BR9809333A - Protease inhibitors - Google Patents
Protease inhibitorsInfo
- Publication number
- BR9809333A BR9809333A BR9809333-9A BR9809333A BR9809333A BR 9809333 A BR9809333 A BR 9809333A BR 9809333 A BR9809333 A BR 9809333A BR 9809333 A BR9809333 A BR 9809333A
- Authority
- BR
- Brazil
- Prior art keywords
- disease
- protease inhibitors
- compounds
- arthritis
- oesteoarthritis
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Biophysics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
"INIBIDORES DE PROTEASES" A presente invenção fornece os compostos de fórmula (I), os quais inibem proteases, inclusive a catepsina K, composições farmacêuticas desses compostos, e método para tratar com eles as doenças de excessiva perda óssea ou degradação de cartilagem ou matriz, inclusive a osteoporose; doença gengival, inclusive gengivite e periodontite; artrite, mais especificamente, oesteoartrite e artrite reumatóide; doença de Paget; hipercalcemia maligna; e doença do metabolismo ósseo."PROTEASE INHIBITORS" The present invention provides the compounds of formula (I), which inhibit proteases, including cathepsin K, pharmaceutical compositions of these compounds, and a method of treating with them diseases of excessive bone loss or degradation of cartilage or matrix , including osteoporosis; gum disease, including gingivitis and periodontitis; arthritis, more specifically, Oesteoarthritis and rheumatoid arthritis; Paget's disease; malignant hypercalcemia; and bone metabolism disease.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4506797P | 1997-04-29 | 1997-04-29 | |
PCT/US1998/008740 WO1998048799A1 (en) | 1997-04-29 | 1998-04-29 | Protease inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9809333A true BR9809333A (en) | 2000-07-04 |
Family
ID=21935831
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9809333-9A BR9809333A (en) | 1997-04-29 | 1998-04-29 | Protease inhibitors |
Country Status (18)
Country | Link |
---|---|
EP (1) | EP1019046A4 (en) |
JP (1) | JP2002504097A (en) |
KR (1) | KR20010020391A (en) |
CN (1) | CN1261276A (en) |
AR (1) | AR012622A1 (en) |
AU (1) | AU7365198A (en) |
BR (1) | BR9809333A (en) |
CA (1) | CA2287989A1 (en) |
CO (1) | CO4940477A1 (en) |
HU (1) | HUP0001294A3 (en) |
IL (1) | IL132629A0 (en) |
MA (1) | MA26487A1 (en) |
NO (1) | NO995268L (en) |
PE (1) | PE69099A1 (en) |
PL (1) | PL337725A1 (en) |
TR (1) | TR199902703T2 (en) |
WO (1) | WO1998048799A1 (en) |
ZA (1) | ZA983522B (en) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR017219A1 (en) | 1997-12-19 | 2001-08-22 | Smithkline Beecham Corp | IMIDAZOL DERIVATIVES 1,4,5 SUBSTITUTES, COMPOSITIONS THAT INCLUDE THEM, PROCEDURE FOR THE PREPARATION OF SUCH DERIVATIVES, USE OF DERIVATIVES TO MANUFACTURE OF A MEDICINAL PRODUCT |
US6100282A (en) * | 1998-01-02 | 2000-08-08 | Hoffman-La Roche Inc. | Thiazole derivatives |
MA26618A1 (en) * | 1998-04-09 | 2004-12-20 | Smithkline Beecham Corp | PHARMACEUTICAL COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF MALARIA |
US6858617B2 (en) | 1998-05-26 | 2005-02-22 | Smithkline Beecham Corporation | Substituted imidazole compounds |
ATE258055T1 (en) | 1998-11-04 | 2004-02-15 | Smithkline Beecham Corp | PYRIDINE-4-YL OR PYRIMIDINE-4-YL SUBSTITUTED PYRAZINE |
CO5150165A1 (en) * | 1998-11-13 | 2002-04-29 | Smithkline Beecham Plc | PROTEASE INHIBITORS: KATEPSIN K TYPE |
US20030144175A1 (en) | 1998-12-23 | 2003-07-31 | Smithkline Beecham Corporation | Protease inhibitors |
JP2003513924A (en) | 1999-11-10 | 2003-04-15 | スミスクライン・ビーチャム・コーポレイション | Protease inhibitor |
US6583137B1 (en) | 1999-11-10 | 2003-06-24 | Smithkline Beecham Corporation | Protease inhibitors |
