HUP0203796A2 - A pharmaceutical dosage form, a method and an apparatus for the continuous production of a microrelief on an ingestible dosage form having a core which can contain a pharmaceutically active substance - Google Patents

A pharmaceutical dosage form, a method and an apparatus for the continuous production of a microrelief on an ingestible dosage form having a core which can contain a pharmaceutically active substance

Info

Publication number
HUP0203796A2
HUP0203796A2 HU0203796A HUP0203796A HUP0203796A2 HU P0203796 A2 HUP0203796 A2 HU P0203796A2 HU 0203796 A HU0203796 A HU 0203796A HU P0203796 A HUP0203796 A HU P0203796A HU P0203796 A2 HUP0203796 A2 HU P0203796A2
Authority
HU
Hungary
Prior art keywords
microrelief
dosage form
active substance
material layer
coating layer
Prior art date
Application number
HU0203796A
Other languages
English (en)
Inventor
Eric Begleiter
Original Assignee
Dimensional Foods Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dimensional Foods Corp filed Critical Dimensional Foods Corp
Publication of HUP0203796A2 publication Critical patent/HUP0203796A2/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/005—Coating of tablets or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/007—Marking tablets or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/10—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of compressed tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2886—Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4891—Coated capsules; Multilayered drug free capsule shells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B30—PRESSES
    • B30B—PRESSES IN GENERAL
    • B30B11/00—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses
    • B30B11/02—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses using a ram exerting pressure on the material in a moulding space
    • B30B11/08—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses using a ram exerting pressure on the material in a moulding space co-operating with moulds carried by a turntable
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B30—PRESSES
    • B30B—PRESSES IN GENERAL
    • B30B11/00—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses
    • B30B11/02—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses using a ram exerting pressure on the material in a moulding space
    • B30B11/14—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses using a ram exerting pressure on the material in a moulding space co-operating with moulds on a movable carrier other than a turntable or a rotating drum
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B30—PRESSES
    • B30B—PRESSES IN GENERAL
    • B30B15/00—Details of, or accessories for, presses; Auxiliary measures in connection with pressing
    • B30B15/06—Platens or press rams
    • B30B15/065—Press rams
    • G—PHYSICS
    • G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
    • G03H—HOLOGRAPHIC PROCESSES OR APPARATUS
    • G03H1/00—Holographic processes or apparatus using light, infrared or ultraviolet waves for obtaining holograms or for obtaining an image from them; Details peculiar thereto
    • G03H1/02—Details of features involved during the holographic process; Replication of holograms without interference recording
    • G03H1/024—Hologram nature or properties
    • G03H1/0244—Surface relief holograms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J2205/00—General identification or selection means
    • A61J2205/20—Colour codes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J2205/00—General identification or selection means
    • A61J2205/40—General identification or selection means by shape or form, e.g. by using shape recognition
    • G—PHYSICS
    • G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
    • G03H—HOLOGRAPHIC PROCESSES OR APPARATUS
    • G03H1/00—Holographic processes or apparatus using light, infrared or ultraviolet waves for obtaining holograms or for obtaining an image from them; Details peculiar thereto
    • G03H1/0005—Adaptation of holography to specific applications
    • G03H2001/0055—Adaptation of holography to specific applications in advertising or decorative art
    • G—PHYSICS
    • G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
    • G03H—HOLOGRAPHIC PROCESSES OR APPARATUS
    • G03H2270/00—Substrate bearing the hologram
    • G03H2270/10—Composition

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mechanical Engineering (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Preparation (AREA)
  • Holo Graphy (AREA)
  • General Preparation And Processing Of Foods (AREA)
  • Diffracting Gratings Or Hologram Optical Elements (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

