BR0314365A - Processos para a fabricação de compostos doadores de no e para a produção da forma a do composto iva, compostos, usos do processo, dos compostos, e da forma a do composto iva, e, formulação farmacêutica - Google Patents

Processos para a fabricação de compostos doadores de no e para a produção da forma a do composto iva, compostos, usos do processo, dos compostos, e da forma a do composto iva, e, formulação farmacêutica

Info

Publication number
BR0314365A
BR0314365A BR0314365-1A BR0314365A BR0314365A BR 0314365 A BR0314365 A BR 0314365A BR 0314365 A BR0314365 A BR 0314365A BR 0314365 A BR0314365 A BR 0314365A
Authority
BR
Brazil
Prior art keywords
compounds
compound form
manufacture
iva compound
processes
Prior art date
Application number
BR0314365-1A
Other languages
English (en)
Inventor
Johan Andersson
Aldo Belli
Vincenzo Cannata
Martin Hedberg
Andreas Palmgren
Sigrid Schuldei
Marika Stroem
Marco Villa
Original Assignee
Nicox Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE0202801A external-priority patent/SE0202801D0/xx
Priority claimed from SE0301476A external-priority patent/SE0301476D0/xx
Application filed by Nicox Sa filed Critical Nicox Sa
Publication of BR0314365A publication Critical patent/BR0314365A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/26—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids
    • C07C303/28—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids by reaction of hydroxy compounds with sulfonic acids or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
    • C07C201/02—Preparation of esters of nitric acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C203/00—Esters of nitric or nitrous acid
    • C07C203/02—Esters of nitric acid
    • C07C203/04—Esters of nitric acid having nitrate groups bound to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/43—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C211/54—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to two or three six-membered aromatic rings
    • C07C211/55—Diphenylamines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/16—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions not involving the amino or carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
    • C07C227/20—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters by hydrolysis of N-acylated amino-acids or derivatives thereof, e.g. hydrolysis of carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/40—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/42—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton with carboxyl groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by saturated carbon chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
    • C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C07C309/66—Methanesulfonates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/08—Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with the hydroxy or O-metal group of organic compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

"PROCESSOS PARA A FABRICAçãO DE COMPOSTOS DOADORES DE NO E PARA A PRODUçãO DA FORMA A DO COMPOSTO IVA, COMPOSTOS, USOS DO PROCESSO, DOS COMPOSTOS, E DA FORMA A DO COMPOSTO IVA, E, FORMULAçãO FARMACêUTICA". A presente invenção refere-se a um novo processo para a preparação de compostos doadores de NO, empregando um intermediário sulfonatado. A invenção refere-se a novos intermediários preparados dele, adequados para fabricação em grande escala de compostos doadores de NO. A invenção refere-se ainda ao uso dos novos intermediários para a fabricação de compostos doadores de NO farmaceuticamente ativos. A invenção referese ainda a uma forma substancialmente cristalina de NSAIDs (medicamentos antiinflamatórios não-esteróides) doadores de NO, especialmente 2-[2(nitróxi)etóxi]etil {2-[(2,6-diclorofenil)amino]fenil}acetato, a sua preparação e a formulações farmacêuticas contendo dita forma cristalina e ao uso de dita forma cristalina na preparação de um medicamento.
BR0314365-1A 2002-09-20 2003-09-18 Processos para a fabricação de compostos doadores de no e para a produção da forma a do composto iva, compostos, usos do processo, dos compostos, e da forma a do composto iva, e, formulação farmacêutica BR0314365A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE0202801A SE0202801D0 (sv) 2002-09-20 2002-09-20 New crystal form
SE0301476A SE0301476D0 (sv) 2003-05-20 2003-05-20 Manufacturing process for no-donating compounds
PCT/SE2003/001465 WO2004026808A1 (en) 2002-09-20 2003-09-18 Manufacturing process for no-donating compounds such as no-donating diclofenac

