HUP0204095A2 - Szubsztituált benzoilguanidinek, eljárás előállításukra, gyógyszerként vagy diagnosztikai szerként történő alkalmazásuk és a vegyületeket tartalmazó gyógyszerkészítmények - Google Patents
Szubsztituált benzoilguanidinek, eljárás előállításukra, gyógyszerként vagy diagnosztikai szerként történő alkalmazásuk és a vegyületeket tartalmazó gyógyszerkészítményekInfo
- Publication number
- HUP0204095A2 HUP0204095A2 HU0204095A HUP0204095A HUP0204095A2 HU P0204095 A2 HUP0204095 A2 HU P0204095A2 HU 0204095 A HU0204095 A HU 0204095A HU P0204095 A HUP0204095 A HU P0204095A HU P0204095 A2 HUP0204095 A2 HU P0204095A2
- Authority
- HU
- Hungary
- Prior art keywords
- production
- group
- compounds
- general formula
- medicament
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- AJDQRQQNNLZLPM-UHFFFAOYSA-N n-(diaminomethylidene)benzamide Chemical class NC(N)=NC(=O)C1=CC=CC=C1 AJDQRQQNNLZLPM-UHFFFAOYSA-N 0.000 title abstract 2
- 239000000032 diagnostic agent Substances 0.000 title 1
- 229940039227 diagnostic agent Drugs 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 239000000460 chlorine Substances 0.000 abstract 2
- 229910052801 chlorine Inorganic materials 0.000 abstract 2
- 229910052731 fluorine Inorganic materials 0.000 abstract 2
- 239000011737 fluorine Substances 0.000 abstract 2
- -1 methoxy, hydroxyl - Chemical class 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical group [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 abstract 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 239000003416 antiarrhythmic agent Substances 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 230000003293 cardioprotective effect Effects 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 239000011630 iodine Chemical group 0.000 abstract 1
- 229910052740 iodine Inorganic materials 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 208000010125 myocardial infarction Diseases 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
- C07C279/22—Y being a hydrogen or a carbon atom, e.g. benzoylguanidines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Endocrinology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Vascular Medicine (AREA)
- Emergency Medicine (AREA)
- Pulmonology (AREA)
- Reproductive Health (AREA)
- Gastroenterology & Hepatology (AREA)
- Surgery (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
A találmány (I) általános képletű benzoilguanidinekre vonatkozik, aholR2 jelentése -Y-p-(C6H4)-R11, -Y-m-(C6H4)-R11 vagy -Y-o-(C6H4)-R11általános képletű csoport; ahol R11 jelentése 1-9 szénatomosheteroaril-csoport, amely szén- vagy nitrogénatomon keresztülkapcsolódik, és amely szubsztituálatlan vagy 1-3-szorosan az alábbicsoportok közül valamelyikkel szubsztituálva van: fluor-, klóratom,trifluor- metil-, metil-, metoxi-, hidroxil-, amino-, metilamino-,dimetilamino- vagy benzilcsoport; Y jelentése oxigén-, kénatom vagy NR12 általános képletű csoport;R12 jelentése hidrogénatom vagy 1-4 szénatomos alkilcsoport; R4jelentése fluor-, klór-, bróm-, jódatom vagy 1-4 szénatomosalkilcsoport; R1 és R3 jelentése az igénypontok szerinti. A vegyületekszívvédő komponenst tartalmazó antiarritmiás gyógyszerkénthasználhatók infarktus megelőzésére és kezelésére. A találmány avegyületek előállítására szolgáló eljárást és a vegyületekettartalmazó gyógyszerészeti készítményeket is magában foglalja. Ó
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10001879A DE10001879A1 (de) | 2000-01-19 | 2000-01-19 | Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| PCT/EP2001/000137 WO2001053256A1 (de) | 2000-01-19 | 2001-01-08 | Substituierte benzoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikament oder diagnostikum sowie sie enthaltendes medikament |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0204095A2 true HUP0204095A2 (hu) | 2003-04-28 |
| HUP0204095A3 HUP0204095A3 (en) | 2005-05-30 |
Family
ID=7627855
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0204095A HUP0204095A3 (en) | 2000-01-19 | 2001-01-08 | Substituted benzoylguanidines, method for their production, their use as a medicament or diagnostic agent and pharmaceutical compositions containing the same |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US6703411B2 (hu) |
| EP (1) | EP1259481B1 (hu) |
| JP (1) | JP4880849B2 (hu) |
| KR (1) | KR100726701B1 (hu) |
