HUP0301956A2 - Mezoprogesztin 11 béta-[4E-(hidroxi-imino-metil)-fenil]-17alfa-metoxi-metil-17béta-metoxi-ösztra-4,9-dién-3-on új szilárd formái - Google Patents
Mezoprogesztin 11 béta-[4E-(hidroxi-imino-metil)-fenil]-17alfa-metoxi-metil-17béta-metoxi-ösztra-4,9-dién-3-on új szilárd formáiInfo
- Publication number
- HUP0301956A2 HUP0301956A2 HU0301956A HUP0301956A HUP0301956A2 HU P0301956 A2 HUP0301956 A2 HU P0301956A2 HU 0301956 A HU0301956 A HU 0301956A HU P0301956 A HUP0301956 A HU P0301956A HU P0301956 A2 HUP0301956 A2 HU P0301956A2
- Authority
- HU
- Hungary
- Prior art keywords
- mesoprogestin
- hydroxyiminomethyl
- dien
- methoxymethyl
- phenyl
- Prior art date
Links
- 239000007787 solid Substances 0.000 title abstract 3
- -1 J 867 oxime Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000035558 fertility Effects 0.000 abstract 1
- 238000002657 hormone replacement therapy Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/36—Antigestagens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
- C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Reproductive Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Gynecology & Obstetrics (AREA)
- Diabetes (AREA)
- Pregnancy & Childbirth (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
A jelen találmány a mezoprogesztin 11b-[4E-(hidroxi-imino-metil)-fenil]-17a-metoxi-metil-17b-metoxi-ösztra-4,9-dién-3-on (J 867 oxim)új szilárd alakú formáira, különösen a J 867 vegyület egy nagyontiszta és stabil amorf, illetve nagymértékben kristályos formájára(anszolvát/anhidrát) vonatkozik, továbbá ezek előállítására ésgyógyszerkészítményekben történő felhasználására. A J 867 oxim szilárdformái előnyösen termékenységi kontrollra és hormonhelyettesítőterápiában alkalmazhatók. Ó
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP00110887A EP1157996A1 (de) | 2000-05-23 | 2000-05-23 | Neue Festkörperformen des Mesoprogestins 11Beta-[4E-(Hydroxyiminomethyl)-phenyl]-17Alpha-methoxymethyl-17Beta-methoxy-estra-4,9-dien-3-on |
| PCT/EP2001/005237 WO2001090137A2 (de) | 2000-05-23 | 2001-05-09 | NEUE FESTKÖRPERFORMEN DES MESOPROGESTINS 11β-[4E-(HYDROXYIMINOMETHYL)-PHENYL]-17α-METHOXYMETHYL-17β-METHOXY-ESTRA-4,9-DIEN-3-ON |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0301956A2 true HUP0301956A2 (hu) | 2003-09-29 |
| HUP0301956A3 HUP0301956A3 (en) | 2010-03-29 |
Family
ID=8168805
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0301956A HUP0301956A3 (en) | 2000-05-23 | 2001-05-09 | Novel solid body forms of mesoprogestin 11betha-[4e-(hydroxyiminomethyl)-phenyl]-17alfa-methoxymethyl-17betha-methoxy-estra-4,9-dien-3-one |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US7799770B2 (hu) |
| EP (3) | EP1157996A1 (hu) |
| JP (1) | JP2003534350A (hu) |
| KR (1) | KR100553292B1 (hu) |
| CN (1) | CN100384867C (hu) |
| AT (1) | ATE397617T1 (hu) |
| AU (2) | AU2001256344B2 (hu) |
| BG (1) | BG65968B1 (hu) |
| BR (1) | BR0111058A (hu) |
| CA (1) | CA2409869C (hu) |
| CZ (1) | CZ2003620A3 (hu) |
| DE (1) | DE50114012D1 (hu) |
| DK (1) | DK1292607T3 (hu) |
| EA (1) | EA005623B1 (hu) |
| EC (2) | ECSP024358A (hu) |
| ES (1) | ES2307613T3 (hu) |
| HR (2) | HRP20021032B1 (hu) |
| HU (1) | HUP0301956A3 (hu) |
| IL (2) | IL152868A0 (hu) |
| ME (1) | MEP15608A (hu) |