Publications (1)

Publication Number Publication Date
BR0314365A true BR0314365A (pt) 2005-07-19

Family

ID=32033036

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0314365-1A BR0314365A (pt) 2002-09-20 2003-09-18 Processos para a fabricação de compostos doadores de no e para a produção da forma a do composto iva, compostos, usos do processo, dos compostos, e da forma a do composto iva, e, formulação farmacêutica

Country Status (13)

Country Link
US (2) US20060122402A1 (pt)
EP (1) EP1558559A1 (pt)
JP (1) JP2006500409A (pt)
KR (1) KR20050057496A (pt)
CN (1) CN1684940A (pt)
AU (1) AU2003265035A1 (pt)
BR (1) BR0314365A (pt)
CA (1) CA2498943A1 (pt)
MX (1) MXPA05003050A (pt)
NZ (1) NZ538727A (pt)
PL (1) PL375321A1 (pt)
RU (1) RU2322434C2 (pt)
WO (1) WO2004026808A1 (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1319202B1 (it) 2000-10-12 2003-09-26 Nicox Sa Farmaci per le malattie a base infiammatoria.
JP2005539089A (ja) 2002-07-03 2005-12-22 ニトロメッド インコーポレーティッド ニトロソ化非ステロイド性抗炎症化合物、組成物および使用方法
US7632866B2 (en) 2002-10-21 2009-12-15 Ramot At Tel Aviv University Derivatives of N-phenylanthranilic acid and 2-benzimidazolone as potassium channel and/or neuron activity modulators
SE0301880D0 (sv) * 2003-06-25 2003-06-25 Astrazeneca Uk Ltd New drug delivery composition
EP2203411B1 (en) 2007-09-20 2016-01-06 Ramot at Tel-Aviv University Ltd. N-phenyl anthranilic acid derivatives and uses thereof
WO2009037705A2 (en) * 2007-09-20 2009-03-26 Ramot At Tel Aviv University Ltd. Esters of n-phenylanthranilic acid for use in the treatment of cancer and inflammation

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1546478A (fr) * 1967-01-27 1968-11-22 Rhone Poulenc Sa Nouveaux dérivés de l'acide benzoyl-3 phénylacétique et leur préparation
DE3811118C1 (pt) * 1988-03-31 1989-10-12 Merckle Gmbh, 7902 Blaubeuren, De
ES2073995B1 (es) * 1993-05-17 1996-03-01 Espanola Explosivos Procedimiento para la obtencion de nitratoalquil oxetanos.
BR9407749A (pt) * 1993-10-06 1997-02-12 Nicox Sa Derivados de ácido processo para a preparaçao dos mesmos e composiçoes farmacêuticas
SI0759899T1 (en) * 1994-05-10 1999-12-31 Nicox S.A. Nitro compounds and their compositions having anti-inflammatory, analgesic and anti-thrombotic acitivities
CA2348741C (en) * 1998-10-30 2010-04-20 Nitromed Inc. Nitrosasted and nitrosylated nonsteroidal antiinflammatory compounds, comositions and methods of use
US6355666B1 (en) * 2000-06-23 2002-03-12 Medinox, Inc. Protected forms of pharmacologically active agents and uses therefor

Also Published As

Publication number Publication date
RU2005107785A (ru) 2005-12-10
WO2004026808A1 (en) 2004-04-01
JP2006500409A (ja) 2006-01-05
CN1684940A (zh) 2005-10-19
KR20050057496A (ko) 2005-06-16
NZ538727A (en) 2008-01-31
RU2322434C2 (ru) 2008-04-20
US20090170934A1 (en) 2009-07-02
US20060122402A1 (en) 2006-06-08
PL375321A1 (en) 2005-11-28
CA2498943A1 (en) 2004-04-01
MXPA05003050A (es) 2005-05-27
EP1558559A1 (en) 2005-08-03
AU2003265035A1 (en) 2004-04-08

