HUP0204111A2 - Új eljárás alfa-(2,4-diszulfo-fenil)-N-terc-butil-nitron és gyógyszerészetileg elfogadható sói előállítására - Google Patents

Új eljárás alfa-(2,4-diszulfo-fenil)-N-terc-butil-nitron és gyógyszerészetileg elfogadható sói előállítására

Info

Publication number
HUP0204111A2
HUP0204111A2 HU0204111A HUP0204111A HUP0204111A2 HU P0204111 A2 HUP0204111 A2 HU P0204111A2 HU 0204111 A HU0204111 A HU 0204111A HU P0204111 A HUP0204111 A HU P0204111A HU P0204111 A2 HUP0204111 A2 HU P0204111A2
Authority
HU
Hungary
Prior art keywords
tert
disulfophenyl
butylnitrone
preparation
pharmaceutically acceptable
Prior art date
Application number
HU0204111A
Other languages
English (en)
Inventor
Jörgen Blixt
Henry Kruk
John Mcginley
Sergei Pouhov
John Vajda
Original Assignee
Astrazeneca Ab,
Centaur Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab,, Centaur Pharmaceuticals, Inc. filed Critical Astrazeneca Ab,
Publication of HUP0204111A2 publication Critical patent/HUP0204111A2/hu
Publication of HUP0204111A3 publication Critical patent/HUP0204111A3/hu
Publication of HU225298B1 publication Critical patent/HU225298B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/45—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton
    • C07C309/46—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton having the sulfo groups bound to carbon atoms of non-condensed six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/02—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of sulfonic acids or halides thereof
    • C07C303/22—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of sulfonic acids or halides thereof from sulfonic acids, by reactions not involving the formation of sulfo or halosulfonyl groups; from sulfonic halides by reactions not involving the formation of halosulfonyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/32—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of salts of sulfonic acids

Abstract

A találmány tárgya új eljárás a-(2,4-diszulfo-fenil)-N-terc-butil-nitron és gyógyszerészetileg elfogadható sói előállítására. Az a-(2,4-diszulfo-fenil)-N-terc-butil-nitront úgy állítják elő, hogy amegfelelő 4-formil-l,3-benzoldiszulfonsav-dinátriumsót oldószerben,előnyösen egy alkoholban, például metanolban vagy alkoholok elegyében,amely 10%-ig terjedő mennyiségű vizet is tartalmazhat N-terc-butil-(hidroxil-ammónium)-acetáttal reagáltatják, egy ekvivalens aldehidre1,25 és 2,5 közötti ekvivalens N-terc-butil(hidroxil-ammónium)-acetátot alkalmazva. A termék kristályosodását izopropil-alkoholnak areakcióelegyhez való adásával érik el. Ó
HU0204111A 2000-01-10 2001-01-04 Novel process for the preparation of alpha-(2,4-disulfophenyl)-n-tert-butylnitrone and pharmaceutically acceptable salts thereof HU225298B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE0000055A SE0000055D0 (sv) 2000-01-10 2000-01-10 Novel process
PCT/SE2001/000007 WO2001051460A1 (en) 2000-01-10 2001-01-04 NOVEL PROCESS FOR THE PREPARATION OF α-(2-4-DISULFOPHENYL)-N-TERT-BUTYLNITRONE AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF

Publications (3)

Publication Number Publication Date
HUP0204111A2 true HUP0204111A2 (hu) 2003-03-28
HUP0204111A3 HUP0204111A3 (en) 2005-05-30
HU225298B1 HU225298B1 (en) 2006-09-28

Family

ID=20278055

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0204111A HU225298B1 (en) 2000-01-10 2001-01-04 Novel process for the preparation of alpha-(2,4-disulfophenyl)-n-tert-butylnitrone and pharmaceutically acceptable salts thereof

Country Status (32)

