ECSP024358A - Nuevas fomas solidas de la meso´rogestina 11beta(4e-hidroxiiminometil)-fenil) 17 alfa-metoximetil-17 beta-metoxi-estra-4,9 -dien-3-ona - Google Patents
Nuevas fomas solidas de la meso´rogestina 11beta(4e-hidroxiiminometil)-fenil) 17 alfa-metoximetil-17 beta-metoxi-estra-4,9 -dien-3-onaInfo
- Publication number
- ECSP024358A ECSP024358A EC2002004358A ECSP024358A ECSP024358A EC SP024358 A ECSP024358 A EC SP024358A EC 2002004358 A EC2002004358 A EC 2002004358A EC SP024358 A ECSP024358 A EC SP024358A EC SP024358 A ECSP024358 A EC SP024358A
- Authority
- EC
- Ecuador
- Prior art keywords
- 11beta
- estra
- rogestina
- hidroxiiminometil
- metoximetil
- Prior art date
Links
- 239000007787 solid Substances 0.000 title abstract 4
- -1 (hydroxyiminomethyl) -phenyl Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000035558 fertility Effects 0.000 abstract 1
- 238000002657 hormone replacement therapy Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/36—Antigestagens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
- C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Endocrinology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Reproductive Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
El invento se refiere a las nuevas formas sólidas de la mesoprogestina 11Beta-(4e(hidroxiiminometil)-fenil)-17a-metoximetil-17B-metoxi-estra-4,9-dien-30na (ixima J 867), especialmente a una forma extrapura y estable, amorfa o extracistalina (forma no solvatada (no solvato)/no hidrato), del compuesto J 867, a un método para su preparación y a su uso en composiciones farmacéutircas. La nuevas formas sólidas se caracterizan especialmente por su alta estabilidad. Estas formas sólidas de la oxima J867 pueden utilizarse especialmente en el control de la fertilidad y en la terapia de reemplazo hormonal.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP00110887A EP1157996A1 (de) | 2000-05-23 | 2000-05-23 | Neue Festkörperformen des Mesoprogestins 11Beta-[4E-(Hydroxyiminomethyl)-phenyl]-17Alpha-methoxymethyl-17Beta-methoxy-estra-4,9-dien-3-on |
Publications (1)
Publication Number | Publication Date |
---|---|
ECSP024358A true ECSP024358A (es) | 2003-03-31 |
Family
ID=8168805
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EC2002004358A ECSP024358A (es) | 2000-05-23 | 2002-11-22 | Nuevas fomas solidas de la meso´rogestina 11beta(4e-hidroxiiminometil)-fenil) 17 alfa-metoximetil-17 beta-metoxi-estra-4,9 -dien-3-ona |
EC2008004358A ECSP084358A (es) | 2000-05-23 | 2008-10-22 | NUEVAS FORMAS SÓLIDAS DE LA MESOPROGESTINA 11ß-[4E-(HIDROXIIMINOMETIL)-FENIL]- 17ALFA-METOXIMETIL-17ß-METOXI-ESTRA-4,9-DIEN-3-ONA |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EC2008004358A ECSP084358A (es) | 2000-05-23 | 2008-10-22 | NUEVAS FORMAS SÓLIDAS DE LA MESOPROGESTINA 11ß-[4E-(HIDROXIIMINOMETIL)-FENIL]- 17ALFA-METOXIMETIL-17ß-METOXI-ESTRA-4,9-DIEN-3-ONA |
Country Status (30)
Country | Link |
---|---|
US (1) | US7799770B2 (es) |
EP (3) | EP1157996A1 (es) |
JP (1) | JP2003534350A (es) |
KR (1) | KR100553292B1 (es) |
CN (1) | CN100384867C (es) |
AT (1) | ATE397617T1 (es) |
AU (2) | AU2001256344B2 (es) |
BG (1) | BG65968B1 (es) |
BR (1) | BR0111058A (es) |
CA (1) | CA2409869C (es) |
CZ (1) | CZ2003620A3 (es) |
DE (1) | DE50114012D1 (es) |
DK (1) | DK1292607T3 (es) |