| CN (1) | CN1184196C (hu) |
| AR (1) | AR027237A1 (hu) |
| AT (1) | ATE530518T1 (hu) |
| AU (1) | AU780466B2 (hu) |
| BR (1) | BR0107660A (hu) |
| CA (1) | CA2397531A1 (hu) |
| CZ (1) | CZ20022465A3 (hu) |
| DE (1) | DE10001879A1 (hu) |
| EE (1) | EE200200381A (hu) |
| HK (1) | HK1051853A1 (hu) |
| HR (1) | HRP20020592A2 (hu) |
| HU (1) | HUP0204095A3 (hu) |
| IL (1) | IL150740A0 (hu) |
| MX (1) | MXPA02006431A (hu) |
| NO (1) | NO20023383L (hu) |
| NZ (1) | NZ520213A (hu) |
| PL (1) | PL356589A1 (hu) |
| RU (1) | RU2267486C2 (hu) |
| SK (1) | SK10382002A3 (hu) |
| TW (1) | TWI240718B (hu) |
| WO (1) | WO2001053256A1 (hu) |
| YU (1) | YU52202A (hu) |
| ZA (1) | ZA200205696B (hu) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10204989A1 (de) * | 2002-02-07 | 2003-08-21 | Aventis Pharma Gmbh | Dihydro-thia-phenanthren-carbonyl-guanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| US20050124666A1 (en) | 2003-11-13 | 2005-06-09 | Aventis Pharma Deutschland Gmbh | Pentafluorosulfanylbenzoylguanidines, process for their preparation, use as a medicament or diagnostic aid, and medicament comprising same |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0556673B1 (de) * | 1992-02-15 | 1997-09-17 | Hoechst Aktiengesellschaft | Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| JP2689058B2 (ja) * | 1992-11-02 | 1997-12-10 | 新日本製鐵株式会社 | 塗装体の乾燥・焼付装置 |
| DE4325822A1 (de) * | 1993-07-31 | 1995-02-02 | Hoechst Ag | Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| DE4328869A1 (de) * | 1993-08-27 | 1995-03-02 | Hoechst Ag | Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| DE4430861A1 (de) * | 1994-08-31 | 1996-03-07 | Merck Patent Gmbh | Heterocyclyl-benzoylguanidine |
| DE4430916A1 (de) * | 1994-08-31 | 1996-03-07 | Merck Patent Gmbh | Alkyl-benzoylguanidin-Derivate |
| DE19529612A1 (de) | 1995-08-11 | 1997-02-13 | Merck Patent Gmbh | Sulfonyl- oder Sulfinyl-benzoylguanidin-Derivate |
| DE19608161A1 (de) * | 1996-03-04 | 1997-09-11 | Hoechst Ag | Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| DE19621319A1 (de) * | 1996-05-28 | 1997-12-04 | Hoechst Ag | Bis-ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| DE19624178A1 (de) | 1996-06-18 | 1998-01-08 | Hoechst Ag | Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
-
2000
- 2000-01-19 DE DE10001879A patent/DE10001879A1/de not_active Withdrawn
-
2001
- 2001-01-08 EP EP01900139A patent/EP1259481B1/de not_active Expired - Lifetime
- 2001-01-08 HU HU0204095A patent/HUP0204095A3/hu unknown
- 2001-01-08 JP JP2001553261A patent/JP4880849B2/ja not_active Expired - Fee Related
- 2001-01-08 AU AU23732/01A patent/AU780466B2/en not_active Ceased
- 2001-01-08 WO PCT/EP2001/000137 patent/WO2001053256A1/de active IP Right Grant
- 2001-01-08 MX MXPA02006431A patent/MXPA02006431A/es active IP Right Grant
- 2001-01-08 CA CA002397531A patent/CA2397531A1/en not_active Abandoned
- 2001-01-08 RU RU2002122089/04A patent/RU2267486C2/ru not_active IP Right Cessation
- 2001-01-08 PL PL01356589A patent/PL356589A1/xx not_active Application Discontinuation
- 2001-01-08 IL IL15074001A patent/IL150740A0/xx unknown
- 2001-01-08 CN CNB018038247A patent/CN1184196C/zh not_active Expired - Fee Related
- 2001-01-08 AT AT01900139T patent/ATE530518T1/de active
- 2001-01-08 SK SK1038-2002A patent/SK10382002A3/sk not_active Application Discontinuation
- 2001-01-08 EE EEP200200381A patent/EE200200381A/xx unknown
- 2001-01-08 YU YU52202A patent/YU52202A/sh unknown
- 2001-01-08 BR BR0107660-4A patent/BR0107660A/pt not_active IP Right Cessation
- 2001-01-08 KR KR1020027009256A patent/KR100726701B1/ko not_active IP Right Cessation
- 2001-01-08 CZ CZ20022465A patent/CZ20022465A3/cs unknown
- 2001-01-08 NZ NZ520213A patent/NZ520213A/en unknown
- 2001-01-17 US US09/760,670 patent/US6703411B2/en not_active Expired - Fee Related
- 2001-01-17 TW TW090100987A patent/TWI240718B/zh not_active IP Right Cessation
- 2001-01-17 AR ARP010100207A patent/AR027237A1/es unknown
-
2002
- 2002-07-12 NO NO20023383A patent/NO20023383L/no not_active Application Discontinuation
- 2002-07-16 HR HR20020592A patent/HRP20020592A2/hr not_active Application Discontinuation
- 2002-07-17 ZA ZA200205696A patent/ZA200205696B/xx unknown
-
2003
- 2003-06-11 HK HK03104145A patent/HK1051853A1/xx not_active IP Right Cessation
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