκυλο)-προπανολαμινες, η διαδικασια παρασκευης τους και οι φαρμακευτικες συνθεσεις στις οποιες περιεχονται |
Country Status (25)
Country | Link |
---|---|
US (3) | US7388031B2 (el) |
EP (1) | EP1341753B1 (el) |
JP (1) | JP4024149B2 (el) |
CN (2) | CN1283622C (el) |
AR (1) | AR031438A1 (el) |
AT (1) | ATE374177T1 (el) |
AU (2) | AU2002222079B2 (el) |
BR (1) | BR0115768A (el) |
CA (1) | CA2429267C (el) |
CY (1) | CY1106997T1 (el) |
CZ (1) | CZ305140B6 (el) |
DE (1) | DE60130676T2 (el) |
DK (1) | DK1341753T3 (el) |
ES (1) | ES2290201T3 (el) |
FR (1) | FR2817257B1 (el) |
HK (1) | HK1055945A1 (el) |
HU (1) | HU229583B1 (el) |
ME (1) | MEP23308A (el) |
MX (1) | MXPA03004884A (el) |
PL (1) | PL206695B1 (el) |
PT (1) | PT1341753E (el) |
RS (1) | RS51571B (el) |
SI (1) | SI1341753T1 (el) |
SK (1) | SK287551B6 (el) |
WO (1) | WO2002044139A1 (el) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2817257B1 (fr) * | 2000-11-30 | 2009-03-20 | Sanofi Synthelabo | Cyclohexyl(alkyl)-propanolamines, leur preparation et compositions pharmaceutiques en contenant |
FR2840301B1 (fr) * | 2002-05-29 | 2007-03-23 | Sanofi Synthelabo | Derives de phenyl-cyclohexyl-propanolamine, leur preparation et leur applicaton en therapeutique |
FR2840304B1 (fr) * | 2002-05-29 | 2007-05-18 | Sanofi Synthelabo | Derives d'oxophenyl-cyclohexyl-propanolamine, leur preparation et leur application en therapeutique |
EP2011490A1 (en) * | 2007-07-05 | 2009-01-07 | Sanofi-Aventis | Beta adrenergic receptor ligand derivatives for modulating apoptosis |
FR2935141B1 (fr) * | 2008-08-21 | 2010-10-08 | Sanofi Aventis | Procede de preparation de l'ester ethylique de l'acide 4-[trans-4-[(phenylmethyl)-amino]cyclohexyl]benzoique et de son sel hemifumarate |
US8569287B2 (en) * | 2008-10-31 | 2013-10-29 | Medivation Technologies, Inc. | Azepino[4,5-B]indoles and methods of use |
CN116143575B (zh) * | 2023-04-21 | 2023-06-30 | 研峰(天津)科学技术应用研究有限公司 | 昆虫信息素原料3-环己基-1-丙炔合成方法 |
Family Cites Families (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4004028A (en) * | 1975-08-06 | 1977-01-18 | Smithkline Corporation | Phenoxypropanolamines |
ATE117980T1 (de) * | 1988-06-03 | 1995-02-15 | Lilly Co Eli | Serotonin-antagonisten. |
US5096908A (en) | 1990-05-04 | 1992-03-17 | Eli Lilly And Company | Method of inhibiting gastric acid secretion |
US5340838A (en) | 1990-05-04 | 1994-08-23 | Eli Lilly And Company | Method of inhibiting gastric acid secretion with 2-phenylcyclopropylamines |
US5158956A (en) | 1990-05-04 | 1992-10-27 | Eli Lilly And Company | Method of inhibiting gastric acid secretion with benzodioxanes |
US5258379A (en) | 1990-05-04 | 1993-11-02 | Eli Lilly And Company | Method of inhibiting gastric acid secretion with n-arylpiperazines |
DE4035961A1 (de) * | 1990-11-02 | 1992-05-07 | Thomae Gmbh Dr K | Cyclische iminoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
