AR021971A1 - PROTEASE INHIBITORS - Google Patents
PROTEASE INHIBITORSInfo
- Publication number
- AR021971A1 AR021971A1 ARP990106648A AR021971A1 AR 021971 A1 AR021971 A1 AR 021971A1 AR P990106648 A ARP990106648 A AR P990106648A AR 021971 A1 AR021971 A1 AR 021971A1
- Authority
- AR
- Argentina
- Prior art keywords
- disease
- cartilage
- matrix
- compounds
- excessive
- Prior art date
Links
Abstract
La presente proporciona inhibidores de proteasas de 4-amino-azepan-3-ona y sus sales, hidratos y solvatos farmacéuticamente aceptables que inhibenproteasas, con inclusion de catepsina K, composiciones farmacéuticas de dichos compuestos, nuevos compuestos intermediarios de los compuestos de este tipo, ymétodos para tratar enfermedades de pérdida osea excesiva o degradacion excesiva de cartílago o matriz, con inclusion de osteoporosis; enfermedad gingival coninclusion de gingivitis y periodontitis; artritis, más específicamente, osteoartritis y artritis reumatoide; enfermedad de Paget; hipercalcemia de caráctermaligno; y enfermedad metabolica osea, que comprende inhibir dicha pérdida osea o degradacion excesiva de cartílago o matriz por administracion de un compuestode la presente a un paciente que se encuentra en necesidad de ello.It provides inhibitors of 4-amino-azepan-3-one proteases and their pharmaceutically acceptable salts, hydrates and solvates that inhibit proteases, including cathepsin K, pharmaceutical compositions of said compounds, novel intermediates of compounds of this type, and methods for treating diseases of excessive bone loss or excessive degradation of cartilage or matrix, including osteoporosis; gingival disease including gingivitis and periodontitis; arthritis, more specifically, osteoarthritis and rheumatoid arthritis; Paget's disease; hypercalcemia of a natural character; and bone metabolic disease, which comprises inhibiting said bone loss or excessive degradation of cartilage or matrix by administering a compound thereof to a patient in need thereof.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11363698P | 1998-12-23 | 1998-12-23 | |
| US16458199A | 1999-11-10 | 1999-11-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR021971A1 true AR021971A1 (en) | 2002-09-04 |
Family
ID=45570254
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP990106648 AR021971A1 (en) | 1998-12-23 | 1999-12-21 | PROTEASE INHIBITORS |
Country Status (1)
| Country | Link |
|---|---|
| AR (1) | AR021971A1 (en) |
-
1999
- 1999-12-21 AR ARP990106648 patent/AR021971A1/en not_active Application Discontinuation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |