DZ2977A1 - 4-Amino-azépam-3-ones inhibitrices de protéases, et compositions pharmaceutiques les contenant. - Google Patents
4-Amino-azépam-3-ones inhibitrices de protéases, et compositions pharmaceutiques les contenant.Info
- Publication number
- DZ2977A1 DZ2977A1 DZ990277A DZ990277A DZ2977A1 DZ 2977 A1 DZ2977 A1 DZ 2977A1 DZ 990277 A DZ990277 A DZ 990277A DZ 990277 A DZ990277 A DZ 990277A DZ 2977 A1 DZ2977 A1 DZ 2977A1
- Authority
- DZ
- Algeria
- Prior art keywords
- amino
- pharmaceutical compositions
- disease
- azepam
- ones
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
- A61P33/12—Schistosomicides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D223/12—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Rheumatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Tropical Medicine & Parasitology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11363698P | 1998-12-23 | 1998-12-23 | |
US16458199P | 1999-11-10 | 1999-11-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
DZ2977A1 true DZ2977A1 (fr) | 2004-03-15 |
Family
ID=26811293
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DZ990277A DZ2977A1 (fr) | 1998-12-23 | 1999-12-22 | 4-Amino-azépam-3-ones inhibitrices de protéases, et compositions pharmaceutiques les contenant. |
Country Status (24)
Country | Link |
---|---|
US (2) | US20020147188A1 (fr) |
EP (1) | EP1158986A4 (fr) |
JP (1) | JP2002533397A (fr) |
KR (1) | KR100630986B1 (fr) |
CN (1) | CN1253441C (fr) |
AT (1) | ATE411294T1 (fr) |
AU (1) | AU768565B2 (fr) |
BR (1) | BR9916488A (fr) |
CA (1) | CA2356671A1 (fr) |
CZ (1) | CZ20012277A3 (fr) |
DE (1) | DE69939752D1 (fr) |
DZ (1) | DZ2977A1 (fr) |
ES (1) | ES2315456T3 (fr) |
GC (1) | GC0000178A (fr) |
HK (1) | HK1043536A1 (fr) |
HU (1) | HUP0104768A3 (fr) |
IL (2) | IL143142A0 (fr) |
NO (1) | NO318910B1 (fr) |
NZ (1) | NZ511710A (fr) |
PE (1) | PE20001340A1 (fr) |
PL (1) | PL350132A1 (fr) |
TR (1) | TR200101869T2 (fr) |
UY (1) | UY25874A1 (fr) |
WO (1) | WO2000038687A1 (fr) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030144175A1 (en) | 1998-12-23 | 2003-07-31 | Smithkline Beecham Corporation | Protease inhibitors |
WO2001034157A1 (fr) * | 1999-11-10 | 2001-05-17 | Smithkline Beecham Corporation | Inhibiteurs de protease |
EP1231921A4 (fr) * | 1999-11-10 | 2004-06-23 | Smithkline Beecham Corp | Inhibiteurs de proteases |
WO2001034599A1 (fr) * | 1999-11-10 | 2001-05-17 | Smithkline Beecham Corporation | Inhibiteurs de protease |
WO2001034565A2 (fr) * | 1999-11-10 | 2001-05-17 | Smithkline Beecham Corporation | Inhibiteurs de protease |
WO2001034154A1 (fr) * | 1999-11-10 | 2001-05-17 | Smithkline Beecham Corporation | Inhibiteurs de protease |
AU1474801A (en) * | 1999-11-10 | 2001-06-06 | Smithkline Beecham Corporation | Protease inhibitors |
WO2001034155A1 (fr) * | 1999-11-10 | 2001-05-17 | Smithkline Beecham Corporation | Inhibiteurs de protease |
