UY26088A1 - PROTEASE INHIBITORS - Google Patents

PROTEASE INHIBITORS

Info

Publication number
UY26088A1
UY26088A1 UY26088A UY26088A UY26088A1 UY 26088 A1 UY26088 A1 UY 26088A1 UY 26088 A UY26088 A UY 26088A UY 26088 A UY26088 A UY 26088A UY 26088 A1 UY26088 A1 UY 26088A1
Authority
UY
Uruguay
Prior art keywords
disease
cartilage
matrix
excessive
proteases
Prior art date
Application number
UY26088A
Other languages
Spanish (es)
Inventor
Dennis Shinji Yamashita
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of UY26088A1 publication Critical patent/UY26088A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D321/00—Heterocyclic compounds containing rings having two oxygen atoms as the only ring hetero atoms, not provided for by groups C07D317/00 - C07D319/00
    • C07D321/12—Eight-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invención proporciona inhibidores de proteasas de 4-amino-4, 5 -dihidro-benzo [b] [1, 4] dioxocin- 3 -ona, y sus sales, hidratos y solvatos farmacéuticamente aceptables que inhiben las proteasas, con inclusión de la catepsina K, composiciones farmacéuticas de tales compuestos, y métodos para tratar enfermedades de pérdida ósea excesiva o degradación excesiva de cartílago o matriz, que incluyen osteoporosis; enfermedad gingival con inclusión de gingivitis y periodontitis, artritis, más específicamente osteoartritis y artritis reumatoide; enfermedad de Paget; hipercalcemia de carácter maligno; y enfermedad metabólica ósea, que comprenden inhibir dicha pérdida ósea o degradación excesiva de cartílago o matriz por administración a un paciente que se encuentra en necesidad de ello de un compuesto de la presente invención.The present invention provides inhibitors of 4-amino-4,5-dihydro-benzo [b] [1,4] dioxocin-3 -one proteases, and their pharmaceutically acceptable salts, hydrates and solvates that inhibit proteases, including cathepsin K, pharmaceutical compositions of such compounds, and methods of treating diseases of excessive bone loss or excessive degradation of cartilage or matrix, including osteoporosis; gingival disease including gingivitis and periodontitis, arthritis, more specifically osteoarthritis and rheumatoid arthritis; Paget's disease; malignant hypercalcemia; and metabolic bone disease, which comprises inhibiting said bone loss or excessive degradation of cartilage or matrix by administration to a patient in need thereof of a compound of the present invention.

UY26088A 1999-03-31 2000-03-29 PROTEASE INHIBITORS UY26088A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US12725099P 1999-03-31 1999-03-31

Publications (1)

Publication Number Publication Date
UY26088A1 true UY26088A1 (en) 2000-10-31

Family

ID=22429122

Family Applications (1)

Application Number Title Priority Date Filing Date
UY26088A UY26088A1 (en) 1999-03-31 2000-03-29 PROTEASE INHIBITORS

Country Status (8)

Country Link
EP (1) EP1173429A4 (en)
JP (1) JP2002540199A (en)
AU (1) AU4066900A (en)
CO (1) CO5180536A1 (en)
HK (1) HK1044758A1 (en)
PE (1) PE20001607A1 (en)
UY (1) UY26088A1 (en)
WO (1) WO2000058296A1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030144175A1 (en) 1998-12-23 2003-07-31 Smithkline Beecham Corporation Protease inhibitors
WO2001034600A1 (en) 1999-11-10 2001-05-17 Smithkline Beecham Corporation Protease inhibitors
US6596715B1 (en) 1999-11-10 2003-07-22 Smithkline Beecham Corporation Protease inhibitors
US6534498B1 (en) 1999-11-10 2003-03-18 Smithkline Beecham Corporation Protease inhibitors
US7071184B2 (en) 2000-03-21 2006-07-04 Smithkline Beecham Corporation Protease inhibitors
US7282512B2 (en) 2002-01-17 2007-10-16 Smithkline Beecham Corporation Cycloalkyl ketoamides derivatives useful as cathepsin K inhibitors
JP2004196696A (en) * 2002-12-18 2004-07-15 Kyowa Hakko Kogyo Co Ltd Arthritis-preventing or treating agent
CN113651795B (en) * 2021-09-14 2022-09-02 江西开源香料有限公司 Synthesis method of watermelon ketone

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5374623A (en) * 1992-08-20 1994-12-20 Prototek, Inc. Cysteine protease inhibitors effective for in vivo use

Also Published As

Publication number Publication date
HK1044758A1 (en) 2002-11-01
PE20001607A1 (en) 2001-03-07
EP1173429A1 (en) 2002-01-23
JP2002540199A (en) 2002-11-26
WO2000058296A1 (en) 2000-10-05
EP1173429A4 (en) 2002-06-19
CO5180536A1 (en) 2002-07-30
AU4066900A (en) 2000-10-16

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Legal Events

Date Code Title Description
109 Application deemed to be withdrawn

Effective date: 20091022