MXPA02006431A - Benzoilguanidinas susbstituidas, metodo para su produccion, su uso como medicamento o agente de diagnostico y un medicamento que contiene las mismas. - Google Patents

Benzoilguanidinas susbstituidas, metodo para su produccion, su uso como medicamento o agente de diagnostico y un medicamento que contiene las mismas.

Info

Publication number
MXPA02006431A
MXPA02006431A MXPA02006431A MXPA02006431A MXPA02006431A MX PA02006431 A MXPA02006431 A MX PA02006431A MX PA02006431 A MXPA02006431 A MX PA02006431A MX PA02006431 A MXPA02006431 A MX PA02006431A MX PA02006431 A MXPA02006431 A MX PA02006431A
Authority
MX
Mexico
Prior art keywords
medicament
benzoylguanidines
production
same
diagnostic agent
Prior art date
Application number
MXPA02006431A
Other languages
English (en)
Inventor
Andreas Weichert
Original Assignee
Aventis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh
Publication of MXPA02006431A publication Critical patent/MXPA02006431A/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
    • C07C279/22—Y being a hydrogen or a carbon atom, e.g. benzoylguanidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Neurology (AREA)
  • Surgery (AREA)
  • Emergency Medicine (AREA)
  • Neurosurgery (AREA)
  • Vascular Medicine (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

La invencion se refiere a benzoilguanidinas de la formula (I), en donde R2 indica -Y-p- (C6H4)-R11, -Y-m-(C6H4)-R11 o -Y- o-(C6H4)-R11; R11 representa al heteroarilo(C1- C9) que esta enlazado via un C o N y que esta no substituido o susbtituido por 1 a 3 sustituyentes seleccionados a partir del grupo que consiste de F, C1, CF3, CH3 metoxi, hidroxi, amino, metilamino, dimetilamino y bencilo; Y representa oxigeno; -S- o NR12; R12 representa H o alquilo (C1-C4); R4 es F, C1, Br, I o alquilo C1-C4; R1 y R3 estan definidos por las reivindicaciones. Dichas benzoilguanidinas son adecuadas para usarse como medicamentos anti-arritmicos que, contienen componentes cardioprotectores para la profilaxis y el tratamiento de infartos y para el tratamiento de angina de pecho. Estas inhiben tambien preventivamente los procesos patofisiologicos asociados con el origen de los defectos provocados por . la isquemia, en particular durante la activacion de la arritmia cardiaca isquemicamente inducida.
MXPA02006431A 2000-01-19 2001-01-08 Benzoilguanidinas susbstituidas, metodo para su produccion, su uso como medicamento o agente de diagnostico y un medicamento que contiene las mismas. MXPA02006431A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10001879A DE10001879A1 (de) 2000-01-19 2000-01-19 Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
PCT/EP2001/000137 WO2001053256A1 (de) 2000-01-19 2001-01-08 Substituierte benzoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikament oder diagnostikum sowie sie enthaltendes medikament

Publications (1)

Publication Number Publication Date
MXPA02006431A true MXPA02006431A (es) 2002-11-29

Family

ID=7627855

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA02006431A MXPA02006431A (es) 2000-01-19 2001-01-08 Benzoilguanidinas susbstituidas, metodo para su produccion, su uso como medicamento o agente de diagnostico y un medicamento que contiene las mismas.