JP2003533432A (ja) * | 1999-11-10 | 2003-11-11 | スミスクライン・ビーチャム・コーポレイション | プロテア−ゼ阻害剤 |
WO2001034159A1 (fr) * | 1999-11-10 | 2001-05-17 | Smithkline Beecham Corporation | Inhibiteurs de protease |
WO2001034153A1 (fr) * | 1999-11-10 | 2001-05-17 | Smithkline Beecham Corporation | Inhibiteurs de proteases |
WO2001034160A1 (fr) * | 1999-11-10 | 2001-05-17 | Smithkline Beecham Corporation | Inhibiteurs de protease |
JP2003513972A (ja) | 1999-11-10 | 2003-04-15 | スミスクライン・ビーチャム・コーポレイション | プロテアーゼ阻害剤 |
CN1416346A (zh) * | 2000-03-21 | 2003-05-07 | 史密丝克莱恩比彻姆公司 | 蛋白酶抑制剂 |
CO5280088A1 (es) * | 2000-04-18 | 2003-05-30 | Smithkline Beecham Corp | Inhibidores de proteasa |
CO5280093A1 (es) * | 2000-04-18 | 2003-05-30 | Smithkline Beecham Corp | Metodos de tratamiento |
CN1444481A (zh) * | 2000-06-14 | 2003-09-24 | 史密丝克莱恩比彻姆公司 | 蛋白酶抑制剂 |
JP2004509083A (ja) * | 2000-09-01 | 2004-03-25 | スミスクライン・ビーチャム・コーポレイション | 治療方法 |
WO2003053331A2 (fr) * | 2000-11-22 | 2003-07-03 | Smithkline Beecham Corporation | Inhibiteurs de la protease |
KR100659427B1 (ko) | 2001-02-20 | 2006-12-18 | 추가이 세이야쿠 가부시키가이샤 | 대사조절인자로서 유용한 말로닐-코에이 데카르복실라제억제제로서의 아졸류 |
US7709510B2 (en) | 2001-02-20 | 2010-05-04 | Chugai Seiyaku Kabushiki Kaisha | Azoles as malonyl-CoA decarboxylase inhibitors useful as metabolic modulators |
EP1401453A4 (fr) * | 2001-05-17 | 2005-04-06 | Smithkline Beecham Corp | Inhibiteurs de protease |
US6982263B2 (en) | 2001-06-08 | 2006-01-03 | Boehringer Ingelheim Pharmaceuticals, Inc. | Nitriles useful as reversible inhibitors of cysteine proteases |
US20050256100A1 (en) * | 2002-05-22 | 2005-11-17 | Jeong Jae U | Protease inhibitors |
WO2003099844A2 (fr) * | 2002-05-22 | 2003-12-04 | Smithkline Beecham Corporation | Inhibiteurs de protease |
KR100962972B1 (ko) * | 2002-07-26 | 2010-06-09 | 주식회사유한양행 | 1-페닐피페리딘-3-온 유도체 및 그의 제조방법 |
JP2006504719A (ja) * | 2002-10-08 | 2006-02-09 | メルク フロスト カナダ アンド カンパニー | 骨粗しょう症の治療において有用なカテプシンk阻害剤としての4−アミノ−アゼパン−3−オン化合物 |
ES2624610T3 (es) | 2003-04-11 | 2017-07-17 | Ptc Therapeutics, Inc. | Compuestos de ácido 1,2,4-oxadiazol benzoico y su uso para la supresión sin sentido y el tratamiento de enfermedades |
ES2309563T3 (es) | 2003-08-01 | 2008-12-16 | Chugai Seiyaku Kabushiki Kaisha | Compuestos de piperidina utiles como inhibidores de malonil coenzima a descarboxilasa. |
CA2533747C (fr) * | 2003-08-01 | 2012-11-13 | Chugai Seiyaku Kabushiki Kaisha | Composes heterocycliques utiles comme inhibiteurs de la malonyl-coa decarboxylase |
DE602004016530D1 (de) | 2003-08-01 | 2008-10-23 | Chugai Pharmaceutical Co Ltd | Azol-verbindungen auf cyanoguanidin-basis als malonyl-coa decarboxylase-hemmer |
CN1910175A (zh) * | 2004-01-08 | 2007-02-07 | 默克弗罗斯特加拿大有限公司 | 组织蛋白酶半胱氨酸蛋白酶抑制剂 |
EP1796793A4 (fr) * | 2004-09-07 | 2009-08-05 | Smithkline Beecham Corp | Nouveaux composes |
MX2008001207A (es) * | 2005-07-26 | 2008-03-24 | Merck Frosst Canada Ltd | Inhibidores de la cisteina proteasa de la familia de la papaina para el tratamiento de enfermedades parasitarias. |
