UY26026A1 - PROTEASE INHIBITORS - Google Patents
PROTEASE INHIBITORSInfo
- Publication number
- UY26026A1 UY26026A1 UY26026A UY26026A UY26026A1 UY 26026 A1 UY26026 A1 UY 26026A1 UY 26026 A UY26026 A UY 26026A UY 26026 A UY26026 A UY 26026A UY 26026 A1 UY26026 A1 UY 26026A1
- Authority
- UY
- Uruguay
- Prior art keywords
- bone
- disease
- cartilage
- proteases
- inhibit
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D321/00—Heterocyclic compounds containing rings having two oxygen atoms as the only ring hetero atoms, not provided for by groups C07D317/00 - C07D319/00
- C07D321/02—Seven-membered rings
- C07D321/04—Seven-membered rings not condensed with other rings
- C07D321/06—1,3-Dioxepines; Hydrogenated 1,3-dioxepines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Physical Education & Sports Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Esta invención proporciona inhibidores de proteasas de 1.3-dioxepin-5-ona de anillo de siete miembros y sales, hidratos y solvatos farmacéuticamente aceptables de los mismos que inhiben proteasas, incluyendo catepsina K, composiciones farmacéuticas de tales compuestos y métodos para tratar enfermedades de pérdida ósea o degradación del cartílago o la matriz excesivas, incluyendo osteoporosis, enfermedad gingival incluyendo gingivitis y periodontitis; artritis, más específicamente osteoartritis y artritis reumatoide; enfermedad de Paget; hipercalcemia maligna, y enfermedad metabólica ósea, que inhiben dicha pérdida ósea o degradación excesiva del cartílago o la matriz, administrando un compuesto de la presente a un paciente que lo necesita.This invention provides inhibitors of seven-membered ring 1,3-dioxepin-5-one proteases and pharmaceutically acceptable salts, hydrates and solvates thereof that inhibit proteases, including cathepsin K, pharmaceutical compositions of such compounds, and methods of treating loss diseases excessive bone or cartilage or matrix degradation, including osteoporosis, gingival disease including gingivitis and periodontitis; arthritis, more specifically osteoarthritis and rheumatoid arthritis; Paget's disease; malignant hypercalcemia, and bone metabolic disease, which inhibit such bone loss or excessive degradation of cartilage or matrix, by administering a compound herein to a patient in need.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12465999P | 1999-03-16 | 1999-03-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UY26026A1 true UY26026A1 (en) | 2000-10-31 |
Family
ID=22416114
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UY26026A UY26026A1 (en) | 1999-03-16 | 2000-02-23 | PROTEASE INHIBITORS |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP1161237A4 (en) |
| JP (1) | JP2002539160A (en) |
| AR (1) | AR022927A1 (en) |
| AU (1) | AU3888200A (en) |
| CO (1) | CO5180542A1 (en) |
| HK (1) | HK1043534A1 (en) |
| PE (1) | PE20001564A1 (en) |
| UY (1) | UY26026A1 (en) |
| WO (1) | WO2000054769A1 (en) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030144175A1 (en) | 1998-12-23 | 2003-07-31 | Smithkline Beecham Corporation | Protease inhibitors |
| WO2001034599A1 (en) | 1999-11-10 | 2001-05-17 | Smithkline Beecham Corporation | Protease inhibitors |
| EP1229914A4 (en) | 1999-11-10 | 2004-06-23 | Smithkline Beecham Corp | Protease inhibitors |
| WO2001034600A1 (en) | 1999-11-10 | 2001-05-17 | Smithkline Beecham Corporation | Protease inhibitors |
| NZ520588A (en) | 2000-03-21 | 2004-06-25 | Smithkline Beecham Corp | Protease inhibitors |
| WO2003062192A1 (en) | 2002-01-17 | 2003-07-31 | Smithkline Beecham Corporation | Cycloalkyl ketoamides derivatives useful as cathepsin k inhibitors |
| JP2004196696A (en) * | 2002-12-18 | 2004-07-15 | Kyowa Hakko Kogyo Co Ltd | Arthritis-preventing or treating agent |
| PL2714675T3 (en) * | 2011-05-27 | 2019-07-31 | Lexicon Pharmaceuticals, Inc. | 4h-thieno[3,2-c]chromene-based inhibitors of notum pectinacetylesterase and methods of their use |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5374623A (en) * | 1992-08-20 | 1994-12-20 | Prototek, Inc. | Cysteine protease inhibitors effective for in vivo use |
| DK0603769T3 (en) * | 1992-12-25 | 1999-06-14 | Mitsubishi Chem Corp | Alpha-amino ketone derivatives |
-
2000
- 2000-02-23 UY UY26026A patent/UY26026A1/en unknown
- 2000-03-14 AR ARP000101121A patent/AR022927A1/en unknown
- 2000-03-16 CO CO00019250A patent/CO5180542A1/en not_active Application Discontinuation
- 2000-03-16 EP EP00917997A patent/EP1161237A4/en not_active Withdrawn
- 2000-03-16 WO PCT/US2000/006888 patent/WO2000054769A1/en not_active Application Discontinuation
- 2000-03-16 PE PE2000000226A patent/PE20001564A1/en not_active Application Discontinuation
- 2000-03-16 AU AU38882/00A patent/AU3888200A/en not_active Abandoned
- 2000-03-16 JP JP2000604845A patent/JP2002539160A/en not_active Withdrawn
-
2002
- 2002-05-13 HK HK02103606.8A patent/HK1043534A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1161237A4 (en) | 2002-03-27 |
| EP1161237A1 (en) | 2001-12-12 |
| JP2002539160A (en) | 2002-11-19 |
| CO5180542A1 (en) | 2002-07-30 |
| HK1043534A1 (en) | 2002-09-20 |
| AU3888200A (en) | 2000-10-04 |
| PE20001564A1 (en) | 2001-02-08 |
| WO2000054769A1 (en) | 2000-09-21 |
| AR022927A1 (en) | 2002-09-04 |
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