EA (1) | EA005623B1 (es) |
EC (2) | ECSP024358A (es) |
ES (1) | ES2307613T3 (es) |
HR (2) | HRP20021032B1 (es) |
HU (1) | HUP0301956A3 (es) |
IL (2) | IL152868A0 (es) |
ME (1) | MEP15608A (es) |
MX (1) | MXPA02011524A (es) |
NO (1) | NO327004B1 (es) |
NZ (1) | NZ522768A (es) |
PL (1) | PL358789A1 (es) |
PT (1) | PT1292607E (es) |
RS (1) | RS50493B (es) |
SK (1) | SK2922003A3 (es) |
UA (1) | UA73988C2 (es) |
WO (1) | WO2001090137A2 (es) |
ZA (1) | ZA200209322B (es) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10218109A1 (de) * | 2002-04-23 | 2003-11-20 | Jenapharm Gmbh | Verfahren zum Herstellen von Kristallen, danach erhältliche Kristalle und deren Verwendung in pharmazeutischen Formulierungen |
DE10218107A1 (de) * | 2002-04-23 | 2003-11-20 | Jenapharm Gmbh | Verfahren zum Herstellen von Kristallen von Steroiden, danach erhältliche Kristalle und deren Verwendung in pharmazeutischen Formulierungen |
WO2006078731A2 (en) * | 2005-01-18 | 2006-07-27 | Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag | Amorphous and crystalline forms of dorzolamide hydrochloride and processes of making same |
US20090054387A1 (en) | 2006-04-18 | 2009-02-26 | Detlef Grawe | Method for preparing 4-[17beta-methoxy-17alpha-methoxymethyl-3-oxestra-4,9-dien-11beta-yl]benzaldehyde (E)-oxime (asoprisnil) |
DE102006018888A1 (de) * | 2006-04-18 | 2007-10-25 | Bayer Schering Pharma Ag | Verfahren zur Herstellung von 4-[17beta-Methoxy-17alpha-methoxymethyl-3-oxoestra-4,9-dien-11beta-yl]benzaldehyd-(E)-oxims (Asoprisnil) |
EP1862468A1 (de) * | 2006-06-02 | 2007-12-05 | Bayer Schering Pharma Aktiengesellschaft | Kristallines 11beta-(4-Acetylphenyl)-20,20,21,21,21-pentafluor-17-hydroxy-19-nor-17alpha-pregna-4,9-dien-3-on |
DE102009034362A1 (de) | 2009-07-20 | 2011-01-27 | Bayer Schering Pharma Aktiengesellschaft | 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-aryl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten |
DE102009034367A1 (de) | 2009-07-20 | 2011-01-27 | Bayer Schering Pharma Aktiengesellschaft | 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-benzyliden-Derivate, Verfahren zu deren Herstellung und deren Verwendung zur Behandlung von Krankheiten |
DE102009034368A1 (de) | 2009-07-20 | 2011-01-27 | Bayer Schering Pharma Aktiengesellschaft | 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-acyloxyalkylenphenyl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten |
DE102009034366A1 (de) | 2009-07-20 | 2011-01-27 | Bayer Schering Pharma Aktiengesellschaft | 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-methylenoxyalkylenaryl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten |
DE102009034525A1 (de) | 2009-07-21 | 2011-01-27 | Bayer Schering Pharma Aktiengesellschaft | 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-aryl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten |
DE102009034526A1 (de) | 2009-07-21 | 2011-02-10 | Bayer Schering Pharma Aktiengesellschaft | 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-ethinylphenyl-Derivate, Verfahren zu deren Herstellung und deren Verwendung zur Behandlung von Krankheiten |
DE102010007722A1 (de) | 2010-02-10 | 2011-08-11 | Bayer Schering Pharma Aktiengesellschaft, 13353 | Progesteronrezeptorantagonisten |