Similar Documents

Publication Publication Date Title
Lednicer The Organic Chemistry of Drug Synthesis, Volume 7
BR9808540A (pt) Composto, processo para a preparação do mesmo, composição farmacêutica e processo para preparação dos mesmos, uso de um composto, e, processo para produzir a imunossupressão
BR0013823A (pt) Formas de apresentação farmacêuticas de tramadol e seu processo de fabricação
BR9803300A (pt) Formulação farmacêutica.
BR0107564A (pt) Composição de gliburida
NO20071498L (no) Substituerte acylhydroksamsyrer samt fremgangsmate for a redusere TNFa-nivaet
CA2213989A1 (en) External preparation for topical administration
UY25148A1 (es) Método para producir una composición farmacéutica que comprende un análogo de ácido gama aminobutírico (gaba) y una droga antiinflamatoria no esteroide (nsaid)
HUP0101246A2 (hu) Meloxicam új galenusi formulációi orális alkalmazásra és eljárás az előállításukra
NO965012D0 (no) Farmasöytisk preparat som omfatter glukagon
BR0214469A (pt) 17alfa-alquil-17beta-óxi-estratrienos e produtos intermediários para sua preparação, aplicação dos 17alfa-alquil-17beta-óxi-estratrienos para a preparação de medicamentos bem como preparações farmacêuticas
WO2004055006A8 (en) Novel compounds having selective inhibiting effect at gsk3
AR037490A1 (es) Composiciones farmaceuticas solidas, proceso para su preparacion, kit para el tratamiento de la obesidad y uso de dichas composiciones en la elaboracion de medicamentos
DOP2002000512A (es) Sales de acido succinato de 5,7,14-triazatetraciclo [10.3.1.0² ¹¹.04,9] hexadeca-2 (11),3,5,7,9-pentaeno y composiciones farmaceuticas de las mismas
JPH08510479A (ja) 眼の炎症障害を処置するための３‐ベンゾイルフェニル酢酸誘導体を含む局所的に投与可能な組成物
BR0208382A (pt) Forma de dosagem oral contendo nicotina
HUP0000140A2 (hu) Tárolással szemben stabil felszabadulásprofillal rendelkező retard tramadolkészítmények és eljárás ezek előállítására
HUP0203444A2 (hu) (S)-2-Etoxi-3-[4-{2-[4-(metánszulfonil-oxi)-fenil]-etoxi}-fenil]-propionsav kristályos formája, eljárás az előállítására, ezt tartalmazó gyógyszerkészítmény és alkalmazása
BR0314365A (pt) Processos para a fabricação de compostos doadores de no e para a produção da forma a do composto iva, compostos, usos do processo, dos compostos, e da forma a do composto iva, e, formulação farmacêutica
BR0107899A (pt) Processo para produzir uma preparação de ingrediente ativo compreendendo ibuprofeno, preparação de ingrediente ativo, uso da mesma, preparação farmacêutica, uso da mesma, processo para produzir formas de dosagem sólidas, e, forma de dosagem sólida
DE60042831D1 (de) Pharmazeutisch aktive sulfonylaminosäurederivate
SE0102440D0 (sv) New compound
PT1268407E (pt) Derivados de amidoxima de acido propenocarboxilico, um processo para a sua preparacao e composicoes farmaceuticas contendo os mesmos
WO2004113391A3 (en) Improved pharmaceutical drug candidates and methods for preparation thereof
ES2201433T3 (es) Estereoisomeros de valnoctamida, metodo para su sintesis y separacion y uso de los mismos.

Legal Events

Date Code Title Description
B25G Requested change of headquarter approved

Owner name: NICOX S.A. (FR)

Free format text: SEDE ALTERADA CONFORME SOLICITADO NA PETICAO NO 020070016104/RJ DE 07/02/2007.

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 8A ANUIDADE(S).

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2142 DE 24/01/2012.