| MX (1) | MXPA02011524A (hu) |
| NO (1) | NO327004B1 (hu) |
| NZ (1) | NZ522768A (hu) |
| PL (1) | PL358789A1 (hu) |
| PT (1) | PT1292607E (hu) |
| RS (1) | RS50493B (hu) |
| SK (1) | SK2922003A3 (hu) |
| UA (1) | UA73988C2 (hu) |
| WO (1) | WO2001090137A2 (hu) |
| ZA (1) | ZA200209322B (hu) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10218107A1 (de) * | 2002-04-23 | 2003-11-20 | Jenapharm Gmbh | Verfahren zum Herstellen von Kristallen von Steroiden, danach erhältliche Kristalle und deren Verwendung in pharmazeutischen Formulierungen |
| DE10218109A1 (de) * | 2002-04-23 | 2003-11-20 | Jenapharm Gmbh | Verfahren zum Herstellen von Kristallen, danach erhältliche Kristalle und deren Verwendung in pharmazeutischen Formulierungen |
| JP2008526780A (ja) * | 2005-01-18 | 2008-07-24 | テバ ジョジセルジャール ザ−トケルエン ムケド レ−スベニュタ−ルシャシャ−グ | ドルゾルアミド塩酸塩の非晶質および結晶質の形態およびそれらを製造する方法 |
| DE102006018888A1 (de) * | 2006-04-18 | 2007-10-25 | Bayer Schering Pharma Ag | Verfahren zur Herstellung von 4-[17beta-Methoxy-17alpha-methoxymethyl-3-oxoestra-4,9-dien-11beta-yl]benzaldehyd-(E)-oxims (Asoprisnil) |
| US20090054387A1 (en) | 2006-04-18 | 2009-02-26 | Detlef Grawe | Method for preparing 4-[17beta-methoxy-17alpha-methoxymethyl-3-oxestra-4,9-dien-11beta-yl]benzaldehyde (E)-oxime (asoprisnil) |
| EP1862468A1 (de) * | 2006-06-02 | 2007-12-05 | Bayer Schering Pharma Aktiengesellschaft | Kristallines 11beta-(4-Acetylphenyl)-20,20,21,21,21-pentafluor-17-hydroxy-19-nor-17alpha-pregna-4,9-dien-3-on |
| DE102009034367A1 (de) | 2009-07-20 | 2011-01-27 | Bayer Schering Pharma Aktiengesellschaft | 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-benzyliden-Derivate, Verfahren zu deren Herstellung und deren Verwendung zur Behandlung von Krankheiten |
| DE102009034366A1 (de) | 2009-07-20 | 2011-01-27 | Bayer Schering Pharma Aktiengesellschaft | 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-methylenoxyalkylenaryl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten |
| DE102009034362A1 (de) | 2009-07-20 | 2011-01-27 | Bayer Schering Pharma Aktiengesellschaft | 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-aryl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten |
| DE102009034368A1 (de) | 2009-07-20 | 2011-01-27 | Bayer Schering Pharma Aktiengesellschaft | 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-acyloxyalkylenphenyl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten |
| DE102009034526A1 (de) | 2009-07-21 | 2011-02-10 | Bayer Schering Pharma Aktiengesellschaft | 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-ethinylphenyl-Derivate, Verfahren zu deren Herstellung und deren Verwendung zur Behandlung von Krankheiten |
| DE102009034525A1 (de) | 2009-07-21 | 2011-01-27 | Bayer Schering Pharma Aktiengesellschaft | 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-aryl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten |
| DE102010007722A1 (de) | 2010-02-10 | 2011-08-11 | Bayer Schering Pharma Aktiengesellschaft, 13353 | Progesteronrezeptorantagonisten |
| DE102010007719A1 (de) | 2010-02-10 | 2011-08-11 | Bayer Schering Pharma Aktiengesellschaft, 13353 | Progesteronrezeptorantagonisten |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4332283A1 (de) * | 1993-09-20 | 1995-04-13 | Jenapharm Gmbh | Neue 11-Benzaldoximestradien-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel |
