BR0107660A - Benzoilguanidinas substituìdas, processo para a sua preparação, seu uso como medicamento ou diagnóstico bem como medicamento contendo as mesmas - Google Patents
Benzoilguanidinas substituìdas, processo para a sua preparação, seu uso como medicamento ou diagnóstico bem como medicamento contendo as mesmasInfo
- Publication number
- BR0107660A BR0107660A BR0107660-4A BR0107660A BR0107660A BR 0107660 A BR0107660 A BR 0107660A BR 0107660 A BR0107660 A BR 0107660A BR 0107660 A BR0107660 A BR 0107660A
- Authority
- BR
- Brazil
- Prior art keywords
- medicine
- well
- preparation
- diagnosis
- substituted
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
- C07C279/22—Y being a hydrogen or a carbon atom, e.g. benzoylguanidines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Emergency Medicine (AREA)
- Surgery (AREA)
- Vascular Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Gastroenterology & Hepatology (AREA)
- Reproductive Health (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
"BENZOILGUANIDINAS SUBSTITUìDAS, PROCESSO PARA A SUA PREPARAçãO, SEU USO COMO MEDICAMENTO OU DIAGNóSTICO BEM COMO MEDICAMENTO CONTENDO AS MESMAS". A invenção refere-se a benzoilguanidinas de fórmula (I), em que R2 significa -Y-p-(C~ 6~H~ 4~)-R11, -Y-m-(C~ 6~H~ 4~)-R11 ou -Y-o-(C~ 6~H~ 4~)-R11; R11 significa (C~ 1~-C~ 9~)-heteroarila, que está ligada através de C ou N e que é não substituída ou substituída com 1 até 3 substituintes escolhidos dos grupos consistindo em F, CI, CF~ 3~, CH~ 3~, metóxi, hidróxi, amino, metilamino, dimetilamino e benzila; Y significa oxigênio, -S- ou NR12; R12 significa H ou (C~ 1~-C~ 4~)-alquila; R4 significa F, CI, Br, I ou C~ 1~-C~ 4~-alquila; R1 e R3 possuem os significados dados nas reivindicações, são adequadas como medicamento antiarrítmicos com componentes cardioprotetores para a profilaxia de infartos e para o tratamento de infartos, bem como para o tratamento da angina pectoris. Elas inibem também, de modo preventivo, os processos patofisiológicos no surgimento de doenças induzidas por isquemia, particularmente no início de arritmias cardíacas induzidas por isquemias.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10001879A DE10001879A1 (de) | 2000-01-19 | 2000-01-19 | Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
PCT/EP2001/000137 WO2001053256A1 (de) | 2000-01-19 | 2001-01-08 | Substituierte benzoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikament oder diagnostikum sowie sie enthaltendes medikament |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0107660A true BR0107660A (pt) | 2002-11-19 |
Family
ID=7627855
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0107660-4A BR0107660A (pt) | 2000-01-19 | 2001-01-08 | Benzoilguanidinas substituìdas, processo para a sua preparação, seu uso como medicamento ou diagnóstico bem como medicamento contendo as mesmas |
Country Status (27)
Country | Link |
---|---|
US (1) | US6703411B2 (pt) |
EP (1) | EP1259481B1 (pt) |
JP (1) | JP4880849B2 (pt) |
KR (1) | KR100726701B1 (pt) |
CN (1) | CN1184196C (pt) |
AR (1) | AR027237A1 (pt) |
AT (1) | ATE530518T1 (pt) |
AU (1) | AU780466B2 (pt) |
BR (1) | BR0107660A (pt) |
CA (1) | CA2397531A1 (pt) |
CZ (1) | CZ20022465A3 (pt) |
DE (1) | DE10001879A1 (pt) |
EE (1) | EE200200381A (pt) |
HK (1) | HK1051853A1 (pt) |
HR (1) | HRP20020592A2 (pt) |
HU (1) | HUP0204095A3 (pt) |
IL (1) | IL150740A0 (pt) |
MX (1) | MXPA02006431A (pt) |
NO (1) | NO20023383L (pt) |
NZ (1) | NZ520213A (pt) |
PL (1) | PL356589A1 (pt) |
RU (1) | RU2267486C2 (pt) |
SK (1) | SK10382002A3 (pt) |
TW (1) | TWI240718B (pt) |
WO (1) | WO2001053256A1 (pt) |
YU (1) | YU52202A (pt) |
ZA (1) | ZA200205696B (pt) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10204989A1 (de) * | 2002-02-07 | 2003-08-21 | Aventis Pharma Gmbh | Dihydro-thia-phenanthren-carbonyl-guanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
