ECSP993293A - PROTEASE INHIBITORS VIII - Google Patents
PROTEASE INHIBITORS VIIIInfo
- Publication number
- ECSP993293A ECSP993293A ECSP993293A ECSP993293A EC SP993293 A ECSP993293 A EC SP993293A EC SP993293 A ECSP993293 A EC SP993293A EC SP993293 A ECSP993293 A EC SP993293A
- Authority
- EC
- Ecuador
- Prior art keywords
- excessive
- compounds
- disease
- protease inhibitors
- cartilage
- Prior art date
Links
- 229940042399 direct acting antivirals protease inhibitors Drugs 0.000 title abstract 2
- 239000000137 peptide hydrolase inhibitor Substances 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 4
- 206010065687 Bone loss Diseases 0.000 abstract 2
- 210000000845 cartilage Anatomy 0.000 abstract 2
- 230000015556 catabolic process Effects 0.000 abstract 2
- 238000006731 degradation reaction Methods 0.000 abstract 2
- 239000011159 matrix material Substances 0.000 abstract 2
- QTLLOLTVQMFWDZ-UHFFFAOYSA-N 4-aminoazepan-3-one Chemical compound NC1CCCNCC1=O QTLLOLTVQMFWDZ-UHFFFAOYSA-N 0.000 abstract 1
- 208000037147 Hypercalcaemia Diseases 0.000 abstract 1
- 208000030136 Marchiafava-Bignami Disease Diseases 0.000 abstract 1
- 208000029725 Metabolic bone disease Diseases 0.000 abstract 1
- 208000010191 Osteitis Deformans Diseases 0.000 abstract 1
- 208000001132 Osteoporosis Diseases 0.000 abstract 1
- 208000027868 Paget disease Diseases 0.000 abstract 1
- 102000035195 Peptidases Human genes 0.000 abstract 1
- 108091005804 Peptidases Proteins 0.000 abstract 1
- 239000004365 Protease Substances 0.000 abstract 1
- 206010003246 arthritis Diseases 0.000 abstract 1
- -1 captesin K Substances 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000024693 gingival disease Diseases 0.000 abstract 1
- 208000007565 gingivitis Diseases 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 230000000148 hypercalcaemia Effects 0.000 abstract 1
- 208000030915 hypercalcemia disease Diseases 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000003211 malignant effect Effects 0.000 abstract 1
- 208000027202 mammary Paget disease Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 201000008482 osteoarthritis Diseases 0.000 abstract 1
- 201000001245 periodontitis Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente invención proporciona inhibidores de proteasa de 4-amino-azepan-3-ona y sus sales, hidratos o solvatos de los mismos aceptables farmacéuticamente, que inhiben proteasas, incluyendo la captesina K, composiciones farmacéuticas de tales compuesto, nuevos compuestos intermedios de los compuestos de este tipo, y métodos para tratar enfermedades de pérdida ósea excesiva o degradación excesiva de cartílago o matriz, con inclusión de osteoporosis; enfermedad gingival con inclusión de gingivitis y periodontitis; artritis, más específicamente, osteoartritis y artritis reumatoide; enfermedad de Paget; hipercalcemia de carácetr maligno; y enfermedad metabólica ósea, que comprende inhibir dicha pérdida ósea o degradación excesiva de cartílago o matriz por administración de un compuesto de la presente invención a un paciente que se encuentra en necesidad de ello.The present invention provides 4-amino-azepan-3-one protease inhibitors and their pharmaceutically acceptable salts, hydrates or solvates thereof, which inhibit proteases, including captesin K, pharmaceutical compositions of such compounds, novel intermediate compounds of the compounds of this type, and methods of treating diseases of excessive bone loss or excessive degradation of cartilage or matrix, including osteoporosis; gingival disease including gingivitis and periodontitis; arthritis, more specifically, osteoarthritis and rheumatoid arthritis; Paget's disease; hypercalcemia of malignant character; and metabolic bone disease, which comprises inhibiting said bone loss or excessive cartilage or matrix degradation by administering a compound of the present invention to a patient in need thereof.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP993293 ECSP993293A (en) | 1999-12-23 | 1999-12-23 | PROTEASE INHIBITORS VIII |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP993293 ECSP993293A (en) | 1999-12-23 | 1999-12-23 | PROTEASE INHIBITORS VIII |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP993293A true ECSP993293A (en) | 2000-05-25 |
Family
ID=42044284
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP993293 ECSP993293A (en) | 1999-12-23 | 1999-12-23 | PROTEASE INHIBITORS VIII |
Country Status (1)
| Country | Link |
|---|---|
| EC (1) | ECSP993293A (en) |
-
1999
- 1999-12-23 EC ECSP993293 patent/ECSP993293A/en unknown
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