CN101505739A (zh) | 2006-03-30 | 2009-08-12 | Ptc医疗公司 | 由具有无义突变的dna生产功能蛋白的方法以及相关疾病的治疗 |
AU2012257779A1 (en) | 2011-05-16 | 2013-11-28 | Bayer Intellectual Property Gmbh | Use of cathepsin K inhibition for the treatment and/or prophylaxis of pulmonary hypertension and/or heart failure |
CN103275070A (zh) * | 2013-05-10 | 2013-09-04 | 郑彪 | 调节单核细胞增殖的四环化合物及其应用 |
CN106455571A (zh) | 2014-03-06 | 2017-02-22 | Ptc医疗公司 | 1,2,4‑噁二唑苯甲酸的药物组合物和盐 |
AR106530A1 (es) | 2015-10-30 | 2018-01-24 | Ptc Therapeutics Inc | Métodos para tratar epilepsia |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1195287B (it) * | 1981-11-05 | 1988-10-12 | Ausonia Farma Srl | Derivato tiazolico,procedimento per la sua preparazione e relative composizioni farmaceutiche |
JPH05140063A (ja) * | 1991-11-19 | 1993-06-08 | Suntory Ltd | ジペプチド誘導体及びそれを有効成分とする骨疾患の予防及び治療剤 |
CA2111930A1 (fr) * | 1992-12-25 | 1994-06-26 | Ryoichi Ando | Derives d'aminocetones |
DE69321087T2 (de) * | 1992-12-25 | 1999-05-20 | Mitsubishi Chem Corp | Alpha-aminoketon Derivate |
JPH06199850A (ja) * | 1992-12-28 | 1994-07-19 | Tanabe Seiyaku Co Ltd | インドール含有ペプチド及びその製法 |
JP3338452B2 (ja) * | 1995-12-12 | 2002-10-28 | 大鵬薬品工業株式会社 | エポキシコハク酸アミド誘導体又はその塩及びこれを含有する医薬 |
US5902882A (en) * | 1996-04-17 | 1999-05-11 | Hoffmann-La Roche Inc. | Assymetric synthesis of azepines |
DZ2285A1 (fr) * | 1996-08-08 | 2002-12-25 | Smithkline Beecham Corp | Inhibiteurs de protéase de la cystéine. |
US6107291A (en) * | 1997-12-19 | 2000-08-22 | Amgen Inc. | Azepine or larger medium ring derivatives and methods of use |
WO2001034154A1 (fr) * | 1999-11-10 | 2001-05-17 | Smithkline Beecham Corporation | Inhibiteurs de protease |
WO2001034155A1 (fr) * | 1999-11-10 | 2001-05-17 | Smithkline Beecham Corporation | Inhibiteurs de protease |
EP1231921A4 (fr) * | 1999-11-10 | 2004-06-23 | Smithkline Beecham Corp | Inhibiteurs de proteases |
AU1474801A (en) * | 1999-11-10 | 2001-06-06 | Smithkline Beecham Corporation | Protease inhibitors |
JP2003513972A (ja) * | 1999-11-10 | 2003-04-15 | スミスクライン・ビーチャム・コーポレイション | プロテアーゼ阻害剤 |
WO2001034153A1 (fr) * | 1999-11-10 | 2001-05-17 | Smithkline Beecham Corporation | Inhibiteurs de proteases |
WO2001034565A2 (fr) * | 1999-11-10 | 2001-05-17 | Smithkline Beecham Corporation | Inhibiteurs de protease |
WO2001034160A1 (fr) * | 1999-11-10 | 2001-05-17 | Smithkline Beecham Corporation | Inhibiteurs de protease |
WO2001034599A1 (fr) * | 1999-11-10 | 2001-05-17 | Smithkline Beecham Corporation | Inhibiteurs de protease |
JP2003533432A (ja) * | 1999-11-10 | 2003-11-11 | スミスクライン・ビーチャム・コーポレイション | プロテア−ゼ阻害剤 |
NL1013996C2 (nl) * | 1999-12-30 | 2001-07-03 | Innas Free Piston Bv | Vrijezuiger aggregaat voor opwekken van hydraulische energie. |
-
1999
- 1999-12-21 TR TR2001/01869T patent/TR200101869T2/xx unknown