A találmány tárgya olyan fogyasztható termék, előnyösen gyógyászatilagaktív anyagot tartalmazó egység dózisforma (10), amelynek információttartalmazó nagyfelbontású mikroreliefet (16) fogadó és megtartóanyagrétege van. A mikrorelief (16) hőformázással állítható elő, éselőnyösen HPMC és/vagy HPC, továbbá lágyító és színezőanyag vizesoldatából van kialakítva. Az alkalmazástól függően egyéb adalékokat,például szilárdítószereket, felületaktív anyagokat és tapadóanyagokatszintén használhatnak. Az anyagokat a mikrorelief (16) által generáltlátható kép vagy effektus kifakulásának vagy színváltozásánakellenőrzésére választják ki és keverik össze megfelelő arányban, hogyaz elfogadhatatlanul magas hőmérsékletnek vagy páratartalomnak valókitétel jelezhető legyen. A dózisformát (10) a mikrorelieffel (16)ellátott, és térfogatában a gyógyszerkészítményt hordozó anyagrétegmaga is képezheti. Egyik előnyös kiviteli alakjában az anyagréteg egy,a gyógyászatilag aktív anyagot tartalmazó magot (14) beborító külsőbevonóréteget (12) képez. A drazsék az ikresedésnek ellenállón vannakkialakítva. A találmány szerinti dózisformák (10) előállítása céljábóla bevonattal ellátott magokat (14) a mikroreliefnek (16) a dózisforma(10) külső bevonórétegében (12) történő replikálását melegítésselmegvalósító hajlékony présformával vagy átírólemezzel együtttovábbítják, amit hűtés, majd az átírólemez bevonórétegtől (12) valóelválasztása követ. Ó
HU0203796A 1999-08-05 2000-08-03 A pharmaceutical dosage form, a method and an apparatus for the continuous production of a microrelief on an ingestible dosage form having a core which can contain a pharmaceutically active substance HUP0203796A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14740699P 1999-08-05 1999-08-05
PCT/US2000/021149 WO2001010464A1 (en) 1999-08-05 2000-08-03 Edible holographic products, particularly pharmaceuticals and methods and apparatus for producing same

Publications (1)

Publication Number Publication Date
HUP0203796A2 true HUP0203796A2 (en) 2003-03-28

Family

ID=22521454

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0203796A HUP0203796A2 (en) 1999-08-05 2000-08-03 A pharmaceutical dosage form, a method and an apparatus for the continuous production of a microrelief on an ingestible dosage form having a core which can contain a pharmaceutically active substance

Country Status (37)

Country Link
US (2) US7083805B2 (hu)
EP (1) EP1206280A4 (hu)
JP (1) JP2003506415A (hu)
KR (1) KR20020059358A (hu)
CN (2) CN1650844A (hu)
AP (1) AP2002002434A0 (hu)
AR (1) AR028158A1 (hu)
AU (1) AU772936C (hu)
BG (1) BG106424A (hu)
BR (1) BR0012920A (hu)
CA (1) CA2378591A1 (hu)
CO (1) CO5200853A1 (hu)
CR (1) CR6572A (hu)
CZ (1) CZ2002207A3 (hu)
EA (1) EA004895B1 (hu)
EE (1) EE200200058A (hu)
GE (1) GEP20043376B (hu)
GT (1) GT200000126A (hu)
HK (1) HK1048437A1 (hu)
HN (1) HN2000000165A (hu)
HR (1) HRP20020199A2 (hu)
HU (1) HUP0203796A2 (hu)
IL (1) IL147943A0 (hu)
IS (1) IS6244A (hu)
MX (1) MXPA02001176A (hu)
NO (1) NO20020545L (hu)
NZ (1) NZ516741A (hu)
OA (1) OA12044A (hu)
PA (1) PA8499001A1 (hu)
PE (1) PE20010664A1 (hu)
PL (1) PL353615A1 (hu)
SK (1) SK1792002A3 (hu)
TR (1) TR200200309T2 (hu)
UY (1) UY26270A1 (hu)
WO (1) WO2001010464A1 (hu)
YU (1) YU7602A (hu)
ZA (1) ZA200200605B (hu)

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