AP9300589A0 (en) | 1992-11-18 | 1994-01-31 | Smithkline Beecham Corp | Novel 17a and 17b substituted acyl-3-carboxy 3,5-diene steroidal compounds, pharmaceutical compositions containing these compounds, and methods for using these compounds to inhibit steroid 5-a-reductase. |
US5451677A (en) * | 1993-02-09 | 1995-09-19 | Merck & Co., Inc. | Substituted phenyl sulfonamides as selective β 3 agonists for the treatment of diabetes and obesity |
IL110857A0 (en) | 1993-09-09 | 1994-11-28 | Lilly Co Eli | Cessation of tobacco use |
CA2134038C (en) | 1994-06-16 | 1997-06-03 | David Taiwai Wong | Potentiation of drug response |
EP0714663A3 (en) | 1994-11-28 | 1997-01-15 | Lilly Co Eli | Potentiation of drug responses by serotonin 1A receptor antagonists |
US5776959A (en) | 1995-06-05 | 1998-07-07 | Washington University | Anticonvulsant and anxiolytic lactam and thiolactam derivatives |
WO1997010822A1 (en) * | 1995-09-21 | 1997-03-27 | Eli Lilly And Company | SELECTIVE β3 ADRENERGIC AGONISTS |
EP0792649A1 (en) | 1996-02-29 | 1997-09-03 | Eli Lilly And Company | Treatment of sleep disorders |
US5958429A (en) | 1996-08-16 | 1999-09-28 | Eli Lilly And Company | Potentiation of serotonin response |
US20020019440A1 (en) | 1996-11-05 | 2002-02-14 | Virbac Sa | Aryloxypropanolamine derivatives, method of preparation and applications thereof |
FR2755439B1 (fr) | 1996-11-05 | 1998-12-24 | Virbac Sa | Derives aryloxypropanolamines, leur procede de preparation et leurs applications |
FR2758460B1 (fr) * | 1997-01-21 | 1999-12-31 | Sanofi Sa | Utilisation des agonistes des recepteurs beta-3 adrenergiques pour la preparation de medicaments cicatrisants |
US5776969A (en) | 1997-02-27 | 1998-07-07 | Eli Lilly And Company | Treatment of sleep disorders |
FR2780057B1 (fr) * | 1998-06-18 | 2002-09-13 | Sanofi Sa | Phenoxypropanolamines, procede pour leur preparation et compositions pharmaceutiques les contenant |
JP2000086603A (ja) | 1998-07-15 | 2000-03-28 | Yoshitomi Pharmaceut Ind Ltd | 桂皮酸アミド誘導体および3―フェニルプロピオン酸アミド誘導体 |
AU2400300A (en) | 1998-12-30 | 2000-07-31 | Eli Lilly And Company | Solution phase synthesis of compounds including amine alcohol functionality |
US6248739B1 (en) | 1999-01-08 | 2001-06-19 | Pharmacia & Upjohn Company | Quinolinecarboxamides as antiviral agents |
US20020019940A1 (en) * | 2000-06-16 | 2002-02-14 | Matteson Craig S. | Method and apparatus for assigning test and assessment instruments to users |
AUPQ841300A0 (en) * | 2000-06-27 | 2000-07-20 | Fujisawa Pharmaceutical Co., Ltd. | New aminoalcohol derivatives |
DK1303509T3 (da) | 2000-07-13 | 2013-01-02 | Lilly Co Eli | Beta3 adrenerge agonister |
FR2817257B1 (fr) | 2000-11-30 | 2009-03-20 | Sanofi Synthelabo | Cyclohexyl(alkyl)-propanolamines, leur preparation et compositions pharmaceutiques en contenant |
US6693125B2 (en) | 2001-01-24 | 2004-02-17 | Combinatorx Incorporated | Combinations of drugs (e.g., a benzimidazole and pentamidine) for the treatment of neoplastic disorders |
