UY26026A1 - Inhibidores de proteasas - Google Patents
Inhibidores de proteasasInfo
- Publication number
- UY26026A1 UY26026A1 UY26026A UY26026A UY26026A1 UY 26026 A1 UY26026 A1 UY 26026A1 UY 26026 A UY26026 A UY 26026A UY 26026 A UY26026 A UY 26026A UY 26026 A1 UY26026 A1 UY 26026A1
- Authority
- UY
- Uruguay
- Prior art keywords
- bone
- disease
- cartilage
- proteases
- inhibit
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D321/00—Heterocyclic compounds containing rings having two oxygen atoms as the only ring hetero atoms, not provided for by groups C07D317/00 - C07D319/00
- C07D321/02—Seven-membered rings
- C07D321/04—Seven-membered rings not condensed with other rings
- C07D321/06—1,3-Dioxepines; Hydrogenated 1,3-dioxepines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
Esta invención proporciona inhibidores de proteasas de 1.3-dioxepin-5-ona de anillo de siete miembros y sales, hidratos y solvatos farmacéuticamente aceptables de los mismos que inhiben proteasas, incluyendo catepsina K, composiciones farmacéuticas de tales compuestos y métodos para tratar enfermedades de pérdida ósea o degradación del cartílago o la matriz excesivas, incluyendo osteoporosis, enfermedad gingival incluyendo gingivitis y periodontitis; artritis, más específicamente osteoartritis y artritis reumatoide; enfermedad de Paget; hipercalcemia maligna, y enfermedad metabólica ósea, que inhiben dicha pérdida ósea o degradación excesiva del cartílago o la matriz, administrando un compuesto de la presente a un paciente que lo necesita.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12465999P | 1999-03-16 | 1999-03-16 |
Publications (1)
Publication Number | Publication Date |
---|---|
UY26026A1 true UY26026A1 (es) | 2000-10-31 |
Family
ID=22416114
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UY26026A UY26026A1 (es) | 1999-03-16 | 2000-02-23 | Inhibidores de proteasas |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP1161237A4 (es) |
JP (1) | JP2002539160A (es) |
AR (1) | AR022927A1 (es) |
AU (1) | AU3888200A (es) |
CO (1) | CO5180542A1 (es) |
HK (1) | HK1043534A1 (es) |
PE (1) | PE20001564A1 (es) |
UY (1) | UY26026A1 (es) |
WO (1) | WO2000054769A1 (es) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030144175A1 (en) | 1998-12-23 | 2003-07-31 | Smithkline Beecham Corporation | Protease inhibitors |
EP1232155A4 (en) | 1999-11-10 | 2002-11-20 | Smithkline Beecham Corp | PROTEASE INHIBITORS |
WO2001034600A1 (en) | 1999-11-10 | 2001-05-17 | Smithkline Beecham Corporation | Protease inhibitors |
EP1229914A4 (en) | 1999-11-10 | 2004-06-23 | Smithkline Beecham Corp | PROTEASE INHIBITORS |
NZ520588A (en) | 2000-03-21 | 2004-06-25 | Smithkline Beecham Corp | Protease inhibitors |
EP1465862A1 (en) | 2002-01-17 | 2004-10-13 | SmithKline Beecham Corporation | Cycloalkyl ketoamides derivatives useful as cathepsin k inhibitors |
JP2004196696A (ja) * | 2002-12-18 | 2004-07-15 | Kyowa Hakko Kogyo Co Ltd | 関節炎の予防剤または治療剤 |
CA2837084C (en) * | 2011-05-27 | 2019-09-17 | Lexicon Pharmaceuticals, Inc. | 4h-thieno[3,2-c]chromene-based inhibitors of notum pectinacetylesterase and methods of their use |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5374623A (en) * | 1992-08-20 | 1994-12-20 | Prototek, Inc. | Cysteine protease inhibitors effective for in vivo use |
DK0603769T3 (da) * | 1992-12-25 | 1999-06-14 | Mitsubishi Chem Corp | Alfa-aminoketonderivater |
-
2000
- 2000-02-23 UY UY26026A patent/UY26026A1/es unknown
- 2000-03-14 AR ARP000101121A patent/AR022927A1/es unknown
- 2000-03-16 WO PCT/US2000/006888 patent/WO2000054769A1/en not_active Application Discontinuation
- 2000-03-16 AU AU38882/00A patent/AU3888200A/en not_active Abandoned
- 2000-03-16 JP JP2000604845A patent/JP2002539160A/ja not_active Withdrawn
- 2000-03-16 EP EP00917997A patent/EP1161237A4/en not_active Withdrawn
- 2000-03-16 CO CO00019250A patent/CO5180542A1/es not_active Application Discontinuation
- 2000-03-16 PE PE2000000226A patent/PE20001564A1/es not_active Application Discontinuation
-
2002
- 2002-05-13 HK HK02103606.8A patent/HK1043534A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
JP2002539160A (ja) | 2002-11-19 |
CO5180542A1 (es) | 2002-07-30 |
PE20001564A1 (es) | 2001-02-08 |
AU3888200A (en) | 2000-10-04 |
EP1161237A1 (en) | 2001-12-12 |
HK1043534A1 (zh) | 2002-09-20 |
AR022927A1 (es) | 2002-09-04 |
WO2000054769A1 (en) | 2000-09-21 |
EP1161237A4 (en) | 2002-03-27 |
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