- 1999-12-21 PL PL99350132A patent/PL350132A1/xx not_active Application Discontinuation
- 1999-12-21 BR BR9916488-4A patent/BR9916488A/pt not_active IP Right Cessation
- 1999-12-21 DE DE69939752T patent/DE69939752D1/de not_active Expired - Lifetime
- 1999-12-21 JP JP2000590640A patent/JP2002533397A/ja active Pending
- 1999-12-21 NZ NZ511710A patent/NZ511710A/en unknown
- 1999-12-21 EP EP99963112A patent/EP1158986A4/fr not_active Withdrawn
- 1999-12-21 AT AT03076211T patent/ATE411294T1/de not_active IP Right Cessation
- 1999-12-21 ES ES03076211T patent/ES2315456T3/es not_active Expired - Lifetime
- 1999-12-21 CN CNB998150932A patent/CN1253441C/zh not_active Expired - Fee Related
- 1999-12-21 CZ CZ20012277A patent/CZ20012277A3/cs unknown
- 1999-12-21 WO PCT/US1999/030730 patent/WO2000038687A1/fr active IP Right Grant
- 1999-12-21 HU HU0104768A patent/HUP0104768A3/hu unknown
- 1999-12-21 CA CA002356671A patent/CA2356671A1/fr not_active Abandoned
- 1999-12-21 IL IL14314299A patent/IL143142A0/xx active IP Right Grant
- 1999-12-21 KR KR1020017007989A patent/KR100630986B1/ko not_active IP Right Cessation
- 1999-12-21 AU AU19411/00A patent/AU768565B2/en not_active Ceased
- 1999-12-22 DZ DZ990277A patent/DZ2977A1/fr active
- 1999-12-22 GC GCP1999461 patent/GC0000178A/en active
- 1999-12-22 UY UY25874A patent/UY25874A1/es not_active Application Discontinuation
- 1999-12-23 PE PE1999001312A patent/PE20001340A1/es not_active Application Discontinuation
-
2001
- 2001-05-14 IL IL143142A patent/IL143142A/en not_active IP Right Cessation
- 2001-06-22 NO NO20013124A patent/NO318910B1/no unknown
-
2002
- 2002-02-13 US US10/074,940 patent/US20020147188A1/en not_active Abandoned
- 2002-05-13 HK HK02103610.2A patent/HK1043536A1/zh unknown
-
2003
- 2003-04-01 US US10/404,142 patent/US20030225061A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CN1350458A (zh) | 2002-05-22 |
UY25874A1 (es) | 2001-08-27 |
HK1043536A1 (zh) | 2002-09-20 |
CZ20012277A3 (cs) | 2001-11-14 |
AU768565B2 (en) | 2003-12-18 |
PE20001340A1 (es) | 2001-01-28 |
HUP0104768A2 (hu) | 2002-04-29 |
ES2315456T3 (es) | 2009-04-01 |
TR200101869T2 (tr) | 2002-01-21 |
EP1158986A4 (fr) | 2002-03-27 |
BR9916488A (pt) | 2001-10-09 |
CA2356671A1 (fr) | 2000-07-06 |
NZ511710A (en) | 2003-12-19 |
HUP0104768A3 (en) | 2002-05-28 |
US20020147188A1 (en) | 2002-10-10 |
AU1941100A (en) | 2000-07-31 |
CN1253441C (zh) | 2006-04-26 |
JP2002533397A (ja) | 2002-10-08 |
ATE411294T1 (de) | 2008-10-15 |
DE69939752D1 (de) | 2008-11-27 |
KR20010089677A (ko) | 2001-10-08 |
IL143142A0 (en) | 2002-04-21 |
NO318910B1 (no) | 2005-05-23 |
NO20013124L (no) | 2001-06-22 |
WO2000038687A1 (fr) | 2000-07-06 |
GC0000178A (en) | 2006-03-29 |
US20030225061A1 (en) | 2003-12-04 |
NO20013124D0 (no) | 2001-06-22 |
IL143142A (en) | 2006-08-20 |
KR100630986B1 (ko) | 2006-10-09 |
EP1158986A1 (fr) | 2001-12-05 |
PL350132A1 (en) | 2002-11-04 |
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