FR2840304B1 (fr) * | 2002-05-29 | 2007-05-18 | Sanofi Synthelabo | Derives d'oxophenyl-cyclohexyl-propanolamine, leur preparation et leur application en therapeutique |
FR2840301B1 (fr) | 2002-05-29 | 2007-03-23 | Sanofi Synthelabo | Derives de phenyl-cyclohexyl-propanolamine, leur preparation et leur applicaton en therapeutique |
AU2003251904A1 (en) | 2002-07-15 | 2004-02-02 | Combinatorx, Incorporated | Combinations of drugs for the treatment of neoplasms |
US20040186131A1 (en) | 2002-08-30 | 2004-09-23 | Wathen Michael W | Method of preventing or treating atherosclerosis or restenosis |
PL378295A1 (pl) | 2003-02-24 | 2006-03-20 | Arena Pharmaceuticals, Inc. | Podstawione pochodne arylowe i heteroarylowe jako modulatory metabolizmu glukozy oraz profilaktyka i leczenie zaburzeń tego metabolizmu |
JP2007528400A (ja) | 2004-03-09 | 2007-10-11 | エラン ファーマシューティカルズ,インコーポレイテッド | 置換ヒドロキシエチルアミン系のアスパラギン酸プロテアーゼ阻害薬 |
-
2000
- 2000-11-30 FR FR0015477A patent/FR2817257B1/fr not_active Expired - Fee Related
-
2001
- 2001-11-29 AR ARP010105555A patent/AR031438A1/es not_active Application Discontinuation
- 2001-11-30 AU AU2002222079A patent/AU2002222079B2/en not_active Ceased
- 2001-11-30 DK DK01998533T patent/DK1341753T3/da active
- 2001-11-30 JP JP2002546509A patent/JP4024149B2/ja not_active Expired - Fee Related
- 2001-11-30 SI SI200130783T patent/SI1341753T1/sl unknown
- 2001-11-30 BR BR0115768-0A patent/BR0115768A/pt active Search and Examination
- 2001-11-30 ES ES01998533T patent/ES2290201T3/es not_active Expired - Lifetime
- 2001-11-30 PL PL364746A patent/PL206695B1/pl unknown
- 2001-11-30 HU HU0400565A patent/HU229583B1/hu not_active IP Right Cessation
- 2001-11-30 EP EP01998533A patent/EP1341753B1/fr not_active Expired - Lifetime
- 2001-11-30 US US10/432,493 patent/US7388031B2/en not_active Expired - Lifetime
- 2001-11-30 CN CNB018198880A patent/CN1283622C/zh not_active Expired - Fee Related
- 2001-11-30 CN CNA2006101518761A patent/CN1935787A/zh active Pending
- 2001-11-30 RS YU41703A patent/RS51571B/en unknown
- 2001-11-30 CA CA2429267A patent/CA2429267C/fr not_active Expired - Fee Related
- 2001-11-30 SK SK652-2003A patent/SK287551B6/sk not_active IP Right Cessation
- 2001-11-30 DE DE60130676T patent/DE60130676T2/de not_active Expired - Lifetime
- 2001-11-30 CZ CZ2003-1499A patent/CZ305140B6/cs not_active IP Right Cessation
- 2001-11-30 ME MEP-233/08A patent/MEP23308A/xx unknown
- 2001-11-30 WO PCT/FR2001/003784 patent/WO2002044139A1/fr active IP Right Grant
- 2001-11-30 AU AU2207902A patent/AU2207902A/xx active Pending
- 2001-11-30 PT PT01998533T patent/PT1341753E/pt unknown
- 2001-11-30 MX MXPA03004884A patent/MXPA03004884A/es active IP Right Grant
- 2001-11-30 AT AT01998533T patent/ATE374177T1/de active
-
2003
- 2003-11-14 HK HK03108328A patent/HK1055945A1/xx not_active IP Right Cessation
-
2006
- 2006-08-15 US US11/464,537 patent/US7419974B2/en not_active Expired - Lifetime
-
2007
- 2007-11-08 CY CY20071101450T patent/CY1106997T1/el unknown
-
2008
