UY27032A1 - Inhibidores de proteasas - Google Patents

Inhibidores de proteasas

Info

Publication number
UY27032A1
UY27032A1 UY27032A UY27032A UY27032A1 UY 27032 A1 UY27032 A1 UY 27032A1 UY 27032 A UY27032 A UY 27032A UY 27032 A UY27032 A UY 27032A UY 27032 A1 UY27032 A1 UY 27032A1
Authority
UY
Uruguay
Prior art keywords
compounds
amino
protease inhibitors
present
disease
Prior art date
Application number
UY27032A
Other languages
English (en)
Inventor
Daniel F Veber
Dennis S Yamashita
Robert W Marquis
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of UY27032A1 publication Critical patent/UY27032A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

La presente invención proporciona inhibidores 1-amino-1-acil-cicloalcano-C-3-6-4 amino-azepan-3-óbucis de proteasas, y sus sales, hidratos y solvatos farmacéuticamente aceptables, que inhiben proteasas, entre ellas la catepsina K, composiciones farmacéuticas de dichos compuestos, nuevos intermedios de dichos compuestos, y métodos para tratar enfermedades de excesiva pérdida de masa ósea o degradación de cartílago o matriz, entre ellas la osteoporosis; enfermedades gingivales, entre ellas la gingivitis y la periodontitis; artritis, más específicamente osteoartritis y artritis reumatoide; la enfermedad de Paget; hipercalcemia de tumores malignos; y enfermedad metabólica de los huesos; administrando uno o más compuestos de la presente invención a un paciente que lo necesita.
UY27032A 2000-11-22 2001-11-21 Inhibidores de proteasas UY27032A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US25250800P 2000-11-22 2000-11-22

Publications (1)

Publication Number Publication Date
UY27032A1 true UY27032A1 (es) 2002-07-31

Family

ID=22956303

Family Applications (1)

Application Number Title Priority Date Filing Date
UY27032A UY27032A1 (es) 2000-11-22 2001-11-21 Inhibidores de proteasas

Country Status (17)

Country Link
EP (1) EP1392657A4 (es)
JP (1) JP2005513083A (es)
KR (1) KR20040004445A (es)
CN (1) CN1635903A (es)
AR (1) AR034278A1 (es)
AU (1) AU2001298052A1 (es)
BR (1) BR0115473A (es)
CA (1) CA2436850A1 (es)
CZ (1) CZ20031403A3 (es)
HU (1) HUP0301964A3 (es)
IL (1) IL155997A0 (es)
MX (1) MXPA03004542A (es)
NO (1) NO20032328L (es)
PL (1) PL366232A1 (es)
UY (1) UY27032A1 (es)
WO (1) WO2003053331A2 (es)
ZA (1) ZA200303848B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030144175A1 (en) 1998-12-23 2003-07-31 Smithkline Beecham Corporation Protease inhibitors
SK13632002A3 (sk) 2000-03-21 2003-02-04 Smithkline Beecham Corporation C1-6-alkyl-4-amino-azepán-3-ónové zlúčeniny, spôsob ich prípravy, farmaceutický prostriedok s ich obsahom, ich použitie a medziprodukty
JP2004503502A (ja) * 2000-06-14 2004-02-05 スミスクライン・ビーチャム・コーポレイション プロテアーゼ阻害剤
CN101970007A (zh) 2007-06-08 2011-02-09 日本化学医药株式会社 脑动脉瘤的治疗或预防药
US20100331545A1 (en) 2007-10-24 2010-12-30 Nippon Chemiphar Co., Ltd. Regulator for signaling toll-like receptor, which comprises cathepsin inhibitor as active ingredient

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002533397A (ja) * 1998-12-23 2002-10-08 スミスクライン・ビーチャム・コーポレイション プロテアーゼ阻害剤
SK13632002A3 (sk) * 2000-03-21 2003-02-04 Smithkline Beecham Corporation C1-6-alkyl-4-amino-azepán-3-ónové zlúčeniny, spôsob ich prípravy, farmaceutický prostriedok s ich obsahom, ich použitie a medziprodukty
JP2004503502A (ja) * 2000-06-14 2004-02-05 スミスクライン・ビーチャム・コーポレイション プロテアーゼ阻害剤

Also Published As

Publication number Publication date
EP1392657A4 (en) 2004-03-10
CN1635903A (zh) 2005-07-06
JP2005513083A (ja) 2005-05-12
IL155997A0 (en) 2003-12-23
EP1392657A2 (en) 2004-03-03
CZ20031403A3 (cs) 2003-10-15
ZA200303848B (en) 2004-06-28
KR20040004445A (ko) 2004-01-13
CA2436850A1 (en) 2003-07-03
WO2003053331A3 (en) 2003-11-13
MXPA03004542A (es) 2003-09-10
WO2003053331A2 (en) 2003-07-03
HUP0301964A3 (en) 2007-09-28
PL366232A1 (en) 2005-01-24
NO20032328L (no) 2003-07-02
BR0115473A (pt) 2004-09-28
NO20032328D0 (no) 2003-05-22
AR034278A1 (es) 2004-02-18
AU2001298052A1 (en) 2003-07-09
HUP0301964A2 (en) 2007-02-28

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Legal Events

Date Code Title Description
109 Application deemed to be withdrawn

Effective date: 20141111