FR2935141B1 - Procede de preparation de l'ester ethylique de l'acide 4-[trans-4-[(phenylmethyl)-amino]cyclohexyl]benzoique et de son sel hemifumarate - Google Patents
Procede de preparation de l'ester ethylique de l'acide 4-[trans-4-[(phenylmethyl)-amino]cyclohexyl]benzoique et de son sel hemifumarateInfo
- Publication number
- FR2935141B1 FR2935141B1 FR0804665A FR0804665A FR2935141B1 FR 2935141 B1 FR2935141 B1 FR 2935141B1 FR 0804665 A FR0804665 A FR 0804665A FR 0804665 A FR0804665 A FR 0804665A FR 2935141 B1 FR2935141 B1 FR 2935141B1
- Authority
- FR
- France
- Prior art keywords
- hemifumarate
- phenylmethyl
- cyclohexyl
- trans
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
- C07C57/13—Dicarboxylic acids
- C07C57/15—Fumaric acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/04—Formation of amino groups in compounds containing carboxyl groups
- C07C227/06—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid
- C07C227/08—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid by reaction of ammonia or amines with acids containing functional groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/46—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
- C07C303/40—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reactions not involving the formation of sulfonamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0804665A FR2935141B1 (fr) | 2008-08-21 | 2008-08-21 | Procede de preparation de l'ester ethylique de l'acide 4-[trans-4-[(phenylmethyl)-amino]cyclohexyl]benzoique et de son sel hemifumarate |
| US13/059,871 US20110190529A1 (en) | 2008-08-21 | 2009-08-18 | Method for preparing the ethyl ester of 4-[trans-4-[(phenylmethyl)-amino]cyclohexyl]benzoic acid and the hemifumarate salt thereof |
| PCT/FR2009/001013 WO2010020719A1 (fr) | 2008-08-21 | 2009-08-18 | Procede de preparation de l'ester ethylique de l'acide 4- [trans-4-[(phenylmethyl)-amino]cyclohexyl] benzoïque et de son sel hemifumarate |
| EP09737019A EP2331492A1 (fr) | 2008-08-21 | 2009-08-18 | Procede de preparation de l'ester ethylique de l'acide 4- [trans-4-[(phenylmethyl)-amino]cyclohexyl]benzoïque et de son sel hemifumarate |
| JP2011523435A JP2012500251A (ja) | 2008-08-21 | 2009-08-18 | ４−［トランス−４−［（フェニルメチル）アミノ］シクロヘキシル］安息香酸のエチルエステルおよびこのヘミフマル酸塩の調製方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0804665A FR2935141B1 (fr) | 2008-08-21 | 2008-08-21 | Procede de preparation de l'ester ethylique de l'acide 4-[trans-4-[(phenylmethyl)-amino]cyclohexyl]benzoique et de son sel hemifumarate |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2935141A1 FR2935141A1 (fr) | 2010-02-26 |
| FR2935141B1 true FR2935141B1 (fr) | 2010-10-08 |
Family
ID=40465096
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR0804665A Expired - Fee Related FR2935141B1 (fr) | 2008-08-21 | 2008-08-21 | Procede de preparation de l'ester ethylique de l'acide 4-[trans-4-[(phenylmethyl)-amino]cyclohexyl]benzoique et de son sel hemifumarate |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20110190529A1 (fr) |
| EP (1) | EP2331492A1 (fr) |
| JP (1) | JP2012500251A (fr) |
| FR (1) | FR2935141B1 (fr) |
| WO (1) | WO2010020719A1 (fr) |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0096006A3 (fr) * | 1982-05-28 | 1984-12-19 | Ciba-Geigy Ag | Dérivés de 3-(ureidocyclohexylamino)-propane-1,2-diol, procédé pour leur préparation, préparations pharmaceutiques contenant ces composés ainsi que leur utilisation thérapeutique |
| FR2817257B1 (fr) * | 2000-11-30 | 2009-03-20 | Sanofi Synthelabo | Cyclohexyl(alkyl)-propanolamines, leur preparation et compositions pharmaceutiques en contenant |
| FR2840304B1 (fr) * | 2002-05-29 | 2007-05-18 | Sanofi Synthelabo | Derives d'oxophenyl-cyclohexyl-propanolamine, leur preparation et leur application en therapeutique |
| FR2840301B1 (fr) * | 2002-05-29 | 2007-03-23 | Sanofi Synthelabo | Derives de phenyl-cyclohexyl-propanolamine, leur preparation et leur applicaton en therapeutique |
| JP4079727B2 (ja) * | 2002-09-06 | 2008-04-23 | セントラル硝子株式会社 | 光学活性１−（フルオロ、トリフルオロメチルまたはトリフルオロメトキシ置換フェニル）アルキルアミンｎ−モノアルキル誘導体とその製造方法 |
| DK1603558T3 (da) * | 2003-02-28 | 2008-09-01 | Servier S A Lab | Fremgangsmåde til fremstilling af perindopril og salte deraf |
-
2008
- 2008-08-21 FR FR0804665A patent/FR2935141B1/fr not_active Expired - Fee Related
-
2009
- 2009-08-18 JP JP2011523435A patent/JP2012500251A/ja not_active Withdrawn
- 2009-08-18 WO PCT/FR2009/001013 patent/WO2010020719A1/fr active Application Filing
- 2009-08-18 EP EP09737019A patent/EP2331492A1/fr not_active Withdrawn
- 2009-08-18 US US13/059,871 patent/US20110190529A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP2331492A1 (fr) | 2011-06-15 |
| US20110190529A1 (en) | 2011-08-04 |
| WO2010020719A1 (fr) | 2010-02-25 |
| JP2012500251A (ja) | 2012-01-05 |
| FR2935141A1 (fr) | 2010-02-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |
Effective date: 20130430 |