Country Link
US (1) US6479697B2 (hu)
EP (1) EP1265856B1 (hu)
JP (1) JP3748821B2 (hu)
KR (1) KR100687167B1 (hu)
CN (1) CN1198798C (hu)
AR (1) AR029431A1 (hu)
AT (1) ATE263753T1 (hu)
AU (1) AU783255B2 (hu)
BR (1) BR0107483A (hu)
CA (1) CA2395971A1 (hu)
CO (1) CO5280203A1 (hu)
DE (1) DE60102679T2 (hu)
DK (1) DK1265856T3 (hu)
EE (1) EE200200385A (hu)
ES (1) ES2217114T3 (hu)
HU (1) HU225298B1 (hu)
IL (2) IL150403A0 (hu)
IS (1) IS6456A (hu)
MX (1) MXPA02006674A (hu)
MY (1) MY122830A (hu)
NO (1) NO20023316L (hu)
NZ (1) NZ519828A (hu)
PL (1) PL357106A1 (hu)
PT (1) PT1265856E (hu)
RU (1) RU2259996C2 (hu)
SE (1) SE0000055D0 (hu)
SK (1) SK9932002A3 (hu)
TR (1) TR200401307T4 (hu)
TW (1) TW572880B (hu)
UA (1) UA71653C2 (hu)
WO (1) WO2001051460A1 (hu)
ZA (1) ZA200204872B (hu)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60320946D1 (de) 2002-02-14 2008-06-26 Willett Int Ltd Elektromagnetventil
US20050059638A1 (en) * 2003-08-04 2005-03-17 Kelly Michael G. Aryl, heteroaromatic and bicyclic aryl nitrone compounds, prodrugs and pharmaceutical compositions of the same to treat human disorders
US20050182060A1 (en) * 2004-02-13 2005-08-18 Kelly Michael G. 2-Substituted and 4-substituted aryl nitrone compounds
US20080193783A1 (en) * 2004-12-01 2008-08-14 Toyo Boseki Kabushiki Kaisha Polyester Resin Film and Process for Producing the Same
WO2006069246A2 (en) * 2004-12-22 2006-06-29 Ambrx, Inc. Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides
WO2007013844A1 (en) * 2005-07-26 2007-02-01 Astrazeneca Ab Use of 4-[(tert-butylimino)benzene-1,3-disulfonate n-oxide against nausea
EP2242360B1 (en) * 2008-02-12 2015-04-08 Tosk, Inc. Doxorubicin adjuvants to reduce toxicity and methods for using the same

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1437188A (fr) 1964-06-17 1966-04-29 Du Pont Procédé de fabrication d'alpha-phényl-nu-méthyl nitrone
US5488145A (en) * 1993-12-23 1996-01-30 Oklahoma Medical Research Foundation 2,4-disulfonyl phenyl butyl nitrone, its salts, and their use as pharmaceutical free radical traps
SE9802507D0 (sv) * 1998-07-10 1998-07-10 Astra Ab Novel salts

Also Published As

Publication number Publication date
US20020128318A1 (en) 2002-09-12
AU2720301A (en) 2001-07-24
RU2259996C2 (ru) 2005-09-10
TW572880B (en) 2004-01-21
MY122830A (en) 2006-05-31
WO2001051460A1 (en) 2001-07-19
PT1265856E (pt) 2004-07-30
KR20020091077A (ko) 2002-12-05
ES2217114T3 (es) 2004-11-01
US6479697B2 (en) 2002-11-12
NO20023316D0 (no) 2002-07-09
ZA200204872B (en) 2003-10-07
JP2003519678A (ja) 2003-06-24
IS6456A (is) 2002-07-04
DE60102679D1 (de) 2004-05-13
CN1395559A (zh) 2003-02-05
CA2395971A1 (en) 2001-07-19
PL357106A1 (en) 2004-07-12
UA71653C2 (en) 2004-12-15
IL150403A0 (en) 2002-12-01
HUP0204111A3 (en) 2005-05-30
TR200401307T4 (tr) 2004-07-21
CO5280203A1 (es) 2003-05-30
IL150403A (en) 2007-06-03
SE0000055D0 (sv) 2000-01-10
KR100687167B1 (ko) 2007-02-27
SK9932002A3 (en) 2003-03-04
RU2002118320A (ru) 2004-02-27
BR0107483A (pt) 2002-09-03
DK1265856T3 (da) 2004-07-05
AR029431A1 (es) 2003-06-25
ATE263753T1 (de) 2004-04-15
EE200200385A (et) 2003-12-15
HU225298B1 (en) 2006-09-28
AU783255B2 (en) 2005-10-06
EP1265856A1 (en) 2002-12-18
MXPA02006674A (es) 2004-09-10
JP3748821B2 (ja) 2006-02-22
NZ519828A (en) 2004-11-26
NO20023316L (no) 2002-07-09
CN1198798C (zh) 2005-04-27
EP1265856B1 (en) 2004-04-07
DE60102679T2 (de) 2004-12-09

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Legal Events

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MM4A Lapse of definitive patent protection due to non-payment of fees