HUP0300188A2 - Karbonsavszármazékok, mint IP-antagonisták, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények - Google Patents

Karbonsavszármazékok, mint IP-antagonisták, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények

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Publication number
HUP0300188A2
HUP0300188A2 HU0300188A HUP0300188A HUP0300188A2 HU P0300188 A2 HUP0300188 A2 HU P0300188A2 HU 0300188 A HU0300188 A HU 0300188A HU P0300188 A HUP0300188 A HU P0300188A HU P0300188 A2 HUP0300188 A2 HU P0300188A2
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HU
Hungary
Prior art keywords
independently
compounds
case
antagonists
preparation
Prior art date
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HU0300188A
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English (en)
Inventor
Richard Leo Cournoyer
Paul Francis Keitz
Lee Edwin Lowrie
Alexander Victor Muehldorf
Counde O'yang
Dennis Mitsugu Yasuda
Original Assignee
F. Hoffmann-La Roche Ag.
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Application filed by F. Hoffmann-La Roche Ag. filed Critical F. Hoffmann-La Roche Ag.
Publication of HUP0300188A2 publication Critical patent/HUP0300188A2/hu
Publication of HUP0300188A3 publication Critical patent/HUP0300188A3/hu

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    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
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Abstract

A találmány általában IP receptor antagonistaként felhasználható (I)általános képletű vegyületekre, az egyedi izomerekre, az izomerekracém vagy nemracém keverékeire, továbbá e vegyületek gyógyászatilagalkalmas sóira vagy szolvátjaira vonatkozik. A képletben R1, R2 és R3jelentése egymástól függetlenül mindenesetben arilcsoport vagyheteroaril-csoport; R4 jelentése karboxil- vagy tetrazolil-csoport; ésA jelentése egymástól függetlenül minden esetben egyeskötés, -O(CH2)p-, -S(CH2)p-; -NR1(CH2)p, -(CH2)pO-, -O(CH2)pO-, -(CH2)p-O(CH2)p-, -(CH2)n-CO(CH2)n-, -CONH-, -(CH2)p-, -HC=CH- vagy -C<C-. Bjelentése egymástól függetlenül minden esetben -(CH2)q-, -CH2O-, -CH2OCH2 vagy -CH2NH-; m, p és q jelentése egymástól függetlenül mindenesetben 1, 2 vagy 3; n és r értéke minden esetben egymástólfüggetlenül 0, 1, 2 vagy 3. A találmány továbbá e vegyületekettartalmazó gyógyszerkészítményekre és ezeknek a vegyületeknek azelőállítására és gyógyászati alkalmazására vonatkozik. Ó
HU0300188A 2000-03-16 2001-03-08 Carboxylic acid derivatives as ip antagonists, process for their preparation and pharmaceutical compositions containing them HUP0300188A3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US19012900P 2000-03-16 2000-03-16
US24712900P 2000-11-10 2000-11-10
PCT/EP2001/002597 WO2001068591A1 (en) 2000-03-16 2001-03-08 Carboxylic acid derivatives as ip antagonists

Publications (2)

Publication Number Publication Date
HUP0300188A2 true HUP0300188A2 (hu) 2003-06-28
HUP0300188A3 HUP0300188A3 (en) 2004-07-28

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ID=26885804

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HU0300188A HUP0300188A3 (en) 2000-03-16 2001-03-08 Carboxylic acid derivatives as ip antagonists, process for their preparation and pharmaceutical compositions containing them

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US (3) US6693098B2 (hu)
EP (1) EP1265853A1 (hu)
JP (1) JP3938689B2 (hu)
KR (1) KR100523119B1 (hu)
CN (1) CN1241909C (hu)
AR (1) AR028252A1 (hu)
AU (2) AU5216801A (hu)
BR (1) BR0109235A (hu)
CA (1) CA2401502C (hu)
CZ (1) CZ20023422A3 (hu)
HK (1) HK1054924A1 (hu)
HR (1) HRP20020733A2 (hu)
HU (1) HUP0300188A3 (hu)
IL (1) IL151478A (hu)
MA (1) MA27679A1 (hu)
MX (1) MXPA02008931A (hu)
NO (1) NO328526B1 (hu)
NZ (1) NZ521028A (hu)
PL (1) PL207869B1 (hu)
RU (1) RU2268258C2 (hu)
WO (1) WO2001068591A1 (hu)
YU (1) YU68102A (hu)

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