DK1341753T3 - Cyclohexyl (alkyl) -propanolaminer, deres fremstilling, og farmaceutiske sammensætninger, der indeholder dem - Google Patents

Cyclohexyl (alkyl) -propanolaminer, deres fremstilling, og farmaceutiske sammensætninger, der indeholder dem

Info

Publication number
DK1341753T3
DK1341753T3 DK01998533T DK01998533T DK1341753T3 DK 1341753 T3 DK1341753 T3 DK 1341753T3 DK 01998533 T DK01998533 T DK 01998533T DK 01998533 T DK01998533 T DK 01998533T DK 1341753 T3 DK1341753 T3 DK 1341753T3
Authority
DK
Denmark
Prior art keywords
propanolamines
cyclohexyl
alkyl
preparation
pharmaceutical compositions
Prior art date
Application number
DK01998533T
Other languages
English (en)
Inventor
Philippe R Bovy
Roberto Cecchi
Gilles Courtemanche
Ambrogio Oliva
Nunzia Viviani
Tiziano Croci
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Application granted granted Critical
Publication of DK1341753T3 publication Critical patent/DK1341753T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/06—Antiabortive agents; Labour repressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/46—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C317/22—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biomedical Technology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Emergency Medicine (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicinal Preparation (AREA)
DK01998533T 2000-11-30 2001-11-30 Cyclohexyl (alkyl) -propanolaminer, deres fremstilling, og farmaceutiske sammensætninger, der indeholder dem DK1341753T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0015477A FR2817257B1 (fr) 2000-11-30 2000-11-30 Cyclohexyl(alkyl)-propanolamines, leur preparation et compositions pharmaceutiques en contenant
PCT/FR2001/003784 WO2002044139A1 (fr) 2000-11-30 2001-11-30 Cyclohexyl(alkyl)-propanolamines, leur preparation et compositions pharmaceutiques en contenant

Publications (1)

Publication Number Publication Date
DK1341753T3 true DK1341753T3 (da) 2008-01-14

Family

ID=8857054

Family Applications (1)

Application Number Title Priority Date Filing Date
DK01998533T DK1341753T3 (da) 2000-11-30 2001-11-30 Cyclohexyl (alkyl) -propanolaminer, deres fremstilling, og farmaceutiske sammensætninger, der indeholder dem

Country Status (25)

Country Link
US (3) US7388031B2 (da)
EP (1) EP1341753B1 (da)
JP (1) JP4024149B2 (da)
CN (2) CN1283622C (da)
AR (1) AR031438A1 (da)
AT (1) ATE374177T1 (da)
AU (2) AU2207902A (da)
BR (1) BR0115768A (da)
CA (1) CA2429267C (da)
CY (1) CY1106997T1 (da)
CZ (1) CZ305140B6 (da)
DE (1) DE60130676T2 (da)
DK (1) DK1341753T3 (da)
ES (1) ES2290201T3 (da)
FR (1) FR2817257B1 (da)
HK (1) HK1055945A1 (da)
HU (1) HU229583B1 (da)
ME (1) MEP23308A (da)
MX (1) MXPA03004884A (da)
PL (1) PL206695B1 (da)
PT (1) PT1341753E (da)
RS (1) RS51571B (da)
SI (1) SI1341753T1 (da)
SK (1) SK287551B6 (da)
WO (1) WO2002044139A1 (da)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2817257B1 (fr) * 2000-11-30 2009-03-20 Sanofi Synthelabo Cyclohexyl(alkyl)-propanolamines, leur preparation et compositions pharmaceutiques en contenant
FR2840301B1 (fr) * 2002-05-29 2007-03-23 Sanofi Synthelabo Derives de phenyl-cyclohexyl-propanolamine, leur preparation et leur applicaton en therapeutique
FR2840304B1 (fr) * 2002-05-29 2007-05-18 Sanofi Synthelabo Derives d'oxophenyl-cyclohexyl-propanolamine, leur preparation et leur application en therapeutique
EP2011490A1 (en) * 2007-07-05 2009-01-07 Sanofi-Aventis Beta adrenergic receptor ligand derivatives for modulating apoptosis
FR2935141B1 (fr) * 2008-08-21 2010-10-08 Sanofi Aventis Procede de preparation de l'ester ethylique de l'acide 4-[trans-4-[(phenylmethyl)-amino]cyclohexyl]benzoique et de son sel hemifumarate
AU2009308708B2 (en) * 2008-10-31 2015-11-19 Medivation Technologies, Inc. Azepino [4, 5-b] indoles and methods of use
CN116143575B (zh) * 2023-04-21 2023-06-30 研峰(天津)科学技术应用研究有限公司 昆虫信息素原料3-环己基-1-丙炔合成方法

Family Cites Families (35)

