HUP0104768A2 - 4-Amino-3-oxo-azepán proteáz inhibitorok és az ezeket tartalmazó gyógyszerkészítmények - Google Patents

4-Amino-3-oxo-azepán proteáz inhibitorok és az ezeket tartalmazó gyógyszerkészítmények

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Publication number
HUP0104768A2
HUP0104768A2 HU0104768A HUP0104768A HUP0104768A2 HU P0104768 A2 HUP0104768 A2 HU P0104768A2 HU 0104768 A HU0104768 A HU 0104768A HU P0104768 A HUP0104768 A HU P0104768A HU P0104768 A2 HUP0104768 A2 HU P0104768A2
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alkyl
group
het
r9r11nc
r5r13nc
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HU0104768A
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English (en)
Inventor
Maxwell David Cummings
Robert Wells Marquis
Yu Ru
Scott Kevin Thompson
Daniel Frank Veber
Dennis Yamashita
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Smithkline Beecham Corp.
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Publication of HUP0104768A2 publication Critical patent/HUP0104768A2/hu
Publication of HUP0104768A3 publication Critical patent/HUP0104768A3/hu

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    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
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    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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  • Chemical & Material Sciences (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
  • Communicable Diseases (AREA)
  • Diabetes (AREA)
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
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Abstract

A tal lm ny t rgy t (I) ltal nos képletű vegyületek - amelyekképletében R1 csoport; R2 hidrogénatom, alkil-, cikloalkil-alkil-, Ar- (0-6 szénatomos alkil)-, Het-(0-6 szénatomos alkil)-, R9C(O)-, R9C(S)-, R9SO2-, R9OC (O)-, R9R11NC(O)-, R9R11NC(S)-, R9(R11)NSO2-, csoport; R3 hidrogénatom, alkil-, alkenil-, alkinil-, Het-(0-6 szénatomos alkil)- és Ar-(0-6 szénatomos alkil)-csoport; R3 és R' egym shoz kapcsolódva pirrolidin-, piperedin- vagy morfolingyűrűt képezhet; R4 alkil-, cikloalkil-alkil-, Ar-(0-6 szénatomos alkil)-csoport, Het-(0-6 szénatomos alkil)-, R5C(O)-, R5C(S)-, R5SO2-, R5OC(O)-, R5R13NC(O)- és R5R13NC(S)- csoport; R''' hidrogénatom, alkil-, cikloalkil-alkil-, Ar-(0-6 szénatomos alkil)- és Het-(0-6 szénatomos alkil)-csoport; X metiléncsoport, kén- vagy oxigénatom; és Z karbonil- vagy metiléncsoport - valamint gyógy szatilag elfogadható sóik, hidr tjaik és szolv tjaik képezik. A tal lm ny mag ban foglalja a hatóanyagként (I) ltal nos képletű vegyületeket tartalmazó gyógyszerkészítményeket és a vegyületek gyógy szati felhaszn l s t alkalmaz s t is olyan betegségek kezelésére, amelyekben jelentős szerepet j tszanak cisztein prote zok, kül"n"sen az excesszív csont- és porcvesztéses betegségek, péld ul az osteoporosis, a periodontitis és az arthritis kezelésére. Ó
HU0104768A 1998-12-23 1999-12-21 4-amino-3-oxo-azepanes as protease inhibitors and pharmaceutical compositions containing the same HUP0104768A3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11363698P 1998-12-23 1998-12-23
US16458199P 1999-11-10 1999-11-10
PCT/US1999/030730 WO2000038687A1 (en) 1998-12-23 1999-12-21 Protease inhibitors

Publications (2)

Publication Number Publication Date
HUP0104768A2 true HUP0104768A2 (hu) 2002-04-29
HUP0104768A3 HUP0104768A3 (en) 2002-05-28

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ID=26811293

Family Applications (1)

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HU0104768A HUP0104768A3 (en) 1998-12-23 1999-12-21 4-amino-3-oxo-azepanes as protease inhibitors and pharmaceutical compositions containing the same

Country Status (24)

Country Link
US (2) US20020147188A1 (hu)
EP (1) EP1158986A4 (hu)
JP (1) JP2002533397A (hu)
KR (1) KR100630986B1 (hu)
CN (1) CN1253441C (hu)
AT (1) ATE411294T1 (hu)
AU (1) AU768565B2 (hu)
BR (1) BR9916488A (hu)
CA (1) CA2356671A1 (hu)
CZ (1) CZ20012277A3 (hu)
DE (1) DE69939752D1 (hu)
DZ (1) DZ2977A1 (hu)
ES (1) ES2315456T3 (hu)
GC (1) GC0000178A (hu)
HK (1) HK1043536A1 (hu)
HU (1) HUP0104768A3 (hu)
IL (2) IL143142A0 (hu)
NO (1) NO318910B1 (hu)
NZ (1) NZ511710A (hu)
PE (1) PE20001340A1 (hu)
PL (1) PL350132A1 (hu)
TR (1) TR200101869T2 (hu)
UY (1) UY25874A1 (hu)
WO (1) WO2000038687A1 (hu)

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JP2003513927A (ja) * 1999-11-10 2003-04-15 スミスクライン・ビーチャム・コーポレイション プロテア−ゼ阻害剤
WO2001034565A2 (en) * 1999-11-10 2001-05-17 Smithkline Beecham Corporation Protease inhibitors
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AU1474801A (en) 1999-11-10 2001-06-06 Smithkline Beecham Corporation Protease inhibitors
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JP2003513928A (ja) * 1999-11-10 2003-04-15 スミスクライン・ビーチャム・コーポレイション プロテアーゼ阻害剤
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HUP0104768A3 (en) 2002-05-28
DE69939752D1 (de) 2008-11-27
BR9916488A (pt) 2001-10-09
JP2002533397A (ja) 2002-10-08
DZ2977A1 (fr) 2004-03-15
HK1043536A1 (zh) 2002-09-20
WO2000038687A1 (en) 2000-07-06
NZ511710A (en) 2003-12-19
EP1158986A1 (en) 2001-12-05
TR200101869T2 (tr) 2002-01-21
KR100630986B1 (ko) 2006-10-09
ATE411294T1 (de) 2008-10-15
EP1158986A4 (en) 2002-03-27
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CZ20012277A3 (cs) 2001-11-14
US20030225061A1 (en) 2003-12-04
ES2315456T3 (es) 2009-04-01
IL143142A (en) 2006-08-20
UY25874A1 (es) 2001-08-27
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GC0000178A (en) 2006-03-29
NO20013124D0 (no) 2001-06-22
AU1941100A (en) 2000-07-31
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