UY26026A1 - PROTEASE INHIBITORS - Google Patents

PROTEASE INHIBITORS

Info

Publication number
UY26026A1
UY26026A1 UY26026A UY26026A UY26026A1 UY 26026 A1 UY26026 A1 UY 26026A1 UY 26026 A UY26026 A UY 26026A UY 26026 A UY26026 A UY 26026A UY 26026 A1 UY26026 A1 UY 26026A1
Authority
UY
Uruguay
Prior art keywords
bone
disease
cartilage
proteases
inhibit
Prior art date
Application number
UY26026A
Other languages
Spanish (es)
Inventor
Scott K Thompson Danie Halbert
Original Assignee
Smithkline Beecham Corportion
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corportion filed Critical Smithkline Beecham Corportion
Publication of UY26026A1 publication Critical patent/UY26026A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D321/00—Heterocyclic compounds containing rings having two oxygen atoms as the only ring hetero atoms, not provided for by groups C07D317/00 - C07D319/00
    • C07D321/02—Seven-membered rings
    • C07D321/04—Seven-membered rings not condensed with other rings
    • C07D321/06—1,3-Dioxepines; Hydrogenated 1,3-dioxepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Esta invención proporciona inhibidores de proteasas de 1.3-dioxepin-5-ona de anillo de siete miembros y sales, hidratos y solvatos farmacéuticamente aceptables de los mismos que inhiben proteasas, incluyendo catepsina K, composiciones farmacéuticas de tales compuestos y métodos para tratar enfermedades de pérdida ósea o degradación del cartílago o la matriz excesivas, incluyendo osteoporosis, enfermedad gingival incluyendo gingivitis y periodontitis; artritis, más específicamente osteoartritis y artritis reumatoide; enfermedad de Paget; hipercalcemia maligna, y enfermedad metabólica ósea, que inhiben dicha pérdida ósea o degradación excesiva del cartílago o la matriz, administrando un compuesto de la presente a un paciente que lo necesita.This invention provides inhibitors of seven-membered ring 1,3-dioxepin-5-one proteases and pharmaceutically acceptable salts, hydrates and solvates thereof that inhibit proteases, including cathepsin K, pharmaceutical compositions of such compounds, and methods of treating loss diseases excessive bone or cartilage or matrix degradation, including osteoporosis, gingival disease including gingivitis and periodontitis; arthritis, more specifically osteoarthritis and rheumatoid arthritis; Paget's disease; malignant hypercalcemia, and bone metabolic disease, which inhibit such bone loss or excessive degradation of cartilage or matrix, by administering a compound herein to a patient in need.

UY26026A 1999-03-16 2000-02-23 PROTEASE INHIBITORS UY26026A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US12465999P 1999-03-16 1999-03-16

Publications (1)

Publication Number Publication Date
UY26026A1 true UY26026A1 (en) 2000-10-31

Family

ID=22416114

Family Applications (1)

Application Number Title Priority Date Filing Date
UY26026A UY26026A1 (en) 1999-03-16 2000-02-23 PROTEASE INHIBITORS

Country Status (9)

Country Link
EP (1) EP1161237A4 (en)
JP (1) JP2002539160A (en)
AR (1) AR022927A1 (en)
AU (1) AU3888200A (en)
CO (1) CO5180542A1 (en)
HK (1) HK1043534A1 (en)
PE (1) PE20001564A1 (en)
UY (1) UY26026A1 (en)
WO (1) WO2000054769A1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030144175A1 (en) 1998-12-23 2003-07-31 Smithkline Beecham Corporation Protease inhibitors
EP1229914A4 (en) 1999-11-10 2004-06-23 Smithkline Beecham Corp Protease inhibitors
US6596715B1 (en) 1999-11-10 2003-07-22 Smithkline Beecham Corporation Protease inhibitors
EP1232154A4 (en) 1999-11-10 2004-06-23 Smithkline Beecham Corp Protease inhibitors
JP2003527429A (en) 2000-03-21 2003-09-16 スミスクライン・ビーチャム・コーポレイション Protease inhibitor
US7282512B2 (en) 2002-01-17 2007-10-16 Smithkline Beecham Corporation Cycloalkyl ketoamides derivatives useful as cathepsin K inhibitors
JP2004196696A (en) * 2002-12-18 2004-07-15 Kyowa Hakko Kogyo Co Ltd Arthritis-preventing or treating agent
US20120302562A1 (en) * 2011-05-27 2012-11-29 Joseph Barbosa 4h-thieno[3,2-c]chromene-based inhibitors of notum pectinacetylesterase and methods of their use

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5374623A (en) * 1992-08-20 1994-12-20 Prototek, Inc. Cysteine protease inhibitors effective for in vivo use
ATE171171T1 (en) * 1992-12-25 1998-10-15 Mitsubishi Chem Corp ALPHA-AMINOKETONE DERIVATIVES

Also Published As

Publication number Publication date
WO2000054769A1 (en) 2000-09-21
PE20001564A1 (en) 2001-02-08
EP1161237A1 (en) 2001-12-12
CO5180542A1 (en) 2002-07-30
JP2002539160A (en) 2002-11-19
EP1161237A4 (en) 2002-03-27
AU3888200A (en) 2000-10-04
HK1043534A1 (en) 2002-09-20
AR022927A1 (en) 2002-09-04

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