UY27032A1 - PROTEASE INHIBITORS - Google Patents
PROTEASE INHIBITORSInfo
- Publication number
- UY27032A1 UY27032A1 UY27032A UY27032A UY27032A1 UY 27032 A1 UY27032 A1 UY 27032A1 UY 27032 A UY27032 A UY 27032A UY 27032 A UY27032 A UY 27032A UY 27032 A1 UY27032 A1 UY 27032A1
- Authority
- UY
- Uruguay
- Prior art keywords
- compounds
- amino
- protease inhibitors
- present
- disease
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Abstract
La presente invención proporciona inhibidores 1-amino-1-acil-cicloalcano-C-3-6-4 amino-azepan-3-óbucis de proteasas, y sus sales, hidratos y solvatos farmacéuticamente aceptables, que inhiben proteasas, entre ellas la catepsina K, composiciones farmacéuticas de dichos compuestos, nuevos intermedios de dichos compuestos, y métodos para tratar enfermedades de excesiva pérdida de masa ósea o degradación de cartílago o matriz, entre ellas la osteoporosis; enfermedades gingivales, entre ellas la gingivitis y la periodontitis; artritis, más específicamente osteoartritis y artritis reumatoide; la enfermedad de Paget; hipercalcemia de tumores malignos; y enfermedad metabólica de los huesos; administrando uno o más compuestos de la presente invención a un paciente que lo necesita.The present invention provides 1-amino-1-acyl-cycloalkane-C-3-6-4 amino-azepan-3-obucis protease inhibitors, and their pharmaceutically acceptable salts, hydrates and solvates, which inhibit proteases, including cathepsin K, pharmaceutical compositions of said compounds, new intermediates of said compounds, and methods for treating diseases of excessive bone loss or degradation of cartilage or matrix, including osteoporosis; gingival diseases, including gingivitis and periodontitis; arthritis, more specifically osteoarthritis and rheumatoid arthritis; Paget's disease; hypercalcemia of malignant tumors; and metabolic bone disease; administering one or more compounds of the present invention to a patient in need thereof.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25250800P | 2000-11-22 | 2000-11-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UY27032A1 true UY27032A1 (en) | 2002-07-31 |
Family
ID=22956303
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UY27032A UY27032A1 (en) | 2000-11-22 | 2001-11-21 | PROTEASE INHIBITORS |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP1392657A4 (en) |
| JP (1) | JP2005513083A (en) |
| KR (1) | KR20040004445A (en) |
| CN (1) | CN1635903A (en) |
| AR (1) | AR034278A1 (en) |
| AU (1) | AU2001298052A1 (en) |
| BR (1) | BR0115473A (en) |
| CA (1) | CA2436850A1 (en) |
| CZ (1) | CZ20031403A3 (en) |
| HU (1) | HUP0301964A3 (en) |
| IL (1) | IL155997A0 (en) |
| MX (1) | MXPA03004542A (en) |
| NO (1) | NO20032328L (en) |
| PL (1) | PL366232A1 (en) |
| UY (1) | UY27032A1 (en) |
| WO (1) | WO2003053331A2 (en) |
| ZA (1) | ZA200303848B (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030144175A1 (en) | 1998-12-23 | 2003-07-31 | Smithkline Beecham Corporation | Protease inhibitors |
| US7071184B2 (en) | 2000-03-21 | 2006-07-04 | Smithkline Beecham Corporation | Protease inhibitors |
| NZ522965A (en) * | 2000-06-14 | 2004-06-25 | Smithkline Beecham Corp | Protease inhibitors |
| US20110092484A1 (en) | 2007-06-08 | 2011-04-21 | Nippon Chemiphar Co., Ltd. | Therapeutic or prophylactic agent for cerebral aneurysm |
| EP2216047A4 (en) | 2007-10-24 | 2011-12-28 | Nat Univ Corp Tokyo Med & Dent | Regulator for signaling of toll-like receptor, which comprises cathepsin inhibitor as active ingredient |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUP0104768A3 (en) * | 1998-12-23 | 2002-05-28 | Smithkline Beecham Corp | 4-amino-3-oxo-azepanes as protease inhibitors and pharmaceutical compositions containing the same |
| US7071184B2 (en) * | 2000-03-21 | 2006-07-04 | Smithkline Beecham Corporation | Protease inhibitors |
| NZ522965A (en) * | 2000-06-14 | 2004-06-25 | Smithkline Beecham Corp | Protease inhibitors |
-
2001
- 2001-11-19 EP EP01275089A patent/EP1392657A4/en not_active Withdrawn
- 2001-11-19 MX MXPA03004542A patent/MXPA03004542A/en unknown
- 2001-11-19 AU AU2001298052A patent/AU2001298052A1/en not_active Abandoned
- 2001-11-19 WO PCT/US2001/051647 patent/WO2003053331A2/en not_active Application Discontinuation
- 2001-11-19 BR BR0115473-7A patent/BR0115473A/en not_active Application Discontinuation
- 2001-11-19 PL PL01366232A patent/PL366232A1/en not_active Application Discontinuation
- 2001-11-19 IL IL15599701A patent/IL155997A0/en unknown
- 2001-11-19 KR KR10-2003-7006807A patent/KR20040004445A/en not_active Application Discontinuation
- 2001-11-19 HU HU0301964A patent/HUP0301964A3/en unknown
- 2001-11-19 CZ CZ20031403A patent/CZ20031403A3/en unknown
- 2001-11-19 CA CA002436850A patent/CA2436850A1/en not_active Abandoned
- 2001-11-19 JP JP2003554091A patent/JP2005513083A/en not_active Withdrawn
- 2001-11-19 CN CNA018220533A patent/CN1635903A/en active Pending
- 2001-11-20 AR ARP010105409A patent/AR034278A1/en unknown
- 2001-11-21 UY UY27032A patent/UY27032A1/en not_active Application Discontinuation
-
2003
- 2003-05-16 ZA ZA200303848A patent/ZA200303848B/en unknown
- 2003-05-22 NO NO20032328A patent/NO20032328L/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BR0115473A (en) | 2004-09-28 |
| AR034278A1 (en) | 2004-02-18 |
| EP1392657A4 (en) | 2004-03-10 |
| ZA200303848B (en) | 2004-06-28 |
| CN1635903A (en) | 2005-07-06 |
| WO2003053331A2 (en) | 2003-07-03 |
| WO2003053331A3 (en) | 2003-11-13 |
| NO20032328L (en) | 2003-07-02 |
| CA2436850A1 (en) | 2003-07-03 |
| JP2005513083A (en) | 2005-05-12 |
| HUP0301964A2 (en) | 2007-02-28 |
| IL155997A0 (en) | 2003-12-23 |
| PL366232A1 (en) | 2005-01-24 |
| KR20040004445A (en) | 2004-01-13 |
| AU2001298052A1 (en) | 2003-07-09 |
| NO20032328D0 (en) | 2003-05-22 |
| HUP0301964A3 (en) | 2007-09-28 |
| EP1392657A2 (en) | 2004-03-03 |
| MXPA03004542A (en) | 2003-09-10 |
| CZ20031403A3 (en) | 2003-10-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 109 | Application deemed to be withdrawn |
Effective date: 20141111 |