US20050124666A1 (en) | 2003-11-13 | 2005-06-09 | Aventis Pharma Deutschland Gmbh | Pentafluorosulfanylbenzoylguanidines, process for their preparation, use as a medicament or diagnostic aid, and medicament comprising same |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0556673B1 (de) * | 1992-02-15 | 1997-09-17 | Hoechst Aktiengesellschaft | Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
JP2689058B2 (ja) * | 1992-11-02 | 1997-12-10 | 新日本製鐵株式会社 | 塗装体の乾燥・焼付装置 |
DE4325822A1 (de) * | 1993-07-31 | 1995-02-02 | Hoechst Ag | Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
DE4328869A1 (de) | 1993-08-27 | 1995-03-02 | Hoechst Ag | Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
DE4430916A1 (de) * | 1994-08-31 | 1996-03-07 | Merck Patent Gmbh | Alkyl-benzoylguanidin-Derivate |
DE4430861A1 (de) | 1994-08-31 | 1996-03-07 | Merck Patent Gmbh | Heterocyclyl-benzoylguanidine |
DE19529612A1 (de) | 1995-08-11 | 1997-02-13 | Merck Patent Gmbh | Sulfonyl- oder Sulfinyl-benzoylguanidin-Derivate |
DE19608161A1 (de) * | 1996-03-04 | 1997-09-11 | Hoechst Ag | Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
DE19621319A1 (de) * | 1996-05-28 | 1997-12-04 | Hoechst Ag | Bis-ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
DE19624178A1 (de) | 1996-06-18 | 1998-01-08 | Hoechst Ag | Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
-
2000
- 2000-01-19 DE DE10001879A patent/DE10001879A1/de not_active Withdrawn
-
2001
- 2001-01-08 KR KR1020027009256A patent/KR100726701B1/ko not_active IP Right Cessation
- 2001-01-08 SK SK1038-2002A patent/SK10382002A3/sk not_active Application Discontinuation
- 2001-01-08 AU AU23732/01A patent/AU780466B2/en not_active Ceased
- 2001-01-08 CZ CZ20022465A patent/CZ20022465A3/cs unknown
- 2001-01-08 RU RU2002122089/04A patent/RU2267486C2/ru not_active IP Right Cessation
- 2001-01-08 JP JP2001553261A patent/JP4880849B2/ja not_active Expired - Fee Related
- 2001-01-08 BR BR0107660-4A patent/BR0107660A/pt not_active IP Right Cessation
- 2001-01-08 EP EP01900139A patent/EP1259481B1/de not_active Expired - Lifetime
- 2001-01-08 EE EEP200200381A patent/EE200200381A/xx unknown
- 2001-01-08 AT AT01900139T patent/ATE530518T1/de active
- 2001-01-08 CN CNB018038247A patent/CN1184196C/zh not_active Expired - Fee Related
- 2001-01-08 WO PCT/EP2001/000137 patent/WO2001053256A1/de active IP Right Grant
- 2001-01-08 YU YU52202A patent/YU52202A/sh unknown
- 2001-01-08 MX MXPA02006431A patent/MXPA02006431A/es active IP Right Grant
- 2001-01-08 PL PL01356589A patent/PL356589A1/xx not_active Application Discontinuation
- 2001-01-08 IL IL15074001A patent/IL150740A0/xx unknown
- 2001-01-08 CA CA002397531A patent/CA2397531A1/en not_active Abandoned
- 2001-01-08 NZ NZ520213A patent/NZ520213A/en unknown
- 2001-01-08 HU HU0204095A patent/HUP0204095A3/hu unknown
- 2001-01-17 AR ARP010100207A patent/AR027237A1/es unknown
- 2001-01-17 TW TW090100987A patent/TWI240718B/zh not_active IP Right Cessation
- 2001-01-17 US US09/760,670 patent/US6703411B2/en not_active Expired - Fee Related
-
2002
- 2002-07-12 NO NO20023383A patent/NO20023383L/no not_active Application Discontinuation
- 2002-07-16 HR HR20020592A patent/HRP20020592A2/hr not_active Application Discontinuation
- 2002-07-17 ZA ZA200205696A patent/ZA200205696B/xx unknown
-
2003
- 2003-06-11 HK HK03104145A patent/HK1051853A1/xx not_active IP Right Cessation
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B25D | Requested change of name of applicant approved |
Owner name: SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) Free format text: ALTERADO DE: AVENTIS PHARMA DEUTSCHLAND GMBH |
|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 8A, 9A E 10A ANUIDADE(S). |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2116 DE 26/07/2011. |