WO2001034599A1 (en) | 1999-11-10 | 2001-05-17 | Smithkline Beecham Corporation | Protease inhibitors |
US6797720B2 (en) | 1999-12-03 | 2004-09-28 | Ono Pharmaceutical Co., Ltd. | 1,3,4-oxadiazoline derivative and an agent comprising its derivative as active ingredient |
KR20020062312A (en) * | 1999-12-03 | 2002-07-25 | 오노 야꾸힝 고교 가부시키가이샤 | 1,3,4-oxadiazoline derivatives and drugs containing these derivatives as the active ingredient |
CN1416346A (en) | 2000-03-21 | 2003-05-07 | 史密丝克莱恩比彻姆公司 | Peotease inhibitors |
EP1465862A1 (en) | 2002-01-17 | 2004-10-13 | SmithKline Beecham Corporation | Cycloalkyl ketoamides derivatives useful as cathepsin k inhibitors |
CA2490468A1 (en) * | 2002-07-04 | 2004-01-22 | Aventis Pharma S.A. | Novel thiophene acyl hydrazino derivatives, method for preparing same, use thereof as medicines, pharmaceutical compositions and novel use |
KR100962972B1 (en) | 2002-07-26 | 2010-06-09 | 주식회사유한양행 | 1-phenylpiperidin-3-one derivatives and processes for the preparation thereof |
WO2011015524A2 (en) * | 2009-08-03 | 2011-02-10 | Bayer Cropscience Ag | Fungicide heterocycles derivatives |
ES2779748T3 (en) * | 2012-08-23 | 2020-08-19 | Janssen Biopharma Inc | Compounds for the treatment of paramyxovirus infections |
CN114716426A (en) | 2013-08-21 | 2022-07-08 | 詹森生物制药有限公司 | Antiviral compounds |
MA41614A (en) | 2015-02-25 | 2018-01-02 | Alios Biopharma Inc | ANTIVIRAL COMPOUNDS |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CZ132798A3 (en) * | 1995-10-30 | 1999-02-17 | Smithkline Beecham Corporation | Protease inhibitors |
-
1998
- 1998-04-24 MA MA25047A patent/MA26487A1/en unknown
- 1998-04-27 PE PE1998000320A patent/PE69099A1/en not_active Application Discontinuation
- 1998-04-28 ZA ZA983522A patent/ZA983522B/en unknown
- 1998-04-29 AR ARP980101999A patent/AR012622A1/en unknown
- 1998-04-29 PL PL98337725A patent/PL337725A1/en unknown
- 1998-04-29 WO PCT/US1998/008740 patent/WO1998048799A1/en not_active Application Discontinuation
- 1998-04-29 CO CO98023491A patent/CO4940477A1/en unknown
- 1998-04-29 AU AU73651/98A patent/AU7365198A/en not_active Abandoned
- 1998-04-29 BR BR9809333-9A patent/BR9809333A/en not_active IP Right Cessation
- 1998-04-29 JP JP54738998A patent/JP2002504097A/en active Pending
- 1998-04-29 CN CN98806641A patent/CN1261276A/en active Pending
- 1998-04-29 IL IL13262998A patent/IL132629A0/en unknown
- 1998-04-29 KR KR1019997010013A patent/KR20010020391A/en not_active Application Discontinuation
- 1998-04-29 TR TR1999/02703T patent/TR199902703T2/en unknown
- 1998-04-29 HU HU0001294A patent/HUP0001294A3/en unknown
- 1998-04-29 EP EP98920926A patent/EP1019046A4/en not_active Withdrawn
- 1998-04-29 CA CA002287989A patent/CA2287989A1/en not_active Abandoned
-
1999
- 1999-10-28 NO NO995268A patent/NO995268L/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
WO1998048799A1 (en) | 1998-11-05 |
CA2287989A1 (en) | 1998-11-05 |
KR20010020391A (en) | 2001-03-15 |
EP1019046A4 (en) | 2002-11-27 |
HUP0001294A2 (en) | 2001-04-28 |
EP1019046A1 (en) | 2000-07-19 |
ZA983522B (en) | 1998-10-29 |
PE69099A1 (en) | 1999-09-26 |
HUP0001294A3 (en) | 2001-06-28 |
AR012622A1 (en) | 2000-11-08 |
CO4940477A1 (en) | 2000-07-24 |
TR199902703T2 (en) | 2000-02-21 |
NO995268D0 (en) | 1999-10-28 |
NO995268L (en) | 1999-11-15 |
AU7365198A (en) | 1998-11-24 |
MA26487A1 (en) | 2004-12-20 |
IL132629A0 (en) | 2001-03-19 |
PL337725A1 (en) | 2000-08-28 |
JP2002504097A (en) | 2002-02-05 |
CN1261276A (en) | 2000-07-26 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 5A, 6A, 7A, 8A E 9A ANUIDADES. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1889 DE 20/03/2007. |