Country Status (27)

Country Link
US (1) US6703411B2 (es)
EP (1) EP1259481B1 (es)
JP (1) JP4880849B2 (es)
KR (1) KR100726701B1 (es)
CN (1) CN1184196C (es)
AR (1) AR027237A1 (es)
AT (1) ATE530518T1 (es)
AU (1) AU780466B2 (es)
BR (1) BR0107660A (es)
CA (1) CA2397531A1 (es)
CZ (1) CZ20022465A3 (es)
DE (1) DE10001879A1 (es)
EE (1) EE200200381A (es)
HK (1) HK1051853A1 (es)
HR (1) HRP20020592A2 (es)
HU (1) HUP0204095A3 (es)
IL (1) IL150740A0 (es)
MX (1) MXPA02006431A (es)
NO (1) NO20023383L (es)
NZ (1) NZ520213A (es)
PL (1) PL356589A1 (es)
RU (1) RU2267486C2 (es)
SK (1) SK10382002A3 (es)
TW (1) TWI240718B (es)
WO (1) WO2001053256A1 (es)
YU (1) YU52202A (es)
ZA (1) ZA200205696B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10204989A1 (de) * 2002-02-07 2003-08-21 Aventis Pharma Gmbh Dihydro-thia-phenanthren-carbonyl-guanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
US20050124666A1 (en) 2003-11-13 2005-06-09 Aventis Pharma Deutschland Gmbh Pentafluorosulfanylbenzoylguanidines, process for their preparation, use as a medicament or diagnostic aid, and medicament comprising same

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE158278T1 (de) * 1992-02-15 1997-10-15 Hoechst Ag Ortho-substituierte benzoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikament oder diagnostikum sowie sie enthaltendes medikament
JP2689058B2 (ja) * 1992-11-02 1997-12-10 新日本製鐵株式会社 塗装体の乾燥・焼付装置
DE4325822A1 (de) * 1993-07-31 1995-02-02 Hoechst Ag Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE4328869A1 (de) 1993-08-27 1995-03-02 Hoechst Ag Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE4430861A1 (de) * 1994-08-31 1996-03-07 Merck Patent Gmbh Heterocyclyl-benzoylguanidine
DE4430916A1 (de) 1994-08-31 1996-03-07 Merck Patent Gmbh Alkyl-benzoylguanidin-Derivate
DE19529612A1 (de) * 1995-08-11 1997-02-13 Merck Patent Gmbh Sulfonyl- oder Sulfinyl-benzoylguanidin-Derivate
DE19608161A1 (de) * 1996-03-04 1997-09-11 Hoechst Ag Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19621319A1 (de) * 1996-05-28 1997-12-04 Hoechst Ag Bis-ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19624178A1 (de) 1996-06-18 1998-01-08 Hoechst Ag Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament

Also Published As

Publication number Publication date
BR0107660A (pt) 2002-11-19
IL150740A0 (en) 2003-02-12
JP4880849B2 (ja) 2012-02-22
HK1051853A1 (en) 2003-08-22
YU52202A (sh) 2006-01-16
PL356589A1 (en) 2004-06-28
SK10382002A3 (sk) 2003-04-01
AU780466B2 (en) 2005-03-24
HRP20020592A2 (en) 2004-08-31
NO20023383D0 (no) 2002-07-12
ZA200205696B (en) 2003-11-26
RU2267486C2 (ru) 2006-01-10
EP1259481A1 (de) 2002-11-27
US20010016596A1 (en) 2001-08-23
JP2003520267A (ja) 2003-07-02
KR100726701B1 (ko) 2007-06-13
AU2373201A (en) 2001-07-31
WO2001053256A1 (de) 2001-07-26
HUP0204095A2 (hu) 2003-04-28
DE10001879A1 (de) 2001-07-19
NZ520213A (en) 2004-08-27
ATE530518T1 (de) 2011-11-15
US6703411B2 (en) 2004-03-09
CN1184196C (zh) 2005-01-12
KR20020073175A (ko) 2002-09-19
CZ20022465A3 (cs) 2002-10-16
EP1259481B1 (de) 2011-10-26
CN1395558A (zh) 2003-02-05
EE200200381A (et) 2003-12-15
NO20023383L (no) 2002-09-03
RU2002122089A (ru) 2004-01-10
AR027237A1 (es) 2003-03-19
HUP0204095A3 (en) 2005-05-30
CA2397531A1 (en) 2001-07-26
TWI240718B (en) 2005-10-01

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