| DE19610667C2 (de) * | 1996-03-08 | 1998-04-09 | Schering Ag | (Z)-11ß-[4-(Dimethylamino)phenyl]17ß-hydroxy-17alpha-(3-hydroxy-1-propenyl)estr-4-en-3-on als kristallines Ansolvat |
| AU6335600A (en) * | 1999-07-29 | 2001-02-19 | Eli Lilly And Company | A novel crystalline form of 6-hydroxy-3-(4-[2-(piperidin-1-yl)ethoxy]phenoxy)-2-(4-metho yphenyl)benzo[b]thiophene hydrochloride |
-
2000
- 2000-05-23 EP EP00110887A patent/EP1157996A1/de not_active Withdrawn
-
2001
- 2001-05-09 AT AT01929632T patent/ATE397617T1/de not_active IP Right Cessation
- 2001-05-09 EP EP01929632A patent/EP1292607B1/de not_active Expired - Lifetime
- 2001-05-09 AU AU2001256344A patent/AU2001256344B2/en not_active Ceased
- 2001-05-09 IL IL15286801A patent/IL152868A0/xx unknown
- 2001-05-09 EA EA200201192A patent/EA005623B1/ru not_active IP Right Cessation
- 2001-05-09 EP EP07115136A patent/EP1862469A2/de not_active Withdrawn
- 2001-05-09 WO PCT/EP2001/005237 patent/WO2001090137A2/de active Application Filing
- 2001-05-09 PT PT01929632T patent/PT1292607E/pt unknown
- 2001-05-09 NZ NZ522768A patent/NZ522768A/en unknown
- 2001-05-09 CN CNB018099394A patent/CN100384867C/zh not_active Expired - Fee Related
- 2001-05-09 BR BR0111058-6A patent/BR0111058A/pt not_active IP Right Cessation
- 2001-05-09 KR KR1020027015762A patent/KR100553292B1/ko not_active IP Right Cessation
- 2001-05-09 SK SK292-2003A patent/SK2922003A3/sk not_active Application Discontinuation
- 2001-05-09 ME MEP-156/08A patent/MEP15608A/xx unknown
- 2001-05-09 CZ CZ2003620A patent/CZ2003620A3/cs unknown
- 2001-05-09 US US10/296,463 patent/US7799770B2/en active Active
- 2001-05-09 JP JP2001586324A patent/JP2003534350A/ja active Pending
- 2001-05-09 DE DE50114012T patent/DE50114012D1/de not_active Expired - Lifetime
- 2001-05-09 PL PL01358789A patent/PL358789A1/xx not_active IP Right Cessation
- 2001-05-09 MX MXPA02011524A patent/MXPA02011524A/es active IP Right Grant
- 2001-05-09 RS YUP-887/02A patent/RS50493B/sr unknown
- 2001-05-09 HU HU0301956A patent/HUP0301956A3/hu unknown
- 2001-05-09 CA CA002409869A patent/CA2409869C/en not_active Expired - Lifetime
- 2001-05-09 ES ES01929632T patent/ES2307613T3/es not_active Expired - Lifetime
- 2001-05-09 AU AU5634401A patent/AU5634401A/xx active Pending
- 2001-05-09 DK DK01929632T patent/DK1292607T3/da active
- 2001-09-05 UA UA20021210147A patent/UA73988C2/uk unknown
-
2002
- 2002-11-14 IL IL152868A patent/IL152868A/en not_active IP Right Cessation
- 2002-11-15 ZA ZA200209322A patent/ZA200209322B/en unknown
- 2002-11-22 NO NO20025613A patent/NO327004B1/no not_active IP Right Cessation
- 2002-11-22 EC EC2002004358A patent/ECSP024358A/es unknown
- 2002-12-23 HR HR20021032A patent/HRP20021032B1/xx not_active IP Right Cessation
-
2003
- 2003-02-14 BG BG107557A patent/BG65968B1/bg unknown
-
2008
- 2008-08-29 HR HR20080423A patent/HRP20080423A2/xx not_active Application Discontinuation
- 2008-10-22 EC EC2008004358A patent/ECSP084358A/es unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA9A | Lapse of provisional patent protection due to relinquishment or protection considered relinquished |