HUP0301146A2 - 2-Klór-5-nitrofenil karboxamidszármazékok, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk - Google Patents

2-Klór-5-nitrofenil karboxamidszármazékok, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk

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Publication number
HUP0301146A2
HUP0301146A2 HU0301146A HUP0301146A HUP0301146A2 HU P0301146 A2 HUP0301146 A2 HU P0301146A2 HU 0301146 A HU0301146 A HU 0301146A HU P0301146 A HUP0301146 A HU P0301146A HU P0301146 A2 HUP0301146 A2 HU P0301146A2
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HU
Hungary
Prior art keywords
chlor
nitrophenyl
pharmaceutical compositions
general formula
compositions containing
Prior art date
Application number
HU0301146A
Other languages
English (en)
Inventor
Yoshiya Amemiya
Chie Fukuda
Sachiko Takaishi
Kenji Wakabayashi
Original Assignee
Sankyo Company, Limited
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Publication date
Application filed by Sankyo Company, Limited filed Critical Sankyo Company, Limited
Publication of HUP0301146A2 publication Critical patent/HUP0301146A2/hu
Publication of HUP0301146A3 publication Critical patent/HUP0301146A3/hu

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Abstract

A találmány az új (I) általános képletű 2-klór-5-nitrofenilkarboxamid-származékokra és ezek gyógyászatilag elfogadható sóira vonatkozik,amelyeknek agonista, részleges agonista, antagonista és részlegesantagonista aktivitásuk van a peroxiszom proliferátor aktiváltreceptor g (PPAR g) receptorral szemben, így felhasználhatók retrográdoszteoporózis kezelésére, amelynél az adipociták túlzottdifferenciálódását gátolják és elősegítik az őssejtekből azoszteoblasztok differenciálódását. Ugyancsak felhasználhatók megelőzővagy terápiás jelleggel olyan megbetegedések kezelhetők, mint példáuldiabétesz mellitusz, túlzott adipogenézis, májdíszfunkció, keringésirendellenességek és szívmegbetegedések. Az (I) általános képletben Ajelentése például fenilcsoport, B jelentése például arilcsoport, Xjelentése például oxigénatom és a értéke 0 vagy 1. Ó
HU0301146A 2000-04-28 2001-04-26 2-chlor-5-nitrophenyl carboxamide derivatives, pharmaceutical compositions containing them and their use HUP0301146A3 (en)

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