DE102010007719A1 (de) | 2010-02-10 | 2011-08-11 | Bayer Schering Pharma Aktiengesellschaft, 13353 | Progesteronrezeptorantagonisten |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4332283A1 (de) * | 1993-09-20 | 1995-04-13 | Jenapharm Gmbh | Neue 11-Benzaldoximestradien-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel |
DE19610667C2 (de) * | 1996-03-08 | 1998-04-09 | Schering Ag | (Z)-11ß-[4-(Dimethylamino)phenyl]17ß-hydroxy-17alpha-(3-hydroxy-1-propenyl)estr-4-en-3-on als kristallines Ansolvat |
EP1204656A2 (en) * | 1999-07-29 | 2002-05-15 | Eli Lilly And Company | A crystalline form of 6-hydroxy-3-(4-[2-(piperidin-1-yl) ethoxy] phenoxy)-2-(4-methoxyphenyl) benzo[b]thiophene hydrochloride |
-
2000
- 2000-05-23 EP EP00110887A patent/EP1157996A1/de not_active Withdrawn
-
2001
- 2001-05-09 AU AU2001256344A patent/AU2001256344B2/en not_active Ceased
- 2001-05-09 EA EA200201192A patent/EA005623B1/ru not_active IP Right Cessation
- 2001-05-09 RS YUP-887/02A patent/RS50493B/sr unknown
- 2001-05-09 ES ES01929632T patent/ES2307613T3/es not_active Expired - Lifetime
- 2001-05-09 US US10/296,463 patent/US7799770B2/en active Active
- 2001-05-09 CZ CZ2003620A patent/CZ2003620A3/cs unknown
- 2001-05-09 IL IL15286801A patent/IL152868A0/xx unknown
- 2001-05-09 DE DE50114012T patent/DE50114012D1/de not_active Expired - Lifetime
- 2001-05-09 WO PCT/EP2001/005237 patent/WO2001090137A2/de active Application Filing
- 2001-05-09 EP EP07115136A patent/EP1862469A2/de not_active Withdrawn
- 2001-05-09 AT AT01929632T patent/ATE397617T1/de not_active IP Right Cessation
- 2001-05-09 JP JP2001586324A patent/JP2003534350A/ja active Pending
- 2001-05-09 BR BR0111058-6A patent/BR0111058A/pt not_active IP Right Cessation
- 2001-05-09 PT PT01929632T patent/PT1292607E/pt unknown
- 2001-05-09 CA CA002409869A patent/CA2409869C/en not_active Expired - Lifetime
- 2001-05-09 KR KR1020027015762A patent/KR100553292B1/ko not_active IP Right Cessation
- 2001-05-09 PL PL01358789A patent/PL358789A1/xx not_active IP Right Cessation
- 2001-05-09 DK DK01929632T patent/DK1292607T3/da active
- 2001-05-09 HU HU0301956A patent/HUP0301956A3/hu unknown
- 2001-05-09 AU AU5634401A patent/AU5634401A/xx active Pending
- 2001-05-09 EP EP01929632A patent/EP1292607B1/de not_active Expired - Lifetime
- 2001-05-09 MX MXPA02011524A patent/MXPA02011524A/es active IP Right Grant
- 2001-05-09 CN CNB018099394A patent/CN100384867C/zh not_active Expired - Fee Related
- 2001-05-09 SK SK292-2003A patent/SK2922003A3/sk not_active Application Discontinuation
- 2001-05-09 ME MEP-156/08A patent/MEP15608A/xx unknown
- 2001-05-09 NZ NZ522768A patent/NZ522768A/en unknown
- 2001-09-05 UA UA20021210147A patent/UA73988C2/uk unknown
-
2002
- 2002-11-14 IL IL152868A patent/IL152868A/en not_active IP Right Cessation
- 2002-11-15 ZA ZA200209322A patent/ZA200209322B/en unknown
- 2002-11-22 EC EC2002004358A patent/ECSP024358A/es unknown
- 2002-11-22 NO NO20025613A patent/NO327004B1/no not_active IP Right Cessation
- 2002-12-23 HR HR20021032A patent/HRP20021032B1/xx not_active IP Right Cessation
-
2003
- 2003-02-14 BG BG107557A patent/BG65968B1/bg unknown
-
2008
- 2008-08-29 HR HR20080423A patent/HRP20080423A2/xx not_active Application Discontinuation
- 2008-10-22 EC EC2008004358A patent/ECSP084358A/es unknown
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