TR199902703T2 - Protease inhibitors. - Google Patents

Protease inhibitors.

Info

Publication number
TR199902703T2
TR199902703T2 TR1999/02703T TR9902703T TR199902703T2 TR 199902703 T2 TR199902703 T2 TR 199902703T2 TR 1999/02703 T TR1999/02703 T TR 1999/02703T TR 9902703 T TR9902703 T TR 9902703T TR 199902703 T2 TR199902703 T2 TR 199902703T2
Authority
TR
Turkey
Prior art keywords
disease
protease inhibitors
compounds
periodonditis
osteoprose
Prior art date
Application number
TR1999/02703T
Other languages
Turkish (tr)
Inventor
Marie Halbert Stacie
Michaud Evelyne
Kevin Thompson Scott
Frank Veber Daniel
Original Assignee
Smithkline Beecham Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corporation filed Critical Smithkline Beecham Corporation
Publication of TR199902703T2 publication Critical patent/TR199902703T2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Bu bulus, katepsin K dahil olmak üzere proteazlari önleyen formül (I) bilesikleri ve bu gibi bilesiklerin farmasötik terkiplerini ve, osteoproz; jinjivit ve periodondit dahil olmak üzere jinjival hastaligi; arterit ve özellikle de osteoarteri ve romatizmal arterit; Paget hastaligi; hiperkalsemi veya malignansi ve metabolik kemik hastaligi dahil olmak üzere asiri kemik kaybi veya kikirdak ya da matris bozulumu ile ilgili hastaliklarin tedavisi için metodlar sunmaktadir.The present invention includes compounds of formula (I) and pharmaceutical compositions of such compounds that prevent proteases, including cathepsin K, and osteoprose; gingival disease, including gingivitis and periodonditis; arteritis, and especially osteoarthritis and rheumatic arthritis; Paget's disease; It provides methods for the treatment of diseases related to excessive bone loss or cartilage or matrix disruption, including hypercalcemia or malignancy and metabolic bone disease.

TR1999/02703T 1997-04-29 1998-04-29 Protease inhibitors. TR199902703T2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US4506797P 1997-04-29 1997-04-29

Publications (1)

Publication Number Publication Date
TR199902703T2 true TR199902703T2 (en) 2000-02-21

Family

ID=21935831

Family Applications (1)

Application Number Title Priority Date Filing Date
TR1999/02703T TR199902703T2 (en) 1997-04-29 1998-04-29 Protease inhibitors.

Country Status (18)

Country Link
EP (1) EP1019046A4 (en)
JP (1) JP2002504097A (en)
KR (1) KR20010020391A (en)
CN (1) CN1261276A (en)
AR (1) AR012622A1 (en)
AU (1) AU7365198A (en)
BR (1) BR9809333A (en)
CA (1) CA2287989A1 (en)
CO (1) CO4940477A1 (en)
HU (1) HUP0001294A3 (en)
IL (1) IL132629A0 (en)
MA (1) MA26487A1 (en)
NO (1) NO995268L (en)
PE (1) PE69099A1 (en)
PL (1) PL337725A1 (en)
TR (1) TR199902703T2 (en)
WO (1) WO1998048799A1 (en)
ZA (1) ZA983522B (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1924699A (en) 1997-12-19 1999-07-12 Smithkline Beecham Corporation Compounds of heteroaryl substituted imidazole, their pharmaceutical compositionsand uses
US6100282A (en) * 1998-01-02 2000-08-08 Hoffman-La Roche Inc. Thiazole derivatives
MA26618A1 (en) * 1998-04-09 2004-12-20 Smithkline Beecham Corp PHARMACEUTICAL COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF MALARIA
US6858617B2 (en) 1998-05-26 2005-02-22 Smithkline Beecham Corporation Substituted imidazole compounds
ES2212657T3 (en) 1998-11-04 2004-07-16 Smithkline Beecham Corporation REPLACED PIRAZINAS PIRIDIN-4-IL OR PIRIMIDIN-4-IL.
CO5150165A1 (en) * 1998-11-13 2002-04-29 Smithkline Beecham Plc PROTEASE INHIBITORS: KATEPSIN K TYPE
US20030144175A1 (en) 1998-12-23 2003-07-31 Smithkline Beecham Corporation Protease inhibitors
AU1588901A (en) 1999-11-10 2001-06-06 Smithkline Beecham Corporation Protease inhibitors
WO2001034156A1 (en) 1999-11-10 2001-05-17 Smithkline Beecham Corporation Protease inhibitors
JP2003513972A (en) 1999-11-10 2003-04-15 スミスクライン・ビーチャム・コーポレイション Protease inhibitor
EP1234821A4 (en) * 1999-12-03 2002-10-28 Ono Pharmaceutical Co 1,3,4-oxadiazoline derivatives and drugs containing these derivatives as the active ingredient
US6797720B2 (en) 1999-12-03 2004-09-28 Ono Pharmaceutical Co., Ltd. 1,3,4-oxadiazoline derivative and an agent comprising its derivative as active ingredient
CZ20023168A3 (en) 2000-03-21 2003-02-12 Smithkline Beecham Corporation Protease inhibitors
EP1465862A1 (en) 2002-01-17 2004-10-13 SmithKline Beecham Corporation Cycloalkyl ketoamides derivatives useful as cathepsin k inhibitors
CA2490468A1 (en) * 2002-07-04 2004-01-22 Aventis Pharma S.A. Novel thiophene acyl hydrazino derivatives, method for preparing same, use thereof as medicines, pharmaceutical compositions and novel use
KR100962972B1 (en) 2002-07-26 2010-06-09 주식회사유한양행 1-phenylpiperidin-3-one derivatives and processes for the preparation thereof
WO2011015524A2 (en) * 2009-08-03 2011-02-10 Bayer Cropscience Ag Fungicide heterocycles derivatives
KR20150046259A (en) * 2012-08-23 2015-04-29 앨리오스 바이오파마 인크. Compounds for the treatment of paramoxyvirus viral infections
KR102455034B1 (en) 2013-08-21 2022-10-13 얀센 바이오파마, 인코퍼레이트. Antiviral compounds
MA41614A (en) 2015-02-25 2018-01-02 Alios Biopharma Inc ANTIVIRAL COMPOUNDS

