AR022927A1 - Inhibidores de proteasas - Google Patents
Inhibidores de proteasasInfo
- Publication number
- AR022927A1 AR022927A1 ARP000101121A ARP000101121A AR022927A1 AR 022927 A1 AR022927 A1 AR 022927A1 AR P000101121 A ARP000101121 A AR P000101121A AR P000101121 A ARP000101121 A AR P000101121A AR 022927 A1 AR022927 A1 AR 022927A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- het
- group
- alkenyl
- alkoxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D321/00—Heterocyclic compounds containing rings having two oxygen atoms as the only ring hetero atoms, not provided for by groups C07D317/00 - C07D319/00
- C07D321/02—Seven-membered rings
- C07D321/04—Seven-membered rings not condensed with other rings
- C07D321/06—1,3-Dioxepines; Hydrogenated 1,3-dioxepines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Physical Education & Sports Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente invencion proporciona compuestos de la formula (1): R1, R2, R3, R4, R5, R6, R7, R8, R11, R16 y R17, y R se seleccionan independientemente delgrupo que comprende: H, alquiloC1-6, alqueniloC2-6, alquiniloC2-6, Ar-alquiloC0-6, y Het-alquiloC0-6; R9 se selecciona del grupo que comprende: alquilo C3-6,Ar, Het, CH(R10)Ar, CH(R10) OAr, NR10R11 y CH(R10)NR11R12; R10 se selecciona del grupo que comprende: H, alqueniloC2-6, alquiniloC2-6, cicloalquilC3-11-alquiloC0-6, Ar-alquiloC0-6,Ar-alqueniloC2-6,Ar-alquilinoC2-6, Het-alquiloC0-6, Het-alqueniloC2-6, Het-alquiniloC2-6, y alquiloC1-6,opcionalmente sustituido con OR13,SR13,NR13R14,N(R)CO2R,C02R,CONR13R14, o N(C=NH)NH2; R12 se selecciona del grupo que comprende: R15,R15C(O),R15C(S),R15OC(O) y R15OC(O)NR11CH(R10)(CO); R13 yR14 se seleccionan independientemente del grupo que comprende: H,alquiloC1-6,alqueniloC2-6,Ar-alquiloC0-6,o Het-alquiloC0-6,y R16R17N-alquiloC2-6; R15 seselecciona del grupo que comprende: alquiloC1-6,alqueniloC2-6,Ar-alquiloC0-6,o Het-alquiloC0-6; Ar se selecciona del grup que comprende fenilo y naftilo,opcionalmente sustituidos con uno o más de Ph-alquiloC0-6,Het-alquiloC0-6, alquiloC1-6, alcoxiloC1-6, Ph-alcoxiloC0-6, Het-alcoxiloC0-6, OH, NR13R14, Het--S-alquiloC0-6, (CH2)1-6OH, (CH2)1-6NR13R14, OH(CH3)1-6NR13R14, (CH2)0-6CO2R, O(CH2)1-6C02R,(CH2)1-6SO2, CF3,OCF3 o halogeno; Ph puede estar opcionalmentesustituido con uno o más de alquiloC1-6, alcoxiC1-6,OH,(CH2)1-6NR13R14,CO2R,CF3 o halogeno; dos grupos alquiloC1-6 o alcoxiloC1-6 se pueden combinar paraformar un anillo de 5-7 miembros, saturados o no saturado,condensados sobre el anillo de Ar; y sus sales, hidratos y solvatos farmacéuticamente aceptables queinhiben proteasas incluyendo catepsina K, composiciones farmacéuticas de tales compuestos, y métodos para tratar enfermedades de pérdida osea o degradacion decartílado o matriz excesivas, incluyendo osteoporosis, enfermedad gingival incluyendo gingivitis y periodontitis; artritis, más específicamente osteoartritis yartritis reumatoide; enfermdad de Paget; hipercalcemia de carácter maligno; y enfermedad osea metabolica, que comprende inhibir dicha pérdida osea o la
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12465999P | 1999-03-16 | 1999-03-16 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR022927A1 true AR022927A1 (es) | 2002-09-04 |
Family
ID=22416114
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP000101121A AR022927A1 (es) | 1999-03-16 | 2000-03-14 | Inhibidores de proteasas |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP1161237A4 (es) |
JP (1) | JP2002539160A (es) |
AR (1) | AR022927A1 (es) |
AU (1) | AU3888200A (es) |
CO (1) | CO5180542A1 (es) |
HK (1) | HK1043534A1 (es) |
PE (1) | PE20001564A1 (es) |
UY (1) | UY26026A1 (es) |
WO (1) | WO2000054769A1 (es) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030144175A1 (en) | 1998-12-23 | 2003-07-31 | Smithkline Beecham Corporation | Protease inhibitors |
EP1232154A4 (en) | 1999-11-10 | 2004-06-23 | Smithkline Beecham Corp | PROTEASE INHIBITORS |
US6534498B1 (en) | 1999-11-10 | 2003-03-18 | Smithkline Beecham Corporation | Protease inhibitors |
EP1232155A4 (en) | 1999-11-10 | 2002-11-20 | Smithkline Beecham Corp | PROTEASE INHIBITORS |
CN1416346A (zh) | 2000-03-21 | 2003-05-07 | 史密丝克莱恩比彻姆公司 | 蛋白酶抑制剂 |
EP1465862A1 (en) | 2002-01-17 | 2004-10-13 | SmithKline Beecham Corporation | Cycloalkyl ketoamides derivatives useful as cathepsin k inhibitors |
JP2004196696A (ja) * | 2002-12-18 | 2004-07-15 | Kyowa Hakko Kogyo Co Ltd | 関節炎の予防剤または治療剤 |
JP6166718B2 (ja) * | 2011-05-27 | 2017-07-19 | レクシコン ファーマシューティカルズ インコーポレイテッド | NOTUMペクチンアセチルエステラーゼの4H−チエノ[3,2−c]クロメン系阻害剤及びその使用方法 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5374623A (en) * | 1992-08-20 | 1994-12-20 | Prototek, Inc. | Cysteine protease inhibitors effective for in vivo use |
ES2124281T3 (es) * | 1992-12-25 | 1999-02-01 | Mitsubishi Chem Corp | Derivados de alfa-aminocetonas. |
-
2000
- 2000-02-23 UY UY26026A patent/UY26026A1/es unknown
- 2000-03-14 AR ARP000101121A patent/AR022927A1/es unknown
- 2000-03-16 PE PE2000000226A patent/PE20001564A1/es not_active Application Discontinuation
- 2000-03-16 EP EP00917997A patent/EP1161237A4/en not_active Withdrawn
- 2000-03-16 WO PCT/US2000/006888 patent/WO2000054769A1/en not_active Application Discontinuation
- 2000-03-16 CO CO00019250A patent/CO5180542A1/es not_active Application Discontinuation
- 2000-03-16 JP JP2000604845A patent/JP2002539160A/ja not_active Withdrawn
- 2000-03-16 AU AU38882/00A patent/AU3888200A/en not_active Abandoned
-
2002
- 2002-05-13 HK HK02103606.8A patent/HK1043534A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
AU3888200A (en) | 2000-10-04 |
UY26026A1 (es) | 2000-10-31 |
WO2000054769A1 (en) | 2000-09-21 |
EP1161237A1 (en) | 2001-12-12 |
PE20001564A1 (es) | 2001-02-08 |
HK1043534A1 (zh) | 2002-09-20 |
JP2002539160A (ja) | 2002-11-19 |
EP1161237A4 (en) | 2002-03-27 |
CO5180542A1 (es) | 2002-07-30 |
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