- 2008-06-24 US US12/144,843 patent/US7718646B2/en not_active Expired - Lifetime
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CY1106997T1 (el) | Κυκλοεξυλ(αλκυλο)-προπανολαμινες, η διαδικασια παρασκευης τους και οι φαρμακευτικες συνθεσεις στις οποιες περιεχονται | |
BRPI0410630A (pt) | antagonista de nk1 | |
NO963499L (no) | Hydroksaminsyre- og karboksylsyrederivater, fremgangsmåte for deres fremstilling og anvendelse derav | |
DE69512930D1 (de) | Stilben-derivate verwendbar als cyclooxygenase-2 hemmer | |
NO981628L (no) | (Metylsulfonyl)fenyl-2-(5H)-furanoner som cox-2 inhibitorer | |
NO20083411L (no) | Indaneddiksyrederivater og deres anvendelse som farmasoytiske midler, intermediater og fremgangsmater for fremstilling | |
BR0113989A (pt) | Compostos, composições farmacêuticas, processo para a preparação de uma composição farmacêutica, e, uso de pelo menos um dos compostos | |
BR0212968A (pt) | Composição farmacêutica, composto, e, método para tratar ou prevenir condições mediadas pelo ccr2, mcp-1 ou pela interação destes | |
SE0103836D0 (sv) | Novel compounds | |
IS2833B (is) | 1,5 Bensóþíósepín og notkun þeirra gegn fitublæði | |
BR0108600A (pt) | Composto, processo para a preparação do mesmo, composição farmacêutica, processo para a preparação da mesma, uso de um composto, e, métodos para tratamento de uma doença mediada por quimiocina e para tratamento de uma doença inflamatória | |
AR014261A1 (es) | Compuestos hipolipidemicos de benzotiazepina, composiciones y proceso para su preparacion | |
ES2171723T3 (es) | 3,4-diaril-2-hidroxi-2,5-dihidrofuranos como profarmacos de inhibidores de cox-2. | |
DE60219655D1 (de) | Oxim-analoga von 1-alpha,25-dihydroxy-vitamin-d3 mit geringer calcemischer wirkung | |
ATE232873T1 (de) | Phosphonsaürederivate als ptp-1b-inhibitoren | |
PT89118A (pt) | Processo para a preparacao de derivados de anilina e de composicoes farmaceuticas que os contem | |
BR0100234A (pt) | Compostos de piperidina-4-sulfonamida, processo para a sua preparação e composições farmacêuticas contendo os mesmos | |
BR8900834A (pt) | 1,2,4-triazinodionas substituidas e processo para sua preparacao;compostos intermediarios para as mesmas e processos para sua preparacao;composicoes contra protozoarios parasitarios;processo para o combate dos mesmos;e processo para preparacao de composicoes contra protozoarios parasitarios | |
CY1105345T1 (el) | Φαινυλαλκινια | |
NO962285D0 (no) | N-substituerte azabicykloheptan-derivater anvendt for eksempel som neuroleptika | |
ATE223376T1 (de) | Bisarylcyclobutenderivate als cyclooxygenasehemmer | |
PE45195A1 (es) | Derivado de aminoacido, procedimiento para su preparacion y composicion farmaceutica que lo contiene | |
MX9403032A (es) | Quinolil-dihidropiridinas condensadas, procedimiento para su fabricacion ysu uso en medicamentos. | |
ECSP045372A (es) | Inhibidores de la carboxipeptidasa b plasmática | |
CY1106711T1 (el) | Υποκατεστημενα παραγωγα προπανο-1,3-διαμινης και η φαρμακευτικη χρηση τους |