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AP9801222A0 (en) * 1995-10-30 1998-06-30 Smithkline Beecham Corp Proatease inhibitors.

Also Published As

Publication number Publication date
WO1998048799A1 (en) 1998-11-05
IL132629A0 (en) 2001-03-19
ZA983522B (en) 1998-10-29
MA26487A1 (en) 2004-12-20
EP1019046A1 (en) 2000-07-19
NO995268L (en) 1999-11-15
AU7365198A (en) 1998-11-24
HUP0001294A2 (en) 2001-04-28
HUP0001294A3 (en) 2001-06-28
CN1261276A (en) 2000-07-26
CA2287989A1 (en) 1998-11-05
KR20010020391A (en) 2001-03-15
PE69099A1 (en) 1999-09-26
AR012622A1 (en) 2000-11-08
EP1019046A4 (en) 2002-11-27
PL337725A1 (en) 2000-08-28
NO995268D0 (en) 1999-10-28
JP2002504097A (en) 2002-02-05
BR9809333A (en) 2000-07-04
CO4940477A1 (en) 2000-07-24

Similar Documents

Publication Publication Date Title
TR199800767T2 (en) Protease inhibitors.
TR199902703T2 (en) Protease inhibitors.
NO20013124D0 (en) Protease inhibitors
BR9804437A (en) Compounds for osteoporosis
BR0109356A (en) Protease Inhibitors
SE9901272D0 (en) New improved formulation
NZ537853A (en) Inhibitors of cathepsin K and related cysteine protesases of the CA clan
BR9914044A (en) tetrahydropyride esters
TR200003252T2 (en) Interleukin-1ß converting enzyme succinamide inhibitors.
WO1999059526A3 (en) Protease inhibitors
EA200300018A1 (en) PROTEAS INHIBITORS
UY26088A1 (en) PROTEASE INHIBITORS
UY26026A1 (en) PROTEASE INHIBITORS
BR0115473A (en) Protease Inhibitors
ECSP982486A (en) PROTEASE INHIBITORS II
ECSP982481A (en) PROTEASE INHIBITORS
FR2783518B1 (en) LTA4 HYDROLASE INHIBITORS
NZ324101A (en) Protease inhibitors, pharmaceutical compositions and use thereof
ECSP003403A (en) PROTEASE INHIBITORS XI
ECSP992959A (en) BIS-AMINOMETIL CARBONYL PROTEASE INHIBITORS
UY26771A1 (en) PROTEASE INHIBITORS
AR004703A1 (en) HYDRAZIDIL, BIS-HYDRAZIL AND BIS-AMINOMETIL-CARBONIL, PROTEASE INHIBITORS, A PHARMACEUTICAL COMPOSITION, METHOD FOR INHIBITING PROTEASES, AND USE IN THE PREPARATION OF MEDICINES.
IT1255678B (en) PHARMACEUTICAL COMPOSITIONS FOR THE ADMINISTRATION OF PARATORMONE, ITS BIOLOGICALLY ACTIVE FRAGMENTS OR RECTAL RELATED PEPTIDES.