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ES2067541T3 (es) * 1988-06-03 1995-04-01 Lilly Co Eli Mejoras en antagonistas de la serotonina y relacionadas con ellos.
US5096908A (en) 1990-05-04 1992-03-17 Eli Lilly And Company Method of inhibiting gastric acid secretion
US5258379A (en) 1990-05-04 1993-11-02 Eli Lilly And Company Method of inhibiting gastric acid secretion with n-arylpiperazines
US5158956A (en) 1990-05-04 1992-10-27 Eli Lilly And Company Method of inhibiting gastric acid secretion with benzodioxanes
US5340838A (en) 1990-05-04 1994-08-23 Eli Lilly And Company Method of inhibiting gastric acid secretion with 2-phenylcyclopropylamines
DE4035961A1 (de) * 1990-11-02 1992-05-07 Thomae Gmbh Dr K Cyclische iminoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
IL107611A0 (en) 1992-11-18 1994-02-27 Smithkline Beecham Corp Steroid compounds and pharmaceutical compositions containing them
US5451677A (en) * 1993-02-09 1995-09-19 Merck & Co., Inc. Substituted phenyl sulfonamides as selective β 3 agonists for the treatment of diabetes and obesity
IL110857A0 (en) 1993-09-09 1994-11-28 Lilly Co Eli Cessation of tobacco use
CA2134038C (en) 1994-06-16 1997-06-03 David Taiwai Wong Potentiation of drug response
EP0714663A3 (en) 1994-11-28 1997-01-15 Lilly Co Eli Potentiation of drug responses by serotonin 1A receptor antagonists
US5776959A (en) 1995-06-05 1998-07-07 Washington University Anticonvulsant and anxiolytic lactam and thiolactam derivatives
CN1202106A (zh) * 1995-09-21 1998-12-16 伊莱利利公司 选择性的β3肾上腺素能激动剂
EP0792649A1 (en) 1996-02-29 1997-09-03 Eli Lilly And Company Treatment of sleep disorders
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US20020019440A1 (en) * 1996-11-05 2002-02-14 Virbac Sa Aryloxypropanolamine derivatives, method of preparation and applications thereof
FR2755439B1 (fr) 1996-11-05 1998-12-24 Virbac Sa Derives aryloxypropanolamines, leur procede de preparation et leurs applications
FR2758460B1 (fr) * 1997-01-21 1999-12-31 Sanofi Sa Utilisation des agonistes des recepteurs beta-3 adrenergiques pour la preparation de medicaments cicatrisants
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FR2840304B1 (fr) * 2002-05-29 2007-05-18 Sanofi Synthelabo Derives d'oxophenyl-cyclohexyl-propanolamine, leur preparation et leur application en therapeutique
FR2840301B1 (fr) 2002-05-29 2007-03-23 Sanofi Synthelabo Derives de phenyl-cyclohexyl-propanolamine, leur preparation et leur applicaton en therapeutique
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Also Published As

Publication number Publication date
EP1341753A1 (fr) 2003-09-10
US20040053916A1 (en) 2004-03-18
US20080261949A1 (en) 2008-10-23
US7419974B2 (en) 2008-09-02
ATE374177T1 (de) 2007-10-15
DE60130676D1 (de) 2007-11-08
HUP0400565A3 (en) 2004-08-30
CY1106997T1 (el) 2012-01-25
US7718646B2 (en) 2010-05-18
CA2429267C (fr) 2010-09-28
SK6522003A3 (en) 2003-11-04
ES2290201T3 (es) 2008-02-16
PT1341753E (pt) 2007-11-13
MXPA03004884A (es) 2004-05-04
EP1341753B1 (fr) 2007-09-26
SI1341753T1 (sl) 2007-12-31
HUP0400565A2 (hu) 2004-06-28
AR031438A1 (es) 2003-09-24
AU2002222079B2 (en) 2006-12-14
AU2207902A (en) 2002-06-11
CA2429267A1 (fr) 2002-06-06
MEP23308A (en) 2010-06-10
JP2004514708A (ja) 2004-05-20
CN1283622C (zh) 2006-11-08
JP4024149B2 (ja) 2007-12-19
FR2817257A1 (fr) 2002-05-31
BR0115768A (pt) 2003-12-30
PL206695B1 (pl) 2010-09-30
SK287551B6 (sk) 2011-01-04
HU229583B1 (en) 2014-02-28
CN1478074A (zh) 2004-02-25
CN1935787A (zh) 2007-03-28
YU41703A (sh) 2006-05-25
CZ305140B6 (cs) 2015-05-20
PL364746A1 (en) 2004-12-13
CZ20031499A3 (cs) 2003-08-13
HK1055945A1 (en) 2004-01-30
US7388031B2 (en) 2008-06-17
FR2817257B1 (fr) 2009-03-20
DE60130676T2 (de) 2008-07-17
RS51571B (en) 2011-08-31
US20070015745A1 (en) 2007-01-18
WO2002044139A1 (fr) 2002-06-06

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